Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 21, 2013, Pages 5941-5944

  Mandadapu, Sivakoteswara Rao ^a   Gunnam, Mallikarjuna Reddy ^a   Galasiti Kankanamalage, Anushka C ^a   Uy, Roxanne Adeline Z ^a   Alliston, Kevin R ^a   Lushington, Gerald H ^b   Kim, Yunjeong ^c   Chang, Kyeong Ok ^c   Groutas, William C ^a  

^a WICHITA STATE UNIVERSITY   (United States)

^b LiS Consulting   (United States)

^c KANSAS STATE UNIVERSITY   (United States)

Author keywords

Hydroxyphosphonates; Inhibitors; Norovirus 3CL protease; Transition state mimics

Indexed keywords

ANTIVIRUS AGENT; DIPEPTIDYL ALPHA HYDROXYPHOSPHONATE DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME SPECIFICITY; MOLECULAR MECHANICS; NONHUMAN; NOROVIRUS; NOROVIRUS INFECTION; REPLICON; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION;

NOROVIRUS;

INHIBITORS; NOROVIRUS 3CL PROTEASE; TRANSITION STATE MIMICS; Α-HYDROXYPHOSPHONATES;

ANTIVIRAL AGENTS; CALICIVIRIDAE INFECTIONS; DRUG DESIGN; HUMANS; MOLECULAR DOCKING SIMULATION; NOROVIRUS; ORGANOPHOSPHONATES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84885187592     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.08.073     Document Type: Article

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