Cyclosulfamide-based derivatives as inhibitors of noroviruses

European Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2012, Pages 59-64

  Dou, Dengfeng ^a   Mandadapu, Sivakoteswara R ^a   Alliston, Kevin R ^a   Kim, Yunjeong ^b   Chang, Kyeong Ok ^b   Groutas, William C ^a  

^a WICHITA STATE UNIVERSITY   (United States)

^b KANSAS STATE UNIVERSITY   (United States)

Author keywords

Cell based assay; Cyclosulfamide based inhibitors; Norovirus

Indexed keywords

1 (3 PHENOXYBENZOYL) 4 [2 [5 (3 PHENOXYBENZYL) 1,1 DIOXIDO 1,2,5 THIADIAZOLIDIN 2 YL]ETHYL]PIPERAZINE; 1 (4 CHLOROBENZOYL) 4 [2 [5 (3 PHENOXYBENZYL) 1,1 DIOXIDO 1,2,5 THIADIAZOLIDIN 2 YL]ETHYL]PIPERAZINE; 1 (4 FLUOROBENZOYL) 4 [2 [5 (3 PHENOXYBENZYL) 1,1 DIOXIDO 1,2,5 THIADIAZOLIDIN 2 YL]ETHYL]PIPERAZINE; 1 (N BUTYLSULFONYL) 4 [2 [5 (3 PHENOXYBENZYL) 1,1 DIOXIDO 1,2,5 THIADIAZOLIDIN 2 YL]ETHYL]PIPERAZINE; 1 [2 [5 (3 PHENOXYBENZYL) 1,1 DIOXIDO 1,2,5 THIADIAZOLIDIN 2 YL]ETHYL]PIPERAZINE; 1 BENZYL 4 [2 [5 (3 PHENOXYBENZYL) 1,1 DIOXIDO 1,2,5 THIADIAZOLIDIN 2 YL]ETHYL]PIPERAZINE; 1 ETHOXYCARBONYL 4 [2 [5 (3 PHENOXYBENZYL) 1,1 DIOXIDO 1,2,5 THIADIAZOLIDIN 2 YL]ETHYL]PIPERAZINE; 1 ETHYL 4 [5 (3 PHENOXYBENZYL) 1,1 DIOXIDO 1,2,5 THIADIAZOLIDIN 2 YL]ACETYL PIPERAZINE; 1 METHANESULFONYL 4 [2 [5 (3 PHENOXYBENZYL) 1,1 DIOXIDO 1,2,5 THIADIAZOLIDIN 2 YL]ETHYL]PIPERAZINE; 2 (2 MORPHOLINOETHYL) 5 (3 PHENOXYBENZYL) 1,2,5 THIADIAZOLIDINE 1,1 DIOXIDE; 2 (3 PHENOXYBENZYL) 5 [2 (PIPERIDIN 1 YL)ETHYL] 1,2,5 THIADIAZOLIDINE 1,1 DIOXIDE; 2 [2 [4 (BENZYLSULFONYL)PIPERAZIN 1 YL]ETHYL] 5 (3 PHENOXYBENZYL) 1,2,5 THIADIAZOLIDINE 1,1 DIOXIDE; 2,2' ETHANE 1,2 DIYLBIS[5 (3 PHENOXYBENZYL) 1,2,5 THIADIAZOLIDINE] 1,1,10,10 TETRAOXIDE; 3,3' [2,2' (PIPERAZINE 1,4 DIYL)BIS(ETHANE 2,1 DIYL)]BIS[1 (3 PHENOXYBENZYL)1,2,5 THIADIAZOLIDINE 1,1 DIOXIDE]; ANTIVIRUS AGENT; METHYL N [2 [5 (3 PHENOXYBENZYL) 1,1 DIOXIDO 1,2,5 THIADIAZOLIDIN 2 YL]ETHYL]ISONIPECOTATE; METHYL N [5 (3 PHENOXYBENZYL) 1,1 DIOXIDO 1,2,5 THIADIAZOLIDIN 2 YL]ACETYL ISONIPECOTATE; N [2 [5 (3 PHENOXYBENZYL) 1,1 DIOXIDO 1,2,5 THIADIAZOLIDIN 2 YL]ETHYL]ISONIPECOTIC ACID; N [5 (3 PHENOXYBENZYL) 1,1 DIOXIDO 1,2,5 THIADIAZOLIDIN 2 YL]ACETYL ISONIPECOTIC ACID; SULFAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; NONHUMAN; NOROVIRUS; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION;

AMIDES; ANTIVIRAL AGENTS; CELL LINE; INHIBITORY CONCENTRATION 50; NOROVIRUS; PIPERAZINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84655177725     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.10.019     Document Type: Article

References (17)

1. R.J. Bergmann, J. Gebhardt, E. Gould, P. Tucker, T. Unge, R. Hilgenfeld, and J. Neyts Antivir. Res. 87 2010 162 178
2. H.L. Koo, N. Ajami, R.L. Atmar, and H.L. DuPont Discov. Med. 10 2010 61 70
3. R.L. Atmar Food Environ. Virol. 2 2010 117 126
4. D. Dou, K.-C. Tiew, G. He, S.R. Mandadapu, S. Aravapalli, K.R. Alliston, Y. Kim, K.-O. Chang, and W.C. Groutas Bioorg. Med. Chem. 19 2011 5975 5983
5. D. Dou, S. Mandadapu, K.R. Alliston, Y. Kim, O. K-Chang, and W.C. Groutas Bioorg. Med. Chem. 19 2011 5749 5755
6. P. Gillespie, and R.A. Goodnow Ann. Rep. Med. Chem. 39 2004 293 304
7. K.O. Chang, S.V. Sosnovtsev, G. Belliot, A.D. King, and K.Y. Green Virology 2 2006 463 473
8. K.O. Chang, and D.W. George J. Virol. 22 2007 12111 12118
9. K.O. Chang J. Virol. 83 2009 8587 8595
10. Y. Kim, M. Thapa, D.H. Thuy, and K.-O. Chang Antivir. Res. 89 2011 165 173
11. M. Tan, and X. Jiang Curr. Opin. Investig. Drugs 9 2008 146 151
12. J. Guiard, B. Fiege, P.I. Kitov, T. Peters, and D.R. Bundle Chem. Eur. J. 17 2011 7438 7441
13. C. Rademacher, J. Guiard, P.I. Kitov, B. Fiege, K.P. Dalton, F. Parra, D.R. Bundle, and T. Peters Chem. Eur. J. 17 2011 7442 7453
14. R.W. DeSimone, K.S. Currie, S.A. Mitchell, J.W. Darrow, and D.A. Pippin Comb. Chem. High Trhoughput Screen. 7 2004 473 494
15. M.E. Welsh, S.A. Snyder, and B.R. Stockwell Curr. Opin. Chem. Biol. 14 2010 347 361
16. G.H. Posner, W. Chang, L. Hess, L. Woodard, S. Sinishtaj, A.R. Usera, W. Maio, A.S. Rosenthal, A.S. Kalinda, J.G. D'Angelo, K.S. Petersen, R. Stohler, J. Chollet, J. Santo-Tomas, C. Snyder, M. Rottmann, S. Wittlin, R. Brun, and T.A. Shapiro J. Med. Chem. 51 2008 1035 1042
17. M.L. Bolognesi, A. Cavalli, L. Valgimigli, M. Bartolini, M. Rosini, V. Andrisano, M. Recanatini, and C. Melchiorre J. Med. Chem. 50 2007 6446 6449