Potent norovirus inhibitors based on the acyclic sulfamide scaffold

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 6, 2012, Pages 2111-2118

  Dou, Dengfeng ^a   Tiew, Kok Chuan ^a   Mandadapu, Sivakoteswara Rao ^a   Gunnam, Mallikarjuna Reddy ^a   Alliston, Kevin R ^a   Kim, Yunjeong ^b   Chang, Kyeong Ok ^b   Groutas, William C ^a  

^a WICHITA STATE UNIVERSITY   (United States)

^b KANSAS STATE UNIVERSITY   (United States)

Author keywords

Acyclic sulfamide; Inhibitor; Norovirus

Indexed keywords

2 [BENZYL[N (3 PHENOXYBENZYL)SULFAMOYL]AMINO]ACETIC ACID; 2 [BENZYL[N (TERT BUTOXYCARBONYL) N (3 PHENOXYBENZYL)SULFAMOYL]AMINO]ACETIC ACID; 2 [N (TERT BUTOXYCARBONYL) N (3 PHENOXYBENZYL)SULFAMOYLAMINO] 4 (METHYLTHIO)BUTANOIC ACID; 2 [N (TERT BUTOXYCARBONYL) N (3 PHENOXYBENZYL)SULFAMOYLAMINO]ACETIC ACID; 2 [N (TERT BUTOXYCARBONYL) N (3 PHENOXYBENZYL)SULFAMOYLAMINO]PROPANOIC ACID; 2 [N(3 PHENOXYBENZYL)SULFAMOYLAMINO]ACETIC ACID; 2 [N(3 PHENOXYBENZYL)SULFAMOYLAMINO]PENTANOIC ACID; 2 [N(3 PHENOXYBENZYL)SULFAMOYLAMINO]PROPANOIC ACID; 4 (METHYLTHIO) 2 [N (3 PHENOXYBENZYL)SULFAMOYLAMINO]BUTANOIC ACID; 4 (METHYLTHIO) N (2 MORPHOLINOETHYL) 2 [N (3 PHENOXYBENZYL)SULFAMOYLAMINO]BUTANAMIDE; 4 (METHYTHIO) N (2 MORPHOLINOETHYL) 2 [N (3 PHENOXYBENZYL)SULFAMOYLAMINO]BUTANAMIDE HYDROCHLORIDE; AMINO ACID; CARBOXYLIC ACID; METHYL 2 [[N (TERT BUTOXYCARBONYL) N (3 PHENOXYBENZYL)SULFAMOYL](METHYL)AMINO]ACETATE; METHYL 2 [BENZYL[N (TERT BUTOXYCARBONYL) N (3 PHENOXYBENZYL)SULFAMOYL]AMINO]ACETATE; METHYL 2 [N (3 PHENOXYBENZYL)SULFAMOYLAMINO]ACETATE; METHYL 2 [N (TERT BUTOXYCARBONYL) N (3 PHENOXYBENZYL)SULFAMOYLAMINO] 4 (METHYLTHIO)BUTANOATE; METHYL 2 [N (TERT BUTOXYCARBONYL) N (3 PHENOXYBENZYL)SULFAMOYLAMINO]ACETATE; METHYL 2 [N (TERT BUTOXYCARBONYL) N (3 PHENOXYBENZYL)SULFAMOYLAMINO]PENTANOATE; METHYL 2 [N (TERT BUTOXYCARBONYL) N (3 PHENOXYBENZYL)SULFAMOYLAMINO]PROPANOATE; METHYL 2 [N (TERT BUTOXYCARBONYL)SULFAMOYLAMINO] 4 (METHYLTHIO)BUTANOATE; METHYL 2 [N (TERT BUTOXYCARBONYL)SULFAMOYLAMINO]ACETATE; METHYL 2 [N (TERT BUTOXYCARBONYL)SULFAMOYLAMINO]PROPANOATE; N (2 MORPHOLINOETHYL) 2 [N (3 PHENOXYBENZYL)SULFAMOYLAMINO]ACETAMIDE; N (2 MORPHOLINOETHYL) 2 [N (3 PHENOXYBENZYL)SULFAMOYLAMINO]ACETAMIDE HYDROCHLORIDE; N (2 MORPHOLINOETHYL) 2 [N (3 PHENOXYBENZYL)SULFAMOYLAMINO]PENTANAMIDE; N (2 MORPHOLINOETHYL) 2 [N (3 PHENOXYBENZYL)SULFAMOYLAMINO]PROPANAMIDE; N (2 MORPHOLINOETHYL) 2 [N (3 PHENOXYBENZYL)SULFAMOYLAMINO]PROPANAMIDE HYDROCHLORIDE; SULFANILAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG MECHANISM; DRUG SYNTHESIS; NONHUMAN; NOROVIRUS; PROCESS OPTIMIZATION; PUBLIC HEALTH; REPLICON; SOLUBILITY; VIRUS INFECTION;

AMINO ACIDS; ANIMALS; ANTIVIRAL AGENTS; CALICIVIRIDAE INFECTIONS; CELL LINE; DRUG DESIGN; HUMANS; NOROVIRUS; SULFONAMIDES;

NOROVIRUS;

EID: 84862808296     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.01.030     Document Type: Article

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