Thrombospondin-1 mediates Oncogenic Ras-induced senescence in premalignant lung tumors

Journal of Clinical Investigation

Volumn 123, Issue 10, 2013, Pages 4375-4389

  Baek, Kwan Hyuck ^a,b   Bhang, Dongha ^a   Zaslavsky, Alexander ^a   Wang, Liang Chuan ^c   Vachani, Anil ^c   Kim, Carla F ^d   Albelda, Steven M ^c   Evan, Gerard I ^e   Ryeom, Sandra ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Sungkyunkwan University   (South Korea)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

K RAS PROTEIN; PROTEIN P53; RAS PROTEIN; THROMBOSPONDIN 1; KRAS2 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P21;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL AGING; CONTROLLED STUDY; CYTOPLASM; CYTOSOL; LUNG ALVEOLUS EPITHELIUM; LUNG CARCINOGENESIS; LUNG TUMOR; MOUSE; NONHUMAN; OVERALL SURVIVAL; PHENOTYPE; POSITIVE FEEDBACK; PRECANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SENESCENCE; SIGNAL TRANSDUCTION; TUMOR GROWTH; UPREGULATION; 129 MOUSE; ADENOCARCINOMA; ADENOMA; ANIMAL; C57BL MOUSE; CARCINOGENESIS; EPITHELIUM; GENE EXPRESSION REGULATION; GENETICS; HUMAN; LUNG; METABOLISM; MISSENSE MUTATION; PATHOLOGY; PHYSIOLOGY; PROTEIN TRANSPORT; TRANSGENIC MOUSE; TUMOR CELL CULTURE;

ADENOCARCINOMA; ADENOMA; ANIMALS; CARCINOGENESIS; CELL AGING; EPITHELIUM; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION, MISSENSE; PRECANCEROUS CONDITIONS; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS P21(RAS); THROMBOSPONDIN 1; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84885081970     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI67465     Document Type: Article

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