An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition

Journal of Biological Chemistry

Volumn 287, Issue 53, 2012, Pages 44425-44434

  Shih, Heather H ^a   Tu, Chao ^a   Cao, Wei ^a   Klein, Anne ^a   Ramsey, Renee ^a   Fennell, Brian J ^a   Lambert, Matthew ^a   Ní Shúilleabháin, Deirdre ^a   Autin, Bénédicte ^a   Kouranova, Eugenia ^a   Laxmanan, Sri ^a   Braithwaite, Steven ^a   Wu, Leeying ^a   Ait Zahra, Mostafa ^a   Milici, Anthony J ^a   Dumin, Jo Ann ^a   LaVallie, Edward R ^a   Arai, Maya ^a   Corcoran, Christopher ^a   Paulsen, Janet E ^a   Gill, Davinder ^a   Cunningham, Orla ^a   Bard, Joel ^a   Mosyak, Lydia ^a   Finlay, William J J ^a   more..

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER; ALZHEIMER PATIENTS; BINDING AFFINITIES; BINDING MECHANISMS; BRAIN SAMPLE; COMPLEMENTARITY-DETERMINING REGIONS; DISEASE STATE; DISEASE-ASSOCIATED PROTEINS; FAB FRAGMENTS; MOLECULAR MECHANISM; MOUSE MODELS; PEPTIDE RECOGNITION; PHOSPHATE GROUP; PHOSPHOPEPTIDES; SURFACE PLASMONS; TAU PROTEINS;

BINDING ENERGY; NEURODEGENERATIVE DISEASES; PEPTIDES; PHOSPHORYLATION;

ANTIBODIES;

ANTIBODY; DISULFIDE; EPITOPE; IMMUNOGLOBULIN G; PHOSPHATE; PHOSPHOEPITOPE; TAU PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOSYNTHESIS; BIRD; COMPLEMENTARITY DETERMINING REGION; COMPLEX FORMATION; CONTROLLED STUDY; CROSS REACTION; DISEASE ASSOCIATION; HUMAN; HUMAN TISSUE; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SURFACE PLASMON RESONANCE; TAUOPATHY;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; BRAIN; CHICKENS; EPITOPES; HUMANS; IMMUNOGLOBULIN G; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; TAU PROTEINS;

AVES; MURINAE;

EID: 84871818326     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.415935     Document Type: Article

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