Thyroid hormones and brain development

Hormones, Brain and Behavior Online

Volumn , Issue , 2009, Pages 2005-2034

  Bernal, J ^a  

^a CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

Author keywords

Caudate; Cerebellum; Cretinism; Gene expression; Granular cells; Hypothyroidism; Hypothyroxinemia; MCT8; Myelin; Neurogenesis oligodendrocytes; Prematurity; Purkinje cells; Thyroid; Transporters

Indexed keywords

EID: 84884803684     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-008088783-8.00063-2     Document Type: Chapter

References (325)

1. Adamo A.M., Aloise P.A., Soto E.F., Pasquini J.M. Neonatal hyperthyroidism in the rat produces an increase in the activity of microperoxisomal marker enzymes coincident with biochemical signs of accelerated myelination. Journal of Neuroscience Research 1990, 25:353-359.
2. Altman J., Bayer S.A. Development of the Cerebellar System 1997, CRC Press, Boca Raton, CA.
3. Alvarez-Dolado M., Cuadrado A., Navarro-Yubero C., Sonderegger P., Furley A.J., Bernal J., Muñoz A. Regulation of the L1 cell adhesion molecule by thyroid hormone in the developing brain. Molecular and Cellular Neurobiology 2000, 16:499-514.
4. Alvarez-Dolado M., Gonzalez-Sancho J.M., Bernal J., Muñoz A. Developmental expression of tenascin-C is altered by hypothyroidism in the rat brain. Neuroscience 1998, 84:309-322.
5. Alvarez-Dolado M., Gonzalez-Moreno M., Valencia A., Zenke M., Bernal J., Muñoz A. Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions. Journal of Neurochemistry 1999, 73:2240-2249.
6. Alvarez-Dolado M., Iglesias T., Rodríguez-Peña A., Bernal J., Muñoz A. Expression of neurotrophins and the trk family of neurotrophin receptors in normal and hypothyroid rat brain. Molecular Brain Research 1994, 27:249-257.
7. Alvarez-Dolado M., Ruiz M., del Rio J.A., et al. Thyroid hormone regulates reelin and dab1 expression during brain development. Journal of Neuroscience 1999, 19:6979-6993.
8. Ambrogini P., Cuppini R., Ferri P., et al. Thyroid hormones affect neurogenesis in the dentate gyrus of adult rat. Neuroendocrinology 2005, 81:244-253.
9. Anderson G.W., Schoonover C.M., Jones S.A. Control of thyroid hormone action in the developing rat brain. Thyroid 2003, 13:1039-1056.
10. Aniello F., Couchie D., Bridoux A.M., Gripois D., Nunez J. Splicing of juvenile and adult tau mRNA variants is regulated by thyroid hormone. Proceedings of the National Academy of Sciences of the United States of America 1991, 88:4035-4039.
11. Aniello F., Couchie D., Gripois D., Nunez J. Regulation of five tubulin isotypes by thyroid hormone during brain development. Journal of Neurochemistry 1991, 57:1781-1786.
12. Ausó E., Lavado-Autric R., Cuevas E., DelRey F.E., Morreale de Escobar G., Berbel P. A moderate and transient deficiency of maternal thyroid function at the beginning of fetal neocorticogenesis alters neuronal migration. Endocrinology 2004, 145:4037-4047.
13. Balazs R., Brooksbank B.W.L., Davison A.N., Eayrs J.T., Wilson D.A. The effect of neonatal thyroidectomy on myelination in the rat brain. Brain Research 1969, 15:219-232.
14. Barakat-Walter I., Droz B. Nuclear and cytoplasmic triiodothyronine binding sites in primary sensory neurons and Schwann cells: Radioautographic study during development. Journal of Neuroendocrinology 1995, 7:127-136.
15. Barsano C.P., DeGroot L.J., Getz G.S. The effect of thyroid hormone on in vivo rat liver mitochondria RNA sunthesis. Endocrinology 1977, 100:52-60.
16. Bates J.M., St. Germain D.L., Galton V.A. Expression profiles of the three iodothyronine deiodinases D1, D2 and D3, in the developing rat. Endocrinology 1999, 140:844-851.
17. Baum M.J. Psychosexual development. Fundamental Neuroscience 1999, 1229-1244. Academic Press, San Diego, CA. M.J. Zigmond, F.E. Bloom, S.C. Landis, J.L. Roberts, L.R. Squire (Eds.).
18. Becker K.B., Stephens K.C., Davey J.C., Schneider M.J., Galton V.A. The type 2 and type 3 iodothyronine deiodinases play important roles in coordinating development in Rana catesbeiana tadpoles. Endocrinology 1997, 138:2989-2997.
19. Berbel P., Auso E., Garcia-Velasco J.V., Molina M.L., Camacho M. Role of thyroid hormones in the maturation and organisation of rat barrel cortex. Neuroscience 2001, 107:383-394.
20. Berbel P., Guadaño-Ferraz A., Angulo A., Cerezo J.R. Role of thyroid hormones in the maturation of interhemispheric connections in rat. Behavioural Brain Research 1994, 64:9-14.
21. Berbel P., Guadano-Ferraz A., Martinez M., Quiles J.A., Balboa R., Innocenti G.M. Organization of auditory callosal connections in hypothyroid adult rats. European Journal of Neuroscience 1993, 5:1465-1478.
22. Berbel P., Obregon M.J., Bernal J., Rey F.E., Escobar G.M. Iodine supplementation during pregnancy: A public health challenge. Trends in Endocrinology and Metabolism 2007, 18:338-343.
23. Bernal J. Thyroid hormones and brain development. Vitamins and Hormone 2005, 71:95-122.
24. Bernal J. The significance of thyroid hormone transporters in the brain. Endocrinology 2005, 146:1698-1700.
25. Bernal J. Thyroid hormone receptors in brain development and function. Nature Clinical Practice Endocrinology and Metabolism 2007, 3:249-259.
26. Bernal J., Pekonen F. Ontogenesis of the nuclear 3,5,3′-triiodothyronine receptor in the human fetal brain. Endocrinology 1984, 114:677-679.
27. Berry D.L., Rose C.S., Remo B.F., Brown D.D. The expression pattern of thyroid hormone response genes in remodeling tadpole tissues defines distinct growth and resorption gene expression programs. Developmental Biology 1998, 203:24-35.
28. Bianco A.C., Larsen P.R. Cellular and structural biology of the deiodinases. Thyroid 2005, 15:777-786.
29. Billon N., Jolicoeur C., Tokumoto Y., Vennstrom B., RaffM. Normal timing of oligodendrocyte development depends on thyroid hormone receptor alpha 1 (TRalpha1). EMBO Journal 2002, 21:6452-6460.
30. Billon N., Tokumoto Y., Forrest D., RaffM. Role of thyroid hormone receptors in timing oligodendrocyte differentiation. Developmental Biology 2001, 235:110-120.
31. Blizzard R.M., Chandler R.W., Landing Pettit M.D., West C.D. Maternal autoimmunization to thyroid as probable cause of athyreotic cretinism. New England Journal of Medicine 1960, 263:327-336.
32. 2-subtype, in the developing mammalian nervous system. Journal of Neuroscience 1992, 12:2288-2302.
33. Bradley D.J., Towle H.C., Young W.S.I. Alpha and beta thyroid hormone receptor (TR) gene expression during auditory neurogenesis: Evidence for TR isoform-specific transcriptional regulation in vivo. Proceedings of the National Academy of Sciences of the United States of America 1994, 91:439-443.
34. Bradley D.J., Young W.S., Weinberger C. Differential expression of alpha and beta thyroid hormone receptor genes in rat brain and pituitary. Proceedings of the National Academy of Sciences of the United States of America 1989, 86:7250-7254.
35. Braulke L.J., Klingenspor M., Debarber A., Tobias S.C., Grandy D.K., Scanlan T.S., Heldmaier G. 3-Iodothyronamine: A novel hormone controlling the balance between glucose and lipid utilisation. Journal of Comparative Physiology, B 2008, 178:167-177.
36. Brockmann K., Dumitrescu A.M., Best T.T., Hanefeld F., RefetoffS. X-linked paroxysmal dyskinesia and severe global retardation caused by defective MCT8 gene. Journal of Neurology 2005, 252:663-666.
37. Burmeister L.A., Pachucki J., St. Germain D.L. Thyroid hormones inhibit type 2 iodothyronine deiodinase in the rat cerebral cortex by both pre- and posttranslational mechanisms. Endocrinology 1997, 138:5231-5237.
38. Caelles C., Gonzalez-Sancho J.M., Muñoz A. Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway. Genes and Development 1997, 11:3351-3364.
39. Calvo R., Obregón M.J., Ruiz de Oña C., Escobar del Rey F., Morreale de Escobar G. Congenital hypothyroidism, as studied in rats. Crucial role of maternal thyroxine but not of 3,5,3′-triiodothyronine in the protection of the fetal brain. Journal of Clinical Investigation 1990, 86:889-899.
40. Campos-Barros A., Amma L.L., Faris J.S., Shailam R., Kelley M.W., Forrest D. Type 2 iodothyronine deiodinase expression in the cochlea before the onset of hearing. Proceedings of the National Academy of Sciences of the United States of America 2000, 97:1287-1292.
41. Cao X., Kambe F., Moeller L.C., RefetoffS., Seo H. Thyroid hormone induces rapid activation of Akt/protein kinase B-mammalian target of rapamycin-p70S6K cascade through phosphatidylinositol 3-kinase in human fibroblasts. Molecular Endocrinology 2005, 19:102-112.
42. Carlson D.J., Strait K.A., Schwartz H.L., Oppenheimer J.H. Immunofluorescent localization of thyroid hormone receptor isoforms in glial cells of rat brain. Endocrinology 1994, 135:1831-1836.
43. Casas F., Daury L., Grandemange S., et al. Endocrine regulation of mitochondrial activity: Involvement of truncated RXRalpha and c-Erb alpha1 proteins. FASEB Journal 2003, 17:426-436.
44. Cavalieri R.P., Gavin L.A., Cole R., DeVellis J. Thyroid hormone deiodinases in purified primary glial cell cultures. Brain Research 1986, 364:382-385.
45. Cayrou C., Denver R.J., Puymirat J. Suppression of the basic transcription element-binding protein in brain neuronal cultures inhibits thyroid hormone-induced neurite branching. Endocrinology 2002, 143:2242-2249.
46. Chanoine J.-P., Alex S., Fang S.L., Stone S., Leonard J.L., Köhrle J., Braverman L.E. Role of transthyretin in the transport of thyroxine from the blood to the choroid plexus, the cerebrospinal fluid, and the brain. Endocrinology 1992, 130:933-938.
47. Chomez P., Neveu I., Mansen A., Kiesler E., Larsson L., Vennstrom B., Arenas E. Increased cell death and delayed development in the cerebellum of mice lacking the rev-erbA(alpha) orphan receptor. Development 2000, 127:1489-1498.
48. Clos J., Legrand C., Legrand J. Effects of thyroid state on the formation and early morphological development of Bergmann glia in the developing rat cerebellum. Developmental Neuroscience 1980, 3:199-208.
49. Contempré B., de Escobar G.M., Denef J.F., Dumont J.E., Many M.C. Thiocyanate induces cell necrosis and fibrosis in selenium- and iodine-deficient rat thyroids: A potential experimental model for myxedematous endemic cretinism in central Africa. Endocrinology 2004, 145:994-1002.
50. Contempré B., Dumont J.E., Denef J.F., Many M.C. Effects of selenium deficiency on thyroid necrosis, fibrosis and proliferation: A possible role in myxoedematous cretinism. European Journal of Endocrinology 1995, 133:99-109.
51. Contempré B., Jauniaux E., Calvo R., Jurkovic D., Campbell S., Morreale de Escobar G. Detection of thyroid hormones in human embryonic cavities during the first trimester of pregnancy. Journal of Clinical Endocrinology and Metabolism 1993, 77:1719-1722.
52. Cooney A.J., Leng X., Tsai S.Y., O'Malley B.W.O., Tsai M.J. Multiple mechanism of chicken ovalbumin upstream promoter transcription factor-dependent repression of transactivation by the vitamin D, thyroid hormone, and retinoic acid receptors. Journal of Biological Chemistry 1993, 268:4152-4160.
53. Courtin F., Chantoux F., Francon J. Thyroid hormone metabolism by glial cells in primary culture. Molecular and Cellular Endocrinology 1986, 48:73-84.
54. Courtin F., Liva P., Gavaret J.M., ToruDelbauffe D., Pierre M. Induction of 5-deiodinase activity in astroglial cells by 12-O-tetradecanoylphorbol 13-acetate and fibroblast growth factors. Journal of Neurochemistry 1991, 56:1107-1113.
55. Crantz F.R., Silva J.E., Larsen P.R. An analysis of the sources and quantity of 3,5,3′-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum. Endocrinology 1982, 110:367-375.
56. Croteau W., Davey J.C., Galton V.A., St. Germain D.L. Cloning of the mammalian type II iodothyronine deiodinase: A selenoprotein differentially expressed and regulated in the human brain and other tissues. Journal of Clinical Investigation 1996, 98:405-417.
57. Croteau W., Whittemore S.L., Schneider M.J., St. Germain D.L. Cloning and expression of a cDNA for a mammalian type III iodothyronine deiodinase. Journal of Biological Chemistry 1995, 270:16569-16575.
58. Cuadrado A., Bernal J., Muñoz A. Identification of the mammalian homolog of the splicing regulator suppressor-of-white-apricot as a thyroid hormone regulated gene. Molecular Brain Research 1999, 71:332-340.
59. Cuadrado A., Garcia-Fernandez L.F., Imai T., Okano H., Munoz A. Regulation of tau RNA maturation by thyroid hormone is mediated by the neural RNA-binding protein musashi-1. Molecular and Cellular Neuroscience 2002, 20:198-210.
60. Davis P.J., Davis F.B., Cody V. Membrane receptors mediating thyroid hormone action. Trends in Endocrinology and Metabolism 2005, 16:429-435.
61. de Zegher F., Pernasetti F., Vanhole C., Devlieger H., van den Berghe G., Martial J.A. The prenatal role of thyroid hormone evidenced by fetomaternal Pit-1 deficiency. Journal of Clinical Endocrinology and Metabolism 1995, 80:3127-3130.
62. DelRio J.A., Heimrich B., Borrell V., et al. A role for Cajal-Retzius cells and reelin in the development of hippocampal connections. Nature 1997, 385:70-74.
63. Deladoey J., Vassart G., van Vliet G. Possible non-Mendelian mechanisms of thyroid dysgenesis. Endocrine Development 2007, 10:29-42.
64. Delange F. Neonatal screening for congenital hypothyroidism: Results and perspectives. Hormone Research 1997, 48:51-61.
65. DeLong G.R., Stanbury J.B., Fierro-Benitez R. Neurological signs in congenital iodine-deficiency disorder (endemic cretinism). Developmental Medicine and Child Neurology 1985, 27:317-324.
66. Dellovade T.L., Zhu Y.S., Krey L., PfaffD.W. Thyroid hormone and estrogen interact to regulate behavior. Proceedings of the National Academy of Sciences of the United States of America 1996, 93:12581-12586.
67. Den Ouden A.L., Kok J.H., Verkerk P.H., Brand R., Verloove-Vanhorick S.P. The relation between neonatal thyroxine levels ad neurodevelopmental outcome at age 5 and 9years in a national cohort of very preterm and/or very low birth weight infants. Paediatric Research 1996, 39:142-145.
68. Denver R.J., Ouellet L., Furling D., Kobayashi A., Fujii-Kuriyama Y., Puymirat J. Basic transcription element-binding protein (BTEB) is a thyroid hormone-regulated gene in the developing central nervous system. Evidence for a role in neurite outgrowth. Journal of Biological Chemistry 1999, 274:23128-23134.
69. Desouza L.A., Ladiwala U., Daniel S.M., Agashe S., Vaidya R.A., Vaidya V.A. Thyroid hormone regulates hippocampal neurogenesis in the adult rat brain. Molecular and Cellular Neuroscience 2005, 29:414-426.
70. Dickson P.W., Aldred A.R., Menting J.G.T., Marley P.D., Sawyer W.H., Schreiber G. Thyroxine transport in choroid plexus. Journal of Biological Chemistry 1987, 262:13907-13915.
71. Dobbing J., Sands J. Timing of neuroblast multiplication in developing human brain. Nature 1970, 226:639-640.
72. Dong H., Wade M., Williams A., Lee A., Douglas G.R., Yauk C. Molecular insight into the effects of hypothyroidism on the developing cerebellum. Biochemical and Biophysical Research Communications 2005, 330:1182-1193.
73. Doyle K.P., Suchland K.L., Ciesielski T.M., Lessov N.S., Grandy D.K., Scanlan T.S., Stenzel-Poore M.P. Novel thyroxine derivatives, thyronamine and 3-iodothyronamine, induce transient hypothermia and marked neuroprotection against stroke injury. Stroke 2007, 38:2569-2576.
74. Dratman M.B., Crutchfield F.L., SchoenhoffM.B. Transport of iodothyronines from bloodstream to brain: Contributions by blood: brain and choroid plexus:cerebrospinal fluid barriers. Brain Research 1991, 554:229-236.
75. Dubois J.-M., Glorieux J., Richer F., Deal C.L., Dussault J.H., van Vliet G. Outcome of severe congenital hypothyrodism: Closing the developmental gap with early high dose levothyroxine treatment. Journal of Clinical Endocrinology and Metabolism 1996, 81:222-227.
76. Dumitrescu A.M., Liao X.H., Best T.B., Brockmann K., RefetoffS. A novel syndrome combining thyroid and neurological abnormalities is associated with mutations in a monocarboxylate transporter gene. American Journal of Human Genetics 2004, 74:168-175.
77. Dumitrescu A.M., Liao X.H., Weiss R.E., Millen K., RefetoffS. Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice. Endocrinology 2006, 147:4036-4043.
78. Eayrs J.T., Taylor S.H. The effect of thyroid deficiency induced by methylthiouracil on the maturation of the central nervous system. Journal of Anatomy 1951, 85:350-358.
79. Enriquez J.A., Fernandez-Silva P., Garrido-Perez N., Lopez-Perez M.J., Perez-Martos A., Montoya J. Direct regulation of mitochondrial RNA synthesis by thyroid hormone. Molecular and Cellular Biology 1999, 19:657-670.
80. Ercan-Fang S., Schwartz H.L., Oppenheimer J.H. Isoform specific 3,5,3′-triiodothyronine receptor binding capacity and messenger ribonucleic acid content in rat adenohypophysis: Effect of thyroidal state and comparison with extrapituitary tissues. Endocrinology 1996, 137:3228-3233.
81. Escámez M.J., Guadaño-Ferraz A., Cuadrado A., Bernal J. Type 3 iodothyronine deiodinase is selectively expressed in areas related to sexual differentiation in the newborn rat brain. Endocrinology 1999, 140:5443-5446.
82. Escobar-Morreale H., Obregón M.J., Escobar del Rey F., Morreale de Escobar G. Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats. Journal of Clinical Investigation 1995, 96:2828-2838.
83. Escobar-Morreale H., Obregón M.J., Escobar del Rey F., Morreale de Escobar G. Tissue-specific patterns of changes in 3,5,3′-triiodo-L-thyronine concentrations in thyroidectomized rats infused with increasing doses of the hormone. Which are the regulatory mechanisms?. Biochimie 1999, 81:453-462.
84. Esfandiari A., Courtin F., Lennon A.M., Gavaret J.M., Pierre M. Induction of type III deiodinase activity in astroglial cells by thyroid hormones. Endocrinology 1992, 131:1682-1688.
85. Esfandiari A., Gagelin C., Gavaret J.M., Pavelka S., Lennon A.M., Pierre M., Courtin F. Induction of type III-deiodinase activity in astroglial cells by retinoids. Glia 1994, 11:255-261.
86. Farsetti A., Desvergne B., Hallenbeck P., Robbins J., Nikodem V. Characterization of myelin basic protein thyroid hormone response element and its function in the context of native and heterologous promoter. Journal of Biological Chemistry 1992, 267:15784-15788.
87. Farwell A.P., DiBenedetto D.J., Leonard J.L. Thyroxine targets different pathways of internalization of type II iodothyronine 5′-deiodinase in astrocytes. Journal of Biological Chemistry 1993, 268:5055-5062.
88. Farwell A.P., Dubord-Tomasetti S.A. Thyroid hormone regulates the expression of laminin in the developing rat cerebellum. Endocrinology 1999, 140:4221-4227.
89. Farwell A.P., Leonard J.L. Dissociation of actin polymerization and enzyme inactivation in the hormonal regulation of type II iodothyronine 5′-deiodinase activity in astrocytes. Endocrinology 1992, 131:721-728.
90. Ferreiro B., Bernal J., Goodyer C.G., Branchard C.L. Estimation of nuclear thyroid hormone receptor saturation in human fetal brain and lung during early gestation. Journal of Clinical Endocrinology and Metabolism 1988, 67:853-856.
91. Ferreiro B., Pastor R., Bernal J. T3 receptor occupancy and T3 levels in plasma and cytosol during rat brain development. Acta Endocrinologica (Copenh) 1990, 123:95-99.
92. Fisher D.A. Thyroid function in premature infants. The hypothyroxinemia of prematurity. Clinical Perinatology 1998, 25:999-1014.
93. Fisher D.A., Polk D.H. Maturation of thyroid hormone actions. Research in Congenital Hypothyroidism 1988, 61-77. Plenum Press, New York. F. Delange, D.A. Fisher, D. Glinoer (Eds.).
94. Flamant F., Baxter J.D., Forrest D., et al. International Union of Pharmacology. LIX. The pharmacology and classification of the nuclear receptor superfamily: Thyroid hormone receptors. Pharmacological Reviews 2006, 58:705-711.
95. Flamant F., Poguet A.L., Plateroti M., et al. Congenital hypothyroid Pax8(-/-) mutant mice can be rescued by inactivating the TRalpha gene. Molecular Endocrinology 2002, 16:24-32.
96. Flamant F., Samarut J. Thyroid hormone receptors: Lessons from knockout and knock-in mutant mice. Trends in Endocrinology and Metabolism 2003, 14:85-90.
97. Fliers E., Alkemade A., Wiersinga W.M., Swaab D.F. Hypothalamic thyroid hormone feedback in health and disease. Progress in Brain Research 2006, 153:189-207.
98. Fliers E., Unmehopa U.A., Alkemade A. Functional neuroanatomy of thyroid hormone feedback in the human hypothalamus and pituitary gland. Molecular and Cellular Endocrinology 2006, 251:1-8.
99. Forrest D., Golarai G., Connor J., Curran T. Genetic analysis of thyroid hormone receptors in development and disease. Recent Progress in Hormone Research 1996, 51:1-22.
100. Friesema E.C., Grueters A., Biebermann H., et al. Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation. Lancet 2004, 364:1435-1437.
101. Friesema E.C., Jansen J., Milici C., Visser T.J. Thyroid hormone transporters. Vitamins and Hormone 2005, 70:137-167.
102. Gaiano N., Nye J.S., Fishell G. Radial glial identity is promoted by Notch1 signaling in the murine forebrain. Neuron 2000, 26:395-404.
103. Galton V.A., Martínez E., Hernández A., St. Germain E.A., Bates J.M., St. Germain D.L. Pregnant rat uterus expresses high levels of the type 3 iodothyronine deiodinase. Journal of Clinical Investigation 1999, 103:979-987.
104. Galton V.A., Wood E.T., St. Germain E.A., et al. Thyroid hormone homeostasis and action in the type 2 deiodinase-deficient rodent brain during development. Endocrinology 2007, 148:3080-3088.
105. Ganguli M., Burmeister L.A., Seaberg E.C., Belle S., DeKosky S.T. Association between dementia and elevated TSH: A community-based study. Biological Psychiatry 1996, 40:714-725.
106. Gao F.B., Apperly J., RaffM. Cell-intrinsic timers and thyroid hormone regulate the probability of cell-cycle withdrawal and differentiation of oligodendrocyte precursor cells. Developmental Biology 1998, 197:54-66.
107. García-Fernández L.F., Rausell E., Urade Y., Hayaishi O., Bernal J., Muñoz A. Hypothyroidism alters the expression of prostaglandin D2 synthase/beta trace in specific areas of the developing rat brain. European Journal of Neuroscience 1997, 9:1566-1573.
108. García-Fernández L.F., Urade Y., Hayaishi O., Bernal J., Muñoz A. Identification of a thyroid hormone response element in the promoter region of the rat lipocalin-type prostaglandin D synthase (beta-trace) gene. Molecular Brain Research 1998, 55:321-330.
109. García-Villalba P., Jiménez-Lara A., Aranda A. Vitamin D interferes with transactivation of the growth hormone gene by thyroid hormone and retinoic acid. Molecular and Cellular Biology 1996, 16:318-327.
110. Gerendasy D.D., Sutcliffe J.G. RC3/neurogranin, a postsynaptic calpacitin for setting the response threshold to calcium influxes. Molecular Neurobiology 1997, 15:131-163.
111. Gharami K., Das S. Thyroid hormone-induced morphological differentiation and maturation of astrocytes are mediated through the beta-adrenergic receptor. Journal of Neurochemistry 2000, 75:1962-1969.
112. Ghorbel M.T., Seugnet I., Hadj-Sahraoui N., Topilko P., Levi G., Demeneix B. Thyroid hormone effects on Krox-24 transcription in the post-natal mouse brain are developmentally regulated but are not correlated with mitosis. Oncogene 1999, 18:917-924.
113. Gilbert M.E., Sui L., Walker M.J., et al. Thyroid hormone insufficiency during brain development reduces parvalbumin immunoreactivity and inhibitory function in the hippocampus. Endocrinology 2007, 148:92-102.
114. Glauser L., Barakat-Walter I. Differential distribution of thyroid hormone receptor isoform in rat dorsal root ganglia and sciatic nerve in vivo and in vitro. Journal of Neuroendocrinology 1997, 9:217-227.
115. Glinoer D. The regulation of thyroid function in pregnancy: Pathways of endocrine adaptation from physiology to pathology. Endocrine Reviews 1997, 18:401-433.
116. Goodman J.H., Gilbert M.E. Modest thyroid hormone insufficiency during development induces a cellular malformation in the corpus callosum: A model of cortical dysplasia. Endocrinology 2007, 148:2593-2597.
117. Gould E., Allan M.D., McEwen B.S. Dendritic spine density of adult hippocampal pyramidal cells is sensitive to thyroid hormone. Brain Research 1990, 525:327-329.
118. Gould E., Butcher L.L. Developing cholinergic basal forebrain neurons are sensitive to thyroid hormone. Journal of Neuroscience 1989, 9:3347-3358.
119. Gravel C., Sasseville R., Hawkes R. Maturation of the corpus callosum of the rat: II. Influence of thyroid hormones on the number and maturation of axons. Journal of Comparative Neurology 1990, 291:147-161.
120. Gruters A. Thyroid hormone transporter defects. Endocrine Development 2007, 10:118-126.
121. Guadaño-Ferraz A., Escámez M.J., Morte B., Vargiu P., Bernal J. Transcriptional induction of RC3/neurogranin by thyroid hormone: Differential neuronal sensitivity is not correlated with thyroid hormone receptor distribution in the brain. Molecular Brain Research 1997, 49:37-44.
122. Guadaño-Ferraz A., Escámez M.J., Rausell E., Bernal J. Expression of type 2 iodothyronine deiodinase in hypothyroid rat brain indicates an important role of thyroid hormone in the development of specific primary sensory systems. Journal of Neuroscience 1999, 19:3430-3439.
123. Guadaño-Ferraz A., Obregón M.J., St. Germain D., Bernal J. The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain. Proceedings of the National Academy of Sciences of the United States of America 1997, 94:10391-10396.
124. Haddow J.E., Palomaki G.E., Allan W.C., et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. New England Journal of Medicine 1999, 341:549-555.
125. Hagen G., Elliot W.J. Transport of thyroid hormones in serum and cerebrospinal fluid. Journal of Clinical Endocrinology and Metabolism 1973, 37:415-422.
126. Hagen G.A., Solberg L.A. Brain and cerebrospinal fluid permeability to intravenous thyroid hormones. Endocrinology 1974, 95:1398-1410.
127. Harvey C.B., Bassett J.H., Maruvada P., Yen P.M., Williams G.R. The rat thyroid hormone receptor (TR) deltabeta3 displays cell-, TR isoform-, and thyroid hormone response element-specific actions. Endocrinology 2007, 148:1764-1773.
128. Hashimoto K., Curty F.H., Borges P.P., et al. An unliganded thyroid hormone receptor causes severe neurological dysfunction. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:3998-4003.
129. Hatten M.E. Riding the glial monorail: A common mechanism for glial-guided neuronal migration in different regions of the developing mammalian brain. Trends in Neuroscience 1990, 13:179-184.
130. Hatten M.E., Heintz N. Mechanisms of neural patterning and specification in the developing cerebellum. Annual Review of Neuroscience 1995, 18:385-408.
131. Hatten M.E., Heintz N. Neurogenesis and migration. Fundamental Neuroscience 1999, 451-517. Academic Press, San Diego, CA. M.J. Zigmond, F.E. Bloom, S.C. Landis, J.L. Roberts, L.R. Squire (Eds.).
132. Hernández A., Gholson J.L., Schneider M.J., St. Germain D.L. Isolation and characterization of the mouse gene for the type 3 iodothyronine deiodinase. Endocrinology 1999, 140:124-130.
133. Hernandez A., Martinez M.E., Fiering S., Galton V.A., St. Germain D. Type 3 deiodinase is critical for the maturation and function of the thyroid axis. Journal of Clinical Investigation 2006, 116:476-484.
134. Hernandez A., Martinez M.E., Liao X.H., van Sande J., RefetoffS., Galton V.A., St. Germain D.L. Type 3 deiodinase deficiency results in functional abnormalities at multiple levels of the thyroid axis. Endocrinology 2007, 148:5680-5687.
135. Heuer H. The importance of thyroid hormone transporters for brain development and function. Best Practice and Research Clinical Endocrinology and Metabolism 2007, 21:265-276.
136. Heuer H., Maier M.K., Iden S., Mittag J., Friesema E.C., Visser T.J., Bauer K. The monocarboxylate transporter 8 linked to human psychomotor retardation is highly expressed in thyroid hormone-sensitive neuron populations. Endocrinology 2005, 146:1701-1706.
137. Hodin R.A., Lazar M.A., Wintman B.I., et al. Identification of a thyroid hormone receptor that is pituitary-specific. Science (Wash.) 1989, 244:76-79.
138. Holden K.R., Zuniga O.F., May M.M., Su H., Molinero M.R., Rogers R.C., Schwartz C.E. X-linked MCT8 gene mutations: Characterization of the pediatric neurologic phenotype. Journal of Child Neurology 2005, 20:852-857.
139. Holt A.B., Renfree M.B., Chek D.B. Comparative aspects of brain growth: A critical evaluation of mammalian species used in brain growth research with emphasis on the Tammar wallaby. Fetal Brain Disorders. Recent Approaches to the Problem of Mental Deficiency 1981, 17-43. Elsevier, Amsterdam. B.S. Hetzel, R.M. Smith (Eds.).
140. Huang H., Marsh-Armstrong N., Brown D.D. Metamorphosis is inhibited in transgenic Xenopus laevis tadpoles that overexpress type III deiodinase. Proceedings of the National Academy of Sciences of the United States of America 1998, 96:962-967.
141. Ibarrola N., Rodriguez-Peña A. Hypothyroidism coordinately and transiently affects myelin proein gene expression in most rat brain regions during postnatal development. Brain Research 1997, 752:285-293.
142. Iglesias T., Caubin J., Stunnenberg H.G., Zaballos A., Bernal J., Muñoz A. Thyroid hormone-dependent transcriptional repression of neural cell adhesion molecule during brain maturation. EMBO Journal 1996, 15:4307-4316.
143. Iglesias T., Caubín J., Zaballos A., Bernal J., Muñoz A. Identification of the mitochondrial NADH dehydrogenase subunit 3 (ND3) as a thyroid hormone regulated gene by whole genome PCR analysis. Biochemical and Biophysical Research Communications 1995, 210:995-1000.
144. Iñiguez M.A., de Lecea L., Guadaño-Ferraz A., Morte B., Gerendasy D., Sutcliffe J.G., Bernal J. Cell-specific effects of thyroid hormone on RC3/neurogranin expression in rat brain. Endocrinology 1996, 137:1032-1041.
145. Ishizuka T., Lazar M.A. The N-CoR/histone deacetylase 3 complex is required for repression by thyroid hormone receptor. Molecular and Cellular Biology 2003, 23:5122-5131.
146. Iskaros J., Pickard M., Evans I., Sinha A., Hardiman P., Ekins R. Thyroid hormone receptor gene expression in first trimester human fetal brain. Journal of Clinical Endocrinology and Metabolism 2000, 85:2620-2623.
147. Itoh Y., Esaki T., Kaneshige M., et al. Brain glucose utilization in mice with a targeted mutation in the thyroid hormone alpha or beta receptor gene. Proceedings of the National Academy of Sciences of the United States of America 2001, 98:9913-9918.
148. Izumo S., Mahdavi V. Thyroid hormone receptor alpha isoforms generated by alternative splicing differentially activate myosin HC gene transcription. Nature (Lond.) 1988, 334:539-542.
149. Joffe R.T., Sokolov S.T.H. Thyroid hormones, the brain, and affective disorders. Critical Reviews in Neurobiology 1994, 8:45-63.
150. Jones I., Srinivas M., Ng L., Forrest D. The thyroid hormone receptor beta gene: Structure and functions in the brain and sensory systems. Thyroid 2003, 13:1057-1068.
151. Kamei Y., Xu L., Heinzel T., et al. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors. Cell 1996, 85:403-414.
152. Kaplan M.M., Shaw E.A. Type II iodothyronine 5′-deiodination by human and rat placenta in vitro. Journal of Clinical Endocrinology and Metabolism 1984, 59:253-257.
153. Kaplan M.M., Yaskoski K.A. Maturational patterns of iodothyronine phenolic and tyrosyl ring deiodinase activities in rat cerebrum, cerebellum, and hypothalamus. Journal of Clinical Investigation 1981, 67:1208-1214.
154. Kendall J.W., Jacobs J.J., Kramer R.M. Studies on the transport of hormones from the cerebrospinal fluid to hypothalamus and pituitary. Brain-Endocrine Interaction. Median Eminence: Structure and Function 1971, 342-349. Karger, Munich. K.M. Knigge, D.E. Scott, A. Weindl (Eds.).
155. Kester M.H., Martinez de Mena R., Obregon M.J., et al. Iodothyronine levels in the human developing brain: Major regulatory roles of iodothyronine deiodinases in different areas. Journal of Clinical Endocrinology and Metabolism 2004, 89:3117-3128.
156. Kirkegaard C., Faber J. Free thyroxine and 3,3′,5′-triiodothyronine levels in cerebrospinal fluid in patients with endogenous depression. Acta Endocrinologica (Copenh.) 1991, 124:166-172.
157. Koenig R.J., Lazar M.A., Hodin R.A., Brent G.A., Larsen P.R., Chin W.W., Moore D.D. Inhibition of thyroid hormone action by a non-hormone binding c-erba protein generated by alternative mRNA splicing. Nature 1989, 337:659-661.
158. Koibuchi N., Chin W.W. RORα gene expression in the perinatal rat cerebellum: Ontogeny and thyroid hormone regulation. Endocrinology 1998, 139:2335-2341.
159. Koibuchi N., Iwasaki T. Regulation of brain development by thyroid hormone and its modulation by environmental chemicals. Endocrine Journal 2006, 53:295-303.
160. Kolodny J.M., Leonard J.L., Larsen P.R., Silva J.E. Studies of nuclear 3,5,3′-triiodothyronine binding in primary cultures of rat brain. Endocrinology 1985, 117:1848-1857.
161. Kooistra L., Crawford S., van Baar A.L., Brouwers E.P., Pop V.J. Neonatal effects of maternal hypothyroxinemia during early pregnancy. Pediatrics 2006, 117:161-167.
162. Koopdonk-Kool J.M., de Vijlder J.J., Veenboer G.J.M., et al. Type II and type III deiodinase activity in human placenta as a function of gestational age. Journal of Clinical Endocrinology and Metabolism 1996, 81:2154-2158.
163. Koritschoner N.P., Alvarez-Dolado M., Kurz S.M., et al. Thyroid hormone regulates the obesity gene tub. EMBO Reports 2001, 2:499-504.
164. La Gamma E.F., van Wassenaer A.G., Golombek S.G., et al. Neonatal thyroxine supplementation for transient hypothyroxinemia of prematurity: Beneficial or detrimental?. Treaties of Endocrinology 2006, 5:335-346.
165. Langlois M.F., Zanger K., Monden T., Safer J.D., Hollenberg A.N., Wondisford F.E. A unique role of the beta-2 thyroid hormone receptor isoform in negative regulation by thyroid hormone. Mapping of a novel amino-terminal domain important for ligand-independent activation. Journal of Biological Chemistry 1997, 272:24927-24933.
166. Larsen P.R., Berry M.J. Nutritional and hormonal regulation of thyroid hormone deiodinases. Annual Review of Nutrition 1995, 15:323-352.
167. Larsen P.R., Silva J.R., Kaplan M.M. Relationships between circulating and intracellular thyroid hormones. Physiological and clinical implications. Endocrine Reviews 1981, 2:87-102.
168. Laterra J., Goldstein G.W. Ventricular organization of cerebrospinal fluid: Blood-brain barrier, brain edema and hydrocephalus. Principles of Neural Science 2000, 1288-1301. McGraw-Hill, New York. E.R. Kandel, J.H. Schwartz, T.M. Jessell (Eds.).
169. Laureno R. Neurologic manifestations of thyroid disease. Endocrinologist 1996, 6:467-473.
170. Lauterman J., ten Cate W.-J.F. Postnatal expression of the rat alpha-thyroid hormone receptor in the rat cochlea. Hearing Research 1997, 107:23-28.
171. Lazar M.A., Hodin R.A., Chin W.W. Human carboxyl-terminal variant of a-type c-erbA inhibits trans-activation by thyroid hormone receptors without binding thyroid hormone. Proceedings of the National Academy of Sciences of the United States of America 1989, 86:7771-7774.
172. Lazar M.A., Hodin R.A., Darling D.S., Chin W.W. A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit. Molecular and Cellular Biology 1989, 9:1128-1136.
173. Lechan R.M., Fekete C. Infundibular tanycytes as modulators of neuroendocrine function: Hypothetical role in the regulation of the thyroid and gonadal axis. Acta Biomedica 2007, 78(supplement 1):84-98.
174. Lechan R.M., Qi Y., Berrodin T.J., et al. Immunocytochemical delineation of thyroid hormone receptor b2-like immunoreactivity in the rat central nervous system. Endocrinology 1993, 132:2461-2469.
175. Legrand J. Analyse de l'action morphogénétic des hormones thyroïdiennes sur le cervelet du jeune rat. Archives de Anatomie Microscopique et de Morphologie Expérimentale 1967, 56:205-244.
176. Legrand J. Effects of thyroid hormones on central nervous system. Neurobehavioral Teratology 1984, 331-363. Elsevier, Amsterdam. J. Yanai (Ed.).
177. Lemkine G.F., Raj A., Alfama G., et al. Adult neural stem cell cycling in vivo requires thyroid hormone and its alpha receptor. FASEB Journal 2005, 19:863-865.
178. Leonard J.L., Farwell A.P., Yen P.M., Chin W.W., Stula M. Differential expression of thyroid hormone receptor isoforms in neurons and astroglial cells. Endocrinology 1994, 135:548-555.
179. Leonard J.L., Kaplan M.M., Visser T.J., Silva J.E., Larsen P.R. Cerebral cortex responds rapidly to thyroid hormones. Science 1981, 214:571-573.
180. Leonard J.L., Siegristkaiser C.A., Zuckerman C.J. Regulation of type-II iodothyronine 5′-deiodinase by thyroid hormone-inhibition of actin polymerization blocks enzyme inactivation in cAMP-stimulated glial cells. Journal of Biological Chemistry 1990, 265:940-946.
181. Levinton A., Paneth N., Reuss M.L., et al. Hypothyroxinemia of prematurity and the risk of cerebral white matter damage. Journal of Pediatrics 1999, 134:706-711.
182. Lima F.R., Gervais A., Colin C., Izembart M., Neto V.M., Mallat M. Regulation of microglial development: A novel role for thyroid hormone. Journal of Neuroscience 2001, 21:2028-2038.
183. Lima F.R., Goncalves N., Gomes F.C., de Freitas M.S., Moura Neto V. Thyroid hormone action on astroglial cells from distinct brain regions during development. International Journal of Developmental Neuroscience 1998, 16:19-27.
184. Lindholm D., Castren E., Tsoulfas P., et al. Neurotrophin-3 induced by tri-iodothyronine in cerebellar granullar cells promotes Purkinje cell differentiation. Journal of Cell Biology 1993, 122:443-450.
185. Lorenzo P.I., Menard C., Miller F.D., Bernal J. Thyroid hormone-dependent regulation of Ta1 a-tubulin during brain development. Molecular and Cellular Neuroscience 2002, 19:333-343.
186. Luo M., Faure R., Dussault J.H. Ontogenesis of nuclear T3 receptors in primary cultured astrocytes and neurons. Brain Research 1986, 381:275-280.
187. Luo Y., Denker B.M. Interaction of heterotrimeric G protein Galphao with Purkinje cell protein-2. Evidence for a novel nucleotide exchange factor. Journal of Biological Chemistry 1999, 274:10685-10688.
188. Maberly G.F. Iodine deficiency disorders: Contemporary scientific issues. Journal of Nutrition 1994, 124:1473S-1478S.
189. Madeira M.D., Cadete-Leite A., Andrade J.P., Paula-Barbosa M.M. Effects of hypothyroidism upon the granular layer of the dentate gyrus in male and female adult rats: A morphometric study. Journal of Comparative Neurology 1991, 314:171-186.
190. Madeira M.D., Paula-Barbosa M., Cadete-Leite A., Tavares M.A. Unbiased estimate of cerebellar granule cell numbers in hypothyroid and in sex-age-matched control rats. Journal fur Hirnforschung 1988, 29:587-594.
191. Madeira M.D., Paula-Barbosa M., Cadete-Leite A., Tavares M.A. Unbiased estimate of hippocampal granule cell numbers in hypothyroid and in sex-age-matched control rats. Journal fur Hirnforschung 1988, 29:643-650.
192. Madeira M.D., Pereira A., Cadete-Leite A., Paula-Barbosa M.M. Estimates of volumes and pyramidal cell numbers in the prelimbic subarea of the prefrontal cortex in experimental hypothyroid rats. Journal of Anatomy 1990, 171:41-56.
193. Mallol J., Obregón M.J., Morreale de Escobar G. Analytical artifacts in radioimmunoassay of L-thyroxine in human milk. Clinical Chemistry 1982, 28:1277-1282.
194. Malone M.J., Rosman N.P., Szoke M., Davis D. Myelination of brain in experimental hypothyroidism. An electron-microscopic and biochemical study of purified myelin isolates. Journal of Neurological Science 1975, 26:1-11.
195. Man E.B., Serunian S.A. Thyroid function in human pregnancy. Development or retardation of 7-year-old progeny of hypothyroxinemic women. American Journal of Obstetics and Gynecology 1976, 125:949-957.
196. Manzano J., Bernal J., Morte B. Influence of thyroid hormones on maturation of rat cerebellar astrocytes. International Journal of Developmental Neuroscience 2007, 25:171-179.
197. Manzano J., Cuadrado M., Morte B., Bernal J. Influence of thyroid hormone and thyroid hormone receptors in the generation of cerebellar GABAergic interneurons from precursor cells. Endocrinology 2007, 148:5746-5751.
198. Manzano J., Morte B., Scanlan T.S., Bernal J. Differential effects of triiodothyronine and the thyroid hormone receptor beta-specific agonist GC-1 on thyroid hormone target genes in the brain. Endocrinology 2003, 144:5480-5487.
199. Marin-Padilla M. Dual origin of the mammalian neocortex and evolution of the cortical plate. Anatomy and Embryology 1978, 152:109-126.
200. Marin-Padilla M. Structural organization of the human cerebral cortex prior to the appearance of the cortical plate. Anatomy and Embryology 1983, 168:21-40.
201. Marin-Padilla M. Three-dimensional structural organization of layer I of the human cerebral cortex: A Golgi study. Journal of Comparative Neurology 1990, 299:89-105.
202. Marsh-Armstrong N., Huang H., Remo B.F., Liu T.T., Brown D.D. Asymmetric growth and development of the Xenopus laevis retina during metamorphosis is controlled by type III deiodinase. Neuron 1999, 24:871-878.
203. Martel J., Cayrou C., Puymirat J. Identification of new thyroid hormone-regulated genes in rat brain neuronal cultures. NeuroReport 2002, 13:1849-1851.
204. Martinez de Arrieta C., Morte B., Coloma A., Bernal J. The human RC3 gene homolog, NRGN contains a thyroid hormone-responsive element located in the first intron. Endocrinology 1999, 140:335-343.
205. Martinez-Galan J.R., Pedraza P., Santacana M., Escobar del Ray F., Morreale de Escobar G., Ruiz-Marcos A. Early effects of iodine deficiency on radial glial cells of the hippocampus of the rat fetus. A model of neurological cretinism. Journal of Clinical Investigation 1997, 99:2701-2709.
206. McCarrison R. Endemic cretinism. The Thyroid Gland in Health and Disease 1917, 124-147. Bailliére, Tindall and Cox, London.
207. Mellström B., Naranjo J.R., Santos A., González A.M., Bernal J. Independent expression of the α and β c-erbA genes in developing rat brain. Molecular Endocrinology 1991, 5:1339-1350.
208. Mellström B., Pipaon C., Naranjo J.R., Perez-Castillo A., Santos A. Differential effect of thyroid hormone on NGFI-A gene expression in developing rat brain. Endocrinology 1994, 135:583-588.
209. Meyer G. Genetic control of neuronal migrations in human cortical development. Advances in Anatomy, Embryology and Cell Biology 2007, 189:1-111. 1 p preceding 1,.
210. Miller L.D., McPhie P., Suzuki H., Kato Y., Liu E.T., Cheng S.Y. Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance. Genome Biology 2004, 5:R31.
211. Miyajima N., Horiuchi R., Shibuya Y., Fukushige S., Matsubara K., Toyoshima K., Yamamoto T. Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus. Cell 1989, 57:31-39.
212. Miyakawa T., Yared E., Pak J.H., Huang F.L., Huang K.P., Crawley J.N. Neurogranin null mutant mice display performance deficits on spatial learning tasks with anxiety related components. Hippocampus 2001, 11:763-775.
213. Montero-Pedrazuela A., Venero C., Lavado-Autric R., et al. Modulation of adult hippocampal neurogenesis by thyroid hormones: Implications in depressive-like behavior. Molecular Psychiatry 2006, 11:361-371.
214. Morreale de Escobar G., Ares S. The hypothyroxinemia of prematurity. Journal of Clinical Endocrinology and Metabolism 1998, 83:713-715.
215. Morreale de Escobar G., Calvo R., Obregón M.J., Escobar del Rey F. Contribution of maternal thyroxine to fetal thyroxine pools in normal rats near term. Endocrinology 1990, 126:2765-2767.
216. Morreale de Escobar G., Escobar del Rey F. Letter to the editor. New England Journal of Medicine 1999, 26:2016-2017.
217. Morreale de Escobar G., Escobar del Rey F., Ruiz-Marcos A. Thyroid hormone and the developing brain. Congenital Hypothyroidism 1983, 85-126. Marcel Decker, New York. J.H. Dussault, P. Walker (Eds.).
218. Morreale de Escobar G., Obregón M.J., Escobar del Rey F. Fetal and maternal thyroid hormones. Hormone Research 1987, 26:12-27.
219. Morreale de Escobar G., Obregón M.J., Escobar del Rey F. Is neuropsychological development related to maternal hypothyroidism, or to maternal hypothyroxinemia?. Journal of Clinical Endocrinology and Metabolism 2000, 85:3975-3987.
220. Morreale de Escobar G., Obregon M.J., Escobar del Rey F. Role of thyroid hormone during early brain development. European Journal of Endocrinology 2004, 151(supplement 3):U25-U37.
221. Morreale de Escobar G., Pastor R., Obregón M.J., Escobar del Rey F. Effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues. Endocrinology 1985, 117:1890-1901.
222. Morte B., Manzano J., Scanlan T., Vennstrom B., Bernal J. Deletion of the thyroid hormone receptor alpha 1 prevents the structural alterations of the cerebellum induced by hypothyroidism. Proceedings of the National Academy of Sciences of the United States of America 2002, 99:3985-3989.
223. Mortimer R.H., Galligan J.P., Cannell G.R., Addison R.S., Roberts M.S. Maternal to fetal thyroxine transmission in the human term placenta is limited by inner ring deiodination. Journal of Clinical Endocrinology and Metabolism 1996, 81:2247-2249.
224. Nagy L., Schwabe J.W. Mechanism of the nuclear receptor molecular switch. Trends in Biochemical Sciences 2004, 29:317-324.
225. Namba N., Etani Y., Kitaoka T., et al. Clinical phenotype and endocrinological investigations in a patient with a mutation in the MCT8 thyroid hormone transporter. European Journal of Pediatrics 2008, 167:785-791.
226. Nataf B., Sfez M. Debut du fonctionnement de la thyroide foetale du rat. CR Société de Biologie 1961, 156:1235-1238.
227. Ng L., Goodyear R.J., Woods C.A., et al. Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase. Proceedings of the National Academy of Sciences of the United States of America 2004, 101:3474-3479.
228. Nicholson J.L., Altman J. The effects of early hypo- and hyperthyroidism on the development of the rat cerebellar cortex. I. Cell proliferation and differentiation. Brain Research 1972, 44:13-23.
229. Noguchi T., Sugisaki T. Hypomyelination in the cerebrum of the congenitally hypothyroid mouse (hyt). Journal of Neurochemistry 1984, 42:891-893.
230. Notterpek L.M., Rome L.H. Functional evidence for the role of axolemma in CNS myelination. Neuron 1994, 13:473-485.
231. Nygard M., Wahlstrom G.M., Gustafsson M.V., Tokumoto Y.M., Bondesson M. Hormone-dependent repression of the E2F-1 gene by thyroid hormone receptors. Molecular Endocrinology 2003, 17:79-92.
232. Oberste-Berghaus C., Zanger K., Hashimoto K., Cohen R.N., Hollenberg A.N., Wondisford F.E. Thyroid hormone-independent interaction between the thyroid hormone receptor beta2 amino terminus and coactivators. Journal of Biological Chemistry 2000, 275:1787-1792.
233. Obregón M.J., Mallol J., Pastor R., Morreale de Escobar G., Escobar del Rey G. L-thyroxine and 3,3′,5-triiodo-L-thyronine in rat embryos before onset of fetal thyroid function. Endocrinology 1984, 114:305-307.
234. Obregón M.J., Ruiz de Oña C., Calvo R., Escobar del Rey F., Morreale de Escobar G. Outer ring iodothyronine deiodinases and thyroid hormone economy: Responses to iodine deficiency in the rat fetus and neonate. Endocrinology 1991, 129:2663-2673.
235. Oetting A., Yen P.M. New insights into thyroid hormone action. Best Practice and Research Clinical Endocrinology and Metabolism 2007, 21:193-208.
236. Palha J.A., Episkopou V., Maeda S., Shimada K., Gottesman M.E. Thyroid hormone metabolism in a transthyretin-null mouse strain. Journal of Biological Chemistry 1994, 269:33135-33139.
237. Palha J.A., Hays M.T., Morreale de Escobar G., Episkopou V., Gottesman M.E., Saraiva M.J. Transthyretin is not essential for thyroxine to reach the brain and other tissues in transthyretin-null mice. American Journal of Physiology 1997, 272:E485-E493.
238. Patel A.J., Rabié A., Lewis P.D., Balázs R. Effects of thyroid deficiency on postnatal cell formation in the cerebellum. A biochemical investigation. Brain Research 1976, 104:33-48.
239. Pérez-Castillo A., Bernal J., Ferreiro B., Pans T. The early ontogenesis of thyroid hormone receptor in the rat fetus. Endocrinology 1985, 117:2457-2461.
240. Pérez-Juste G., Aranda A. The cyclin-dependent kinase inhibitor p27(Kip1) is involved in thyroid hormone-mediated neuronal differentiation. Journal of Biological Chemistry 1999, 19:5026-5031.
241. Pharoah P.O., Buttfield I.H., Hetzel B.S. Neurological damage to the fetus resulting from severe iodine deficiency during pregnancy. Lancet 1971, 1:308-310.
242. Pharoah P.O., Connolly K.J. Effects of maternal iodine supplementation during pregnancy. Archives of Disease in Childhood 1991, 66:145-147.
243. Pietsch C.A., Scanlan T.S., Anderson R.J. Thyronamines are substrates for human liver sulfotransferases. Endocrinology 2007, 148:1921-1927.
244. Poguet A.L., Legrand C., Feng X., Yen P.M., Meltzer P., Samarut J., Flamant F. Microarray analysis of knockout mice identifies cyclin D2 as a possible mediator for the action of thyroid hormone during the postnatal development of the cerebellum. Developmental Biology 2003, 254:188-199.
245. Pop V.J., Kuijpens J.L., van Baar A.L., et al. Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clinical Endocrinology 1999, 50:149-155.
246. Porterfield S.P., Hendrich C.E. Tissue iodothyronine levels in fetuses of control and hypothyroid rats at 13 and 16days gestation. Endocrinology 1992, 131:195-200.
247. Porterfield S.P., Hendrich C.E. The role of thyroid hormones in prenatal and neonatal neurological development - current perspectives. Endocrine Reviews 1993, 14:94-106.
248. Qi J.S., Yuan Y., Desai-Yajnik V., Samuels H.H. Regulation of the mdm2 oncogene by thyroid hormone receptor. Molecular and Cellular Biology 1999, 19:864-872.
249. Quignodon L., Grijota-Martinez C., Compe E., et al. A combined approach identifies a limited number of new thyroid hormone target genes in post-natal mouse cerebellum. Journal of Molecular Endocrinology 2007, 39:17-28.
250. Quignodon L., Vincent S., Winter H., Samarut J., Flamant F. A point mutation in the activation function 2 domain of thyroid hormone receptor alpha1 expressed after CRE-mediated recombination partially recapitulates hypothyroidism. Molecular Endocrinology 2007, 21:2350-2360.
251. Rakic P. Mode of cell migration to the superficial layers of fetal monkey neocortex. Journal of Comparative Neurology 1972, 145:61-83.
252. RefetoffS., Dumitrescu A.M. Syndromes of reduced sensitivity to thyroid hormone: Genetic defects in hormone receptors, cell transporters and deiodination. Best Practice and Research Clinical Endocrinology and Metabolism 2007, 21:277-305.
253. Reuss M.L., Levinton A., Paneth N., Susser M. Thyroxine values from newborn screening of 919 infants born before 29 week's gestation. American Journal of Public Health 1997, 87:1693-1697.
254. Reuss M.L., Paneth N., Pinto-Martin J.A., Lorenz J.M., Susser M. The relation of transient hypothyroxinemia in preterm infants to neurologic development at two years of age. New England Journal of Medicine 1996, 334:821-827.
255. Ribeiro R.C.J., Appriletti J.W., Wagner R.L., et al. Mechanisms of thyroid hormone action: Insights from X-ray crystallographic and functional studies. Recent Progress in Hormone Research 1998, 53:351-394.
256. Riskind P.N., Kolodny J.M., Larsen P.R. The regional distribution of type II 5′-monodeiodinase in euthyroid and hypothyroid rats. Brain Research 1987, 420:194-198.
257. Roberts M.R., Srinivas M., Forrest D., Morreale de Escobar G., Reh T.A. Making the gradient: Thyroid hormone regulates cone opsin expression in the developing mouse retina. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:6218-6223.
258. Rodriguez E.M., Gonzalez C.B., Delannoy L. Cellular organization of the lateral and postinfundibular regions of the median eminence in the rat. Cell Tissue Research 1979, 201:377-408.
259. Rodriguez-Pena A., Ibarrola N., Iniguez M.A., Munoz A., Bernal J. Neonatal hypothyroidism affects the timely expression of myelin-associated glycoprotein in the rat brain. Journal of Clinical Investigation 1993, 91:812-818.
260. Rosenfeld M.G., Lunyak V.V., Glass C.K. Sensors and signals: A coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes and Development 2006, 20:1405-1428.
261. Ruiz-Marcos A., Cartagena P., García A., Escobar del Rey F., Morreale de Escobar G. Rapid effects of adult-onset hypothyroidism on dendritic spines of pyramidal cells of the rat cerebral cortex. Experimental Brain Research 1988, 73:583-588.
262. Ruiz-Marcos A., Sanchez-Toscano F., Obregón M.J., Escobar del Rey F., Morreale de Escobar G. Reversible morphological alterations of cortical neurons in juvenile and adult hypothyroidism in the rat. Brain Research 1980, 185:91-102.
263. Ruiz-Marcos A., Sanchez-Toscano F., Obregón M.J., Escobar del Rey F., Morreale de Escobar G. Thyroxine treatment and recovery of hypothyroidism-induced pyramidal cell damage. Brain Research 1982, 239:559-574.
264. Ruiz de Oña C., Obregón M.J., Escobar del Rey F., Morreale de Escobar G. Developmental changes in rat brain 5′-deiodinase and thyroid hormones during the fetal period: The effects of fetal hypothyroidism and maternal thyroid hormones. Pediatric Research 1988, 24:588-594.
265. Salto C., Kindblom J.M., Johansson C., et al. Ablation of TRalpha2 and a concomitant overexpression of alpha1 yields a mixed hypo- and hyperthyroid phenotype in mice. Molecular Endocrinology 2001, 15:2115-2128.
266. Salvatore D., Low S.C., Berry M., et al. Type 3 iodothyronine deiodinase: Cloning in vitro expression, and functional analysis of the placental selenoenzyme. Journal of Clinical Investigation 1995, 96:2421-2430.
267. Santagata S., Boggon T.J., Baird C.L., et al. G-protein signaling through tubby proteins. Science 2001, 292:2041-2050.
268. Santini F., Chiovato L., Ghirri P., et al. Serum iodothyronines in the human fetus and the newborn: Evidence for an important role of placenta in fetal thyroid hormone homeostasis. Journal of Clinical Endocrinology and Metabolism 1999, 84:493-498.
269. Sap J., Muñoz A., Schmitt J., Stunnenberg H., Vennström B. Repression of transcription mediated at a thyroid hormone response element by the v-erbA oncogene product. Nature 1989, 340:242-244.
270. Sato Y., Buchholz D.R., Paul B.D., Shi Y.B. A role of unliganded thyroid hormone receptor in postembryonic development in Xenopus laevis. Mechanisms of Development 2007, 124:476-488.
271. Scanlan T.S., Suchland K.L., Hart M.E., et al. 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nature Medicine 2004, 10:638-642.
272. Schoonover C.M., Seibel M.M., Jolson D.M., et al. Thyroid hormone regulates oligodendrocyte accumulation in developing rat brain white matter tracts. Endocrinology 2004, 145:5013-5020.
273. Schreiber G., Southwell B.R., Richardson S.J. Hormone delivery systems to the brain-transthyretin. Experimental and Clinical Endocrinology and Diabetes 1995, 103:75-80.
274. Schröder-van der Elst J.P., van der Heide D., Morreale de Escobar G., Obregón M.J. Iodothyronine deiodinase activities in fetal rat tissues at several levels of iodine deficiency: A role for the skin in 3,5,3′-triiodothyronine economy?. Endocrinology 1998, 139:2229-2234.
275. Schwartz C.E., May M.M., Carpenter N.J., et al. Allan-Herndon-Dudley syndrome and the monocarboxylate transporter 8 (MCT8) gene. American Journal of Human Genetics 2005, 77:41-53.
276. Schwartz H.L., Lazar M.A., Oppenheimer J.H. Widespread distribution of immunoreactive thyroid hormone b2 receptor (TRb2) in the nuclei of extrapituitary rat tissues. Journal of Biological Chemistry 1994, 269:24777-24782.
277. Schwartz H.L., Oppenheimer J.H. Ontogenesis of 3,5,3′-triiodothyronine receptors in neonatal rat brain, dissociation between receptor concentration and stimulation of oxygen consumption by 3,5,3′-triiodothyronine. Endocrinology 1978, 103:943-948.
278. Silva J.E., Rudas P. Effects of congenital hypothyroidism on microtubule-associated protein-2 expression in the cerebellum of the rat. Endocrinology 1990, 126:1276-1282.
279. Sjogren M., Alkemade A., Mittag J., et al. Hypermetabolism in mice caused by the central action of an unliganded thyroid hormone receptor alpha1. EMBO Journal 2007, 26:4535-4545.
280. St. Germain D.L. Thyroid hormone deiodination. Current Opinion in Endocrinology and Diabetes 1995, 2:421-428.
281. St. Germain D.L., Galton V.A. The deiodinase family of selenoproteins. Thyroid 1997, 7:655-668.
282. St. Germain D.L., Schwartzman R., Croteau W., Kanamori A., Wang Z., Brown D.D., Galton V.A. A thyroid hormone regulated gene in Xenopus laevis encodes a type III iodothyronine 5-deiodinase. Proceedings of the National Academy of Sciences of the United States of America 1994, 91:7767-7771.
283. Stachelek S.J., Kowalik T.F., Farwell A.P., Leonard J.L. Myosin V plays an essential role in the thyroid hormone-dependent endocytosis of type II iodothyronine 5′-deiodinase. Journal of Biological Chemistry 2000, 275:31701-31707.
284. Steinsapir J., Bianco A.C., Buettner C., Harney J., Larsen P.R. Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center. Endocrinology 2000, 141:1127-1135.
285. Steinsapir J., Harney J., Larsen P.R. Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes. Journal of Clinical Investigation 1998, 102:1895-1899.
286. Storey N.M., Gentile S.U., Ilah H., Russo A., Muessel M., Erxleben C., Armstrong D.L. Rapid signaling at the plasma membrane by a nuclear receptor for thyroid hormone. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:5197-5201.
287. Strait K.A., Schwartz H.L., Perezcastillo A., Oppenheimer J.H. Relationship of C-erbA messenger RNA content to tissue triiodothyronine nuclear binding capacity and function in developing and adult rats. Journal of Biological Chemistry 1990, 265:10514-10521.
288. Sutcliffe J.G. The genes for myelin revisited. Trends in Genetics 1988, 4:211-213.
289. Thilly C.H., Bourdoux P.P., Due D.T., DeLong G.R., Vanderpas J.B., Ermans A.M. Myxedematous cretinism: An indicator of the most severe goiter endemias. Frontiers in Thyroidology 1986, 1081-1084. Plenum Press, New York. E. Medeiros-Neto, E. Gaitan (Eds.).
290. Thompson C.C. Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog. Journal of Neuroscience 1996, 16:7832-7840.
291. Thompson C.C., Bottcher M.C. The product of a thyroid hormone-responsive gene interacts with thyroid hormone receptors. Proceedings of the National Academy of Sciences of the United States of America 1997, 94:8527-8532.
292. Thompson P.J., Burman K.D., Wright F.D., Potter M.W., Wartofsky L. Iodothyronine levels in human cerebrospinal fluid. Journal of Clinical Endocrinology and Metabolism 1982, 54:653-655.
293. Thorpe-Beeston J.G., Nicolaides K.H., Felton C.V., Butler J., McGregor A.M. Maturation of the secretion of thyroid hormone and thyroid stimulating hormone in the fetus. New England Journal of Medicine 1991, 324:532-536.
294. Tinnikov A., Nordstrom K., Thoren P., et al. Retardation of post-natal development caused by a negatively acting thyroid hormone receptor alpha1. EMBO Journal 2002, 21:5079-5087.
295. Tiosano D., Pannain S., Vassart G., et al. The hypothyroidism in an inbred kindred with congenital thyroid hormone and glucocorticoid deficiency is due to a mutation producing a truncated thyrotropin receptor. Thyroid 1999, 9:887-894.
296. Trajkovic M., Visser T.J., Mittag J., et al. Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8. Journal of Clinical Investigation 2007, 117:627-635.
297. Trueba S.S., Auge J., Mattei G., et al. PAX8, TITF1, and FOXE1 gene expression patterns during human development: New insights into human thyroid development and thyroid dysgenesis-associated malformations. Journal of Clinical Endocrinology and Metabolism 2005, 90:455-462.
298. Tsacopoulos M., Magistretti P.J. Metabolic coupling between glia and neurons. Journal of Neuroscience 1996, 16:877-885.
299. Tu H.M., Kim S.W., Salvatore D., Bartha T., Legradi G., Larsen P.R., Lechan R.M. Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone. Endocrinology 1997, 138:3359-3368.
300. Tu H.M., Legradi G., Bartha T., Salvatore D., Lechan R.M., Larsen P.R. Regional expression of the type 3 iodothyronine deiodinase messenger ribonucleic acid in the rat central nervous system and its regulation by thyroid hormone. Endocrinology 1999, 140:784-790.
301. Utiger R.D. Maternal hypothyroidism and fetal development. New England Journal of Medicine 1999, 341:601-602.
302. van den Hove M.F., Beckers C., Devlieger H., de Zegher F., de Nayer P. Hormone synthesis and storage in the thyroid of human preterm and term newborns: Effect of thyroxine treatments. Biochimie 1999, 81:563-570.
303. van Doorn J., Roelfsema F., van der Heide D. Contribution from local conversion of thyroxine to 3,5,3′-triiodothyronine to intracellular 3,5,3′-triiodothyronine in several organs in hypothyroid rats at isotope equilibrium. Acta Endocrinologica (Copenh.) 1982, 101:386-396.
304. van Wassenaer A.G., Kok J.H., de Vijlder J.J., et al. Effects of thyroxine supplementation on neurologic development in infants born at less than 30 weeks' gestation. New England Journal of Medicine 1997, 336:21-26.
305. van Wassenaer A.G., Kok J.H., Dekker F.W., Endert E., de Vijlder J.J. Thyroxine administration to infants of less than 30 weeks gestational age decreases plasma tri-iodothyronine concentrations. European Journal of Endocrinology 1998, 139:508-515.
306. Vargiu P., de Abajo R., Garcia-Ranea J.A., Valencia A., Santisteban P., Crespo P., Bernal J. The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors. Oncogene 2004, 23:559-568.
307. Vargiu P., Morte B., Manzano J., Perez J., de Abajo R., GregorSutcliffe J., Bernal J. Thyroid hormone regulation of rhes, a novel Ras homolog gene expressed in the striatum. Brain Research - Molecular Brain Research 2001, 94:1-8.
308. Vega-Núñez E., Alvarez A.M., Menendez-Hurtado A., Santos A., Pérez-Castillo A. Neuronal mitochondrial morphology and transmembrane potential are severely altered by hypothyroidism during rat brain development. Endocrinology 1997, 138:3771-3778.
309. Vega-Núñez E., Menéndez-Hurtado A., Garesse R., Santos A., Perez-Castillo A. Thyroid hormone-regulated brain mitochondrial genes revealed by differential cDNA cloning. Journal of Clinical Investigation 1995, 96:893-899.
310. Venero C., Guadano-Ferraz A., Herrero A.I., et al. Anxiety, memory impairment, and locomotor dysfunction caused by a mutant thyroid hormone receptor alpha1 can be ameliorated by T3 treatment. Genes and Development 2005, 19:2152-2163.
311. Vermiglio F., LoPresti V.P., Moleti M., et al. Attention deficit and hyperactivity disorders in the offspring of mothers exposed to mild-moderate iodine deficiency: A possible novel iodine deficiency disorder in developed countries. Journal of Clinical Endocrinology and Metabolism 2004, 89:6054-6060.
312. Vulsma T., Gons M.H., de Vijlder J. Maternal-fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid dysgenesis. New England Journal of Medicine 1989, 321:13-16.
313. White D.M., Takeda T., DeGroot L.J., Stefansson K., Arnason B.G. Beta-trace gene expression is regulated by a core promoter and a distal thyroid hormone response element. Journal of Biological Chemistry 1997, 272:14387-14393.
314. Williams F.L., Simpson J., Delahunty C., et al. Developmental trends in cord and postpartum serum thyroid hormones in preterm infants. Journal of Clinical Endocrinology and Metabolism 2004, 89:5314-5320.
315. Winter H., Braig C., Zimmermann U., Engel J., Rohbock K., Knipper M. Thyroid hormone receptor alpha1 is a critical regulator for the expression of ion channels during final differentiation of outer hair cells. Histochemisry and Cell Biology 2007, 128:65-75.
316. Wood W.M., Sarapura V.D., Dowding J.M., Woodmansee W.W., Haakinson D.J., Gordon D.F., Ridgway E.C. Early gene expression changes preceding thyroid hormone-induced involution of a thyrotrope tumor. Endocrinology 2002, 143:347-359.
317. Woods R.J., Sinha A.K., Ekins R.P. Uptake and metabolism of thyroid hormones by the rat foetus early in pregnancy. Clinical Science 1984, 67:359-363.
318. Wrutniak-Cabello C., Casas F., Cabello G. Thyroid hormone action in mitochondria. Journal of Molecular Endocrinology 2001, 26:67-77.
319. Yang Z., Hong S.H., Privalsky M.L. Transcriptional anti-repression. Thyroid hormone receptor beta-2 recruits SMRT corepressor but interferes with subsequent assembly of a functional corepressor complex. Journal of Biological Chemistry 1999, 274:37131-37138.
320. Yasuda T., Ohnishi H., Wataki K., Minagawa M., Minamitami K., Niimi H. Outcome of a baby born from a mother with acquired juvenile
321. Yen P.M. Physiological and molecular basis of thyroid hormone action. Physiological Review 2001, 81:1097-1142.
322. Yusta B., Besnard F., Ortiz-Caro J., Pascual A., Aranda A., Sarlieve L. Evidence for the presence of nuclear 3,5,3′-triiodothyronine receptors in secondary cultures of pure rat oligodendrocytes. Endocrinology 1988, 122:2278-2284.
323. Zerlin M., Levison S.W., Goldman J.E. Early patterns of migration, morphogenesis, and intermediate filament expression of subventricular zone cells in the postnatal rat forebrain. Journal of Neuroscience 1995, 15:7238-7249.
324. Zimmermann M.B. The adverse effects of mild-to-moderate iodine deficiency during pregnancy and childhood: A review. Thyroid 2007, 17:829-835.
325. Zou L., Hagen S.C., Strait K.A., Oppenheimer J.H. Identification of thyroid hormone response elements in rodent Pcp-2, a developmentally regulated gene of cerebellar Purkinje cells. Journal Biological Chemistry 1994, 269:13346-13352.