Nature-inspired design of motif-specific antibody scaffolds

Nature Biotechnology

Volumn 31, Issue 10, 2013, Pages 916-921

  Koerber, James T ^a   Thomsen, Nathan D ^a   Hannigan, Brett T ^b   Degrado, William F ^a   Wells, James A ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DETECTION AND QUANTIFICATIONS; GENERAL SOLUTIONS; MONOCLONAL ANTIBODIES (MABS); PHAGE DISPLAY ANTIBODY LIBRARIES; PHOSPHOTYROSINE; POST-TRANSLATIONAL MODIFICATIONS; ROBUST DEVELOPMENT; THERAPEUTIC APPLICATION;

CHEMICAL DETECTION; DIAGNOSIS; MONOCLONAL ANTIBODIES;

SCAFFOLDS;

ADENOSINE TRIPHOSPHATASE; MOLECULAR SCAFFOLD; MONOCLONAL ANTIBODY; PHOSPHATE BINDING PROTEIN; PHOSPHOSERINE; PHOSPHOTHREONINE; PHOSPHOTYROSINE;

ANTIBODY ENGINEERING; ANTIBODY LIBRARY; ANTIBODY SPECIFICITY; ARTICLE; BACTERIOPHAGE; COMPLEMENTARITY DETERMINING REGION; CRYSTAL STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; HYDROGEN BOND; MOLECULAR RECOGNITION; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SURFACE PLASMON RESONANCE; WESTERN BLOTTING;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANTIBODIES, PHOSPHO-SPECIFIC; ANTIBODY SPECIFICITY; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHOPEPTIDES; PROTEIN ENGINEERING; SINGLE-CHAIN ANTIBODIES;

EID: 84884890910     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt.2672     Document Type: Article

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