The human RC3 gene homolog, NRGN contains a thyroid hormone-responsive element located in the first intron

Endocrinology

Volumn 140, Issue 1, 1999, Pages 335-343

  De Arrieta, Cruz Martínez ^a   Morte, Beatriz ^a   Coloma, Antonio ^a   Bernal, Juan ^a,b  

^a CSIC   (Spain)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALITRETINOIN; GENE PRODUCT; LIOTHYRONINE; LIOTHYRONINE RECEPTOR; NEUROGRANIN; PROTEIN KINASE; RECEPTOR ANTIBODY; THYMIDINE KINASE;

ANIMAL CELL; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; DENDRITIC SPINE; ENZYME SUBSTRATE; GENE EXPRESSION REGULATION; HORMONAL REGULATION; HORMONE RESPONSIVE ELEMENT; HYPOTHYROIDISM; INTRON; LONG TERM POTENTIATION; MENTAL HEALTH; MOLECULAR CLONING; MONKEY; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; THYROID HORMONE RELEASE;

EID: 0032894667     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.1.6461     Document Type: Article

References (51)

1. 1. Watson JB, Battenberg EF, Wong KK, Bloom FE, Sutcliffe JG 1990 Subtractive cDNA cloning of RC3, a rodent cortex-enriched mRNA encoding a novel 78 residue protein. J Neurosci Res 26:397-408
2. 2. Gerendasy DD, Sutcliffe JG 1997 RC3/neurogranin, a postsynaptic calpacitin for setting the response threshold to calcium influxes. Mol Neurobiol 15:131-163
3. 3. Baudier J, Deloulme JC, Van Dorsselaer A, Black D, Matthes WD 1991 Purification and characterization of a brain-specific protein kinase C substrate, neurogranin (p17). Identification of a consensus aminoacid sequence between neurogranin and neuromodulin (GAP-43) that corresponds to the protein kinase C phosphorylation site and the calmodulin-binding domain. J Biol Chem 266:229-237
4. 4. Represa A, Deloulme JC, Sensenbrenner M, Ben-Ari Y, Baudier J 1990 Neurogranin: inmunocytochemical localization of a brain-specific protein kinase C substrate. J Neurosci 10:3782-3792
5. 5. Alvarez-Bolado G. Rodríguez-Sanchez P, Tejero-Díez P, Fairén A, Díez-Guerra FJ 1996 Neurogranin in the development of the rat telencephalon Neuroscience 2:565-580
6. 6. Watson JB, Sutcliffe JG, Fisher RS 1992 Localization of the protein kinase C phosphorylation/calmodulin-binding substrate in dendritic spines of neostriatal neurons. Proc Natl Acad Sci USA 89:8581-8585
7. 7. Martzen MR, Slemmon JR 1995 The dendritic peptide neurogranin can regulate a calmodulin-dependent target. J Neurochem 64:92-100
8. 8. Fedorov NB, Pasinelli P, Oestreicher AB, DeGraan PNE, Reymann KG 1995 Antibodies to postsynaptic PKC substrate neurogranin prevent long-term potentiation in hippocampal CA1 neurons. Eur J Neurosci 7:819-822
9. 9. Gerendasy DD, Herron SR, Watson JB, Sutcliffe JG 1994 Mutational and biophysical studies suggest RC3/neurogranin regulates calmodulin availability. J Biol Chem 269:22420-22426
10. 10. Meyer T, Hanson PI, Stryer L, Schulman H 1992 Calmodulin trapping by calcium-calmodulin-dependent protein kinase. Science 256:1199-1202
11. 11. Brown TH, Chapman PF, Kairiss EW, Keenan CL 1988 Long-term synaptic potentiation. Science 242:724-728
12. 12. Madison DV, Malenka RC, Nicoll RA 1991 Mechanisms underlying long-term potentiation of synaptic transmission. Annu Rev Neurosci 379-397
13. 13. Cohen RW, Margulies JE, Coulter PM, Watson JB 1993 Functional consequences of expression of the neuron-specific, protein kinase C substrate RC3 (neurogranin) in Xenopus oocytes. Brain Res 627:147-152
14. 14. Klann E, Chen S, Sweatt JD 1992 Increased phosphorylation of a 17-kDA protein kinase C substrate (P17) in long term potentiation. J Neurochem 58:1576-1579
15. 15. Iñiguez MA, Rodríguez-Peña A, Ibarrola N, Aguilera M, Muñoz A, Bernal J 1993 Thyroid hormone regulation of RC3, a brain-specific gene encoding a protein kinase C substrate. Endocrinology 133:467-473
16. 16. Iñiguez MA, De Lecea L, Guadaño-Ferraz A, Morte B, Gerendasy D, Sutcliffe JG, Bernal J 1996 Cell-specific effects of thyroid hormone on RC3/neurogranin expression in rat brain. Endocrinology 137:1032-1041
17. 17. Iñiguez MA, Rodríguez-Pena A, Ibarrola N, Morreale de Escobar G, Bernal J 1992 Adult rat brain is sensitive to thyroid hormone. Regulation of RC3/ neurogranin mRNA. J Clin Invest 90:554-558
18. 18. Gould E, Allan MD, McEwen BS 1990 Dendritic spine density of adult hippocampal pyramidal cells is sensitive to thyroid hormone. Brain Res 525:327-329
19. 19. Ruiz-Marcos A, Sanchez-Toscano F, Escobar del Rey F, Morreale de Escobar G 1981 Maturation of pyramidal cells of the cerebral cortex in hypothyroidism. In: Hetzel BS, Smith RM (eds) Fetal Brain Disorders. Recent Approaches to the Problem of Mental Deficiency. Elsevier-North Holland, Amsterdam, pp 205-226
20. 20. Piosik PA, van Groenigen M, Ponne NJ, Bolhuis PA, Baas F 1995 RC3/ neurogranin structure and expression in the caprine brain in relation to congenital hypothyroidism. Mol Brain Res 29:119-130
21. 21. Morte B, Iñiguez MA, Lorenzo PI, Bernal J 1997 Thyroid hormone regulated expression of RC3/neurogranin in the immortalized hypothalamic cell line GT1-7. J Neurochem 69:902-909
22. 22. Evans RM 1988 The steroid and thyroid hormone superfamily. Science 240:889-895
23. 23. Beato M 1989 Gene regulation by steroid hormones. Cell 56:335-344
24. 24. Umesono K, Evans RM 1989 Determinants of target gene specificity for steroid/thyroid hormone receptors. Cell 57:1139-1146
25. 25. Tagami T, Kopp P, Johnson W, Arseven OK, Jameson JL 1998 The thyroid hormone receptor variant α2 is a weak antagonist because it is deficient in interactions with nuclear receptor corepressors. Endocrinology 139:2535-2544
26. 26. Umesomo K, Murakami K, Thompson CC, Evans RM 1991 Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. Cell 65:1255-1266
27. 27. Glass CK 1994 Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers. Endocr Rev 15:391-407
28. 28. Martinez de Arrieta C, Pérez Jurado LP, Bernal J, Coloma A 1997 Structure, organization, and chromosomal mapping of the human neurogranin gene Genomics 41:243-249
29. 29. Chang JW, Schumacher E, Coulter P, Vinters HV, Watson JB 1997 Dendritic translocation of RC3/neurogranin mRNA in normal aging, Alzheimer disease and fronto-temporal dementia. J Neuropathol Exp Neurol 56:1105-1118
30. 30. Iniguez MA, Morte B, Rodríguez-Pena A, Munoz A, Gerendasy D, Sutcliffe JG, Bernal J 1994 Characterization of the promoter region and flanking sequences of the neuron-specific gene RC3 (neurogranin). Mol Brain Res 27:205-214
31. 31. Sap J, Muñoz A, Schmitt J, Stunnenberg H, Vennstrom B 1989 Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product. Nature 340:242-244
32. 32. Chen C, Okayama H 1987 High efficiency transformation of mammaliam cells by plasmid DNA. Mol Cell Biol 7:2745-2752
33. 33. Sambrook J, Fritsch EF, Maniatis T 1989 Molecular Cloning: A Laboratory Manual, ed 2. Cold Spring Harbor Laboratory, Cold Spring Harbor
34. 34. Caubín J, Iglesias T, Bernal J, Munoz A, Márquez G, Barbero JL, Zaballos A 1994 Isolation of genomic DNA fragments corresponding to genes modulated in vivo by a transcription factor. Nucleic Acids Res 22:4132-4138
35. 35. Wahlström G, Sjöberg M, Anderson M, Nordström K, Vennström B 1992 Binding characteristics of the thyroid hormone receptor homo-and heterodimers to consensus AGGTCA repeat motifs. Mol Endocrinol 6:1013-1022
36. 36. Guadaño-Ferraz A, Escamez MJ, Morte B, Vargiu P, Bernal J 1997 Transcriptional induction of RC3/neurogranin by thyroid hormone: differential neuronal sensitivity is not correlated with thyroid hormone receptor distribution in the brain. Mol Brain Res 49:37-44
37. 37. Sato T, Xiao DM, Li H, Huang FL, Huang KP 1995 Structure and regulation of the gene encoding the neuron-specific protein kinase C substrate neurogranin (RC3 protein). J Biol Chem 270:10814-10822
38. 38. Harbers M, Wahlström G, Vennström B 1996 Transactivation by the thyroid hormone receptor is dependent on the spacer sequence in hormone response elements containing directly repeated half-sites. Nucleic Acids Res 24:2252-2259
39. 39. Sap J, de Magistris L, Stunnenberg H, Vennström B 1990 A major thyroid hormone response element in the third intron of the rat growth hormone gene. EMBO J 9:887-896
40. 40. Legrand J 1984 Effects of thyroid hormones on central nervous system. In: Yanai J (ed) Neurobehavioural Teratology. Elsevier, Amsterdam, pp 331-363
41. 41. Porterfield SP, Hendrich CE 1993 The role of thyroid hormones in prenatal and neonatal neurological development. Current perspectives. Endocr Rev 14:94-106
42. 42. Bernal J, Nunez J 1995 Thyroid hormones and brain development. Eur J Endocrinol 133:390-398
43. 43. Baldini IM, Vita A, Mauri MC, Amodei V, Carrisi M, Bravin S, Cantalamessa L 1997 Psychopathological and cognitive features in subclinical hypothyroidism. Prog Neuropsychopharmacol Biol Psychiatry 21:925-935.
44. 44. Iglesias T, Caubín J, Zaballos A, Bernal J, Muñoz A 1995 Identification of the mitochondrial NADH dehydrogenase subunit 3 (ND3) as a thyroid hormone regulated gene by whole genome PCR analysis. Biochem Biophys Res Commun 210:995-1000
45. 45. Zechel C, Shen XQ, Chen JY, Chen ZP, Chambon P, Gronemeyer H 1994 The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats. EMBO J 13:1425-1433
46. 46. Perlman T, Rangarajan PN, Umesono K, Evans RM 1993 Determinants for selective RAR and TR recognition of direct repeat HREs. Genes Dev 7:1411-1422
47. 47. Iglesias T, Caubín J, Stunnenberg HG, Zaballos A, Bernal J, Muñoz A 1996 Thyroid hormone-dependent transcriptional repression of neural cell adhesion molecule during brain maturation. EMBO J 15:4307-4316
48. 48. Hagen SG, Larson R. J, Strait K A, Oppenheimer JH 1996 A Purkinje cell protein-2 intronic thyroid hormone response element binds developmentally regulated thyroid hormone receptor-nuclear protein complexes. J Mol Neurosci 7:245-255
49. 49. Farsetti A, Desvergne B, Hallenbeck P, Robbins J, Nikodem VM 1992 Characterization of myelin basic protein thyroid response element and its function in the context of native and heterologous promoter. J Biol Chem 267:15784-15789
50. 50. García-Fernandez LF, Urade Y, Hayaishi O, Bernal J, Muñoz A 1998 Identification of a thyroid hormone response element in the promoter region of the rat lipocalin-type prostaglandin D2 synthase (β-trace) gene. Mol Brain Res 55:321-330
51. 51. White DM, Takeda T, DeGroot LJ, Stefansson K, Arnason BG 1997 β-Trace gene expression is regulated by a core promoter and a distal thyroid hormone response element. J Biol Chem 272:14387-14393