In vitro and in vivo performance of porcine islets encapsulated in interfacially photopolymerized poly(ethylene glycol) diacrylate membranes

Cell Transplantation

Volumn 8, Issue 3, 1999, Pages 293-306

  Cruise, Gregory M ^a,b,c   Hegre, Orion D ^d   Lamberti, Francis V ^d   Hager, Steven R ^d   Hill, Ron ^d,e   Scharp, David S ^d   Hubbell, Jeffrey A ^f  

^a California Institute of Technology   (United States)

^b The University of Texas at Austin   (United States)

^c CardioSynopsis Inc   (United States)

^d Neocrin Company   (United States)

^e Genset Corporation   (United States)

^f UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Encapsulation; Hydrogel; Islets of Langerhans; Poly(ethylene glycol)

Indexed keywords

GLUCOSE; INSULIN; MACROGOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL STIMULATION; CELL VIABILITY; CONTROLLED STUDY; ENCAPSULATION; GLUCOSE BLOOD LEVEL; GRAFT SURVIVAL; HYDROGEL; INSULIN RELEASE; MALE; MEMBRANE FORMATION; MOUSE; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; RAT; SWINE;

ANIMALIA; SUIDAE; SUS SCROFA;

EID: 0032810120     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.1177/096368979900800310     Document Type: Article

References (22)

1. Chicheportiche, D.; Reach, G. In vitro kinetics of insulin release by microencapsulated rat islets: Effect of the size of the microcapsules. Diabetologia 31:54-57; 1988.
2. Colton, C. K.; Avgoustiniatos, E. S. Bioengineering in development of the hybrid artificial pancreas, J. Biomech. Eng. 113:152-170; 1991.
3. Colton, C. K. Implantable biohybrid artificial organs. Cell Transplant. 4:415-436; 1995.
4. Crooks, C. A.; Douglas, J. A.; Broughton, R. L.; Sefton, M. V. Microencapsulation of mammalian cells in a HEMA-MMA copolymer: Effects on capsule morphology and permeability, J. Biomed. Mater. Sci. 24:1241-1262; 1990.
5. Cruise, G. M.; Hegre, O. D.; Scharp, D. S.; Hubbell, J. A. A sensitivity study of the key parameters in the interfacial photopolymerization of poly(ethylene glycol) diacrylate upon porcine islets. Biotech. Bioeng. 57:655-665; 1998.
6. Cruise, G. M.; Scharp, D. S.; Hubbell, J. A. Characterization of permeability and network structure of interfacially photopolymerized poly(ethylene glycol) diacrylate hydrogels. Biomaterials 19:1287-1294; 1998.
7. Darquy, S.; Reach, G. Immunoisolation of pancreatic β cells by microencapsulation. Diabetologia 28:776-780; 1985.
8. Dupuy, B.; Gin, H.; Baquey, C.; Ducassou, D. In situ polymerization of a microencapsulating medium around living cells. J. Biomed. Mater. Res. 22:1061-1070; 1988.
9. Dupuy, B.; Gin, H.; Baquey, C.; Ducassou, D.; Aubertin, J. Agarose beads in paraffin oil as interfaces to encapsulate living cells: Tests of function with islets of Langerhans. Artif. Organs 11:314; 1987.
10. Dust, J. M.; Fang, Z.; Harris, J. M. Proton NMR characterization of poly(ethylene glycols) and derivatives. Macromolecules 23:3743-3746; 1990.
11. Fritschy, W. M.; Wolters, G. H. J.; Van Schilfgaarde, R. Effect of alginate-polylysine-alginate microencapsulation on in vitro insulin release from rat pancreatic islets. Diabetes 40:37-43; 1991.
12. Iwata, H.; Kobayashi, K.; Takagi, T.; Oka, T.; Yang, H.; Amemiya, H.; Tsuji, T.; Ito, F. Feasibility of agarose microbeads with xenogeneic islets as a bioartificial pancreas. J. Biomed. Mater. Res. 28:1003-1011; 1994.
13. Iwata, H.; Takagi, T.; Kobayashi, K.; Oka, T.; Tsuji, T.; Ito, F. Strategy for developing microbeads applicable to islet xenotransplantation into a spontaneous diabetic NOD mouse, J. Biomed. Mater. Res. 28:1201-1207; 1994.
14. Kowalski, L.; Falqui, L.; Lacy, P. E.; Scharp, D. W. Production of marked prolongation of survival of canine islets xenografts in mice by antilymphocyte sera and L3T4 antibody. Transplantation 52:1094-1097; 1991.
15. Lim, F.; Sun, A. M. Microencapsulated islets as bioartificial endocrine pancreas. Science 210:908-910; 1980.
16. Lum, Z. P.; Tai, I.; Krestow, M.; Norton, J.; Vacek, I.; Sun, A. M. Prolonged reversal of diabetic state in NOD mice by xenografts of encapsulated rat islets. Diabetes 40: 1511-1516; 1991.
17. Marchetti, P.; Scharp, D. W.; Finke, E. H.; Swanson, C. J.; Olack, B. J.; Gerasimidi-Vazeou, D.; Giannarelli, R.; Navalesi, R.; Lacy, P. E. Prolonged survival of discordant porcine islet xenografts. Transplantation 61:1100-1102; 1996.
18. Pathak, C. P.; Sawhney, A. S.; Hubbell, J. A. Rapid photopolymerization of immunoprotective gels in contact with cells and tissue. J. Am. Chem. Soc. 114:8311-8312; 1992.
19. Ricordi, C.; Lacy, P. E.; Finke, E. H.; Olack, B. J.; Scharp, D. Automated method for isolation of human pancreatic islets. Diabetes 37:413-420; 1988.
20. Ricordi, C.; Scharp, D. W.; Lacy, P. E. Reversal of diabetes in nude mice after transplantation of fresh and 7 day cultured (24 C) human pancreatic islets. Transplantation 45:994-996; 1988.
21. Sawhney, A. S.; Pathak, C. P.; Hubbell, J. A. Modification of islet of Langerhan surfaces with immunoprotective poly(ethylene glycol) coatings via interfacial photopolymerization. Biotech. Bioeng. 44:383-386; 1994.
22. Valdes-Aguilera, O.; Pathak, C. P.; Shi, J.; Watson, D.; Neckers, D. C. Photopolymerization studies using visible light photoinitiators. Macromolecules 25:541-547; 1992.