메뉴 건너뛰기




Volumn 86, Issue 6, 2013, Pages 703-710

Antimitotic drugs in cancer chemotherapy: Promises and pitfalls

Author keywords

Cancer; Chemotherapy; Mitosis

Indexed keywords

7 HYDROXYSTAUROSPORINE; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; AURORA KINASE INHIBITOR; BORTEZOMIB; CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; DOCETAXEL; DOXORUBICIN; FLAVOPIRIDOL; FLUDARABINE; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; IRINOTECAN; JNJ 7706621; LENALIDOMIDE; MITOXANTRONE; N [4 [6 METHOXY 7 (3 MORPHOLINOPROPOXY) 4 QUINAZOLINYLAMINO]PHENYL]BENZAMIDE; OXALIPLATIN; P 276 00; PURVALANOL B; RITUXIMAB; SANGIVAMYCIN LIKE MOLECULE 6; TG 02; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORINOSTAT;

EID: 84885185563     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.07.010     Document Type: Note
Times cited : (77)

References (89)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-74.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0037108873 scopus 로고    scopus 로고
    • 2-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1
    • Yu Q, La Rose J, Zhang H, Takemura H, Kohn KW, Pommier Y. UCN-01 inhibits p53 up-regulation and abrogates gamma-radiation-induced G(2)-M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1. Cancer Research 2002; 62: 5743-8. (Pubitemid 35204730)
    • (2002) Cancer Research , vol.62 , Issue.20 , pp. 5743-5748
    • Yu, Q.1    La Rose, J.2    Zhang, H.3    Takemura, H.4    Kohn, K.W.5    Pommier, Y.6
  • 3
    • 78649684224 scopus 로고    scopus 로고
    • PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01
    • Dudgeon C, Wang P, Sun X, Peng R, Sun Q, Yu J, et al. PUMA induction by FoxO3a mediates the anticancer activities of the broad-range kinase inhibitor UCN-01. Molecular Cancer Therapeutics 2010; 9: 2893-902.
    • (2010) Molecular Cancer Therapeutics , vol.9 , pp. 2893-2902
    • Dudgeon, C.1    Wang, P.2    Sun, X.3    Peng, R.4    Sun, Q.5    Yu, J.6
  • 4
    • 33846424957 scopus 로고    scopus 로고
    • 2 checkpoint abrogation
    • DOI 10.1158/0008-5472.CAN-06-2548
    • Vogel C, Hager C, Bastians H. Mechanisms of mitotic cell death induced by chemotherapy-mediated G2 checkpoint abrogation. Cancer Research 2007; 67: 339-45. (Pubitemid 46142793)
    • (2007) Cancer Research , vol.67 , Issue.1 , pp. 339-345
    • Vogel, C.1    Hager, C.2    Bastians, H.3
  • 5
    • 84855431740 scopus 로고    scopus 로고
    • Inhibitors targeting mitosis: Tales of how great drugs against a promising target were brought down by a flawed rationale
    • Komlodi-Pasztor E, Sackett DL, Fojo AT. Inhibitors targeting mitosis: tales of how great drugs against a promising target were brought down by a flawed rationale. Clinical Cancer Research 2012; 18: 51-63.
    • (2012) Clinical Cancer Research , vol.18 , pp. 51-63
    • Komlodi-Pasztor, E.1    Sackett, D.L.2    Fojo, A.T.3
  • 6
    • 84872520610 scopus 로고    scopus 로고
    • Potentiation of in vitro and in vivo antitumor efficacy of doxorubicin by cyclin-dependent kinase inhibitor P 276-00 in human non-small cell lung cancer cells
    • Rathos MJ, Khanwalkar H, Joshi K, Manohar SM, Joshi KS. Potentiation of in vitro and in vivo antitumor efficacy of doxorubicin by cyclin-dependent kinase inhibitor P 276-00 in human non-small cell lung cancer cells. BMC Cancer 2013; 13: 29.
    • (2013) BMC Cancer , vol.13 , pp. 29
    • Rathos, M.J.1    Khanwalkar, H.2    Joshi, K.3    Manohar, S.M.4    Joshi, K.S.5
  • 8
    • 84869207629 scopus 로고    scopus 로고
    • Sangivamycin-like molecule 6 exhibits potent anti-multiple myeloma activity through inhibition of cyclin-dependent kinase-9
    • Dolloff NG, Allen JE, Dicker DT, Aqui N, Vogl D, Malysz J, et al. Sangivamycin-like molecule 6 exhibits potent anti-multiple myeloma activity through inhibition of cyclin-dependent kinase-9. Molecular Cancer Therapeutics 2012; 11: 2321-30.
    • (2012) Molecular Cancer Therapeutics , vol.11 , pp. 2321-2330
    • Dolloff, N.G.1    Allen, J.E.2    Dicker, D.T.3    Aqui, N.4    Vogl, D.5    Malysz, J.6
  • 9
    • 80655129636 scopus 로고    scopus 로고
    • VMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells
    • Ringer L, Sirajuddin P, Heckler M, Ghosh A, Suprynowicz F, Yenugonda VM, et al. VMY-1-103 is a novel CDK inhibitor that disrupts chromosome organization and delays metaphase progression in medulloblastoma cells. Cancer Biology and Therapy 2011; 12: 818-26.
    • (2011) Cancer Biology and Therapy , vol.12 , pp. 818-826
    • Ringer, L.1    Sirajuddin, P.2    Heckler, M.3    Ghosh, A.4    Suprynowicz, F.5    Yenugonda, V.M.6
  • 11
    • 84877099149 scopus 로고    scopus 로고
    • The investigational aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in Malignant bladder cancer cells in vitro and in vivo
    • Zhou N, Singh K, Mir MC, Parker Y, Lindner D, Dreicer R, et al. The investigational aurora kinase A inhibitor MLN8237 induces defects in cell viability and cell-cycle progression in malignant bladder cancer cells in vitro and in vivo. Clinical Cancer Research 2013; 19: 1717-28.
    • (2013) Clinical Cancer Research , vol.19 , pp. 1717-1728
    • Zhou, N.1    Singh, K.2    Mir, M.C.3    Parker, Y.4    Lindner, D.5    Dreicer, R.6
  • 12
    • 67650073265 scopus 로고    scopus 로고
    • Cell cycle kinases as therapeutic targets for cancer
    • Lapenna S, Giordano A. Cell cycle kinases as therapeutic targets for cancer. Nature Reviews Drug Discovery 2009; 8: 547-66.
    • (2009) Nature Reviews Drug Discovery , vol.8 , pp. 547-566
    • Lapenna, S.1    Giordano, A.2
  • 13
    • 84879420631 scopus 로고    scopus 로고
    • Plk1 is upregulated in androgen-insensitive prostate cancer cells and its inhibition leads to necroptosis
    • Deeraksa A, Pan J, Sha Y, Liu XD, Eissa NT, Lin SH, et al. Plk1 is upregulated in androgen-insensitive prostate cancer cells and its inhibition leads to necroptosis. Oncogene 2013; 32: 2973-83.
    • (2013) Oncogene , vol.32 , pp. 2973-2983
    • Deeraksa, A.1    Pan, J.2    Sha, Y.3    Liu, X.D.4    Eissa, N.T.5    Lin, S.H.6
  • 14
    • 0033778278 scopus 로고    scopus 로고
    • Mutations in the plk gene lead to instability of plk protein in human tumour cell lines
    • Simizu S, Osada H. Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines. Nature Cell Biology 2000; 2: 852-4.
    • (2000) Nature Cell Biology , vol.2 , pp. 852-854
    • Simizu, S.1    Osada, H.2
  • 15
    • 76749159360 scopus 로고    scopus 로고
    • Pololike kinase 1 (Plk1) as a novel drug target in chronic myeloid leukemia: Overriding imatinib resistance with the plk1 inhibitor BI 2536
    • Gleixner KV, Ferenc V, Peter B, Gruze A, Meyer RA, Hadzijusufovic E, et al. Pololike kinase 1 (Plk1) as a novel drug target in chronic myeloid leukemia: overriding imatinib resistance with the Plk1 inhibitor BI 2536. Cancer Research 2010; 70: 1513-23.
    • (2010) Cancer Research , vol.70 , pp. 1513-1523
    • Gleixner, K.V.1    Ferenc, V.2    Peter, B.3    Gruze, A.4    Meyer, R.A.5    Hadzijusufovic, E.6
  • 16
    • 79954498856 scopus 로고    scopus 로고
    • Polo-like kinase 1 (Plk1) is expressed by cutaneous T-cell lymphomas (CTCLs), and its downregulation promotes cell cycle arrest and apoptosis
    • Nihal M, Stutz N, Schmit T, Ahmad N, Wood GS. Polo-like kinase 1 (Plk1) is expressed by cutaneous T-cell lymphomas (CTCLs), and its downregulation promotes cell cycle arrest and apoptosis. Cell Cycle 2011; 10: 1303-11.
    • (2011) Cell Cycle , vol.10 , pp. 1303-1311
    • Nihal, M.1    Stutz, N.2    Schmit, T.3    Ahmad, N.4    Wood, G.S.5
  • 19
    • 80053894934 scopus 로고    scopus 로고
    • Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2] thiazolo[5,4-d]pyrimidin -6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent
    • Theoclitou ME, Aquila B, Block MH, Brassil PJ, Castriotta L, Code E, et al. Discovery of (+)-N-(3-aminopropyl)-N-[1-(5-benzyl-3-methyl-4-oxo-[1,2] thiazolo[5,4-d]pyrimidin -6-yl)-2-methylpropyl]-4-methylbenzamide (AZD4877), a kinesin spindle protein inhibitor and potential anticancer agent. Journal of Medicinal Chemistry 2011; 54: 6734-50.
    • (2011) Journal of Medicinal Chemistry , vol.54 , pp. 6734-6750
    • Theoclitou, M.E.1    Aquila, B.2    Block, M.H.3    Brassil, P.J.4    Castriotta, L.5    Code, E.6
  • 20
    • 74549223522 scopus 로고    scopus 로고
    • Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer
    • Purcell JW, Davis J, Reddy M, Martin S, Samayoa K, Vo H, et al. Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. Clinical Cancer Research 2010; 16: 566-76.
    • (2010) Clinical Cancer Research , vol.16 , pp. 566-576
    • Purcell, J.W.1    Davis, J.2    Reddy, M.3    Martin, S.4    Samayoa, K.5    Vo, H.6
  • 21
    • 75149121482 scopus 로고    scopus 로고
    • ARRY-520, a novel KSP inhibitor with potent activity in hematological and taxane-resistant tumor models
    • Woessner R, Tunquist B, Lemieux C, Chlipala E, Jackinsky S, Dewolf Jr W, et al. ARRY-520, a novel KSP inhibitor with potent activity in hematological and taxane-resistant tumor models. Anticancer Research 2009; 29: 4373-80.
    • (2009) Anticancer Research , vol.29 , pp. 4373-4380
    • Woessner, R.1    Tunquist, B.2    Lemieux, C.3    Chlipala, E.4    Jackinsky, S.5    Dewolf Jr., W.6
  • 22
    • 52649172153 scopus 로고    scopus 로고
    • Survivin: Key regulator of mitosis and apoptosis and novel target for cancer therapeutics
    • Mita AC, Mita MM, Nawrocki ST, Giles FJ. Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics. Clinical Cancer Research 2008; 14: 5000-5.
    • (2008) Clinical Cancer Research , vol.14 , pp. 5000-5005
    • Mita, A.C.1    Mita, M.M.2    Nawrocki, S.T.3    Giles, F.J.4
  • 26
    • 84858333989 scopus 로고    scopus 로고
    • Antitumor activity of a small-molecule inhibitor of the histone kinase haspin
    • Huertas D, SolerM, MoretoJ, VillanuevaA, MartinezA, VidalA, et al. Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene 2012; 31: 1408-18.
    • (2012) Oncogene , vol.31 , pp. 1408-1418
    • Huertas, D.1    Soler, M.2    Moreto, J.3    Villanueva, A.4    Martinez, A.5    Vidal, A.6
  • 27
    • 79955492036 scopus 로고    scopus 로고
    • MK-1775, a potent wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts
    • Rajeshkumar NV, De Oliveira E, Ottenhof N, Watters J, Brooks D, Demuth T, et al. MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts. Clinical Cancer Research 2011; 17: 2799-806.
    • (2011) Clinical Cancer Research , vol.17 , pp. 2799-2806
    • Rajeshkumar, N.V.1    De Oliveira, E.2    Ottenhof, N.3    Watters, J.4    Brooks, D.5    Demuth, T.6
  • 28
    • 33846608696 scopus 로고    scopus 로고
    • Cell cycle regulation bythe wee1 inhibitor PD0166285, pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line
    • Hashimoto O, Shinkawa M, Torimura T, Nakamura T, Selvendiran K, Sakamoto M, et al. Cell cycle regulation bythe Wee1 inhibitor PD0166285, pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line. BMC Cancer 2006; 6: 292.
    • (2006) BMC Cancer , vol.6 , pp. 292
    • Hashimoto, O.1    Shinkawa, M.2    Torimura, T.3    Nakamura, T.4    Selvendiran, K.5    Sakamoto, M.6
  • 29
    • 77954611291 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of SNS-032, a potent and selective cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma
    • Tong WG, Chen R, Plunkett W, Siegel D, Sinha R, Harvey RD, et al. Phase I and pharmacologic study of SNS-032, a potent and selective Cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma. Journal of Clinical Oncology 2010; 28: 3015-22.
    • (2010) Journal of Clinical Oncology , vol.28 , pp. 3015-3022
    • Tong, W.G.1    Chen, R.2    Plunkett, W.3    Siegel, D.4    Sinha, R.5    Harvey, R.D.6
  • 30
    • 80052396603 scopus 로고    scopus 로고
    • A phase I pharmacokinetic and pharmacodynamic study of AT7519, a cyclin-dependent kinase inhibitor in patients with refractory solid tumors
    • Mahadevan D, Plummer R, Squires MS, RensvoldD, Kurtin S, Pretzinger C, et al. A phase I pharmacokinetic and pharmacodynamic study of AT7519, a cyclin-dependent kinase inhibitor in patients with refractory solid tumors. Annals of Oncology 2011; 22: 2137-43.
    • (2011) Annals of Oncology , vol.22 , pp. 2137-2143
    • Mahadevan, D.1    Plummer, R.2    Squires, M.S.3    Rensvold, D.4    Kurtin, S.5    Pretzinger, C.6
  • 31
    • 78649634707 scopus 로고    scopus 로고
    • Phase I evaluation of seliciclib (R-roscovitine), a novel oral cyclin-dependent kinase inhibitor, in patients with advanced Malignancies
    • Le Tourneau C, Faivre S, Laurence V, Delbaldo C, Vera K, Girre V, et al. Phase I evaluation of seliciclib (R-roscovitine), a novel oral cyclin-dependent kinase inhibitor, in patients with advanced malignancies. European Journal of Cancer 2010; 46: 3243-50.
    • (2010) European Journal of Cancer , vol.46 , pp. 3243-3250
    • Le Tourneau, C.1    Faivre, S.2    Laurence, V.3    Delbaldo, C.4    Vera, K.5    Girre, V.6
  • 32
    • 77952902915 scopus 로고    scopus 로고
    • Clinical activity of sequential flavopiridol, cytosine arabinoside, and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia
    • Karp JE, Blackford A, Smith BD, Alino K, Seung AH, Bolanos-Meade J, et al. Clinical activity of sequential flavopiridol, cytosine arabinoside, and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia. Leukemia Research 2010; 34: 877-82.
    • (2010) Leukemia Research , vol.34 , pp. 877-882
    • Karp, J.E.1    Blackford, A.2    Smith, B.D.3    Alino, K.4    Seung, A.H.5    Bolanos-Meade, J.6
  • 33
    • 84861210266 scopus 로고    scopus 로고
    • Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma
    • Leonard JP, LaCasce AS, Smith MR, Noy A, Chirieac LR, Rodig SJ, et al. Selective CDK4/6 inhibition with tumor responses by PD0332991 in patients with mantle cell lymphoma. Blood 2012; 119: 4597-607.
    • (2012) Blood , vol.119 , pp. 4597-4607
    • Leonard, J.P.1    LaCasce, A.S.2    Smith, M.R.3    Noy, A.4    Chirieac, L.R.5    Rodig, S.J.6
  • 34
    • 84880695940 scopus 로고    scopus 로고
    • Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-amplified well-differentiated or dedifferentiated liposarcoma
    • Dickson MA, Tap WD, Keohan ML, D'Angelo SP, Gounder MM, Antonescu CR, et al. Phase II trial of the CDK4 inhibitor PD0332991 in patients with advanced CDK4-amplified well-differentiated or dedifferentiated liposarcoma. Journal of Clinical Oncology 2013; 31: 2024-8.
    • (2013) Journal of Clinical Oncology , vol.31 , pp. 2024-2028
    • Dickson, M.A.1    Tap, W.D.2    Keohan, M.L.3    D'Angelo, S.P.4    Gounder, M.M.5    Antonescu, C.R.6
  • 35
    • 84865681647 scopus 로고    scopus 로고
    • Phase II study of MLN8237 (alisertib), an investigational aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma
    • Matulonis UA, SharmaS, Ghamande S, Gordon MS, Del Prete SA, Ray-Coquard I, et al. Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma. Gynecologic Oncology 2012; 127: 63-9.
    • (2012) Gynecologic Oncology , vol.127 , pp. 63-69
    • Matulonis, U.A.1    Sharma, S.2    Ghamande, S.3    Gordon, M.S.4    Del Prete, S.A.5    Ray-Coquard, I.6
  • 36
    • 84865741266 scopus 로고    scopus 로고
    • Phase I study of aurora A kinase inhibitor MLN8237 in advanced solid tumors: Safety, pharmacokinetics, pharmacodynamics, and bioavailability of two oral formulations
    • Dees EC, Cohen RB, von Mehren M, Stinchcombe TE, Liu H, Venkatakrishnan K, et al. Phase I study of aurora A kinase inhibitor MLN8237 in advanced solid tumors: safety, pharmacokinetics, pharmacodynamics, and bioavailability of two oral formulations. Clinical Cancer Research 2012; 18: 4775-84.
    • (2012) Clinical Cancer Research , vol.18 , pp. 4775-4784
    • Dees, E.C.1    Cohen, R.B.2    Von Mehren, M.3    Stinchcombe, T.E.4    Liu, H.5    Venkatakrishnan, K.6
  • 37
    • 84865700741 scopus 로고    scopus 로고
    • Phase I pharmacokinetic/pharmacodynamic study of MLN8237, an investigational, oral, selective aurora a kinase inhibitor, in patients with advanced solid tumors
    • Cervantes A, Elez E, Roda D, Ecsedy J, Macarulla T, Venkatakrishnan K, et al. Phase I pharmacokinetic/pharmacodynamic study of MLN8237, an investigational, oral, selective aurora a kinase inhibitor, in patients with advanced solid tumors. Clinical Cancer Research 2012; 18: 4764-74.
    • (2012) Clinical Cancer Research , vol.18 , pp. 4764-4774
    • Cervantes, A.1    Elez, E.2    Roda, D.3    Ecsedy, J.4    Macarulla, T.5    Venkatakrishnan, K.6
  • 38
    • 82955217793 scopus 로고    scopus 로고
    • Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia
    • Lowenberg B, Muus P, Ossenkoppele G, Rousselot P, Cahn JY, Ifrah N, et al. Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia. Blood 2011; 118: 6030-6.
    • (2011) Blood , vol.118 , pp. 6030-6036
    • Lowenberg, B.1    Muus, P.2    Ossenkoppele, G.3    Rousselot, P.4    Cahn, J.Y.5    Ifrah, N.6
  • 39
  • 40
    • 84873570889 scopus 로고    scopus 로고
    • MK-0457, an aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia
    • Giles FJ, Swords RT, Nagler A, Hochhaus A, Ottmann OG, Rizzieri DA, et al. MK-0457, an Aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia. Leukemia 2013; 27: 113-7.
    • (2013) Leukemia , vol.27 , pp. 113-117
    • Giles, F.J.1    Swords, R.T.2    Nagler, A.3    Hochhaus, A.4    Ottmann, O.G.5    Rizzieri, D.A.6
  • 41
    • 79951826390 scopus 로고    scopus 로고
    • Phase I dose escalation study of MK-0457, a novel aurora kinase inhibitor, in adult patients with advanced solid tumors
    • Traynor AM, Hewitt M, Liu G, Flaherty KT, Clark J, Freedman SJ, et al. Phase I dose escalation study of MK-0457, a novel Aurora kinase inhibitor, in adult patients with advanced solid tumors. Cancer Chemotherapy and Pharmacology 2011; 67: 305-14.
    • (2011) Cancer Chemotherapy and Pharmacology , vol.67 , pp. 305-314
    • Traynor, A.M.1    Hewitt, M.2    Liu, G.3    Flaherty, K.T.4    Clark, J.5    Freedman, S.J.6
  • 42
    • 84871945991 scopus 로고    scopus 로고
    • Predictive biomarkers of sensitivity to the aurora and angiogenic kinase inhibitor ENMD-2076 in preclinical breast cancer models
    • Diamond JR, Eckhardt SG, Tan AC, Newton TP, Selby HM, Brunkow KL, et al. Predictive biomarkers of sensitivity to the aurora and angiogenic kinase inhibitor ENMD-2076 in preclinical breast cancer models. Clinical Cancer Research 2013; 19: 291-303.
    • (2013) Clinical Cancer Research , vol.19 , pp. 291-303
    • Diamond, J.R.1    Eckhardt, S.G.2    Tan, A.C.3    Newton, T.P.4    Selby, H.M.5    Brunkow, K.L.6
  • 43
    • 84871613362 scopus 로고    scopus 로고
    • Randomized phase II study of danusertib in patients with metastatic castration-resistant prostate cancer after docetaxel failure
    • Meulenbeld HJ, Bleuse JP, Vinci EM, Raymond E, Vitali G, Santoro A, et al. Randomized phase II study of danusertib in patients with metastatic castration-resistant prostate cancer after docetaxel failure. BJU International 2013; 111: 44-52.
    • (2013) BJU International , vol.111 , pp. 44-52
    • Meulenbeld, H.J.1    Bleuse, J.P.2    Vinci, E.M.3    Raymond, E.4    Vitali, G.5    Santoro, A.6
  • 44
    • 84860485132 scopus 로고    scopus 로고
    • A phase I dose escalation study of AT9283, a small molecule inhibitor of aurora kinases, in patients with advanced solid Malignancies
    • Arkenau HT, Plummer R, Molife LR, Olmos D, Yap TA, Squires M, et al. A phase I dose escalation study of AT9283, a small molecule inhibitor of aurora kinases, in patients with advanced solid malignancies. Annals of Oncology 2012; 23: 1307-13.
    • (2012) Annals of Oncology , vol.23 , pp. 1307-1313
    • Arkenau, H.T.1    Plummer, R.2    Molife, L.R.3    Olmos, D.4    Yap, T.A.5    Squires, M.6
  • 45
    • 80053353928 scopus 로고    scopus 로고
    • Phase I, open-label, multicentre, dose-escalation, pharmacokinetic and pharmaco-dynamic trial of the oral aurora kinase inhibitor PF-03814735 in advanced solid tumours
    • Schoffski P, Jones SF, Dumez H, Infante JR, Van Mieghem E, Fowst C, et al. Phase I, open-label, multicentre, dose-escalation, pharmacokinetic and pharmaco-dynamic trial of the oral aurora kinase inhibitor PF-03814735 in advanced solid tumours. European Journal of Cancer 2011; 47: 2256-64.
    • (2011) European Journal of Cancer , vol.47 , pp. 2256-2264
    • Schoffski, P.1    Jones, S.F.2    Dumez, H.3    Infante, J.R.4    Van Mieghem, E.5    Fowst, C.6
  • 46
    • 84859402436 scopus 로고    scopus 로고
    • Phase I study of rigosertib, an inhibitor of the phosphatidylinositol 3-kinase and polo-like kinase 1 pathways, combined with gemcitabine in patients with solid tumors and pancreatic cancer
    • MaWW, MessersmithWA, Dy GK, Weekes CD, WhitworthA, RenC, et al. Phase I study of Rigosertib, an inhibitor of the phosphatidylinositol 3-kinase and Polo-like kinase 1 pathways, combined with gemcitabine in patients with solid tumors and pancreatic cancer. Clinical Cancer Research 2012; 18: 2048-55.
    • (2012) Clinical Cancer Research , vol.18 , pp. 2048-2055
    • Ma, W.W.1    Messersmith, W.A.2    Dy, G.K.3    Weekes, C.D.4    Whitworth, A.5    Ren, C.6
  • 47
    • 84655164874 scopus 로고    scopus 로고
    • A phase I, dose-escalation study of the novel polo-like kinase inhibitor volasertib (BI 6727) in patients with advanced solid tumours
    • Schoffski P, Awada A, Dumez H, Gil T, Bartholomeus S, Wolter P, et al. A phase I, dose-escalation study of the novel Polo-like kinase inhibitor volasertib (BI 6727) in patients with advanced solid tumours. European Journal of Cancer 2012; 48: 179-86.
    • (2012) European Journal of Cancer , vol.48 , pp. 179-186
    • Schoffski, P.1    Awada, A.2    Dumez, H.3    Gil, T.4    Bartholomeus, S.5    Wolter, P.6
  • 48
    • 79956014825 scopus 로고    scopus 로고
    • Phase I study of GSK461364, a specific and competitive polo-like kinase 1 inhibitor, in patients with advanced solid Malignancies
    • Olmos D, Barker D, Sharma R, Brunetto AT, Yap TA, Taegtmeyer AB, et al. Phase I study of GSK461364, a specific and competitive Polo-like kinase 1 inhibitor, in patients with advanced solid malignancies. Clinical Cancer Research 2011; 17: 3420-30.
    • (2011) Clinical Cancer Research , vol.17 , pp. 3420-3430
    • Olmos, D.1    Barker, D.2    Sharma, R.3    Brunetto, A.T.4    Yap, T.A.5    Taegtmeyer, A.B.6
  • 50
    • 78049278014 scopus 로고    scopus 로고
    • A pediatric phase I trial and pharmacokinetic study of ispinesib: A children's oncology group phase I consortium study
    • Souid AK, Dubowy RL, Ingle AM, Conlan MG, Sun J, Blaney SM, et al. A pediatric phase I trial and pharmacokinetic study of ispinesib: a Children's Oncology Group phase I consortium study. Pediatr Blood Cancer 2010; 55: 1323-8.
    • (2010) Pediatr Blood Cancer , vol.55 , pp. 1323-1328
    • Souid, A.K.1    Dubowy, R.L.2    Ingle, A.M.3    Conlan, M.G.4    Sun, J.5    Blaney, S.M.6
  • 51
    • 79955627902 scopus 로고    scopus 로고
    • A phase I study of ispinesib, a kinesin spindle protein inhibitor, administered weekly for three consecutive weeks of a 28-day cycle in patients with solid tumors
    • Burris HA, 3rd, Jones SF, Williams DD, Kathman SJ, Hodge JP, et al. A phase I study of ispinesib, a kinesin spindle protein inhibitor, administered weekly for three consecutive weeks of a 28-day cycle in patients with solid tumors. Investigational New Drugs 2011; 29: 467-72.
    • (2011) Investigational New Drugs , vol.29 , pp. 467-472
    • Burris III, H.A.1    Jones, S.F.2    Williams, D.D.3    Kathman, S.J.4    Hodge, J.P.5
  • 52
    • 84863335493 scopus 로고    scopus 로고
    • A phase 1 dose-escalation study of ARRY-520, a kinesin spindle protein inhibitor, in patients with advanced myeloid leukemias
    • Khoury HJ, Garcia-Manero G, Borthakur G, Kadia T, Foudray MC, Arellano M, et al. A phase 1 dose-escalation study of ARRY-520, a kinesin spindle protein inhibitor, in patients with advanced myeloid leukemias. Cancer 2013; 118: 3556-64.
    • (2013) Cancer , vol.118 , pp. 3556-3564
    • Khoury, H.J.1    Garcia-Manero, G.2    Borthakur, G.3    Kadia, T.4    Foudray, M.C.5    Arellano, M.6
  • 53
    • 84880924613 scopus 로고    scopus 로고
    • Phase II study to assess the efficacy, safety and tolerability of the mitotic spindle kinesin inhibitor AZD4877 in patients with recurrent advanced urothelial cancer
    • Jones R, Vuky J, Elliott T, Mead G, Arranz JA, Chester J, et al. Phase II study to assess the efficacy, safety and tolerability of the mitotic spindle kinesin inhibitor AZD4877 in patients with recurrent advanced urothelial cancer. Investigational New Drugs 2012; 31: 1001-7.
    • (2012) Investigational New Drugs , vol.31 , pp. 1001-1007
    • Jones, R.1    Vuky, J.2    Elliott, T.3    Mead, G.4    Arranz, J.A.5    Chester, J.6
  • 54
    • 79953770295 scopus 로고    scopus 로고
    • A first in human study of SB-743921, a kinesin spindle protein inhibitor, to determine pharmacokinetics, biologic effects and establish arecommended phase II dose
    • Holen KD, Belani CP, Wilding G, Ramalingam S, Volkman JL, Ramanathan RK, et al. A first in human study of SB-743921, a kinesin spindle protein inhibitor, to determine pharmacokinetics, biologic effects and establish arecommended phase II dose. Cancer Chemotherapy and Pharmacology 2011; 67: 447-54.
    • (2011) Cancer Chemotherapy and Pharmacology , vol.67 , pp. 447-454
    • Holen, K.D.1    Belani, C.P.2    Wilding, G.3    Ramalingam, S.4    Volkman, J.L.5    Ramanathan, R.K.6
  • 55
    • 84861681511 scopus 로고    scopus 로고
    • Reduced efficacy of the plk1 inhibitor BI 2536 on the progression of hepatocellular carcinoma due to low intratumoral drug levels
    • Haupenthal J, Bihrer V, Korkusuz H, Kollmar O, Schmithals C, Kriener S, et al. Reduced efficacy of the Plk1 inhibitor BI 2536 on the progression of hepatocellular carcinoma due to low intratumoral drug levels. Neoplasia 2012; 14: 410-9.
    • (2012) Neoplasia , vol.14 , pp. 410-419
    • Haupenthal, J.1    Bihrer, V.2    Korkusuz, H.3    Kollmar, O.4    Schmithals, C.5    Kriener, S.6
  • 56
    • 84855405497 scopus 로고    scopus 로고
    • The proliferation rate paradox in antimitotic chemotherapy
    • Mitchison TJ. The proliferation rate paradox in antimitotic chemotherapy. Molecular Biology of the Cell 2012; 23: 1-6.
    • (2012) Molecular Biology of the Cell , vol.23 , pp. 1-6
    • Mitchison, T.J.1
  • 57
    • 33744996707 scopus 로고    scopus 로고
    • Mitotic Checkpoint Slippage in Humans Occurs via Cyclin B Destruction in the Presence of an Active Checkpoint
    • DOI 10.1016/j.cub.2006.04.043, PII S0960982206015405
    • Brito DA, Rieder CL. Mitotic checkpoint slippage in humans occurs via cyclin B destruction in the presence of an active checkpoint. Current Biology 2006; 16: 1194-200. (Pubitemid 43867292)
    • (2006) Current Biology , vol.16 , Issue.12 , pp. 1194-1200
    • Brito, D.A.1    Rieder, C.L.2
  • 58
  • 59
    • 84878663198 scopus 로고    scopus 로고
    • A tumor suppressor role of the bub3 spindle checkpoint protein after apoptosis inhibition
    • Morais da Silva S, Moutinho-Santos T, Sunkel CE. A tumor suppressor role of the Bub3 spindle checkpoint protein after apoptosis inhibition. Journal of Cell Biology 2013; 201: 385-93.
    • (2013) Journal of Cell Biology , vol.201 , pp. 385-393
    • Morais Da Silva, S.1    Moutinho-Santos, T.2    Sunkel, C.E.3
  • 60
    • 84869054115 scopus 로고    scopus 로고
    • Cyclin-dependent kinase-1 (Cdk1)/ cyclin B1 dictates cell fate after mitotic arrest via phosphoregulation of antiapoptotic bcl-2 proteins
    • Sakurikar N, Eichhorn JM, Chambers TC. Cyclin-dependent kinase-1 (Cdk1)/ cyclin B1 dictates cell fate after mitotic arrest via phosphoregulation of antiapoptotic Bcl-2 proteins. Journal of Biological Chemistry 2012; 287: 39193-204.
    • (2012) Journal of Biological Chemistry , vol.287 , pp. 39193-39204
    • Sakurikar, N.1    Eichhorn, J.M.2    Chambers, T.C.3
  • 61
    • 77954884045 scopus 로고    scopus 로고
    • Phosphorylation of mcl-1 by CDK1-cyclin B1 initiates its cdc20-dependent destruction during mitotic arrest
    • Harley ME, Allan LA, Sanderson HS, Clarke PR. Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest. EMBO Journal 2010; 29: 2407-20.
    • (2010) EMBO Journal , vol.29 , pp. 2407-2420
    • Harley, M.E.1    Allan, L.A.2    Sanderson, H.S.3    Clarke, P.R.4
  • 62
    • 83955161188 scopus 로고    scopus 로고
    • Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of mcl-1, promoting its degradation and freeing bak from sequestration
    • Chu R, Terrano DT, Chambers TC. Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration. Biochemical Pharmacology 2012; 83: 199-206.
    • (2012) Biochemical Pharmacology , vol.83 , pp. 199-206
    • Chu, R.1    Terrano, D.T.2    Chambers, T.C.3
  • 63
    • 82655181322 scopus 로고    scopus 로고
    • Cooperative phosphorylation of FADD by AurA and plk1 in response to taxol triggers both apoptotic and necrotic cell death
    • Jang MS, Lee SJ, Kang NS, Kim E. Cooperative phosphorylation of FADD by AurA and Plk1 in response to taxol triggers both apoptotic and necrotic cell death. Cancer Research 2011; 71: 7207-15.
    • (2011) Cancer Research , vol.71 , pp. 7207-7215
    • Jang, M.S.1    Lee, S.J.2    Kang, N.S.3    Kim, E.4
  • 64
    • 84870908872 scopus 로고    scopus 로고
    • Aurora kinase ainhibition-induced autophagy triggers drug resistance in breast cancer cells
    • Zou Z, YuanZ, Zhang Q, LongZ, Chen J, Tang Z, et al. Aurora kinase Ainhibition-induced autophagy triggers drug resistance in breast cancer cells. Autophagy 2012; 8: 1798-810.
    • (2012) Autophagy , vol.8 , pp. 1798-1810
    • Zou, Z.1    Yuan, Z.2    Zhang, Q.3    Long, Z.4    Chen, J.5    Tang, Z.6
  • 65
    • 79953126542 scopus 로고    scopus 로고
    • Phase 1 and pharmacokinetic study of bolus-infusion flavopiridol followed by cytosine arabinoside and mitoxantrone for acute leukemias
    • Karp JE, Smith BD, Resar LS, Greer JM, Blackford A, Zhao M, et al. Phase 1 and pharmacokinetic study of bolus-infusion flavopiridol followed by cytosine arabinoside and mitoxantrone for acute leukemias. Blood 2011; 117: 3302-10.
    • (2011) Blood , vol.117 , pp. 3302-3310
    • Karp, J.E.1    Smith, B.D.2    Resar, L.S.3    Greer, J.M.4    Blackford, A.5    Zhao, M.6
  • 66
    • 80053398390 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models
    • Feldmann G, Mishra A, Bisht S, Karikari C, Garrido-Laguna I, Rasheed Z, et al. Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models. Cancer Biology and Therapy 2011; 12: 598-609.
    • (2011) Cancer Biology and Therapy , vol.12 , pp. 598-609
    • Feldmann, G.1    Mishra, A.2    Bisht, S.3    Karikari, C.4    Garrido-Laguna, I.5    Rasheed, Z.6
  • 67
    • 77950650401 scopus 로고    scopus 로고
    • In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762
    • Mitchell JB, Choudhuri R, Fabre K, Sowers AL, Citrin D, Zabludoff SD, et al. In vitro and in vivo radiation sensitization of human tumor cells by a novel checkpoint kinase inhibitor, AZD7762. Clinical Cancer Research 2010; 16: 2076-84.
    • (2010) Clinical Cancer Research , vol.16 , pp. 2076-2084
    • Mitchell, J.B.1    Choudhuri, R.2    Fabre, K.3    Sowers, A.L.4    Citrin, D.5    Zabludoff, S.D.6
  • 68
    • 68049107474 scopus 로고    scopus 로고
    • PF-00477736 mediates checkpoint kinase 1 signaling pathway and potentiates docetaxel-induced efficacy in xenografts
    • Zhang C, Yan Z, Painter CL, Zhang Q, Chen E, Arango ME, et al. PF-00477736 mediates checkpoint kinase 1 signaling pathway and potentiates docetaxel-induced efficacy in xenografts. Clinical Cancer Research 2009; 15: 4630-4640.
    • (2009) Clinical Cancer Research , vol.15 , pp. 4630-4640
    • Zhang, C.1    Yan, Z.2    Painter, C.L.3    Zhang, Q.4    Chen, E.5    Arango, M.E.6
  • 70
    • 84867422165 scopus 로고    scopus 로고
    • BAY 1000394, a novel cyclin-dependent kinase inhibitor, with potent antitumor activity in mono- and in combination treatment upon oral application
    • Siemeister G, Lucking U, Wengner AM, Lienau P, Steinke W, Schatz C, et al. BAY 1000394, a novel cyclin-dependent kinase inhibitor, with potent antitumor activity in mono- and in combination treatment upon oral application. Molecular Cancer Therapeutics 2012; 11: 2265-73.
    • (2012) Molecular Cancer Therapeutics , vol.11 , pp. 2265-2273
    • Siemeister, G.1    Lucking, U.2    Wengner, A.M.3    Lienau, P.4    Steinke, W.5    Schatz, C.6
  • 71
    • 78649971294 scopus 로고    scopus 로고
    • Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines
    • Payton M, Bush TL, Chung G, Ziegler B, Eden P, McElroy P, et al. Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines. Cancer Research 2010; 70: 9846-54.
    • (2010) Cancer Research , vol.70 , pp. 9846-9854
    • Payton, M.1    Bush, T.L.2    Chung, G.3    Ziegler, B.4    Eden, P.5    McElroy, P.6
  • 73
    • 70349566478 scopus 로고    scopus 로고
    • KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation
    • Shiotsu Y, Kiyoi H, Ishikawa Y, Tanizaki R, Shimizu M, Umehara H, et al. KW-2449, a novel multikinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation. Blood 2009; 114: 1607-17.
    • (2009) Blood , vol.114 , pp. 1607-1617
    • Shiotsu, Y.1    Kiyoi, H.2    Ishikawa, Y.3    Tanizaki, R.4    Shimizu, M.5    Umehara, H.6
  • 74
    • 73949087301 scopus 로고    scopus 로고
    • MK-5108, a highly selective aurora - A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel
    • Shimomura T, Hasako S, Nakatsuru Y, Mita T, Ichikawa K, Kodera T, et al. MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel. Molecular Cancer Therapeutics 2010; 9: 157-66.
    • (2010) Molecular Cancer Therapeutics , vol.9 , pp. 157-166
    • Shimomura, T.1    Hasako, S.2    Nakatsuru, Y.3    Mita, T.4    Ichikawa, K.5    Kodera, T.6
  • 75
    • 67651154329 scopus 로고    scopus 로고
    • GSK1070916, a potent aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models
    • Hardwicke MA, Oleykowski CA, Plant R, Wang J, Liao Q, Moss K, et al. GSK1070916, a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models. Molecular Cancer Therapeutics 2009; 8: 1808-17.
    • (2009) Molecular Cancer Therapeutics , vol.8 , pp. 1808-1817
    • Hardwicke, M.A.1    Oleykowski, C.A.2    Plant, R.3    Wang, J.4    Liao, Q.5    Moss, K.6
  • 77
    • 84859414644 scopus 로고    scopus 로고
    • TAK-960, a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple dosing regimens
    • Hikichi Y, Honda K, Hikami K, Miyashita H, Kaieda I, Murai S, et al. TAK-960, a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple dosing regimens. Molecular Cancer Therapeutics 2012; 11: 700-9.
    • (2012) Molecular Cancer Therapeutics , vol.11 , pp. 700-709
    • Hikichi, Y.1    Honda, K.2    Hikami, K.3    Miyashita, H.4    Kaieda, I.5    Murai, S.6
  • 78
    • 84864329202 scopus 로고    scopus 로고
    • A phase I trial of MK-0731, a kinesin spindle protein (KSP) inhibitor, in patients with solid tumors
    • Holen K, DiPaola R, Liu G, Tan AR, Wilding G, Hsu K, et al. A phase I trial of MK-0731, a kinesin spindle protein (KSP) inhibitor, in patients with solid tumors. Investigational New Drugs 2013; 30: 1088-95.
    • (2013) Investigational New Drugs , vol.30 , pp. 1088-1095
    • Holen, K.1    DiPaola, R.2    Liu, G.3    Tan, A.R.4    Wilding, G.5    Hsu, K.6
  • 79
    • 84859744596 scopus 로고    scopus 로고
    • First-time-in-human study of GSK923295, a novel antimitotic inhibitor of centromere-associated protein E (CENP-E), in patients with refractory cancer
    • Chung V, Heath EI, Schelman WR, Johnson BM, Kirby LC, Lynch KM, et al. First-time-in-human study of GSK923295, a novel antimitotic inhibitor of centromere-associated protein E (CENP-E), in patients with refractory cancer. Cancer Chemotherapy and Pharmacology 2012; 69: 733-41.
    • (2012) Cancer Chemotherapy and Pharmacology , vol.69 , pp. 733-741
    • Chung, V.1    Heath, E.I.2    Schelman, W.R.3    Johnson, B.M.4    Kirby, L.C.5    Lynch, K.M.6
  • 80
    • 84155164905 scopus 로고    scopus 로고
    • C.D.K.I-71 a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol
    • Liu X, Shi S, Lam F, Pepper C, Fischer PM, Wang S. C.D.K.I-71 a novel CDK9 inhibitor, is preferentially cytotoxic to cancer cells compared to flavopiridol. International Journal of Cancer 2012; 130: 1216-26.
    • (2012) International Journal of Cancer , vol.130 , pp. 1216-1226
    • Liu, X.1    Shi, S.2    Lam, F.3    Pepper, C.4    Fischer, P.M.5    Wang, S.6
  • 81
    • 79957604201 scopus 로고    scopus 로고
    • Ibulocydine is a novel prodrug cdk inhibitor that effectively induces apoptosis in hepatocellular carcinoma cells
    • Cho SJ, Kim YJ, Surh YJ, Kim BM, Lee SK. Ibulocydine is a novel prodrug Cdk inhibitor that effectively induces apoptosis in hepatocellular carcinoma cells. Journal of Biological Chemistry 2011; 286: 19662-71.
    • (2011) Journal of Biological Chemistry , vol.286 , pp. 19662-19671
    • Cho, S.J.1    Kim, Y.J.2    Surh, Y.J.3    Kim, B.M.4    Lee, S.K.5
  • 82
    • 77957174099 scopus 로고    scopus 로고
    • A CDK inhibitor, effectively suppresses src-mediated transformation by inhibiting both CDKs and c-src
    • Hikita T, Oneyama C, Okada M, Purvalanol A. a CDK inhibitor, effectively suppresses Src-mediated transformation by inhibiting both CDKs and c-Src. Genes to Cells 2010; 15: 1051-62.
    • (2010) Genes to Cells , vol.15 , pp. 1051-1062
    • Hikita, T.1    Oneyama, C.2    Okada, M.3    Purvalanol, A.4
  • 84
    • 80053229630 scopus 로고    scopus 로고
    • Polo-box domain in hibitor poloxin activates the spindle assembly check point and in hibits tumor growth in vivo
    • Yuan J, Sanhaji M, Kramer A, Reindl W, Hofmann M, Kreis NN, et al. Polo-box domain in hibitor poloxin activates the spindle assembly check point and in hibits tumor growth in vivo. American Journal of Pathology 2011; 179: 2091-9.
    • (2011) American Journal of Pathology , vol.179 , pp. 2091-2099
    • Yuan, J.1    Sanhaji, M.2    Kramer, A.3    Reindl, W.4    Hofmann, M.5    Kreis, N.N.6
  • 86
    • 84861176263 scopus 로고    scopus 로고
    • Inhibition of eg5 acts synergistically with checkpoint abrogation in promoting mitotic catastrophe
    • Chen Y, Chow JP, Poon RY. Inhibition of Eg5 acts synergistically with checkpoint abrogation in promoting mitotic catastrophe. Molecular Cancer Research 2012; 10: 626-35.
    • (2012) Molecular Cancer Research , vol.10 , pp. 626-635
    • Chen, Y.1    Chow, J.P.2    Poon, R.Y.3
  • 87
    • 84877610547 scopus 로고    scopus 로고
    • Markedly additive antitumor activity with the combination of a selective survivin suppressant YM155 and alemtuzumab in adult T-cell leukemia
    • Chen J, Pise-Masison CA, Shih JH, Morris JC, Janik JE, Conlon KC, et al. Markedly additive antitumor activity with the combination of a selective survivin suppressant YM155 and alemtuzumab in adult T-cell leukemia. Blood 2013; 121: 2029-37.
    • (2013) Blood , vol.121 , pp. 2029-2037
    • Chen, J.1    Pise-Masison, C.A.2    Shih, J.H.3    Morris, J.C.4    Janik, J.E.5    Conlon, K.C.6
  • 88
    • 78650322902 scopus 로고    scopus 로고
    • Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase
    • Colombo R, Caldarelli M, Mennecozzi M, Giorgini ML, Sola F, Cappella P, et al. Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase. Cancer Research 2010; 70: 10255-64.
    • (2010) Cancer Research , vol.70 , pp. 10255-10264
    • Colombo, R.1    Caldarelli, M.2    Mennecozzi, M.3    Giorgini, M.L.4    Sola, F.5    Cappella, P.6
  • 89
    • 83355174038 scopus 로고    scopus 로고
    • Characterization of the cellular and antitumor effects of MPI-0479605, a small-molecule inhibitor of the mitotic kinase mps1
    • Tardif KD, Rogers A, Cassiano J, Roth BL, Cimbora DM, McKinnon R, et al. Characterization of the cellular and antitumor effects of MPI-0479605, a small-molecule inhibitor of the mitotic kinase Mps1. Molecular Cancer Therapeutics 2011; 10: 2267-75.
    • (2011) Molecular Cancer Therapeutics , vol.10 , pp. 2267-2275
    • Tardif, K.D.1    Rogers, A.2    Cassiano, J.3    Roth, B.L.4    Cimbora, D.M.5    McKinnon, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.