Benzodiazepine treatment induces subtype-specific changes in GABA A receptor trafficking and decreases synaptic inhibition

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 45, 2012, Pages 18595-18600

  Jacob, Tija C ^a   Michels, Guido ^b   Silayeva, Liliya ^c   Haydon, Julia ^c   Succol, Francesca ^d   Moss, Stephen J ^c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLOGNE   (Germany)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

Diazepam; GABAergic; Lysosome

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE; FLUMAZENIL; FLURAZEPAM; LEUPEPTIN;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CELL MEMBRANE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG BINDING SITE; DRUG MECHANISM; EMBRYO; ENDOCYTOSIS; HIPPOCAMPUS; LYSOSOME; NEUROMUSCULAR SYNAPSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN DEPLETION; RAT;

ANIMALS; BENZODIAZEPINES; BINDING SITES; CELL MEMBRANE; ENDOCYTOSIS; INHIBITORY POSTSYNAPTIC POTENTIALS; LEUPEPTINS; NEURAL INHIBITION; NEURONS; PROTEIN SUBUNITS; PROTEIN TRANSPORT; RATS; RECEPTORS, GABA-A; SYNAPSES;

EID: 84868560218     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1204994109     Document Type: Article

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