Folding dynamics of the trp-cage miniprotein: Evidence for a native-like intermediate from combined time-resolved vibrational spectroscopy and molecular dynamics simulations

Journal of Physical Chemistry B

Volumn 117, Issue 39, 2013, Pages 11490-11501

  Meuzelaar, Heleen ^a   Marino, Kristen A ^a   Huerta Viga, Adriana ^a   Panman, Matthijs R ^a   Smeenk, Linde E J ^a   Kettelarij, Albert J ^a   Van Maarseveen, Jan H ^a   Timmerman, Peter ^a,b   Bolhuis, Peter G ^a   Woutersen, Sander ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b Pepscan Systems   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDES; HYDROPHOBICITY; MOLECULAR DYNAMICS; PROTEINS;

FOLDED CONFORMATION; FOLDING INTERMEDIATES; MOLECULAR DYNAMICS SIMULATIONS; POLYPROLINE II HELIX; PROTEIN FOLDING MECHANISMS; THEORETICAL INVESTIGATIONS; TIME RESOLVED INFRARED SPECTROSCOPY; VIBRATIONAL RESPONSE;

RELAXATION PROCESSES;

PEPTIDE; TRP CAGE PEPTIDE; TRP-CAGE PEPTIDE;

ABSORPTION; ARTICLE; CHEMICAL PHENOMENA; CHEMISTRY; COMPARATIVE STUDY; INFRARED SPECTROSCOPY; KINETICS; LASER; MOLECULAR DYNAMICS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SPECTROSCOPY; SYNTHESIS; TEMPERATURE; TIME; TRANSITION TEMPERATURE; VIBRATION;

ABSORPTION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; LASERS; MOLECULAR DYNAMICS SIMULATION; PEPTIDES; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SPECTRUM ANALYSIS; TEMPERATURE; TIME FACTORS; TRANSITION TEMPERATURE; VIBRATION;

EID: 84885138820     PISSN: 15206106     EISSN: 15205207     Source Type: Journal    
DOI: 10.1021/jp404714c     Document Type: Article

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