Agonist-dependent endocytosis of γ-aminobutyric acid type A (GABAA) receptors revealed by a γ2(R43Q) epilepsy mutation

Journal of Biological Chemistry

Volumn 288, Issue 39, 2013, Pages 28254-28265

  Chaumont, Severine ^a,b,f   André, Caroline ^a,b   Perrais, David ^a,c   Boué Grabot, Eric ^a,d   Taly, Antoine ^e   Garret, Maurice ^a,b  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b UMR 5287   (France)

^c University of Bordeaux   (France)

^d INSTITUT DES MALADIES NEURODÉGÉNÉRATIVES   (France)

^e INST DE BIOLOGIE PHYSICO CHIMIQUE   (France)

^f UNIV MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOBUTYRIC ACIDS; CONFORMATIONAL CHANGE; EPILEPSY MUTATIONS; EXTRACELLULAR DOMAINS; GABAA RECEPTORS; POINT MUTATIONS; RECEPTOR ENDOCYTOSIS; RECEPTOR TRAFFICKING;

AMINO ACIDS;

MOLECULAR BIOLOGY;

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; CLATHRIN; DYNAMIN;

ARTICLE; CELL MEMBRANE; CELL STRAIN COS7; CELL SURFACE; CONFORMATIONAL TRANSITION; ENDOCYTOSIS; EPILEPSY; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; IMMUNOCYTOCHEMISTRY; INTERNALIZATION; NEUROTRANSMISSION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; QUANTITATIVE ANALYSIS; WILD TYPE;

GABA RECEPTORS; NEUROBIOLOGY; NEUROLOGICAL DISEASES; RECEPTOR ENDOCYTOSIS; TRAFFICKING;

ANIMALS; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COS CELLS; ENDOCYTOSIS; EPILEPSY; GABA-A RECEPTOR AGONISTS; GABA-A RECEPTOR ANTAGONISTS; HEK293 CELLS; HIPPOCAMPUS; HUMANS; MICROSCOPY, FLUORESCENCE; MODELS, MOLECULAR; NERVOUS SYSTEM DISEASES; NEURONS; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, GABA-A; SYNAPTIC TRANSMISSION;

EID: 84884805732     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.470807     Document Type: Article

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