Structure-based design of a general class of mechanism-based inhibitors of the serine proteinases employing a novel amino acid-derived heterocyclic scaffold

Biochemistry

Volumn 36, Issue 16, 1997, Pages 4739-4750

  Groutas, William C ^a   Kuang, Rongze ^a   Venkataraman, Radhika ^a   Epp, Jeffrey B ^a   Ruan, Sumei ^a   Prakash, Om ^b  

^a WICHITA STATE UNIVERSITY   (United States)

^b KANSAS STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN G; LEUKOCYTE ELASTASE; PROTEINASE; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; THIADIAZOLE DERIVATIVE; TRYPSIN;

ACYLATION; ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITOR COMPLEX; ENZYME SPECIFICITY; MICHAELIS CONSTANT; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

AMINO ACIDS; AUTOANTIGENS; CATHEPSINS; DRUG DESIGN; HETEROCYCLIC COMPOUNDS; HUMANS; LEUKOCYTE ELASTASE; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MYELOBLASTIN; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

BOVINAE;

EID: 0030993410     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9628937     Document Type: Article

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