Tissue engineering for insulin replacement in diabetes

Scaffolding in Tissue Engineering

Volumn , Issue , 2005, Pages 585-608

  Lewis, Amy S ^a   Colton, Clark K ^a  

^a Massachusetts of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84885120261     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (181)

1. American Diabetes Association, Economic costs of diabetes in the US in 2002, Diabetes Care, 26(3), 917-932, 2003.
2. Centers for Disease Control. National Diabetes Fact Sheet: General Information and National Estimates on Diabetes in The United States, 2000, US Department of Health and Human Services, Centers for Disease Control and Prevention, Atlanta, GA, 2002.
3. Sutherland, D. E. R., Is immunosuppression justified for nonuremic diabetic patients to keep them insulin independent? (the argument for), Transplant. Proc., 34, 1927-1928, 2002.
4. The Diabetes Control and Complications Trial Research Group, The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus, N. Engl. J. Med., 329(14), 977-986, 1993.
5. Plotnick, L. P., Clark, L. M., Brancati, F. L., and Erlinger, T., Safety and effectiveness of insulin pump therapy in children and adolescents with type 1 diabetes, Diabetes Care, 26(4), 1142-1146, 2003.
6. Kost, J., Mitragotri, S., Gabbay, R. A., Pishko, M., and Langer, R., Transdermal monitoring of glucose and other analytes using ultrasound, Nat. Med., 6(3), 347-350, 2000.
7. Mitragori, S., Coleman, M., Kost, J., and Langer, R., Analysis of ultrasonically extracted interstitial fluid as a predictor of blood glucose levels, J. Appl. Physiol., 89, 961-966, 2000.
8. Cefalu, W. T., Evaluation of alternative strategies for optimizing glycemia: progress to date, Am. J. Med., 113(6A), 23S-35S, 2002.
9. Gough, D., Armour, J., and Baker, D., Advances and prospects in glucose assay technologies, Diabetologia, 40, S102-S107, 1997.
10. Gerritsen, M., Jansen, J., and Lutterman, J., Performance of subcutaneously implanted sensors for continuous monitoring, Netherlands J. Med., 54, 167-179, 1999.
11. Koschchinsky, T., and Heinemann, L., Sensors for glucose monitoring: technical and clinical aspects, Diabetes Metab. Res. Rev., 17, 113-123, 2001.
12. Abel, P. U., and von Woedtke, T., Biosensors for in vivo glucose measurement: can we cross the experimental stage, Biosens. Bioelectron., 17, 1059-1070, 2002.
13. Frost, M. C., and Meyerhoff, M. E., Implantable chemical sensors for real-time clinical monitoring: progress and challenges, Curr. Opin. Chem. Biol., 6, 633-641, 2002.
14. Galaev, I. Y., and Mattiasson, B., “Smart” polymers and what they could do in biotechnology and medicine, Trends Biotechnol., 17, 335-340, 1999.
15. Shapiro, A. M. J., Lakey, J. R. T., Ryan, E. A., Korbutt, G. S., Toth, E., Warnock, G. L., Kneteman, N. M., and Rajotte, R. V., Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen, N. Engl. J. Med., 343(4), 230-238, 2000.
16. Burridge, P. W., Shapiro, A. M. J., Ryan, E. A., and Lakey, J. R. T., Future trends in clinical islet transplantation, Transplant. Proc., 34, 3347-3348, 2002.
17. Weir, G. C., and Bonner-Weir, S., Scientific and political impediments to successful islet transplantation, Diabetes, 46(8), 1247-1256, 1997.
18. De Vos, P., Van Straaten, J. F. M., Nieuwenhuizen, A. G., de Groot, M., Ploeg, R. J., De Haan, B. J., and Van Schilfgaarde, R., Why do microencapsulated islet grafts fail in the absence of fibrotic overgrowth?, Diabetes, 48(7), 1381-1388, 1999.
19. Colton, C. K., and Avgoustiniatos, E. S., Bioengineering in development of the hybrid artificial pancreas, Trans. ASME, 113, 152-170, 1991.
20. Colton, C. K., Engineering issues in islet immunoisolation, In Pancreatic Islet Transplantation Volume III: Immunoisolation of Pancreatic Islets, Lanza, R. P., and Chick, W. L., eds., R.G. Landes Company, Austin, pp. 13-20, 1994.
21. Colton, C. K., Implantable biohybrid artificial organs, Cell Transplant., 4(4), 415-436, 1995.
22. Avgoustiniatos, E. S., Wu, H., and Colton, C. K., Engineering challenges in immunoisolation device development, In Principles of Tissue Engineering, Lanza, R. P., Langer, R., and Vacanti, J., eds., Academic Press, San Diego, CA, pp. 331 -350, 2000.
23. O’Connell, P., Commentaries: pancreatic islet xenotransplantation, Xenotransplantation, 9, 367-375, 2002.
24. Omer, A., Duvivier-Kali, V. F., Trivedi, N., Wilmot, K., Bonner-Weir, S., and Weir, G. C., Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice, Diabetes, 52, 69-75, 2003.
25. Tatarkiewicz, K., Hollister-Lock, J., Quickel, R. R., Colton, C. K., Bonner-Weir, S., and Weir, G. C., Reversal of hyperglycemia in mice after subcutaneous transplantation of macroencapsulated islets, Transplantation, 67(5), 665-671, 1999.
26. Hsu, B. R.-S., Hsueh, C., Fu, S.-H., Hsu, S., and Juang, J.-H., A removable tubing for implanting islet graft and studying immunosuppression, Transplant. Proc., 34, 1462, 2002.
27. Colton, C. K., The engineering of xenogeneic islet transplantation by immunoisolation, Diabetes, Nutrition Metab., 5(Suppl. 1), 145-149, 1992.
28. Bach, F. H., and Fineberg, H. V., Call for moratorium on xenotransplants, Nature, 391, 326, 1998.
29. Sun, Y., Ma, X., Zhou, D., Vacek, I., and Sun, A. M., Normalization of diabetes in spontaneously diabetic cynomologous monkeys by xenografts of microencapsulated porcine islets without immunosuppression, J. Clin. Invest., 98(6), 1417-1422, 1996.
30. Boyce, N., Down on the organ farm, US News World Rep., 134(21), 47, 2003.
31. Binette, T. M., Dufour, J. M., and Korbutt, G. S., In vitro maturation of neonatal porcine islets: a novel method for the study of islet development and xenotransplantation, Ann. NY Acad. Sci., 944, 47-61, 2001.
32. Korbutt, G. S., Elliott, J. F., Ao, Z., Flashner, M., Warnock, G. L., and Rajotte, R. V., Microencapsulation of neonatal porcine islets: long-term reversal of diabetes in nude mice and in vitro protection from human complement mediated cytolysis, Transplant. Proc., 29, 2128, 1997.
33. Bonner-Weir, S., and Sharma, A., Pancreatic stem cells, J. Pathol., 197, 519-526, 2002.
34. Kaczorowki, D. J., Patterson, E. S., Jastromb, W. E., and Shamblott, M. J., Glucose-responsive insulin-producing cells from stem cells, Diabetes/Metab. Res. Rev., 18, 442-450, 2002.
35. Scharfmann, R., Alternative sources of beta cells for cell therapy of diabetes, Eur. J. Clin. Invest., 33, 595-600, 2003.
36. Bonner-Weir, S., Taneja, M., Weir, G. C., Tatarkiewicz, K., Song, K.-H., Sharma, A., and O’Neil, J. J., In vitro cultivation of human islets from expanded ductal tissue, Proc. Natl Acad. Sci., 97(14), 7999-8004, 2000.
37. Ramiya, V. K., Maraist, M., Arfors, K. E., Schatz, D. A., Peck, A. B., and Cornelius, J. G., Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells, Nat. Med., 6(3), 278-282, 2000.
38. Peck, A. B., Cornelius, J. G., Chaudhari, M., Shatz, D., and Ramiya, V. K., Use of in vitro-generated, stem cell-derived islets to cure type 1 diabetes: how close are we?, Ann. NY Acad. Sci., 958, 59-68, 2002.
39. Gu, G., Dubauskaite, J., and Melton, D. A., Direct evidence for the pancreatic lineage: NGN3 + cells are islet progenitors and are distinct from duct progenitors, Development, 129, 2447-2457, 2002.
40. Treutelaar, M. K., Skidmore, J. M., Dias-Leme, C. L., Hara, M., Zhang, L., Simeone, D., Martin, D. M., and Burant, C. F., Nestin-lineage cells contribute to the microvasculature but not endocrine cells of the islet, Diabetes, 52, 2503-2512, 2003.
41. Soria, B., Roche, E., Berna, G., Leon-Quinto, T., Reig, J. A., and Martin, F., Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice, Diabetes, 49(2), 157-162, 2000.
42. Lumelsky, N., Blondel, O., Laeng, P., Velasco, I., Ravin, R., and McKay, R., Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets, Science, 292, 1389-1394, 2001.
43. Rajagopal, J., Anderson, W. J., Kume, S., Martinez, O. I., and Melton, D. A., Insulin staining of ES cell progeny from insulin uptake, Science, 299, 363, 2003.
44. Hori, Y., Rulifson, I. C., Tsai, B. C., Heit, J. J., Cahoy, J. D., and Kim, S. K., Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells, Proc. Natl Acad. Sci., 99(25), 16105-16110, 2002.
45. Blyszczuk, P., Czyz, J., Kania, G., Wagner, M., Roll, U., St-Onge, L., and Wobus, A. M., Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells, Proc. Natl Acad. Sci., 100(3), 998-1003, 2003.
46. Kahan, B. W., Jacobson, L. M., Hullett, D. A., Ochoada, J. M., Oberley, T. D., Lang, K. M., and Odorico, J. S., Pancreatic precursors and differentiated islet cell types from murine embryonic stem cells: an in vitro model to study islet differentiation, Diabetes, 52, 2016-2024, 2003.
47. Assady, S., Maor, G., Amit, M., Itskovitz-Eldor, J., Skorecki, K. L., and Tzukerman, M., Insulin production by human embryonic stem cells, Diabetes, 50(8), 1691-1697, 2001.
48. Efrat, S., Fusco-DeMane, D., Lemberg, H., Al Emran, O., and Wang, X., Conditional transformation of a pancreatic p-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene, Proc. Natl Acad. Sci., 92, 3576-3580, 1995.
49. Fleischer, N., Chen, C., Manju, S., Leiser, M., Rossetti, L., Pralong, W., and Efrat, S., Functional analysis of a conditionally transformed pancreatic beta-cell line, Diabetes, 47(9), 1419-1425, 1998.
50. Efrat, S., Genetically engineered pancreatic p-cell lines for cell therapy of diabetes, Ann. NY Acad. Sci., 875, 286-293, 1999.
51. + channel-dependent and independent glucose-stimulated insulin secretion, Diabetes, 49, 424-430, 2000.
52. Chen, G., Hohmeier, H. E., Gasa, R., Tran, V. V., and Newgard, C. B., Selection of insulinoma cell lines with resistance to interleukin-1p and y-interferon-induced cytotoxicity, Diabetes, 49, 562-570, 2000.
53. Efrat, S., Cell replacement therapy for type 1 diabetes, TRENDS Mol. Med., 8(7), 334-339, 2002.
54. Rokstad, A. M., Kulseng, B., Strand, B. L., Skjark-Braek, G., and Espevik, T., Transplantation of alginate microcapsules with proliferating cells in mice: capsular overgrowth and survival of encapsulated cells of mice and human origin, Ann. NY Acad. Sci., 944, 216-225, 2001.
55. Eizirik, D. L., and Mandrup-Poulsen, T., A choice of death — the signal-transduction of immune-mediated beta-cell apoptosis, Diabetologia, 44, 2115-2133, 2001.
56. Thomas, H. E., and Kay, T. W. H., Beta cell destruction in the development of autoimmune diabetes in the non-obese diabetic (NOD) mouse, Diabetes/Metab. Res. Rev., 16, 251-261, 2000.
57. Kaneto, H., Fujii, J., Seo, H. G., Suzuki, K., Matsuoka, T.-A., Nakamura, M., Tatsumi, H., Yamasaki, Y., Kamada, T., and Taniguchi, N., Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells, Diabetes, 44(7), 733-738, 1995.
58. Wiegand, F., Kroncke, K.-D., and Kolb-Bachofen, V., Macrophage-generated nitric oxide as cytotoxic factor in destruction of alginate-encapsulated islets, Transplantation, 56(5), 1206-1212, 1993.
59. Hunger, R. E., Muller, S., Laissue, J. A., Hess, M. W., Carnaud, C., Garcia, I., and Mueller, C., Inhibition of submandibular and lacrimal gland infiltration in nonobese diabetic mice by transgenic expression of soluble TNF-receptor p55, J. Clin. Invest., 98(4), 954-961, 1996.
60. Welsh, N., Bendtzen, K., and Welsh, M., Expression of an insulin/interleukin-1 receptor antagonist hybrid gene in insulin-producing cell lines (HIT-T15 and NIT-1) confers resistance against interleukin-1-induced nitric oxide production, J. Clin. Invest., 95(4), 1717-1722, 1995.
61. Gray, D. W., An overview of the immune system with specific reference to membrane encapsulation and islet transplantation, Ann. NY Acad. Sci., 944, 226-239, 2001.
62. Waegell, W., Babineau, M., Hart, M., Dixon, K., McRae, B., Wallace, C., Leach, M., Ratnofsky, S., Belanger, A., Hirst, G., Rossini, A., Appel, M., Mordes, J., Greiner, D., and Banerjee, S., A420983, a novel, small molecule inhibitor of LCK prevents allograft rejection, Transplant. Proc., 34, 1411-1417, 2002.
63. Sanchez-Fueyo, A., Weber, M., Domenig, C., Strom, T. B., and Zheng, X. X., Tracking the immunoregulatory mechanisms active during allograft tolerance, J. Immunol., 168, 2274-2281, 2002.
64. Lau, H. T., Yu, M., Fontana, A., and Stoeckert, C. J., Prevention of islet allograft rejection with engineering myoblasts expressing FasL in mice, Science, 273, 109-112, 1996.
65. Korbutt, G. S., Elliott, J. F., and Rajotte, R. V., Cotransplantation of allogeneic islets with allogeneic testicular cell aggregates allows long-term graft survival without systemic immunosuppression, Diabetes, 46(2), 317-322, 1997.
66. Calafiore, R., Luca, G., Calvitti, M., Neri, L. M., Basta, G., Capitani, S., Becchetti, E., and Brunetti, P., Cellular support systems for alginate microcapsules containing islets, as composite bioartificial pancreas, Ann. NY Acad. Sci., 944, 240-252, 2001.
67. Siebers, U., Horcher, A., Brandhorst, H., Brandhorst, D., Hering, B., Federlin, K., Bretzel, R. G., and Zekorn, T., Analysis of the cellular reaction towards microencapsulated xenogeneic islets after intrapertioneal transplantation, J. Mol. Med., 77, 215-218, 1999.
68. Weber, C. J., Safley, S., Hagler, M., and Kapp, J., Evaluation of graft-host response for various tissue sources and animal models, Ann. NY Acad. Sci., 875, 233-254, 1999.
69. Iwata, H., Murakami, Y., and Ikada, Y., Control of complement activities for immunoisolation, Ann. NY Acad. Sci., 875, 7-23, 1999.
70. White, D. J. G., and Yannoutsos, N., Production of pigs transgenic for human DAF to overcome complement-mediated hyperacute xenograft rejection in man, Res. Immunol., 147, 88-94, 1996.
71. Bottino, R., Fernandez, L. A., Ricordi, C., Lehmann, R., Tsan, M.-F., Oliver, R., and Inverardi, L., Transplantation of allogeneic islets of Langerhans in the rat liver: effects of macrophage depletion on graft survival and microenvironment activation, Diabetes, 47(3), 316-323, 1998.
72. De Vos, P., De Haan, B. J., Wolters, G. H. J., Strubbe, J. H., and Van Schilfgaarde, R., Improved biocompatibility but limited graft survival after purification of alginate for microencapsulation of pancreatic islets, Diabetologia, 40, 262-270, 1997.
73. Avgoustiniatos, E. S., and Colton, C. K., Effect of external oxygen mass transfer resistance on viability of immunoisolated tissue, Ann. NY Acad. Sci., 831, 145-167, 1997.
74. Trivedi, N., Keegan, M., Steil, G. M., Hollister-Lock, J., Hasenkamp, W. M., Colton, C. K., Bonner-Weir, S., and Weir, G. C., Islets in alginate macrobeads reverse diabetes despite minimal acute insulin secretory responses, Transplantation, 71(2), 203-211, 2001.
75. Li, R. H., Materials for immunoisolated cell transplantation, Adv. Drug Deliv. Rev., 33, 87-109, 1998.
76. Hou, Q. P., and Bae, Y. H., Biohybrid artificial pancreas based on macrocapsule device, Adv. Drug Deliv. Rev., 35, 271-287, 1999.
77. Lanza, R. P., Borland, K. M., Staruk, J. E., Appel, M. C., Solomon, B. A., and Chick, W. L., Transplantation of encapsulated canine islets into spontaneously diabetic BB/Wor rats without immunosuppression, Endocrinology, 131(2), 637-642, 1992.
78. Lembert, N., Petersen, P., Wesche, J., Enderle, A., Doser, M., Planck, H., Becker, H. D., and Ammon, H. P. T., In vitro test of new biomaterials for the development of a bioartificial pancreas, Ann. NY Acad. Sci., 944, 271-276, 2001.
79. Loudovaris, T., Jacobs, S., Young, S., Maryanov, D., Brauker, J., and Johnson, R. C., Correction of diabetic nod mice with insulinomas implanted within Baxter immunoisolated devices, J. Mol. Med., 77, 219-222, 1999.
80. Yang, Z., Chen, M., Fialkow, L. B., Ellett, J. D., Wu, R., and Nadler, J. L., Survival of pancreatic islet xenografts in NOD mice with the Theracyte device, Transplant. Proc., 34, 3349-3350, 2002.
81. Brauker, J., Martinson, L., Young, S., and Johnson, R. C., Local inflammatory response around diffusion chambers containing xenografts. Nonspecific destruction of tissues and decreased local vascularization, Transplantation, 61(12), 1671-1677, 1996.
82. McKenzie, A. W., Georgiou, H. M., Zhan, Y., Brady, J. L., and Lew, A. M., Protection of xenografts by a combination of immunoisolation and a single dose of anti-CD4 antibody, Cell Transplant., 10, 183-193, 2001.
83. Loudovaris, T., Mandel, T., and Charlton, B., CD4 + T cell mediated destruction of xenografts within cell-impermeable membranes in the absence of CD8 + T cells and B cells, Transplantation, 61(12), 1678-1684, 1996.
84. Suzuki, K., Bonner-Weir, S., Trivedi, N., Yoon, K.-H., Hollister-Lock, J., Colton, C. K., and Weir, G. C., Function and survival of macroencapsulated syngeneic islets transplanted into streptozocin-diabetic mice, Transplantation, 66(1), 21-28, 1998.
85. Rafael, E., Wernerson, A., Arner, P., Wu, G. S., and Tibell, A., In vivo evaluation of glucose permeability of an immunoisolation device intended for islet transplantation: a novel application of the microdialysis technique, Cell Transplant., 8, 317-326, 1999.
86. Rafael, E., Gazelius, B., Wu, G. S., and Tibell, A., Longitudinal studies on the microcirculation around Theracyte™ immunoisolated device, using the laser Doppler technique, Cell Transplant., 9, 107-113, 2000.
87. Rafael, E., Wu, G. S., Hultenby, K., Tibell, A., and Wernerson, A., Improved survival of macroencapsulated islets of Langerhans by preimplantation of the immunoisolating device: a morphometric study, Cell Transplant., 12, 407-412, 2003.
88. Suzuki, K., Bonner-Weir, S., Hollister-Lock, J., Colton, C. K., and Weir, G. C., Number and volume of islets transplanted in immunobarrier devices, Cell Transplant., 7(1), 47-52, 1998.
89. Carr-Brendel, V., Geller, R., Thomas, T., Boggs, D., Young, S., Crudele, J., Martinson, L., Maryanov, D., Johnson, R., and Brauker, J., Transplantation of cells in an immunoisolation device for gene therapy, Methods Mol. Biol., 63, 373-387, 1997.
90. Geller, R., Loudovaris, T., Neuenfeldt, S., Johnson, R., and Brauker, J., Use of an immunoisolation device for cell transplantation and tumor immunotherapy, Ann. NY Acad. Sci., 831, 438-451, 1997.
91. Geller, R., Neuenfeldt, S., Levon, S., Maryanov, D., Thomas, T., and Brauker, J., Immunoisolation of tumor cells: generation of antitumor immunity through indirect presentation of antigen, J. Immunother., 20(2), 131-137, 1997.
92. Brauker, J., Frost, G., Dwarki, V., Nijjar, T., Chin, R., Carr-Brendel, V., Jasunas, C., Hodgett, D., Stone, W., Cohen, L., and Johnson, R., Sustained expression of high levels of human factor IX from human cells implanted within an immunoisolation device into athymic rodents, Hum. Gene Ther., 9(6), 879-888, 1998.
93. Tibell, A., Rafael, E., Wennberg, L., Nordenstrom, J., Bergstrom, M., Geller, R. L., Loudovaris, T., Johnson, R. C., Brauker, J. H., Neuenfeldt, S., and Wernerson, A., Survival of macroencapsulated allogeneic parathyroid tissue one year after transplantation in nonimmunosuppressed humans, Cell Transplant., 10, 591-599, 2001.
94. Storrs, R., Dorian, R., King, S. R., Lakey, J., and Rilo, H., Preclinical development of the islet sheet, Ann. NY Acad. Sci., 944, 252-266, 2001.
95. Kessler, L., Legeay, G., West, R., Belcourt, A., and Pinget, M., Physicochemical and biological studies of corona-treated artificial membranes used for pancreatic islets encapsulation: mechanism of diffusion and interface modification, J. Biomed. Mater. Res., 34, 235-245, 1997.
96. Desai, T. A., Hansford, D., and Ferrari, M., Characterization of micromachined silicon membranes for immunoisolation and bioseparation applications, J. Membr. Sci., 159, 221-231, 1999.
97. Kurian, P., and Kennedy, J. P., Novel tricontinuous hydrophilic-lipophilic-oxyphilic membranes: synthesis and characterization, J. Polym. Sci.: Part A: Polym. Chem., 40, 1209-1217, 2002.
98. Renken, A., and Hunkeler, D., Microencapsulation: a review of polymers and technologies with a focus on bioartificial organs, Polimery, 43(9), 530-539, 1998.
99. Orive, G., Hernandez, R. M., Gascon, A. R., Calafiore, R., Chang, T. M. S., De Vos, P., Hortelano, G., Hunkeler, D., Lacik, I., Shapiro, A. M. J., and Pedraz, J. L., Cell encapsulation: promise and progress, Nat. Med., 9(1), 104-107, 2003.
100. Sakai, S., Ono, T., Ijima, H., and Kawakami, K., Control of molecular weight cut-off for immunoisolation by multilayering glycol chitosan-alginate polyion complex on alginate-based microcapsules, J. Microencapsulation, 17(6), 691-699, 2000.
101. Bartkowiak, A., Optimal conditions of transplantable binary polyelectrolyte microcapsules, Ann. NY Acad. Sci., 944, 120-134, 2001.
102. Sakai, S., Ono, T., Ijima, H., and Kawakami, K., Newly developed aminopropyl-silicate immunoisolation membrane for a microcapsule-shaped bioartificial pancreas, Ann. NY Acad. Sci., 944, 277-283, 2001.
103. Cruise, G. M., Hegre, O. D., Lamberti, F. V., Hager, S. R., Hill, R., Scharp, D. S., and Hubbell, J. A., In vitro and in vivo performance of porcine islets encapsulated in interfacially photopolymerized poly(ethylene glycol) diacrylate membranes, Cell Transplant., 8, 293-306, 1999.
104. May, M. H., and Sefton, M. V., Conformai coating of small particles and cell aggregates at a liquidliquid interface, Ann. NY Acad. Sci., 875, 126-134, 1999.
105. Abalovich, A., Jatimliansky, C., Digex, E., Arias, M., Altamirano, A., Amorena, C., Martinez, B., and Nacucchio, M., Pancreatic islets microencapsulation with polylactide-co-glycolide, Transplant. Proc., 33, 1977-1979, 2001.
106. Hunkeler, D., Polymers for bioartificial organs, Trends Polym. Sci., 5(9), 286-293, 1997.
107. De Vos, P., Hamel, A. F., and Tatarkiewicz, K., Considerations for successful transplantation of encapsulated pancreatic islets, Diabetologia, 45, 159-173, 2002.
108. Lim, F., and Sun, A. M., Microencapsulated islets as bioartificial endocrine pancreas, Science, 210(21), 908-910, 1980.
109. Strand, B. L., Morch, Y. A., Espevik, T., and Skjak-Braek, G., Visualization of alginate-poly-L-lysine-alginate microcapsules by confocal laser scanning microscopy, Biotechnol. Bioeng., 82(4), 386-394, 2003.
110. Strand, B. L., Gaserod, O., Kulseng, B., Espevik, T., and Skjak-Braek, G., Alginate-polylysine-alginate microcapsules: effect of size reduction on capsule properties, J. Microencapsulation, 19(5), 615-630, 2002.
111. Goosen, M. A., Physico-chemical and mass transfer considerations in microencapsulation, Ann. NY Acad. Sci., 875, 84-104, 1999.
112. Poncelet, D., Production of alginate beads by emulsification/internal gelation, Ann. NY Acad. Sci., 944, 74-82, 2001.
113. Thu, B., Bruheim, P., Espevik, T., Smidsrod, O., Soon-Shiong, P., and Skjak-Braek, G., Alginate polycation microcapsules II. Some functional properties, Biomaterials, 17, 1069-1079, 1996.
114. Thu, B., Bruheim, P., Espevik, T., Smidsrod, O., Soon-Shiong, P., and Skjak-Braek, G., Alginate polycation microcapsules I. Interaction between alginate and polycation, Biomaterials, 17, 1031-1040, 1996.
115. De Groot, M., Keizer, P. P. M., De Haan, B. J., Schuurs, T. A., Leuvenink, H. G. D., Van Schilfgaarde, R., and De Vos, P., Microcapsules and their ability to protect against cytokin-mediated dysfunction, Transplant. Proc., 33, 1711-1712, 2001.
116. Van Schilfgaarde, R., and De Vos, P., Factors influencing the properties and performance of microcapsules for immunoprotection of pancreatic islets, J. Mol. Med., 77, 199-205, 1999.
117. Wandrey, C., and Sainz Vidal, D., Purification of polymeric biomaterials, Ann. NY Acad. Sci., 944, 187-197, 2001.
118. Zimmermann, U., Thurmer, F., Jork, A., Weber, M., Mimietz, S., Hillgartner, M., Brunnenmeier, F., Zimmermann, H., Westphal, I., Fuhr, G., Noth, U., Haase, A., Steinert, A., and Hendrich, C., A novel class of amitogenic alginate microcapsules for long-term immunoisolated transplantation, Ann. NY Acad. Sci., 944, 199-215, 2001.
119. Soon-Shiong, P., Otterlie, M., Skjak-Braek, G., Smidsrod, O., Heintz, R., Lanza, R. P., and Espevik, T., An immunologic basis for the fibrotic reaction to implanted microcapsules, Transplant. Proc., 23(1), 758-759, 1991.
120. De Vos, P., Hoogmoed, C. G., and Busscher, H. J., Chemistry and biocompatibility of alginate-PLL capsules for immunoprotection of mammalian cells, J. Biomed. Mater. Res., 60, 252-259, 2002.
121. Van Hoogmoed, C. G., Busscher, H. J., and De Vos, P., Fourier transform infrared spectroscopy studies of alginate-PLL capsules with varying compositions, J. Biomed. Mater. Res., 67A, 172-178, 2003.
122. De Vos, P., van Hoogmoed, C. G., van Zanten, J., Netter, S., Strubbe, J. H., and Busscher, H. J., Long-term biocompatibility, chemistry, and function of microencapsulated pancreatic islets, Biomaterials, 24, 305-312, 2003.
123. King, A., Strand, B., Rokstad, A.-M., Kulseng, B., Andersson, A., Skjak-Braek, G., and Sandler, S., Improvement of the biocompatibility of alginate/poly-L-lysine/alginate microcapsules by the use of epimerized alginate as a coating, J. Biomed. Mater. Res., 64A, 533-539, 2003.
124. De Vos, P., van Hoogmoed, C. G., De Haan, B. J., and Busscher, H. J., Tissue responses against immunoisolating alginate-PLL capsules in the immediate posttransplant period, J. Biomed. Mater. Res., 62, 430-437, 2002.
125. De Vos, P., Smedema, I., Van Goor, H., Moes, H., Van Zanten, J., Netters, S., De Leij, L. F. M., De Haan, A., and De Haan, B. J., Association between macrophage activation and function of micro-encapsulated rat islets, Diabetologia, 46, 666-673, 2002.
126. Safley, S. A., Kapp, J. A., and Weber, C. J., Proliferative and cytokine responses in CTLA4-Ig-treated diabetic NOD mice transplanted with microencapsulated neonatal porcine ICCs, Cell Transplant., 11, 695-705, 2002.
127. Duvivier-Kali, V. F., Omer, A., Parent, R. J., O’Neil, J. J., and Weir, G. C., Complete protection of islets against allorejection and autoimmunity by a simple barium-alginate membrane, Diabetes, 50, 1698-1705, 2001.
128. Omer, A., Keegan, M., Czismadia, E., De Vos, P., Van Rooijen, N., Bonner-Weir, S., and Weir, G. C., Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats, Xenotransplantation, 10, 240-251, 2003.
129. Zekorn, T. D. C., Horcher, A., Siebers, U., Federlin, K., and Bretzel, R. G., Synergistic effect of microencapsulation and immunoalteration on islet allograft survival in bioartificial pancreas, J. Mol. Med., 77, 193-198, 1999.
130. Pathak, C. P., Sawhney, A. S., and Hubbell, J. A., Rapid photopolymerization of immunoprotective gels in contact with cells and tissues, J. Am. Chem. Soc., 114(21), 8311-8312, 1992.
131. Desai, N. P., Sojomihardjo, A., Yao, Z., Ron, N., and Soon-Shiong, P., Interpenetrating polymer networks of alginate and polyethylene glycol for encapsulation of islets of Langerhans, J. Microencapsulation, 17(6), 677-690, 2000.
132. Prokop, A., Hunkeler, D., DiMari, S., Haralson, M. A., and Wang, T. G., Water soluble polymers for immunoisolation I: complex coacervation and cytotoxicity, Adv. Polym. Sci., 136, 1-51, 1998.
133. Prokop, A., Hunkeler, D., Powers, A. C., Whitesell, R. R., and Wang, T. G., Water soluble polymers for immunoisolation II: evaluation of multicomponent microencapsulation systems, Adv. Polym. Sci., 136, 53-73, 1998.
134. Bartkowiak, A., Canaple, L., Ceausoglu, I., Nurdin, N., Renken, A., Rindisbacher, L., Wandrey, C., Desvergne, B., and Hunkeler, D., New multicomponent capsules for immunoisolation, Ann. NY Acad. Sci., 875, 135-145, 1999.
135. Wang, T., Lacik, I., Brissova, M., Anilkumar, A. V., Prokop, A., Hunkeler, D., Green, R., Shahrokhi, K., and Powers, A. C., An encapsulation system for the immunoisolation of pancreatic islets, Nat. Biotechnol., 15, 358-362, 1997.
136. Sefton, M. V., May, M. H., Lahooti, S., and Babensee, J. E., Making microencapsulation work: conformal coating, immobilization gels and in vivo performance, J. Control. Release, 65, 173-186, 2000.
137. Risbud, M., Hardikar, A., and Bhonde, R., Chitosan-polyvinyl pyrrolidone hydrogels as candidate for islet immunoisolation: in vitro biocompatibility evaluation, Cell Transplant., 9, 25-31, 2000.
138. Risbud, M. V., Bhonde, M. R., and Bhonde, R. R., Effects of chitosan-polyvinyl pyrrolidone hydrogel on proliferation and cytokine expression of endothelial cells: implications in islet immunoisolation, J. Biomed. Mater. Res., 57, 300-305, 2001.
139. O’Shea, G. M., and Sun, A. M., Encapsulation of rat islets of Langerhans prolongs xenograft survival in diabetic mice, Diabetes, 35, 943-946, 1986.
140. Fan, M.-Y., Lum, Z.-P., Fu, X.-W., Levesque, L., Tai, I. T., and Sun, A. M., Reversal of diabetes in BB rats by transplantation of encapsulated pancreatic islets, Diabetes, 39, 519-522, 1990.
141. Soon-Shiong, P., Feldman, E., Nelson, R., Komtebedde, J., Smidsrod, O., Skjak-Braek, G., Espevik, T., Heintz, R., and Lee, M., Successful reversal of spontaneous diabetes in dogs by intraperitoneal microencapsulated islets, Transplantation, 54(5), 769-774, 1992.
142. De Vos, P., Vegter, D., Strubbe, J. H., De Haan, B. J., and Van Schilfgaarde, R., Impaired glucose tolerance in recipients of an intraperitoneally implanted microencapsulated islet allograft is caused by the slow diffusion of insulin through the peritoneal membrane, Transplant. Proc., 29, 756-757, 1997.
143. Soon-Shiong, P., Treatment of type I diabetes using encapsulated islets, Adv. Drug Deliv. Rev., 35, 259-270, 1999.
144. Elliott, R. B., Escobar, L., Garkavenko, O., Croxson, M. C., Schroeder, B. A., McGregor, M., Ferguson, G., Beckman, N., and Ferguson, S., No evidence of infection with porcine endogenous retrovirus in recipients of encapsulated porcine islet xenografts, Cell Transplant., 9, 895-901, 2000.
145. Tatarkiewicz, K., Garcia, M., Omer, A., Van Schilfgaarde, R., and De Vos, P., C-peptide responses after meal challenge in mice transplanted with microencapsulated rat islets, Diabetologia, 44, 646-653, 2001.
146. Soon-Shiong, P., Heintz, R. E., Merideth, N., Yao, Q. X., Yao, Z., Zheng, T., Murphy, M., Moloney, M. K., Schmehl, M., Harris, M., Mendez, R., Mendez, R., and Sandford, P. A., Insulin independence in a type 1 diabetic patient after encapsulated islet transplantation, Lancet, 343, 950-951, 1994.
147. Carlsson, P.-O., Liss, P., Andersson, A., and Jansson, L., Measurements of oxygen tension in native and transplanted rat pancreatic islets, Diabetes, 47(7), 1027-1032, 1998.
148. Schrezenmeir, J., Gero, L., Laue, C., Kirchgessner, J., Muller, A., Huls, A., Passmann, R., Hahn, H. J., Kunz, L., Mueller-Klieser, W., and Altman, J. J., The role of oxygen supply in islet transplantation, Transplant. Proc., 24(6), 2925-2929, 1992.
149. Dionne, K. E., Colton, C. K., and Yarmush, M. L., Effect of oxygen on isolated pancreatic tissue, Trans. Am. Soc. Artif. Intern. Organs, 35(3), 739-741, 1989.
150. Ohta, M., Nelson, D., Nelson, J., Meglasson, M. D., and Erecinska, M., Oxygen and temperature dependence of stimulated insulin secretion in isolated rat islets of Langerhans, J. Biol. Chem., 265(29), 17525-17532, 1990.
151. Dionne, K. E., Colton, C. K., and Yarmush, M. L., Effect of hypoxia on insulin secretion by isolated rat and canine islets of Langerhans, Diabetes, 42, 12-21, 1993.
152. Schrezenmeir, J., Gero, L., Solhdju, M., Kirchgessner, J., Laue, C., Beyer, J., Stier, H., and Muller-Klieser, W., Relation between secretory function and oxygen supply in isolated islet organs, Transplant. Proc., 26(2), 809-813, 1994.
153. De Groot, M., Schuurs, T. A., Keizer, P. P. M., Fekken, S., Leuvenink, H. G. D., and Van Schilfgaarde, R., Response of encapsulated rat pancreatic islets to hypoxia, Cell Transplant., 12, 867-875, 2003.
154. Avgoustiniatos, E. S., and Colton, C. K., Design considerations in immunoisolation, In Principles of Tissue Engineering, Lanza, R., Langer, R., and Chick, W., eds., R.G. Landes Company, Austin, pp. 333-346, 1997.
155. Dulong, J.-L., Legallais, C., Darquy, S., and Reach, G., A novel model of solute transport in ahollow-fiber bioartificial pancreas based on a finite element method, Biotechnol. Bioeng., 78(5), 576-582, 2002.
156. De Vos, P., Vegter, D., De Haan, B. J., Strubbe, J. H., Bruggink, J. E., and Van Schilfgaarde, R., Kinetics of intraperitoneally infused insulin in rats: functional implications for the bioartificial pancreas, Diabetes, 45(8), 1102-1107, 1996.
157. Brauker, J., Martinson, L., Hill, R., Young, S., Carr-Brendel, V., and Johnson, R. C., Neovascularization of immunoisolation membranes: the effect of membrane architecture and encapsulated tissue, Transplant. Proc., 24(6), 2924, 1992.
158. Brauker, J., Carr-Brendel, V., Martinson, L., Crudele, J., Johnston, W., and Johnson, R. C., Neovascularization of synthetic membranes directed by membrane microarchitecture, J. Biomed. Mater. Res., 29(12), 1517-1524, 1995.
159. Padera, R. F., and Colton, C. K., Time course of membrane microarchitecture-driven neovascularization, Biomaterials, 17, 277-284, 1996.
160. Trivedi, N., Steil, G. M., Colton, C. K., Bonner-Weir, S., and Weir, G. C., Improved vascularization of planar membrane diffusion devices following continuous infusion of vascular endothelial growth factor, Cell Transplant., 9, 115-124, 2000.
161. Calafiore, R., Basta, G., Luca, G., Boselli, C., Bufalari, A., Bufalari, A., Cassarani, M. P., Giustozzi, G. M., and Brunetti, P., Transplantation of pancreatic islets contained in minimal volume microcapsules in diabetic high mammalians, Ann. NY Acad. Sci., 875, 219-232, 1999.
162. Wu, H., Avgoustiniatos, E. S., Swette, L., Bonner-Weir, S., Weir, G. C., and Colton, C. K., In situ electrochemical oxygen generation with an immunoisolated device, Ann. NY Acad. Sci., 875, 105-125, 1999.
163. Wu, H., The Effect of Oxygen on Cultured Islets. Ph.D. thesis, MIT, Cambridge, MA, in progress.
164. Riess, J. G., Fluorocarbon-based in vivo oxygen transport and delivery systems, Vox Sang, 61, 225-239, 1991.
165. Riess, J. G., Fluorocarbon emulsions-designing an efficient shuttle service for the respiratory gases — the so-called “blood substitutes”, In Fluorine Chemistry at the Millenium, Banks, R. E., ed., Elsevier, Amsterdam, pp. 385-431, 2000.
166. Brasile, L., Clarke, J., Green, E., and Haisch, C., The feasibility of organ preservation at warmer temperatures, Transplant. Proc., 128(1), 349-351, 1996.
167. Voiglio, E. J., Zarif, L., Gorry, F. C., Krafft, M.-P., Margonari, J., Martin, X., Riess, J., and Dubernard, J. M., Aerobic preservation of organs using a new perflubron/lecithin emulsion stabilized by molecular dowels, J. Surg. Res., 63, 439-446, 1996.
168. Matsumoto, S., and Kuroda, Y., Perfluorocarbon for organ preservation before transplantation, Transplantation, 74(12), 1804-1809, 2002.
169. Zekorn, T., Siebers, U., Bretzel, R. G., Heller, S., Meder, U., Ruttkay, H., Zimmermann, U., and Federlin, K., Impact of the perfluorochemical FC43 on function of isolated islets, Horm. Metab. Res., 23, 302-303, 1991.
170. Poncelet, D., Leung, R., Centomo, L., and Neufeld, R. J., Microencapsulation of silicone oils within polyacrylamide-polyethylene membranes as oxygen carriers for bioreactor oxygenation, J. Chem. Technol. Biotechnol., 57, 253-263, 1993.
171. Nishide, H., Chen, X. S., and Tsuchida, E., Facilitated oxygen transport with modified and encapsulated hemoglobins across non-flowing solution membrane, Artif. Cells Blood Substit. Immobil. Biotechnol., 25, 335-346, 1997.
172. Colton, C. K., Stroeve, P., and Zahka, J. G., Mechanism of oxygen transport augmentation by hemoglobin, J. Appl. Physiol., 35(2), 307-309, 1973.
173. Schrezenmeir, J., Hyder, A., Vreden, M., Laue, C., and Mueller-Klieser, W., Oxygen profile of microencapsulated islets: effect of immobilised hemoglobin in the alginate matrix, Transplant. Proc., 33, 3511-3516, 2001.
174. Chae, S. Y., Kim, S. W., and Bae, Y. H., Effect of cross-linked hemoglobin on functionality and viability of microencapsulated pancreatic islets, Tissue Eng., 8(3), 379-394, 2002.
175. Schrezenmeir, J., Velten, F., and Beyer, J., Immobilized hemoglobin improves islet function and viability in the bioartificial in vitro and in vivo, Transplant. Proc., 26(2), 792-800, 1994.
176. Papas, K. K., Colton, C. K., Gounarides, J. S., Roos, E. S., Jarema, M. A. C., Shapiro, M. J., Cheng, L. L., Cline, G. W., Shulman, G. I., Wu, H., Bonner-Weir, S., and Weir, G. C., NMR spectroscopy in beta cell engineering and islet transplantation, Ann. NY Acad. Sci., 944, 96-119, 2001.
177. Noth, U., Grohn, P., Jork, A., Zimmermann, U., Hasse, A., and Lutz, J., 19F-MRI in vivo determination of the partial oxygen pressure in perfluorocarbon-loaded alginate capsules implanted into the peritoneal cavity and different tissues, Magn. Reson. Med., 42, 1039-1047, 1999.
178. 2+-alginate beads, Artif. Cells Blood Substit. Immobil. Biotechnol., 28(2), 129-146, 2000.
179. Constantinidis, I., Rober, J., Rober Long, J., Weber, C., Safley, S., and Sambanis, A., Non-invasive monitoring of a bioartificial pancreas in vitro and in vivo, Ann. NY Acad. Sci., 944, 83-95, 2001.
180. Zhao, M., Beauregard, D. A., Loizou, L., Davletov, B., and Brindle, K. M., Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent, Nat. Med., 7(11), 1241-1244, 2001.
181. Thorens, B., Dupraz, P., and Cottet, S., Engineering tolerance into transplanted beta cell lines, Ann. NY Acad. Sci., 944, 267-270, 2001.