Superbinder SH2 domains act as antagonists of cell signaling

Science Signaling

Volumn 5, Issue 243, 2012, Pages

  Kaneko, Tomonori ^a   Huang, Haiming ^b   Cao, Xuan ^a   Li, Xing ^a   Li, Chengjun ^a   Voss, Courtney ^a   Sidhu, Sachdev S ^b   Li, Shawn S C ^a  

^a WESTERN UNIVERSITY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; PHOSPHATE; PROTEIN KINASE FYN; PROTEIN SH2; TYROSINE;

AMINO ACID SUBSTITUTION; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CRYSTALLOGRAPHY; HUMAN; HUMAN CELL; HYDROPHOBICITY; LIGAND BINDING; MAMMAL CELL; MUTANT; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CELL SURFACE DISPLAY TECHNIQUES; CRYSTALLOGRAPHY; DIRECTED MOLECULAR EVOLUTION; HEK293 CELLS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTO-ONCOGENE PROTEINS C-FYN; RECEPTOR, EPIDERMAL GROWTH FACTOR; SRC HOMOLOGY DOMAINS; TYROSINE;

MAMMALIA;

EID: 84866875515     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2003021     Document Type: Article

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