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Volumn 34, Issue 10, 2013, Pages 2409-2414

N-methylnitrosourea aggravates gastrointestinal polyposis in Lkb1+/- mice

Author keywords

[No Author keywords available]

Indexed keywords

CELECOXIB; CYCLOOXYGENASE 2; METHYLNITROSOUREA; PROTEIN KINASE LKB1; PROTEIN P53;

EID: 84885094670     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt188     Document Type: Article
Times cited : (1)

References (45)
  • 1
    • 0023152311 scopus 로고
    • Genodermatoses with malignant potential
    • Mallory, S.B. et al. (1987) Genodermatoses with malignant potential. Dermatol. Clin., 5, 221-230.
    • (1987) Dermatol. Clin. , vol.5 , pp. 221-230
    • Mallory, S.B.1
  • 2
    • 0035126870 scopus 로고    scopus 로고
    • Genetic testing for cancer predisposition
    • Eng, C. et al. (2001) Genetic testing for cancer predisposition. Annu. Rev. Med., 52, 371-400.
    • (2001) Annu. Rev. Med. , vol.52 , pp. 371-400
    • Eng, C.1
  • 3
    • 78651095553 scopus 로고    scopus 로고
    • High cancer risk and increased mortality in patients with Peutz-Jeghers syndrome
    • van Lier, M.G. et al. (2011) High cancer risk and increased mortality in patients with Peutz-Jeghers syndrome. Gut, 60, 141-147.
    • (2011) Gut , vol.60 , pp. 141-147
    • van Lier, M.G.1
  • 4
    • 0032906537 scopus 로고    scopus 로고
    • Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer
    • Ylikorkala, A. et al. (1999) Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer. Hum. Mol. Genet., 8, 45-51.
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 45-51
    • Ylikorkala, A.1
  • 5
    • 28844507521 scopus 로고    scopus 로고
    • High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome
    • Aretz, S. et al. (2005) High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome. Hum. Mutat., 26, 513-519.
    • (2005) Hum. Mutat. , vol.26 , pp. 513-519
    • Aretz, S.1
  • 6
    • 33745966059 scopus 로고    scopus 로고
    • LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome
    • Volikos, E. et al. (2006) LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome. J. Med. Genet., 43, e18.
    • (2006) J. Med. Genet. , vol.43
    • Volikos, E.1
  • 7
    • 0037089467 scopus 로고    scopus 로고
    • Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice
    • Miyoshi, H. et al. (2002) Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Cancer Res., 62, 2261-2266.
    • (2002) Cancer Res. , vol.62 , pp. 2261-2266
    • Miyoshi, H.1
  • 8
    • 0037068461 scopus 로고    scopus 로고
    • Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
    • Bardeesy, N. et al. (2002) Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature, 419, 162-167.
    • (2002) Nature , vol.419 , pp. 162-167
    • Bardeesy, N.1
  • 9
    • 0037125996 scopus 로고    scopus 로고
    • Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis
    • Rossi, D.J. et al. (2002) Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis. Proc. Natl Acad. Sci. USA, 99, 12327-12332.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 12327-12332
    • Rossi, D.J.1
  • 10
    • 41349114071 scopus 로고    scopus 로고
    • LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis
    • Katajisto, P. et al. (2008) LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis. Nat. Genet., 40, 455-459.
    • (2008) Nat. Genet. , vol.40 , pp. 455-459
    • Katajisto, P.1
  • 11
    • 59249096211 scopus 로고    scopus 로고
    • Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine
    • Shorning, B.Y. et al. (2009) Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine. PLoS One, 4, e4264.
    • (2009) PLoS One , vol.4
    • Shorning, B.Y.1
  • 12
    • 34948868190 scopus 로고    scopus 로고
    • Peutz-Jeghers syndrome polyps are polyclonal with expanded progenitor cell compartment
    • de Leng, W.W. et al. (2007) Peutz-Jeghers syndrome polyps are polyclonal with expanded progenitor cell compartment. Gut, 56, 1475-1476.
    • (2007) Gut , vol.56 , pp. 1475-1476
    • de Leng, W.W.1
  • 13
    • 77952033717 scopus 로고    scopus 로고
    • Impaired gastric gland differentiation in Peutz-Jeghers syndrome
    • Udd, L. et al. (2010) Impaired gastric gland differentiation in Peutz-Jeghers syndrome. Am. J. Pathol., 176, 2467-2476.
    • (2010) Am. J. Pathol. , vol.176 , pp. 2467-2476
    • Udd, L.1
  • 14
    • 84860581329 scopus 로고    scopus 로고
    • Aberrant intestinal stem cell lineage dynamics in Peutz-Jeghers syndrome and familial adenomatous polyposis consistent with protracted clonal evolution in the crypt
    • Langeveld, D. et al. (2012) Aberrant intestinal stem cell lineage dynamics in Peutz-Jeghers syndrome and familial adenomatous polyposis consistent with protracted clonal evolution in the crypt. Gut, 61, 839-846.
    • (2012) Gut , vol.61 , pp. 839-846
    • Langeveld, D.1
  • 15
    • 0033692749 scopus 로고    scopus 로고
    • Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome
    • Miyaki, M. et al. (2000) Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome. Cancer Res., 60, 6311-6313.
    • (2000) Cancer Res. , vol.60 , pp. 6311-6313
    • Miyaki, M.1
  • 16
    • 0035142924 scopus 로고    scopus 로고
    • Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome
    • Entius, M.M. et al. (2001) Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome. J. Clin. Pathol., 54, 126-131.
    • (2001) J. Clin. Pathol. , vol.54 , pp. 126-131
    • Entius, M.M.1
  • 17
    • 0037102428 scopus 로고    scopus 로고
    • Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice
    • Nakau, M. et al. (2002) Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. Cancer Res., 62, 4549-4553.
    • (2002) Cancer Res. , vol.62 , pp. 4549-4553
    • Nakau, M.1
  • 18
    • 38849193504 scopus 로고    scopus 로고
    • Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas
    • Contreras, C.M. et al. (2008) Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas. Cancer Res., 68, 759-766.
    • (2008) Cancer Res. , vol.68 , pp. 759-766
    • Contreras, C.M.1
  • 19
    • 56549107692 scopus 로고    scopus 로고
    • Osteogenic tumours in Lkb1-deficient mice
    • Robinson, J. et al. (2008) Osteogenic tumours in Lkb1-deficient mice. Exp. Mol. Pathol., 85, 223-226.
    • (2008) Exp. Mol. Pathol. , vol.85 , pp. 223-226
    • Robinson, J.1
  • 20
    • 33645022897 scopus 로고    scopus 로고
    • Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant mice
    • Takeda, H. et al. (2006) Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant mice. Oncogene, 25, 1816-1820.
    • (2006) Oncogene , vol.25 , pp. 1816-1820
    • Takeda, H.1
  • 21
    • 0032946456 scopus 로고    scopus 로고
    • The hamartoma-adenoma-carcinoma sequence
    • Bosman, F.T. (1999) The hamartoma-adenoma-carcinoma sequence. J. Pathol., 188, 1-2.
    • (1999) J. Pathol. , vol.188 , pp. 1-2
    • Bosman, F.T.1
  • 22
    • 0032893658 scopus 로고    scopus 로고
    • Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence
    • Wang, Z.J. et al. (1999) Allelic imbalance at the LKB1 (STK11) locus in tumours from patients with Peutz-Jeghers' syndrome provides evidence for a hamartoma-(adenoma)-carcinoma sequence. J. Pathol., 188, 9-13.
    • (1999) J. Pathol. , vol.188 , pp. 9-13
    • Wang, Z.J.1
  • 23
    • 29244431680 scopus 로고    scopus 로고
    • Mucosal prolapse in the pathogenesis of Peutz- Jeghers polyposis
    • Jansen, M. et al. (2006) Mucosal prolapse in the pathogenesis of Peutz- Jeghers polyposis. Gut, 55, 1-5.
    • (2006) Gut , vol.55 , pp. 1-5
    • Jansen, M.1
  • 24
    • 5144232989 scopus 로고    scopus 로고
    • Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2
    • Udd, L. et al. (2004) Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2. Gastroenterology, 127, 1030-1037.
    • (2004) Gastroenterology , vol.127 , pp. 1030-1037
    • Udd, L.1
  • 25
    • 39749102904 scopus 로고    scopus 로고
    • Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling
    • Wei, C. et al. (2008) Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling. Clin. Cancer Res., 14, 1167-1171.
    • (2008) Clin. Cancer Res. , vol.14 , pp. 1167-1171
    • Wei, C.1
  • 26
    • 67749110462 scopus 로고    scopus 로고
    • Oral rapamycin reduces tumour burden and vascularization in Lkb1(+/-) mice
    • Robinson, J. et al. (2009) Oral rapamycin reduces tumour burden and vascularization in Lkb1(+/-) mice. J. Pathol., 219, 35-40.
    • (2009) J. Pathol. , vol.219 , pp. 35-40
    • Robinson, J.1
  • 27
    • 55449124298 scopus 로고    scopus 로고
    • Metformin suppresses intestinal polyp growth in ApcMin/+ mice
    • Tomimoto, A. et al. (2008) Metformin suppresses intestinal polyp growth in ApcMin/+ mice. Cancer Sci., 99, 2136-2141.
    • (2008) Cancer Sci. , vol.99 , pp. 2136-2141
    • Tomimoto, A.1
  • 28
    • 70350436136 scopus 로고    scopus 로고
    • Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation
    • McCarthy, A. et al. (2009) Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation. J. Pathol., 219, 306-316.
    • (2009) J. Pathol. , vol.219 , pp. 306-316
    • McCarthy, A.1
  • 29
    • 77949469320 scopus 로고    scopus 로고
    • Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy
    • Contreras, C.M. et al. (2010) Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy. Dis. Model. Mech., 3, 181-193.
    • (2010) Dis. Model. Mech. , vol.3 , pp. 181-193
    • Contreras, C.M.1
  • 30
    • 39749194712 scopus 로고    scopus 로고
    • Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms
    • Hezel, A.F. et al. (2008) Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Mol. Cell. Biol., 28, 2414-2425.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 2414-2425
    • Hezel, A.F.1
  • 31
    • 42049113832 scopus 로고    scopus 로고
    • Lkb1 deficiency causes prostate neoplasia in the mouse
    • Pearson, H.B. et al. (2008) Lkb1 deficiency causes prostate neoplasia in the mouse. Cancer Res., 68, 2223-2232.
    • (2008) Cancer Res. , vol.68 , pp. 2223-2232
    • Pearson, H.B.1
  • 32
    • 39149083762 scopus 로고    scopus 로고
    • LKB1 deficiency sensitizes mice to carcinogen- induced tumorigenesis
    • Gurumurthy, S. et al. (2008) LKB1 deficiency sensitizes mice to carcinogen- induced tumorigenesis. Cancer Res., 68, 55-63.
    • (2008) Cancer Res. , vol.68 , pp. 55-63
    • Gurumurthy, S.1
  • 34
    • 0026665020 scopus 로고
    • Induction of adenocarcinomas in the glandular stomach of BALB/c mice treated with N-methyl-N-nitrosourea
    • Tatematsu, M. et al. (1992) Induction of adenocarcinomas in the glandular stomach of BALB/c mice treated with N-methyl-N-nitrosourea. Jpn. J. Cancer Res., 83, 915-918.
    • (1992) Jpn. J. Cancer Res. , vol.83 , pp. 915-918
    • Tatematsu, M.1
  • 35
    • 0033790792 scopus 로고    scopus 로고
    • p53 knockout mice (-/-) are more susceptible than (+/-) or (+/+) mice to N-methyl-N-nitrosourea stomach carcinogenesis
    • Yamamoto, M. et al. (2000) p53 knockout mice (-/-) are more susceptible than (+/-) or (+/+) mice to N-methyl-N-nitrosourea stomach carcinogenesis. Carcinogenesis, 21, 1891-1897.
    • (2000) Carcinogenesis , vol.21 , pp. 1891-1897
    • Yamamoto, M.1
  • 36
    • 0037188430 scopus 로고    scopus 로고
    • Independent variation in susceptibilities of six different mouse strains to induction of pepsinogen-altered pyloric glands and gastric tumor intestinalization by N-methyl-N-nitrosourea
    • Yamamoto, M. et al. (2002) Independent variation in susceptibilities of six different mouse strains to induction of pepsinogen-altered pyloric glands and gastric tumor intestinalization by N-methyl-N-nitrosourea. Cancer Lett., 179, 121-132.
    • (2002) Cancer Lett. , vol.179 , pp. 121-132
    • Yamamoto, M.1
  • 37
    • 0030938002 scopus 로고    scopus 로고
    • Dose-dependent induction of both pepsinogenaltered pyloric glands and adenocarcinomas in the glandular stomach of C3H mice treated with N-methyl-N-nitrosourea
    • Yamamoto, M. et al. (1997) Dose-dependent induction of both pepsinogenaltered pyloric glands and adenocarcinomas in the glandular stomach of C3H mice treated with N-methyl-N-nitrosourea. Jpn. J. Cancer Res., 88, 238-244.
    • (1997) Jpn. J. Cancer Res. , vol.88 , pp. 238-244
    • Yamamoto, M.1
  • 38
    • 0023852363 scopus 로고
    • Coefficient induction of pepsinogen 1-decreased pyloric glands and gastric cancers in five different strains of rats treated with N-methyl-N'-nitro-N-nitrosoguanidine
    • Tatematsu, M. et al. (1988) Coefficient induction of pepsinogen 1-decreased pyloric glands and gastric cancers in five different strains of rats treated with N-methyl-N'-nitro-N-nitrosoguanidine. Carcinogenesis, 9, 495-498.
    • (1988) Carcinogenesis , vol.9 , pp. 495-498
    • Tatematsu, M.1
  • 39
    • 82955240559 scopus 로고    scopus 로고
    • Celecoxib: a review of its use for symptomatic relief in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis
    • McCormack, P.L. (2011) Celecoxib: a review of its use for symptomatic relief in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Drugs, 71, 2457-2489.
    • (2011) Drugs , vol.71 , pp. 2457-2489
    • McCormack, P.L.1
  • 40
    • 84863989524 scopus 로고    scopus 로고
    • Microbial and histopathologic considerations in the use of mouse models of inflammatory bowel diseases
    • Schoeb, T.R. et al. (2012) Microbial and histopathologic considerations in the use of mouse models of inflammatory bowel diseases. Inflamm. Bowel Dis., 18, 1558-1565.
    • (2012) Inflamm. Bowel Dis. , vol.18 , pp. 1558-1565
    • Schoeb, T.R.1
  • 41
    • 1642451874 scopus 로고    scopus 로고
    • Chemoprevention of gastric cancer by celecoxib in rats
    • Hu, P.J. et al. (2004) Chemoprevention of gastric cancer by celecoxib in rats. Gut, 53, 195-200.
    • (2004) Gut , vol.53 , pp. 195-200
    • Hu, P.J.1
  • 42
    • 29244474612 scopus 로고    scopus 로고
    • Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis
    • Wei, C. et al. (2005) Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis. Cancer Res., 65, 11297-11303.
    • (2005) Cancer Res. , vol.65 , pp. 11297-11303
    • Wei, C.1
  • 43
    • 0028025254 scopus 로고
    • Conformational effects of environmentally induced, cancer-related mutations in the p53 protein
    • Brandt-Rauf, P.W. et al. (1994) Conformational effects of environmentally induced, cancer-related mutations in the p53 protein. Proc. Natl Acad. Sci. USA, 91, 9262-9266.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 9262-9266
    • Brandt-Rauf, P.W.1
  • 44
    • 34547926839 scopus 로고    scopus 로고
    • LKB1 modulates lung cancer differentiation and metastasis
    • Ji, H. et al. (2007) LKB1 modulates lung cancer differentiation and metastasis. Nature, 448, 807-810.
    • (2007) Nature , vol.448 , pp. 807-810
    • Ji, H.1
  • 45
    • 35548952703 scopus 로고    scopus 로고
    • Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization
    • Partanen, J.I. et al. (2007) Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization. Proc. Natl Acad. Sci. USA, 104, 14694-14699.
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 14694-14699
    • Partanen, J.I.1


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