Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 14, 2012, Pages 4820-4826

  Mandadapu, Sivakoteswara Rao ^a   Weerawarna, Pathum M ^a   Gunnam, Mallikarjuna Reddy ^a   Alliston, Kevin R ^a   Lushington, Gerald H ^b   Kim, Yunjeong ^c   Chang, Kyeong Ok ^c   Groutas, William C ^a  

^a WICHITA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF KANSAS   (United States)

^c KANSAS STATE UNIVERSITY   (United States)

Author keywords

Ketoamides; Norovirus; Norovirus 3CL protease; Transition state inhibitors

Indexed keywords

ALPHA KETOHETEROCYCLE DERIVATIVE; ANTIVIRUS AGENT; PEPTIDYL ALPHA KETOAMIDE DERIVATIVE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; NONHUMAN; NOROVIRUS; REPLICON;

AMIDES; CYSTEINE ENDOPEPTIDASES; HETEROCYCLIC COMPOUNDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NOROVIRUS; PEPTIDES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

NOROVIRUS; NORWALK VIRUS;

EID: 84863425147     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.05.055     Document Type: Article

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