Genetically engineered pancreatic β-cell lines for cell therapy of diabetes

Annals of the New York Academy of Sciences

Volumn 875, Issue , 1999, Pages 286-293

  Efrat, Shimon ^a,b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INSULIN; VIRUS VECTOR;

ADENOVIRUS; ALLOGRAFT; ANTIGEN PRESENTATION; CELL DIVISION; CELL LINE; CELL TRANSFORMATION; CELL TRANSPLANTATION; CELLULAR IMMUNITY; CONFERENCE PAPER; GENETIC MANIPULATION; GRAFT REJECTION; HUMAN; HUMAN CELL; IMMUNOMODULATION; IN VIVO CULTURE; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

ADENOVIRIDAE; MUS MUSCULUS;

EID: 0032773593     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb08511.x     Document Type: Conference Paper

References (22)

1. 1. VALERA, A., C. FILLAT, C. COSTA, et al. 1994. Regulated expression of human insulin in the liver of transgenic mice corrects diabetic alterations. FASEB J. 8: 440-447.
2. 2. KOLODKA, T.M., M. FINEGOLD, L. Moss, et al. 1995 Gene therapy for diabetes mellitus in rats by hepatic expression of insulin. Proc. Natl. Acad. Sci. USA 92: 3293-3297.
3. 3. LIPES, M.A., E.M. COOPER, R. SKELLY, et al. 1996. Insulin-secreting non-islet cells are resistant to autoimmune destruction. Proc. Natl. Acad. Sci. USA 93: 8595-8600.
4. 4. HOLZ, G.G. & J.F. HABENER. 1992. Signal transduction crosstalk in the endocrine system: pancreatic β cells and the glucose competence concept. Trends Biochem. Sci. 17: 388-393.
5. 5. POSSELT, A.M., C.F. BARKER, J.E. TOMASZEWSKI, et al. 1990. Induction of donor-specific unresponsiveness by intrathymic islet transplantation. Science 249: 1293-1295.
6. 6. POSSELT, A.M., J.S. ODORICO, C.F. BARKER, et al. 1992. Promotion of pancreatic islet allograft survival by intrathymic transplantation of bone marrow. Diabetes 41: 771-775.
7. 7. LAU, H.T., M. YU, A. FONTANA, et al. 1996. Prevention of islet allograft rejection with engineered myoblasts expressing FasL in mice. Science 273: 109-112.
8. 8. PEARSON, T.C., D.Z. ALEXANDER, R. HENDRIX, et al. 1996. CTLA4-Ig plus bone marrow induces long-term allograft survival and donor-specific unresponsiveness in the murine model. Evidence for hematopoietic chimerism. Transplantation 61: 997-1004.
9. 9. EFRAT, S., S. LINDE, H. KOFOD, et al. 1988. Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene. Proc. Natl. Acad. Sci. USA 85: 9037-9041.
10. 10. D'AMBRA, R., M. SURANA, S. EFRAT, et al. 1990. Regulation of insulin secretion from β-cell lines derived from transgenic mice insulinomas resembles that of normal β-cells. Endocrinology 126: 2815-2822.
11. 11. EFRAT, S., M. LEISER, M. SURANA, et al. 1993. Murine insulinoma cell line with normal glucose-regulated insulin secretion. Diabetes 42: 901-907.
12. 12. KNAACK, D., D.M. FIORE, M. SURANA, et al. 1994. Clonal insulinoma cell line which stably maintains correct glucose responsiveness. Diabetes 43: 1413-1417.
13. 13. GOSSEN, M. & H. BUJARD. 1992. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89: 5547-5551.
14. 14. EFRAT, S., D. FUSCO-DEMANE, H. LEMBERG, et al. 1995. Conditional transformation of a pancreatic β-cell line derived from transgenic mice expressing a tetracycline-regulated oncogene. Proc. Natl. Acad. Sci. USA 92: 3576-3580.
15. 15. FLEISCHER, N., C. CHEN, M. SURANA, et al. 1998. Functional analysis of a conditionally-transformed pancreatic β-cell line. Diabetes 47: 1419-1425.
16. 16. GOSSEN, M., S. FREUNDLIEB, G. BENDER, et al. 1995. Transcriptional activation by tetracyclines in mammalian cells. Science 268: 1766-1769.
17. 17. WOLD, W.S.M. & L.R. GOODING. 1991. Region E3 of adenovirus: a cassette of genes involved in host immunosurveillance and virus-cell interactions. Virology 184: 1-8.
18. 18. WOLD, W.S.M. 1993. Adenovirus genes that modulate the sensitivity of virus-infected cells to lysis by TNF. J. Cell. Biochem. 53: 329-335.
19. 19. EFRAT, S., G. FEJER, M. BROWNLEE, et al. 1995. Prolonged survival of murine pancreatic islet allografts mediated by adenovirus early region 3 immunoregulatory transgenes. Proc. Natl. Acad. Sci. USA 92: 6947-6951.
20. 20. COX, J.H., J.W. YEWDELL, L.C. EISENLOHR, et al. 1990. Antigen presentation requires transport of MHC class I molecules from the endoplasmic reticulum. Science 247: 715-718.
21. 21. BEIER, D.C., J.H. COX, D.R. VINING, et al. 1994. Association of human class 1 MHC alleles with the adenovirus E3/19K protein. J. Immunol. 152: 3862-3872.
22. 22. WANG, S., G. BEATTIE, M. MALLY, et al. 1997. Isolation and characterization of a cell line from the epithelial cells of the human fetal pancreas. Cell Transplant 6: 59-67.