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Volumn 382, Issue 2, 2013, Pages 375-384

Smad7 regulates terminal maturation of chondrocytes in the growth plate

Author keywords

BMP, bone morphogenetic protein; Cartilage; Chondrocytes; ER stress; Growth plate; Hypoxia; Mouse; Smad; TGF , transforming growth factor

Indexed keywords

BONE MORPHOGENETIC PROTEIN; COLLAGEN TYPE 10; COLLAGEN TYPE 2; CYCLINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD7 PROTEIN; SMAD8 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1;

EID: 84884820709     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2013.08.021     Document Type: Article
Times cited : (39)

References (49)
  • 1
    • 33747762981 scopus 로고    scopus 로고
    • Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis
    • Andersson O., Reissmann E., Ibanez C.F. Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis. EMBO Rep. 2006, 7:831-837.
    • (2006) EMBO Rep. , vol.7 , pp. 831-837
    • Andersson, O.1    Reissmann, E.2    Ibanez, C.F.3
  • 3
    • 7544242737 scopus 로고    scopus 로고
    • Conditional deletion of the TGF-beta type II receptor in Col2a expressing cells results in defects in the axial skeleton without alterations in chondrocyte differentiation or embryonic development of long bones
    • Baffi M.O., Slattery E., Sohn P., Moses H.L., Chytil A., Serra R. Conditional deletion of the TGF-beta type II receptor in Col2a expressing cells results in defects in the axial skeleton without alterations in chondrocyte differentiation or embryonic development of long bones. Dev. Biol. 2004, 276:124-142.
    • (2004) Dev. Biol. , vol.276 , pp. 124-142
    • Baffi, M.O.1    Slattery, E.2    Sohn, P.3    Moses, H.L.4    Chytil, A.5    Serra, R.6
  • 5
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck R., Zhang Y.E. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003, 425:577-584.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 6
    • 80053189525 scopus 로고    scopus 로고
    • Smad6 is essential to limit BMP signaling during cartilage development
    • Estrada K.D., Retting K.N., Chin A.M., Lyons K.M. Smad6 is essential to limit BMP signaling during cartilage development. J. Bone Miner. Res. 2011, 26:2498-2510.
    • (2011) J. Bone Miner. Res. , vol.26 , pp. 2498-2510
    • Estrada, K.D.1    Retting, K.N.2    Chin, A.M.3    Lyons, K.M.4
  • 10
    • 0035842885 scopus 로고    scopus 로고
    • The N domain of Smad7 is essential for specific inhibition of transforming growth factor-beta signaling
    • Hanyu A., Ishidou Y., Ebisawa T., Shimanuki T., Imamura T., Miyazono K. The N domain of Smad7 is essential for specific inhibition of transforming growth factor-beta signaling. J. Cell Biol. 2001, 155:1017-1027.
    • (2001) J. Cell Biol. , vol.155 , pp. 1017-1027
    • Hanyu, A.1    Ishidou, Y.2    Ebisawa, T.3    Shimanuki, T.4    Imamura, T.5    Miyazono, K.6
  • 14
    • 55449107515 scopus 로고    scopus 로고
    • Regulation of TGF-beta family signaling by E3 ubiquitin ligases
    • Inoue Y., Imamura T. Regulation of TGF-beta family signaling by E3 ubiquitin ligases. Cancer Sci. 2008, 99:2107-2112.
    • (2008) Cancer Sci. , vol.99 , pp. 2107-2112
    • Inoue, Y.1    Imamura, T.2
  • 15
    • 0033531948 scopus 로고    scopus 로고
    • Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells
    • Ishisaki A., Yamato K., Hashimoto S., Nakao A., Tamaki K., Nonaka K., ten Dijke P., Sugino H., Nishihara T. Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells. J. Biol. Chem. 1999, 274:13637-13642.
    • (1999) J. Biol. Chem. , vol.274 , pp. 13637-13642
    • Ishisaki, A.1    Yamato, K.2    Hashimoto, S.3    Nakao, A.4    Tamaki, K.5    Nonaka, K.6    ten Dijke, P.7    Sugino, H.8    Nishihara, T.9
  • 16
    • 55249108036 scopus 로고    scopus 로고
    • Smad7 Inhibits chondrocyte differentiation at multiple steps during endochondral bone formation and down-regulates p38 MAPK pathways
    • Iwai T., Murai J., Yoshikawa H., Tsumaki N. Smad7 Inhibits chondrocyte differentiation at multiple steps during endochondral bone formation and down-regulates p38 MAPK pathways. J. Biol. Chem. 2008, 283:27154-27164.
    • (2008) J. Biol. Chem. , vol.283 , pp. 27154-27164
    • Iwai, T.1    Murai, J.2    Yoshikawa, H.3    Tsumaki, N.4
  • 17
    • 0027727196 scopus 로고
    • A dominant negative mutation in the alpha 1 (X) collagen gene produces spondylometaphyseal defects in mice
    • Jacenko O., LuValle P., Solum K., Olsen B.R. A dominant negative mutation in the alpha 1 (X) collagen gene produces spondylometaphyseal defects in mice. Prog. Clin. Biol. Res. 1993, 383B:427-436.
    • (1993) Prog. Clin. Biol. Res. , vol.383 B , pp. 427-436
    • Jacenko, O.1    LuValle, P.2    Solum, K.3    Olsen, B.R.4
  • 18
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg H.M. Developmental regulation of the growth plate. Nature 2003, 423:332-336.
    • (2003) Nature , vol.423 , pp. 332-336
    • Kronenberg, H.M.1
  • 22
    • 84871901528 scopus 로고    scopus 로고
    • Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-beta/Smad3-NF.kappaB-dependent mechanisms in mice
    • Liu G.X., Li Y.Q., Huang X.R., Wei L., Chen H.Y., Shi Y.J., Heuchel R.L., Lan H.Y. Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-beta/Smad3-NF.kappaB-dependent mechanisms in mice. PLoS One 2013, 8:e53573.
    • (2013) PLoS One , vol.8
    • Liu, G.X.1    Li, Y.Q.2    Huang, X.R.3    Wei, L.4    Chen, H.Y.5    Shi, Y.J.6    Heuchel, R.L.7    Lan, H.Y.8
  • 23
    • 0031685620 scopus 로고    scopus 로고
    • TGF-beta signal transduction
    • Massague J. TGF-beta signal transduction. Annu. Rev. Biochem. 1998, 67:753-791.
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 753-791
    • Massague, J.1
  • 25
    • 67650985957 scopus 로고    scopus 로고
    • Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development
    • Matsunobu T., Torigoe K., Ishikawa M., de Vega S., Kulkarni A.B., Iwamoto Y., Yamada Y. Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development. Dev. Biol. 2009, 332:325-338.
    • (2009) Dev. Biol. , vol.332 , pp. 325-338
    • Matsunobu, T.1    Torigoe, K.2    Ishikawa, M.3    de Vega, S.4    Kulkarni, A.B.5    Iwamoto, Y.6    Yamada, Y.7
  • 26
    • 33747691662 scopus 로고    scopus 로고
    • Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression
    • McMahon S., Charbonneau M., Grandmont S., Richard D.E., Dubois C.M. Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression. J. Biol. Chem. 2006, 281:24171-24181.
    • (2006) J. Biol. Chem. , vol.281 , pp. 24171-24181
    • McMahon, S.1    Charbonneau, M.2    Grandmont, S.3    Richard, D.E.4    Dubois, C.M.5
  • 27
    • 0032695265 scopus 로고    scopus 로고
    • Mouse patched1 controls body size determination and limb patterning
    • Milenkovic L., Goodrich L.V., Higgins K.M., Scott M.P. Mouse patched1 controls body size determination and limb patterning. Development 1999, 126:4431-4440.
    • (1999) Development , vol.126 , pp. 4431-4440
    • Milenkovic, L.1    Goodrich, L.V.2    Higgins, K.M.3    Scott, M.P.4
  • 28
    • 0034747252 scopus 로고    scopus 로고
    • BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation
    • Minina E., Wenzel H.M., Kreschel C., Karp S., Gaffield W., McMahon A.P., Vortkamp A. BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation. Development 2001, 128:4523-4534.
    • (2001) Development , vol.128 , pp. 4523-4534
    • Minina, E.1    Wenzel, H.M.2    Kreschel, C.3    Karp, S.4    Gaffield, W.5    McMahon, A.P.6    Vortkamp, A.7
  • 29
    • 3843087354 scopus 로고    scopus 로고
    • Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-beta superfamily signaling
    • Mochizuki T., Miyazaki H., Hara T., Furuya T., Imamura T., Watabe T., Miyazono K. Roles for the MH2 domain of Smad7 in the specific inhibition of transforming growth factor-beta superfamily signaling. J. Biol. Chem. 2004, 279:31568-31574.
    • (2004) J. Biol. Chem. , vol.279 , pp. 31568-31574
    • Mochizuki, T.1    Miyazaki, H.2    Hara, T.3    Furuya, T.4    Imamura, T.5    Watabe, T.6    Miyazono, K.7
  • 31
    • 0038107486 scopus 로고    scopus 로고
    • Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads
    • Murakami G., Watabe T., Takaoka K., Miyazono K., Imamura T. Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads. Mol. Biol. Cell. 2003, 14:2809-2817.
    • (2003) Mol. Biol. Cell. , vol.14 , pp. 2809-2817
    • Murakami, G.1    Watabe, T.2    Takaoka, K.3    Miyazono, K.4    Imamura, T.5
  • 33
    • 0038325620 scopus 로고    scopus 로고
    • HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes
    • Pfander D., Cramer T., Schipani E., Johnson R.S. HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes. J. Cell Sci. 2003, 116:1819-1826.
    • (2003) J. Cell Sci. , vol.116 , pp. 1819-1826
    • Pfander, D.1    Cramer, T.2    Schipani, E.3    Johnson, R.S.4
  • 35
    • 66349117431 scopus 로고    scopus 로고
    • BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation
    • Retting K.N., Song B., Yoon B.S., Lyons K.M. BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation. Development 2009, 136:1093-1104.
    • (2009) Development , vol.136 , pp. 1093-1104
    • Retting, K.N.1    Song, B.2    Yoon, B.S.3    Lyons, K.M.4
  • 36
    • 0014983906 scopus 로고
    • Chemical basis for the histological use of safranin O in the study of articular cartilage
    • Rosenberg L. Chemical basis for the histological use of safranin O in the study of articular cartilage. J. Bone Joint Surg. Am. 1971, 53:69-82.
    • (1971) J. Bone Joint Surg. Am. , vol.53 , pp. 69-82
    • Rosenberg, L.1
  • 37
    • 0242606953 scopus 로고    scopus 로고
    • Adenoviral overexpression of Smad-7 and Smad-6 differentially regulates TGF-beta-mediated chondrocyte proliferation and proteoglycan synthesis
    • Scharstuhl A., Diepens R., Lensen J., Vitters E., van Beuningen H., van der Kraan P., van den Berg W. Adenoviral overexpression of Smad-7 and Smad-6 differentially regulates TGF-beta-mediated chondrocyte proliferation and proteoglycan synthesis. Osteoarthritis Cartilage 2003, 11:773-782.
    • (2003) Osteoarthritis Cartilage , vol.11 , pp. 773-782
    • Scharstuhl, A.1    Diepens, R.2    Lensen, J.3    Vitters, E.4    van Beuningen, H.5    van der Kraan, P.6    van den Berg, W.7
  • 38
    • 0035499204 scopus 로고    scopus 로고
    • Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival
    • Schipani E., Ryan H.E., Didrickson S., Kobayashi T., Knight M., Johnson R.S. Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev. 2001, 15:2865-2876.
    • (2001) Genes Dev. , vol.15 , pp. 2865-2876
    • Schipani, E.1    Ryan, H.E.2    Didrickson, S.3    Kobayashi, T.4    Knight, M.5    Johnson, R.S.6
  • 39
    • 0030727351 scopus 로고    scopus 로고
    • Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis
    • Serra R., Johnson M., Filvaroff E.H., LaBorde J., Sheehan D.M., Derynck R., Moses H.L. Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. J. Cell Biol. 1997, 139:541-552.
    • (1997) J. Cell Biol. , vol.139 , pp. 541-552
    • Serra, R.1    Johnson, M.2    Filvaroff, E.H.3    LaBorde, J.4    Sheehan, D.M.5    Derynck, R.6    Moses, H.L.7
  • 40
    • 0033532057 scopus 로고    scopus 로고
    • Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling
    • Shi X., Yang X., Chen D., Chang Z., Cao X. Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling. J. Biol. Chem. 1999, 274:13711-13717.
    • (1999) J. Biol. Chem. , vol.274 , pp. 13711-13717
    • Shi, X.1    Yang, X.2    Chen, D.3    Chang, Z.4    Cao, X.5
  • 42
    • 0033567213 scopus 로고    scopus 로고
    • Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    • St-Jacques B., Hammerschmidt M., McMahon A. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. 1999, 13:2072-2086.
    • (1999) Genes Dev. , vol.13 , pp. 2072-2086
    • St-Jacques, B.1    Hammerschmidt, M.2    McMahon, A.3
  • 43
    • 0037072760 scopus 로고    scopus 로고
    • Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes
    • Valcourt U., Gouttenoire J., Moustakas A., Herbage D., Mallein-Gerin F. Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes. J. Biol. Chem. 2002, 277:33545-33558.
    • (2002) J. Biol. Chem. , vol.277 , pp. 33545-33558
    • Valcourt, U.1    Gouttenoire, J.2    Moustakas, A.3    Herbage, D.4    Mallein-Gerin, F.5
  • 45
    • 71449099881 scopus 로고    scopus 로고
    • Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription
    • Wang W., Lian N., Li L., Moss H.E., Wang W., Perrien D.S., Elefteriou F., Yang X. Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription. Development 2009, 136:4143-4153.
    • (2009) Development , vol.136 , pp. 4143-4153
    • Wang, W.1    Lian, N.2    Li, L.3    Moss, H.E.4    Wang, W.5    Perrien, D.S.6    Elefteriou, F.7    Yang, X.8
  • 46
    • 54549089738 scopus 로고    scopus 로고
    • Hypoxia signalling through mTOR and the unfolded protein response in cancer
    • Wouters B.G., Koritzinsky M. Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nat. Rev. Cancer 2008, 8:851-864.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 851-864
    • Wouters, B.G.1    Koritzinsky, M.2
  • 48
    • 58049197169 scopus 로고    scopus 로고
    • PTEN deficiency causes dyschondroplasia in mice by enhanced hypoxia-inducible factor 1alpha signaling and endoplasmic reticulum stress
    • Yang G., Sun Q., Teng Y., Li F., Weng T., Yang X. PTEN deficiency causes dyschondroplasia in mice by enhanced hypoxia-inducible factor 1alpha signaling and endoplasmic reticulum stress. Development 2008, 135:3587-3597.
    • (2008) Development , vol.135 , pp. 3587-3597
    • Yang, G.1    Sun, Q.2    Teng, Y.3    Li, F.4    Weng, T.5    Yang, X.6
  • 49
    • 0035795409 scopus 로고    scopus 로고
    • TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
    • Yang X., Chen L., Xu X., Li C., Huang C., Deng C.X. TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage. J. Cell Biol. 2001, 153:35-46.
    • (2001) J. Cell Biol. , vol.153 , pp. 35-46
    • Yang, X.1    Chen, L.2    Xu, X.3    Li, C.4    Huang, C.5    Deng, C.X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.