Malignant transformation of human fibroblast cell strain MSU-1.1 by N-methyl N-nitrosourea: Evidence of elimination of p53 by homologous recombination

Cancer Research

Volumn 60, Issue 15, 2000, Pages 4105-4111

  Boley, S E ^a   McManus, T P ^a   Maher, V M ^a   McCormick, J J ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O METHYLGUANINE; GLYCINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; METHYLNITROSOUREA; PROTEIN P53; SERINE;

AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CELL STRAIN; CELL SUBPOPULATION; CHROMOSOME 17P; CYTOTOXICITY; FIBROBLAST; GENE INACTIVATION; GENE LOSS; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSACTIVATION;

ALLELES; CARCINOGENS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; CODON; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FIBROBLASTS; GENE DELETION; GENES, P53; GUANINE; HOMOZYGOTE; HUMANS; LOSS OF HETEROZYGOSITY; METHYLNITROSOUREA; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; RECOMBINATION, GENETIC; TRANS-ACTIVATION (GENETICS);

EID: 0033879575     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Characteristics of an infinite life span diploid human fibroblast cell strain and a near-diploid strain arising from a clone of cells expressing a transfected v-myc oncogene
2. Malignant transformation of human fibroblasts caused by expression of a transfected T24 HRAS oncogene
3. Malignant transformation of human fibroblasts by a transfected N-ras oncogene
4. Malignant transformation of human fibroblast strain MSU-1.1 by (±)-7β,8α-dihydroxy-9α, 10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene
5. Malignant transformation of human fibroblasts by ionizing radiation
6. Dose-dependent transformation of cells of human fibroblast cell strain MSU-1.1 by cobalt-60 gamma radiation and characterization of the transformed cells
7. p53, the cellular gatekeeper for growth and division
8. p53: Puzzle and paradigm. Genes Dev.
9. Database of p53 gene somatic mutations in human tumors and cell lines
10. Mutation spectrum of the p53 gene in bone and soft tissue sarcomas
11. Wild-type p53 can inhibit oncogene-mediated focus formation
12. The p53 proto-oncogene can act as a suppressor of transformation
13. Chemical mutagenesis
14. 6-methylguanine-DNA-methyltransferase activity and resistance of human cells to the cytotoxic and mutagenic effect of N-methyl-N'-nitro-N-nitrosoguanidine
15. 6-methylguanine-DNA-methyltransferase in human fibroblasts increases the mutagenic response to N-methyl-N'-nitro-N-nitrosoguanidine
16. 6-alkylguanine-DNA alkyltransferase on the frequency and spectrum of mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine in the HPRT gene of diploid human fibroblasts
17. Molecular analysis of complex human cell populations: Mutational spectra of MNNG and ICR-191
18. N-Methyl-N-nitrosourea-induced mutations in human cells. Effects of the transcriptional activity of the target gene
19. 6-methylguanine-DNA methyltransferase in cell survival, mutagenesis and carcinogenesis
20. 6-alkylguanine-DNA transferases
21. 6-alkylguanine
22. 6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents
23. Mammalian p53 can function as a transcription factor in yeast
24. Screening patients for heterozygous p53 mutations using a functional assay in yeast
25. Mismatch amplification mutation assay (MAMA): Application to the c-H-ras gene
26. Comparatiye study of DNase I sensitivity at the X-linked human HPRT locus. Somat
27. Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N-methyl-N-nitrosourea, N-ethyl-N-nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma. Some applications of high-pressure liquid chromatography
28. 6-Methylguanine induces intrachromosomal recombination in human cells
29. 6-methylguanine in human leukocyte DNA after intravenous exposure to dacarbazine
30. 6-methylguanine in human DNA after therapeutic exposure to methylating agents and its relationship with biological effects
31. Loss of p53 in benzene-induced thymic lymphomas in p53+/-mice: Evidence of homologous recombination