In vitro endocrine disruption potential of organophosphate flame retardants via human nuclear receptors

Toxicology

Volumn 314, Issue 1, 2013, Pages 76-83

  Kojima, Hiroyuki ^a   Takeuchi, Shinji ^a   Itoh, Toshihiro ^b   Iida, Mitsuru ^c   Kobayashi, Satoshi ^a   Yoshida, Takahiko ^b  

^a HOKKAIDO INSTITUTE OF PUBLIC HEALTH   (Japan)

^b ASAHIKAWA MEDICAL COLLEGE   (Japan)

^c OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Flame retardant; Human; Nuclear receptor; Organophosphate; Reporter gene assay

Indexed keywords

ANDROGEN RECEPTOR; CELL NUCLEUS RECEPTOR; CIPROFIBRATE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FLAME RETARDANT; ORGANOPHOSPHATE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATE; PIOGLITAZONE; PREGNANE X RECEPTOR; RETINOIC ACID RECEPTOR ALPHA; RETINOID X RECEPTOR ALPHA; THYROID HORMONE RECEPTOR ALPHA; THYROID HORMONE RECEPTOR BETA; TRIBUTYL PHOSPHATE; BETA GALACTOSIDASE; CELL RECEPTOR; ENDOCRINE DISRUPTOR; ORGANOPHOSPHORUS COMPOUND;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; ENDOCRINE DISEASE; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; TRANSACTIVATION; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CHLOROCEBUS AETHIOPS; CHO CELL LINE; COS 1 CELL LINE; CRICETULUS; DOSE RESPONSE; DRUG EFFECTS; GENETIC TRANSCRIPTION; GENETICS; HAMSTER; HUMAN; METABOLISM; PLASMID; REPORTER GENE; TOXICITY;

ANIMALS; BETA-GALACTOSIDASE; CERCOPITHECUS AETHIOPS; CHO CELLS; COS CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE DISRUPTORS; FLAME RETARDANTS; GENES, REPORTER; HUMANS; ORGANOPHOSPHORUS COMPOUNDS; PLASMIDS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION, GENETIC;

EID: 84885363534     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2013.09.004     Document Type: Article

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