Thrombospondins I and II messenger RNA expression in lung carcinoma: Relationship with p53 alterations, angiogenic growth factors, and vascular density

Clinical Cancer Research

Volumn 5, Issue 1, 1999, Pages 155-161

  Fontanini, Gabriella ^a,b   Boldrini, Laura ^a   Calcinai, Alessandra ^a   Chinè, Silvana ^a   Lucchi, Marco ^a   Mussi, Alfredo ^a   Angeletti, Carlo Alberto ^a   Basolo, Fulvio ^a   Bevilacqua, Generoso ^a  

^a UNIVERSITY OF PISA   (Italy)

^b Division of Pathology   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; FIBROBLAST GROWTH FACTOR; GROWTH FACTOR; MESSENGER RNA; PROTEIN P53; THROMBOSPONDIN; THROMBOSPONDIN 1; VASCULOTROPIN;

ADULT; AGED; ANGIOGENESIS; ARTICLE; CLINICAL ARTICLE; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG CARCINOMA; LUNG NON SMALL CELL CANCER; MALE; MICROVASCULATURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR SUPPRESSOR GENE;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, NON-SMALL-CELL LUNG; ENDOTHELIAL GROWTH FACTORS; FEMALE; FIBROBLAST GROWTH FACTORS; GENES, P53; HUMANS; LUNG NEOPLASMS; LYMPHOKINES; MALE; MIDDLE AGED; MUTATION; NEOVASCULARIZATION, PATHOLOGIC; POLYMERASE CHAIN REACTION; RNA, MESSENGER; THROMBOSPONDIN 1; THROMBOSPONDINS; TUMOR SUPPRESSOR PROTEIN P53; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0032926188     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Folkman, J. What is the evidence that tumors are angiogenesis dependent? J. Natl. Cancer Inst., 82: 4-6, 1990.
2. Roberts, D. D. Regulation of tumor growth and metastasis by thrombospondin-1. FASEB J., 10: 1183-1191, 1996.
3. Varani, J., Dixit, V. M., Fligiel, S. E., McKeever, P. E., and Carey, T. E. Thrombospondin-induced attachment and spreading of human squamous carcinoma cells. Exp. Cell. Res., 167: 376-390, 1986.
4. Roberts, D. D., Sherwood, J. A., and Ginsburg, V. Platelets thrombospondin mediates attachments and spreading of human melanoma cells. J. Cell Biol., 104: 131-139, 1987.
5. Tuszynski, G. P., Gasic, T. B., Rothman, V. L., Knudsen, K. A., and Gasic, G. J. Thrombospondin, a potentiator of tumor cell metastasis. Cancer Res., 47: 4130-4133, 1987.
6. Wong, S. Y., Purdie, A. T., and Han, P. Thrombospondin and other possible related matrix proteins in malignant and benign breast disease. An immunohistochemical study. Am. J. Pathol., 140: 1473-1482, 1992.
7. Riser, B. L., Varani, J., O'Rourke, K., and Dixit, V. M. Thrombospondin binding by human squamous carcinoma and melanoma cells: relationship to biological activity. Exp. Cell. Res., 174: 319-329, 1988.
8. Castle, V. P., Ou, X., O'Rourke, K., and Dixit, V. M. High level thrombospondin 1 expression in two NIH 3T3 cloned lines confers serum- and anchorage-independent growth. J. Biol. Chem., 268:2899-2903, 1993.
9. Tuszynski, G. P., Nicosia, R. F. Localization of thrombospondin and its cystein-serine-valine-threonine-cysteine-glycine-specific receptor in human breast carcinoma. Lab. Invest., 70: 228-233, 1994.
10. Clezardin, P., Frappart, L., Clerget, M., Pechoux, C., and Delmas, P. D. Expression of thrombospondin (TSP1) and its receptors (CD36 and CD51) in normal, hyperplastic, and neoplastic human breast. Cancer Res., 53: 1421-1430, 1993.
11. Zabrenetzky, V., Harris, C. C., Steeg, P. S., and Roberts, D. D. Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung, and breast carcinoma cell lines. Int. J. Cancer, 59; 191-195, 1994.
12. Weinstat-Saslow, D. L., Zabrenetzky, V. S., VanHoutte, K., Frazier, W. A., Roberts, D. D., and Steeg, P. S. Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell lines reduces primary tumor growth, metastatic potential, and angiogenesis. Cancer Res., 54: 6504-6511, 1994.
13. Castle, V. P., Vishva, M. D., and Polverini, P. J. Thrombospondin 1 suppresses tumorigenesis and angiogenesis in serum- and anchorage-independent NIH 3T3 cells. Lab. Invest., 77: 51-61, 1997.
14. Dameron, K. M., Volpert, O. G., Tainsky, M. A., and Bouck, N. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science (Washington DC), 205: 1582-1584, 1994.
15. Bertin, N., Clezardin, P., Kubiak, R., and Frappart, L. Thrombospondin-1 and 2 messenger RNA expression in normal, benign, and neoplastic human breast tissues: correlation with prognostic factors, tumor angiogenesis, and fibroblastic desmoplasia. Cancer Res., 57: 396-399, 1997.
16. Loganadane, L. D., Berge, N., Legrand, C., and Fauvel-Lafeve, F. Endothelial cell proliferation regulated by cytokines modulates throm-bospondin-1 secretion into subendothelium. Cytokines, 9: 740-746, 1997.
17. Patel, V. A., Hill, D. J., Eggo, M. C., Sheppard, M. C., Becks, G. P., and Logan, A. Changes in the immunohistochemical localisation of fibroblast growth factor-2, transforming growth factor-βl and thrombospondin-1 are associated with early angiogenic events in the hyperplastic rat thyroid. J. Endocrinol., 148: 485-499, 1996.
18. Kieser, A., Weich, H. A., Brandner, G., Marmé, D., and Kolch, W. Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression. Oncogene, 9: 964-969, 1994.
19. Mukhopadhyay, D., Tsiokas, L., and Sukhatme, V. Wild-type p53 and v-Src opposing influence on human vascular endothelial growth factor gene expression. Cancer Res., 57: 6161-6165, 1997.
20. Fontanini, G., Vignati, S., Boldrini, L., Chinè, S., Silvestri, V., Lucchi, M., Mussi, A., Angeletti, C. A., And Bevilacqua, G. Vascular endothelial growth factor (VEGF) is associated with neovascularization and influences progression of non-small cell lung carcinoma (NSCLC). Clin. Cancer Res., 3: 861-865, 1997.
21. Fontanini, G., Lucchi, M., Vignati, S., Mussi, A., Ciardiello, F., De Laurentiis, M., De Placido, S., Basolo, F., Angeletti, C. A., and Bevilacqua, G. Angiogenesis as a prognostic indicator of survival in non-small cell lung carcinoma: a prospective study. J. Natl. Cancer Inst., 89: 881-886, 1997.
22. Fontanini, G., Vignati, S., Lucchi, M., Mussi, A., Calcinai, A. Boldrini, L., Chiné, S., Silvestri, V., Angeletti, C. A., Basolo, F., and Bevilacqua, G. Neoangiogenesis and p53 protein in lung cancer: their prognostic role and their relation with vascular endothelial growth factor (VEGF) expression. Br. J. Cancer, 75: 1295-1301, 1997.
23. WHO. Histological typing of lung tumours. Am. J. Clin. Pathol., 77: 123-136, 1982.
24. nd ed.), pp. 115-122. Philadelphia: J. P. Lippincott, 1992.
25. Taraboletti, G., Belotti, D., Borsotti, P., Vergani, V., Rusnati, M., Presta, M., and Giavazzi, R. The 140-kilodalton antiangiogenic fragment of thrombospondin-1 binds to basic fibroblast growth factor. Cell Growth Differ., 8: 471-479, 1997.
26. Grossfeld, G. D., Ginsberg, D. A., Stein, J. P., Bochner, B. H., Esrig, D., Groshen, S., Dunn, M., Nichols, Taylor, C. R., Skinner, D. G., and Cote, R. J. Thrombospondin l expression in bladder cancer: association with p53 alterations, tumor angiogenesis, and tumor progression. J. Natl. Cancer Inst., 89: 219-227, 1997.
27. Agani, F., Kirsch, G., Friedman, S. L., Kastan, M., and Semenza, G. L. p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene. Cancer Res., 57: 4474-4478, 1998.
28. Takahashi, Y., Bucana, C. D., Cleary, K. R., and Ellis, L. M. p53, vessel count, and vascular endothelial growth factor expression in human colon cancer. Int. J. Cancer, 79: 34-38, 1998.