A structural study of norovirus 3C protease specificity: Binding of a designed active site-directed peptide inhibitor

Biochemistry

Volumn 50, Issue 2, 2011, Pages 240-249

  Hussey, Robert J ^a   Coates, Leighton ^f   Gill, Raj S ^b   Erskine, Peter T ^b   Coker, Shu Fen ^b   Mitchell, Ed ^c   Cooper, Jonathan B ^b   Wood, Steve ^b   Broadbridge, Robert ^d   Clarke, Ian N ^e   Lambden, Paul R ^e   Shoolingin Jordan, Peter M ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

^d E2 Knowle Village Business Park   (United Kingdom)

^e UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^f OAK RIDGE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BINDING GROUPS; CYSTEINE PROTEASE; ETHYL ESTERS; FUNCTIONAL PROTEINS; NOROVIRUSES; PEPTIDE INHIBITORS; RECOGNITION SEQUENCE; STRUCTURAL STUDIES; SUBSTRATE RECOGNITION; VIRAL POLYPROTEIN; VIRAL REPLICATION; X-RAY STRUCTURE;

AMINO ACIDS; ESTERS; PEPTIDES;

ENVIRONMENTAL REGULATIONS;

ACETYLGLUTAMYLPHENYLALAMYLGLUTAMINYLLEUCYLGLUTAMINYL PROPENYL ETHYL ESTER; CYSTEINE; CYSTEINE PROTEINASE; NUCLEOPHILE; PROTEIN INHIBITOR; SOUTHAMPTON NOROVIRUS 3C PROTEASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME KINETICS; ENZYME SPECIFICITY; MOLECULAR RECOGNITION; NONHUMAN; NOROVIRUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA CLEAVAGE; VIRUS REPLICATION;

AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; CALICIVIRIDAE INFECTIONS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NOROVIRUS; PEPTIDES; PROTEASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY; VIRAL PROTEINS;

NOROVIRUS;

EID: 78651355832     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1008497     Document Type: Article

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