Garlic as an anti-diabetic agent: Recent progress and patent reviews

Recent Patents on Food, Nutrition and Agriculture

Volumn 5, Issue 2, 2013, Pages 105-127

  Padiya, Raju ^a   Banerjee, Sanjay K ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Ajoene; Allicin; Allyl mercaptan; Animal studies; Diabetes; Garlic; Human studies; Patent; S allyl cysteine

Indexed keywords

ALLIUM SATIVUM; ANIMALIA;

EID: 84885358033     PISSN: 22127984     EISSN: 18761429     Source Type: Journal    
DOI: 10.2174/18761429113059990002     Document Type: Article

References (120)

1. Banerjee SK, Maulik SK. Effect of garlic on cardiovascular disorders: A review. Nutr J 2002; 1:4.
2. Ensminger AH. Foods & nutrition encyclopedia. Volume 1 CRC Press 1994; ISBN 0-8493-8980-1.
3. Simonetti G, Schuler S, ed. Simon & Schuster's Guide to Herbs and Spices. Simon & Schuster Inc. 1990; ISBN 0-671-73489-X.
4. Mukherjee S, Lekli I, Goswami S, Das DK. Freshly crushed garlic is a superior cardioprotective agent than processed garlic. J Agric Food Chem 2009; 57:7137-44.
5. Rivlin RS. Historical perspective on the use of garlic. J Nutr 2001;131:951S-4S. (Pubitemid 32194987)
6. Agarwal KC. Therapeutic actions of garlic constituents. Med Res Rev 1996; 16:111-4.
7. Augusti KT, Sheela CG. Antiperoxide effect of S-allyl cysteine sulfoxide, a insulin secretagogue, in diabetic rats. Experientia 1996; 52:115-20.
8. Cerqueira MT. Bridging the knowledge-action gap in diabetes along the U.S.-Mexico border. Revista panamerica de Salud Publica 2010; 28:139-40.
9. Nichols GA, Moler EJ. Cardiovascular disease, heart failure, chronic kidney disease and depression independently increase the risk of incident diabetes. Diabetologia. 2011; 54:523-6.
10. Banerjee SK, Mukherjee PK, Maulik SK. Garlic as an antioxidant: The good, the bad and the ugly. Phytother Res 2003;17:97-06.
11. Eric block. Garlic and Other Alliums: The Lore and the Science, Royal Society of Chemistry 2010; ISBN 0-85404-190-7.
12. Farva D, Goji LA, Joseph PK, Augusti KT. Effects of garlic oil on streptozotocin-diabetic rats maintained on normal and high fat diets. Ind J Biochem Biophys 1986; 23:24-7. (Pubitemid 16092353)
13. Ohaeri OC. Effect of garlic oil on the levels of various enzymes in the serum and tissue of streptozotocin diabetic rats. Bio Sci Rep 2001; 2:19-24. (Pubitemid 32703509)
14. Kumar GR, Reddy KP. Reduced nociceptive responses in mice with alloxan induced hyperglycemia after garlic (Allium sativum) treatment. Ind J Exp Biol 1999; 37:662-6. (Pubitemid 29309689)
15. Mathew PT, Augusti KT. Studies on the effect of allicin (diallyldisulphideoxide) on alloxan diabetes I. Hypoglycemic action and enhancement of serum insulin effect and glycogen synthesis. Ind J Biochem Biophys 1973; 10:209-12.
16. Banerjee SK, Maulik M, Mancahanda SC, Dinda A, Gupta SK, Maulik SK, et al. Dose dependent induction of endogenous antioxidant by chronic administration of garlic in rat heart. Life Sci 2002; 70:1509-18. (Pubitemid 34164545)
17. Javed H, Khan MM, Khan A, Vaibhav K, Ahmad A, Khuwaja G, Ahmed ME, Raza SS, Ashafaq M, Tabassum R, Siddiqui MS, El- Agnaf OM, Safhi MM, Islam F, et al. S-allyl cysteine attenuates oxidative stress associated cognitive impairment and neurodegeneration in mouse model of streptozotocin-induced experimental dementia of Alzheimer's type. Brain Res 2011; 1389:133-42.
18. Kumar GR, Reddy KP. Reduced nociceptive responses in mice with alloxan induced hyperglycemia after garlic (Allium sativum Linn.) treatment. Ind J Exp Biol 1999; 37:662-6. (Pubitemid 29309689)
19. Madkor HR, Mansour SW, Ramadan G. Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic rats. Br J Nutr 2011; 105:1210-7.
20. Saravanan G, Ponmurugan P. Beneficial effect of S-allylcysteine (SAC) on blood glucose and pancreatic antioxidant system in streptozotocin diabetic rats. Plant Foods Hum Nutr 2010; 65:374-8.
21. Saravanan G, Ponmurugan P, Senthil Kumar GP, Rajarajan T. Antidiabetic effect of S-allylcysteine: Effect on plasma and tissue glycoproteins in experimental diabetes. Phytomedicine 2010; 17:1086-9.
22. Jain RC, Vyas CR. Garlic in alloxan-induced diabetic rabbits. Am J Clin Nutr 1975; 28:684-5.
23. Sheela CG, Augusti KT. Antidiabetic effects of S-allyl cysteine sulphoxide isolated from garlic Allium sativum Linn. Ind J Exp Biol 1992; 30:523-6.
24. Kasuga S, Ushijima M, Morihara N, Itakura Y, Nakata Y. Effect of aged garlic extract (AGE) on hyperglycemia induced by immobilization stress in mice. Nippon Yakurigaku Zassh 1999;114:191-7. (Pubitemid 29436719)
25. Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia 1990; 33:462-4. (Pubitemid 20254867)
26. Mathew PT, Augusti KT. Studies on the effect of allicin (diallyl disulphide-oxide) on alloxan diabetes I. Hypoglycaemic action and enhancement of serum insulin effect and glycogen synthesis. Ind J Biochem Biophys 1973; 10:209-12.
27. Jain RC, Vyas CR. Hypoglycemic action of onion and garlic. Lancet 1973; 2:1491.
28. Jain RC, Vyas CR. Garlic in alloxan-induced diabetic rabbits. Am J Clin Nutr 1975; 28:684-685.
29. Banerjee SK, Maulik M, Manchanda SC, Dinda AK, Das TK, Maulik SK. Garlic-induced alteration in rat liver and kidney morphology and associated changes in endogenous antioxidant status. Food Chem Toxicol 2001; 39:793-7. (Pubitemid 32575246)
30. Ashraf R, Khan RA, Ashraf I. Garlic (Allium sativum) supplementation with standard antidiabetic agent provides better diabetic control in type 2 diabetes patients. Pak J Pharm Sci 2011; 24:565-70.
31. Sobenin IA, Nedosugova LV, Filatova LV, Balabolkin MI, Gorchakova TV, Orekhov AN, et al. Metabolic effects of time-released garlic powder tablets in type 2 diabetes mellitus: The results of double- blinded placebo-controlled study. Acta Diabetol 2008; 45:1-6. (Pubitemid 351238270)
32. Zhang XH, Lowe D, Giles P, Fell S, Connock MJ, Maslin DJ, et al. Gender may affect the action of garlic oil on plasma cholesterol and glucose levels of normal subjects. J Nutr 2001; 131:1471-8. (Pubitemid 32422969)
33. Li G, Shi Z, Jia H, Ju J, Wang X, Xia Z, Qin L, Ge C, Xu Y, Cheng L, Chen P, Yuan G, et al. A clinical investigation on garlicin injection for treatment of unstable angina pectoris and its actions on plasma endothelin and blood sugar levels. J Tradit Chin Med 2000; 20:243-6.
34. Kiesewetter H, Jung F, Pindur G, Jung EM, Mrowietz C, Wenzel E. Effect of garlic on thrombocyte aggregation, microcirculation, and other risk factors. Int J Clin Pharmacol Ther Toxicol 1991; 29:151-5.
35. Bordia A, Verma SK, Srivastava KC. Effect of garlic (Allium sativum) on blood lipids, blood sugar, fibrinogen and fibrinolytic activity in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids 1998; 58:257-63. (Pubitemid 28275895)
36. Ali M, Thomson M. Consumption of garlic clove a day could be beneficial in preventing thrombosis. Prostaglandins Leukot Essent Fatty acids 1995; 53:211-2.
37. Jain AK, Vargas R, Gotzkowsky S, McMahon FG. Can garlic reduce levels of serum lipids? A controlled clinical study. Am J Med 1993; 94:632-5. (Pubitemid 23166711)
38. Patumraj S, Tewit S, Amatyakul S, Jariyapongskul A, Maneesri S, Kasantikul V, Shepro D, et al. Comparative effects of garlic and aspirin on diabetic cardiovascular complications. Drug Deliv 2000; 7:91-96. (Pubitemid 30399617)
39. Padiya R, Khatua TN, Bagul PK, Kuncha M, Banerjee SK. Garlic improves insulin sensitivity and associated metabolic syndromes in fructose fed rats. Nutr Metab 2011; 8:53.
40. Chang SH, Liu CJ, Kuo CH, Chen H, Lin WY, Teng KY, Chang SW, Tsai CH, Tsai FJ, Huang CY, Tzang BS, Kuo WW, et al. Garlic Oil Alleviates MAPKs- And IL-6-mediated Diabetes-related Cardiac Hypertrophy in STZ-induced DM Rats. Evid Based Complement Alternat Med 2011; 2011:950150.
41. Ou HC, Tzang BS, Chang MH, Liu CT, Liu HW, Lii CK, Bau DT, Chao PM, Kuo WW, et al. Cardiac contractile dysfunction and apoptosis in streptozotocin- induced diabetic rats are ameliorated by garlic oil supplementation. J Agric Food Chem 2010; 58:10347-55.
42. Drobiova H, Thomson M, Al-Qattan K, Peltonen-Shalaby R, Al- Amin Z, Ali M, et al. Garlic Increases Antioxidant Levels in Diabetic and Hypertensive Rats Determined by a Modified Peroxidase Method. Evid Based Complement Alternat Med 2011; 2011:703049.
43. Kanth VR, Uma Maheswara Reddy P, Raju TN. Attenuation of streptozotocin-induced oxidative stress in hepatic and intestinal tissues of Wistar rat by methanolic-garlic extract. Acta Diabetol 2008; 45:243-51.
44. Mariee AD, Abd-Allah GM, El-Yamany MF. Renal oxidative stress and nitric oxide production in streptozotocin-induced diabetic nephropathy in rats: The possible modulatory effects of garlic (Allium sativum L.). Biotechnol Appl Biochem 2009; 52:227-32.
45. Raju TN, Kanth VR, Lavanya K. Effect of methanolic extract of Allium sativum (AS) in delaying cataract in STZ-induced diabetic rats. J Ocul Biol Dis Infor 2008; 1:46-54.
46. Hosseini M, Shafiee SM, Baluchnejadmojarad T. Garlic extract reduces serum angiotensin converting enzyme (ACE) activity in nondiabetic and streptozotocin-diabetic rats. Pathophysiology 2007; 14:109-12. (Pubitemid 47539095)
47. Tsao SM, Liu WH, Yin MC. Two diallyl sulphides derived from garlic inhibit meticillin-resistant Staphylococcus aureus infection in diabetic mice. J Med Microbiol 2007; 56:803-8.
48. Eidi A, Eidi M, Esmaeili E. Antidiabetic effect of garlic (Allium sativum L.) in normal and streptozotocin-induced diabetic rats. Phytomedicine 2006; 13:624-9. (Pubitemid 44666394)
49. Musabayane CT, Bwititi PT, Ojewole JA. Effects of oral administration of some herbal extracts on food consumption and blood glucose levels in normal and streptozotocin-treated diabetic rats. Methods Find Exp Clin Pharmacol 2006; 28:223-8. (Pubitemid 44013392)
50. Ohaeri OC, Adoga GI. Anticoagulant modulation of blood cells and platelet reactivity by garlic oil in experimental diabetes mellitus. Biosci Rep 2006; 26:1-6.
51. Liu CT, Wong PL, Lii CK, Hse H, Sheen LY. Antidiabetic effect of garlic oil but not diallyl disulfide in rats with streptozotocininduced diabetes. Food Chem Toxicol 2006; 44:1377-84. (Pubitemid 44192407)
52. Liu CT, Hse H, Lii CK, Chen PS, Sheen LY. Effects of garlic oil and diallyl trisulfide on glycemic control in diabetic rats. Eur J Pharmacol 2005; 516:165-73. (Pubitemid 40799353)
53. Baluchnejadmojarad T, Roghani M. Endothelium-dependent and - independent effect of aqueous extract of garlic on vascular reactivity on diabetic rats. Fitoterapia 2003; 74:630-7. (Pubitemid 37443450)
54. Baluchnejadmojarad T, Roghani M. Garlic extract attenuates timedependent changes in the reactivity of isolated aorta in streptozotocin- diabetic rats. Life Sci 2003; 73:2281-9. (Pubitemid 36980825)
55. Anwar MM, Meki AR. Oxidative stress in streptozotocin-induced diabetic rats: effects of garlic oil and melatonin. Comp Biochem Physiol A Mol Integr Physiol 2003; 135:539-47. (Pubitemid 37289114)
56. Baluchnejadmojarad T, Roghani M, Homayounfar H, Hosseini M. Beneficial effect of aqueous garlic extract on the vascular reactivity of streptozotocin-diabetic rats. J Ethnopharmacol 2003; 85:139-44. (Pubitemid 36170065)
57. Ohaeri OC. Effect of garlic oil on the levels of various enzymes in the serum and tissue of streptozotocin diabetic rats. Biosci Rep 2001; 21:19-24. (Pubitemid 32703509)
58. Patumraj S, Tewit S, Amatyakul S, Jariyapongskul A, Maneesri S, Kasantikul V, Shepro D, et al. Comparative effects of garlic and aspirin on diabetic cardiovascular complications. Drug Deliv 2000; 7:91-6. (Pubitemid 30399617)
59. Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Traditional plant treatments for diabetes. Studies in normal and streptozotocin diabetic mice. Diabetologia 1990; 33:462-4. (Pubitemid 20254867)
60. Nasim SA, Dhir B, Samar F, Rashmi K, Mahmooduzzafa, Mujib A, et al. Sulphur treatment alters the therapeutic potency of alliin obtained from garlic leaf extract. Food Chem Toxicol 2009; 47:888- 92.
61. Hashem RM, Mahmoud MF, El-Moselhy MA, Soliman HM. Interleukin- 10 to tumor necrosis factor-alpha ratio is a predictive biomarker in nonalcoholic fatty liver disease: interleukin-10 to tumor necrosis factor-alpha ratio in steatohepatitis. Eur J Gastroenterol Hepatol 2008; 20:995-1001.
62. Jelodar GA, Maleki M, Motadayen MH, Sirus S. Effect of fenugreek, onion and garlic on blood glucose and histopathology of pancreas of alloxan-induced diabetic rats. Indian J Med Sci 2005; 59:64-9. (Pubitemid 40975979)
63. El-Demerdash FM, Yousef MI, El-Naga NI. Biochemical study on the hypoglycemic effects of onion and garlic in alloxan-induced diabetic rats. Food Chem Toxicol 2005; 43:57-63. (Pubitemid 39575733)
64. Augusti KT, Sheela CG. Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin secretagogue, in diabetic rats. Experientia 1996; 52:115-20.
65. Sheela CG, Kumud K, Augusti KT. Anti-diabetic effects of onion and garlic sulfoxide amino acids in rats. Planta Med 1995; 61:356- 7.
66. Asdaq SM, Inamdar MN. Pharmacodynamic and Pharmacokinetic Interactions of Propranolol with Garlic (Allium sativum) in Rats. Evid Based Complement Alternat Med 2011; 2011:824042.
67. Asdaq SM, Inamdar MN. The potential benefits of a garlic and hydrochlorothiazide combination as antihypertensive and cardioprotective in rats. J Nat Med 2011; 65:81-8.
68. Asdaq SM, Inamdar MN. Potential of garlic and its active constituent, S-allyl cysteine, as antihypertensive and cardioprotective in presence of captopril. Phytomedicine 2010; 17:1016-26.
69. Vazquez-Prieto MA, Rodriguez Lanzi C, Lembo C, Galmarini CR, Miatello RM. Garlic and onion attenuates vascular inflammation and oxidative stress in fructose-fed rats. J Nutr Metab 2011; 2011:475216.
70. Jalal R, Bagheri SM, Moghimi A, Rasuli MB. Hypoglycemic effect of aqueous shallot and garlic extracts in rats with fructose-induced insulin resistance. J Clin Biochem Nutr 2007; 41:218-23. (Pubitemid 350221830)
71. Madkor HR, Mansour SW, Ramadan G. Modulatory effects of garlic, ginger, turmeric and their mixture on hyperglycaemia, dyslipidaemia and oxidative stress in streptozotocin-nicotinamide diabetic rats. Br J Nutr 2011;105: 1210-7.
72. Younis F, Mirelman D, Rabinkov A, Rosenthal T. S-allylmercapto- captopril: A novel compound in the treatment of Cohen- Rosenthal diabetic hypertensive rats. J Clin Hypertens. 2010; 12:451-5.
73. Islam MS, Choi H. Comparative effects of dietary ginger (Zingiber officinale) and garlic (Allium sativum) investigated in a type 2 diabetes model of rats. J Med Food 2008; 11:152-9. (Pubitemid 351450508)
74. Lee YM, Gweon OC, Seo YJ, Im J, Kang MJ, Kim MJ, Kim JI, et al. Antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes mellitus. Nutr Res Pract 2009; 3:156-61.
75. Hattori A, Yamada N, Nishikawa T, Fukuda H, Fujino T. Antidiabetic effects of ajoene in genetically diabetic KK-A(y) mice. J Nutr Sci Vitaminol 2005; 51:382-4. (Pubitemid 41727434)
76. Guan, Z., Wang, J., Zhang, X. Method for making selenium garlic capsule. CN1109289 (1995).
77. Wang, X. Preparation containing dehydrated garlic. CN1104905 (1995).
78. Wang, X. Garlic oral administration liquid. CN1104904 (1995).
79. Guo, X. Garlic capsule and making method thereof. CN1086135 (1994).
80. Friedrich, K., - Dr Med, K. New use of compsns. contg. garlic and fenugreek - for oral treatment of diabetes. DE4236409 (1994).
81. Qingyu, X. Bolus contg. garlic extract, and its processing art. CN1161219 (1997).
82. Abaka, J.K. Diabetes therapy. GB2304046 (1997).
83. Du, H., Lei, X., Li, W. Compound garlic oil capsule and its producing method. CN1107341 (1995).
84. Luo, H., Gao, Y. Application of garlic total saponin in preparing medicaments and foods for resisting oxidative stress damage. CN101596268 (2009).
85. Hwa, K.M., kwang, K.S., Hae, Y.I., Chang, L.H. Composition for preventing or treating diabetes or complications of diabetes mellitus comprising an extract of Korea angelica roots and wild garlic leaves as an active ingredient. KR20120034554 (2012).
86. Hwa, K.M., Kwang, K.S., Hae, Y.I., Chang, L.H. composition for preventing or treating diabetes or diabetes complications, containing composite composition of Angelicae gigantis radix extract and wild garlic leaves extract as active ingredient. WO2012021014 (2012).
87. Yasen, K. Health-care nutrient solution and method for preparing same. CN102228233 (2011).
88. Won, C.S., Hee, C.S. A composition for preventing or treating diabetes based on Eisenia bicyclis. KR20110057586 (2011).
89. Li, W., Zou, X., Li, X. Chinese patent drug for treating diabetes and preparation method thereof. CN102100874 (2011).
90. Whan, C.Y., Sik, Y. Anti-inflammatory composition comprising 5- hydroxymethylfurfural. KR20110042630 (2011).
91. Whan, C.Y., Sik, Y., Jae, S.Y. anti-inflammatory composition comprising extracts from black aged garlic. KR20110042607 (2011).
92. Chel, G.K., Rye, I.H. composition of health food. KR20110019569 (2011).
93. Ho, P.J. A nature spice. KR20110014421 (2011).
94. In, K.J., Cheon, K.O., Eun, I.J. preparation method of bioactive pill of aged black garlic showing improving effects on hyperglycemia and insulin resistance. KR20110001302 (2011).
95. Gyu, K.W., Kap, L.W., Sung, K.J., Joo, P.K. A functional beverage comprising deep sea water, extract of black garlic, extract of Jujubae fructus and organic acid. KR20100114974 (2010).
96. In, K.J., Hee, J.S., Jung, K.M. Composition comprising the sugaring extract of Allium sativum L. for lowering blood glucose or preventing and treating diabetes mellitus. KR20100098096 (2010).
97. In, K.J., Cheon, G.O., Jung, K.M., Jin, K.M., Eun, K.M., Hyun, S.J., Ju, S.Y. Composition comprising the dried powder of black garlic or extract thereof for treating and preventing lipid metabolism disorder and diabetic complication disease. KR20100026600 (2010).
98. Hong, J.W., Jung, C.H., Whan, C.Y., Tae, Y.S., Dong, C.S., Shin, K.S., Composition for the prevention and the treatment of obesity and diabetes containing alnus firma sieb. et zucc extracts or compounds separated there from as an effective ingredient. KR20100003992 (2010).
99. Ho, K.K., Ja, K.H., Nam, L.K., Hwan, K.S. New method for preparing the low molecular fucoidan from the brown algae fermentation. KR20100001375 (2010).
100. Kanako, K. Life style related disease improving agent. JP2009298742 (2009).
101. Ji, J. Special-purpose medicaments for treating diabetes and complication thereof. CN101239147 (2008).
102. Won, P.S., Sook, J.Y., Ha, L.D., Young, K.E., Nazneen, S., Young, K.M. Garden product for improving diabetes. KR20090055107 (2009).
103. Won, P.S., Sook, J.Y., Ha, L.D., Young, K.E., Nazneen, S., Young, K.M. Salad composition for improving diabetes comprising garden products. KR20090055103 (2009).
104. Cao, Y. Green bean curd and preparation thereof. CN101238835 (2008).
105. Horace, M. Cold-remedy food supplement for simultaneously lowering blood pressure and sustaining blood sugar. US7348033 ( 2008).
106. Sun, K.E. Germ microbe. KR20070028269 (2007).
107. Isaac, E. Compositions and methods for treating diabetes. US2007167395 (2007).
108. Choi, M. Method processing a functional food for the descent of blood sugar. KR20070008761 (2007).
109. Gji, C.Y., Jeong, I.E., Mi, L.E., Hwan, J.L. Selenium-enriched garlic extract isolated from garlic having improved anticancer activity and improved inhibiting activity of hypertension and diabetes and use thereof. KR20050020084 (2005).
110. Ho, D.M. Hardtack comprising silkworm powder which resolves hungry feeling and reduces blood sugar level of patient suffering from diabetes and preparation method thereof. KR20050001733 (2005).
111. Do, K.H., Sook, L.M. Sauce composition for seasoning ribs containing extract of Astragali radix, Radix angelicae sinensis, Glycyrrhizae radix and Lycii fructus. KR20040083886 (2004).
112. Park, J.I. Method for manufacturing functional health food using garlic and onion. KR20040043717 (2004).
113. Seung, C.J. Restaurant for preventing diabetes and method for managing the same. KR20020092301 (2002).
114. Qingze, W. Sheep fed gramineous brushwood. CN1480068 (2004).
115. Soo, L.J. Roborant. KR20030089864 (2003).
116. Xiaoyan, L., xiaohong, L., Yanhong, L. Health-care gingerscallion- garlic food containing rich element iron nutrients and its preparing process. CN1382392 (2002).
117. Shuyan, W. Granule mixture beverage of Multi alae and Glossy ganoderma powder. CN1370471 (2002).
118. Masanori, K., Ayumi, S., Isao, N., Sumihiro, S., Yoichi, I. Garlic fermented composition. JP2002154981 (2002).
119. Masanori, K., Ayumi, S., Isao, N., Sumihiro, S., Yoichi, I. Fermented garlic composition. US6146638 (2000).
120. Su, C.B. The preparation method of vinegar red pepper paste. KR20000033042 (2000).