TRPM8 activation by menthol, icilin, and cold is differentially modulated by intracellular pH

Journal of Neuroscience

Volumn 24, Issue 23, 2004, Pages 5364-5369

  Andersson, David A ^a,b   Chase, Henry W N ^a   Bevan, Stuart ^a  

^a Novatis Inst for Medical Sciences   (United Kingdom)

^b Novartis Inst for Medical Sciences   (United Kingdom)

Author keywords

Menthol; Pain; pH; Sensory neurons; Temperature; TRP channels

Indexed keywords

1 (2 HYDROXYPHENYL) 4 (3 NITROPHENYL) 1,2,3,6 TETRAHYDROPYRIMIDIN 2 ONE; CALCIUM; CATION CHANNEL; FURA 2; MEMBRANE PROTEIN; MENTHOL; PROTEIN TRPM8; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG;

ACIDIFICATION; AMPLITUDE MODULATION; ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CHO CELL; COLD; CONCENTRATION RESPONSE; CONTROLLED STUDY; COOLING; ELECTROPHYSIOLOGY; EVOKED RESPONSE; INTRACELLULAR TRANSPORT; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; REGULATORY MECHANISM; TEMPERATURE MEASUREMENT; VOLTAGE CLAMP;

ANIMALS; CHO CELLS; COLD; CRICETINAE; CRICETULUS; ELECTROPHYSIOLOGY; FLUORESCENT DYES; FURA-2; HYDROGEN-ION CONCENTRATION; ION CHANNELS; MENTHOL; NEOPLASM PROTEINS; PYRIMIDINONES;

EID: 2942536048     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0890-04.2004     Document Type: Article

References (23)

1. Behrendt HJ, Germann T, Gillen C, Hatt H, Jostock R (2004) Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol 141:737-745.
2. Galla JH (2000) Metabolic alkalosis. J Am Soc Nephrol 11:369-375.
3. Garcia-Martinez C, Morenilla-Palao C, Planells-Cases R, Merino JM, Ferrer-Montiel A (2000) Identification of an aspartic residue in the P-loop of the vanilloid receptor that modulates pore properties. J Biol Chem 275:32552-32558.
4. Heppner TJ, Bonev AD, Santana LF, Nelson MT (2002) Alkaline pH shifts Ca2+ sparks to Ca2+ waves in smooth muscle cells of pressurized cerebral arteries. Am J Physiol Heart Circ Physiol 283:H2169-H2176.
5. Jordt SE, Tominaga M, Julius D (2000) Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc Natl Acad Sci USA 97:8134-8139.
6. Joseph SK, Rice HL, Williamson JR (1989) The effect of external calcium and pH on inositol trisphosphate-mediated calcium release from cerebellum microsomal fractions. Biochem J 258:261-265.
7. Klement W, Arndt JO (1992) The role of nociceptors of cutaneous veins in the mediation of cold pain in man. J Physiol 449:73-83.
8. Kress M, Fetzer S, Reeh PW, Vyklicky L (1996) Low pH facilitates capsaicin responses in isolated sensory neurons of the rat. Neurosci Lett 211:5-8.
9. Laffey JG, Kavanagh BP (2002) Hypocapnia. N Engl J Med 347:43-53.
10. Maingret F, Lauritzen I, Patel AJ, Heurteaux C, Reyes R, Lesage F, Lazdunski M, Honore E (2000) TREK-1 is a heat-activated background K(+) channel. EMBO J 19:2483-2491.
11. McKemy DD, Neuhausser WM, Julius D (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416:52-58.
12. McLatchie LM, Bevan S (2001) The effects of pH on the interaction between capsaicin and the vanilloid receptor in rat dorsal root ganglia neurons. Br J Pharmacol 132:899-908.
13. Nealen ML, Gold MS, Thut PD, Caterina MJ (2003) TRPM8 mRNA is expressed in a subset of cold-responsive trigeminal neurons from rat. J Neurophysiol 90:515-520.
14. Peier AM, Moqrich A, Hergarden AC, Reeve AJ, Andersson DA, Story GM, Earley TJ, Dragoni I, McIntyre P, Bevan S, Patapoutian A (2002) A TRP channel that senses cold stimuli and menthol. Cell 108:705-715.
15. Poteser M, Wakabayashi I, Rosker C, Teubl M, Schindl R, Soldatov NM, Romanin C, Groschner K (2003) Crosstalk between voltage-independent Ca2+ channels and L-type Ca2+ channels in A7r5 vascular smooth muscle cells at elevated intracellular pH: evidence for functional coupling between L-type Ca2+ channels and a 2-APB-sensitive cation channel. Circ Res 92:888-896.
16. Reid G, Babes A, Pluteanu F (2002) A cold- and menthol-activated current in rat dorsal root ganglion neurones: properties and role in cold transduction. J Physiol (Lond) 545:595-614.
17. Savidge JR, Ranasinghe SP, Rang HP (2001) Comparison of intracellular calcium signals evoked by heat and capsaicin in cultured rat dorsal root ganglion neurons and in a cell line expressing the rat vanilloid receptor, VR1. Neuroscience 102:177-184.
18. Somjen GG, Tombaugh GC (1998) pH modulation of neuronal excitability and central nervous system functions. In: pH and brain function (Kaila K, Ransom BR, eds), pp 373-394. New York: Wiley.
19. Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, Earley TJ, Hergarden AC, Andersson DA, Hwang SW, McIntyre P, Jegla T, Bevan S, Patapoutian A (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112:819-829.
20. Tombaugh GC, Somjen GG (1998) pH modulation of voltage-gated ion channels. In: pH and brain function (Kaila K, Ransom BR, eds), pp 395-416. New York: Wiley.
21. Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, Basbaum Al, Julius D (1998) The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21:531-543.
22. Tsavaler L, Shapero MH, Morkowski S, Laus R (2001) Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res 61:3760-3769.
23. Worley PF, Baraban JM, Supattapone S, Wilson VS, Snyder SH (1987) Characterization of inositol trisphosphate receptor binding in brain. Regulation by pH and calcium. J Biol Chem 262:12132-12136.