Thyroid hormones inhibit type 2 iodothyronine deiodinase in the rat cerebral cortex by both pre- and posttranslational mechanisms

Endocrinology

Volumn 138, Issue 12, 1997, Pages 5231-5237

  Burmeister, Lynn A ^a   Pachucki, John ^a   St Germain, Donald L ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THYROID HORMONE; THYROXINE DEIODINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; ENZYME INHIBITION; HYPERTHYROIDISM; HYPOTHYROIDISM; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN PROCESSING; PROTEIN SYNTHESIS REGULATION; RAT; TRANSCRIPTION REGULATION;

EID: 0030691866     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.12.5602     Document Type: Article

References (46)

1. Dratman M, Crutchfield F, Gordon G, Jennings A 1983 Iodothyronine homeostasis in rat brain during hypo and hyperthyroidism. Am J Physiol 245:E185-E193
2. van Doorn J, van der Heide D, Roelfsema F 1984 The contribution of local thyroxine monoiodination to intracellular 3,5,3′-triiodothyronine in several tissues of hyperthyroid rats at isotopic equilbrium. Endocrinology 115:174-182
3. Crantz F, Larsen P 1980 Rapid thyroxine to 3,5,3′-triiodothyronine conversion and nuclear 3,5,3′-triiodothyronine binding in rat cerebral cortex and cerebellum. J Clin Invest:935-938
4. Crantz F, Silva J, Larson P 1982 An analysis of the sources and quantity of 3,5,3′-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum. Endocrinology 110:367-375
5. van Doorn J, van der Heide D, Roelfsema F 1983 Sources and quantity of 3,5,3′-triiodothyronine in several tissues of the rat. J Clin Invest 72:1778-1792
6. Kaplan M 1984 The role of thyroid hormone deiodination in the regulation of hypothalamo-pituitary function. Neuroendocrinology 38:254-260
7. van Doorn J, Roelfsema F, van der Heide D 1982 Contribution from local conversion of thyroxine to 3,5,3′-triiodothyronine to intracellular 3,5,3′-triiodothyronine in several organs in hypothyroid rats at isotope equilibrium. Acta Endocrinol (Copenh) 101:386-396
8. Kaplan M 1980 Thyroxine 5′-monodeiodination in rat anterior pituitary homogenate. Endocrinology 106:567-576
9. Kaplan M, McCann U, Yaskoski K, Larsen P, Leonard J 1981 Anatomical distribution of phenolic and tyrosyl ring deiodinases in the nervous system of normal and hypothyroid rats. Endocrinology 109:397-402
10. Kaplan M, Yaskoski K 1981 Maturational patterns of iodothyronine phenolic and tyrosyl ring deiodinase activities in rat cerebrum, cerebellum and hypothalamus. J Clin Invest 67:1208-1212
11. Silva J, Larsen P 1978 Contributions of plasma triiodothyronine to nuclear thyroxine monodeiodination to triiodothyronine to nuclear triiodothyronine receptor saturation in pituitary, liver and kidney of hypothyroid rats. J Clin Invest 61:1247-1259
12. Leonard J, Kaplan M, Visser T, Silva J, Larsen P 1981 Cerebral cortex responds rapidly to thyroid hormones. Science 214:571-573
13. Croteau W, Davey J, Galton V, St Germain DL 1996 Cloning of the mammalian type II iodothyronine deiodinase. A selenoprotein differentially expressed and regulated in huma and rat brain and other tissues. J Clin Invest 98:405-417
14. 3 sources and uptake. Thyroid 6:S-87 (Abstract)
15. Leonard J, Silva J, Kaplan M, Mellen S, Visser T, Larsen P 1984 Acute posttranscriptional regulation of cerebrocortical and pituitary iodothyronine 5′-deioinases by thyroid hormone. Endocrinology 114:998-1004
16. Silva J, Leonard J 1985 Regulation of rat cerebrocortical and adenohypophyseal type II 5′-deiodinase by thyroxine, triiodothyronine, and reverse triiodothyronine. Endocrinology 116:1627-1635
17. St Germain D 1985 Metabolic effect of 3,3′,5′-triiodothyronine in cultured growth hormone-producing rat pituitary tumor cells. J Clin Invest 76:890-893
18. Silva J, Larsen P 1986 Interrelationships among thyroxine, growth hormone, and the sympathetic nervous system in the regulation of 5′-iodothyronine deiodinaes in rat brown adipose tissue. J Clin Invest 77:1214-1223
19. St Germain D 1988 The effects and interactions of substrates, inhibitors, and the cellular thiol-disulfide balance on the regulation of type II iodothyronine 5′-deiodinase. Endocrinology 122:1860-1868
20. Leonard J, Siegrist-Kaiser C, Zuckerman C 1990 Regulation of type II iodothyronine 5′-deiodinase by thyroid hormone. J Biol Chem 265:940-946
21. Siegrist-Kaiser C, Juge-Aubry C, Tranter M, Leonard J 1990 Thyroxine dependent modulation of actin polymerization in cultured astrocytes: a novel, extra-nuclear action of thyroid hormone. J Biol Chem 265:5296-5302
22. Farwell A, Lynch R, Okulicz W, Comi A, Leonard J 1990 The actin cytoskeleton mediates the hormonally regulated translocation of type II iodothyronine 5′-deiodinase in astrocytes. J Biol Chem 265:18546-18553
23. Obregon M, Larsen P, Silva J 1986 The role of 3,3′,5′-triiodothyronine in the regulation of type II iodothyronine 5′-deiodinase in the rat cerebral cortex. Endocrinology 119:186-192
24. Ruiz-de-Oña C, Obreg-n M, Escobar del Rey, Morreale de Escobar G 1988 Developmental changes in rat brain 5′-deiodinase and thyroid hormones during the fetal period: the effects of fetal hypothyroidism and maternal thyroid hormones. Pediatr Res 24:588-594
25. Oppenheimer J, Schwartz H, Strait K 1995 An Integrated View of Thyroid Hormone Action in Vivo. Raven Press, New York, pp 249-268
26. Farwell A, DiBenedetto D, Leonard J 1993 Thyroxine targets different pathways of internalization of type II iodothyronine 5′-deiodinase in astrocytes. J Biol Chem 268:5055-5062
27. Davey J, Becker K, Schneider M, Germain DS, Galton V 1995 Cloning of a cDNA for the type II iodothyronine deiodinase. J Biol Chem 270:26786-26789
28. Kaplan M, Utiger R 1978 Iodothyronine metabolism in liver and kidney homogenates from hyperthyroid and hypothyroid rats. Endocrinology 103:156-161
29. Jennings A, Crutchfield F, Dratman M 1984 Effect of hypothyroidism and hyperthyroidism on triiodothyronine production in perfused rat liver. Endocrinology 114:992-997
30. Oppenheimer J, Schwartz H, Lane J, Thompson M 1991 Functional relationship of thyroid hormone-induced lipogenesis, lipolysis, and thermogenesis in the rat. J Clin Invest 87:125-132
31. Oppenheimer J, Coulombe P, Schwartz H, Gutfeld N 1978 Nonlinear (amplified) relationship between nuclear occupancy by triiodothyronine and the appearance rate of hepatic α-glycerophosphate dehydrogenase and malic enzyme in the rat. J Clin Invest 61:987-997
32. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
33. Derman E, Krauter K, Walling L, Weinberger C, Ray M, Darnell J 1981 Transcriptional control in the production of liver-specific mRNAs. Cell 23:731-739
34. Church G, Gilbert W 1984 Genomic sequencing. Proc Natl Acad Sci USA 81:1991-1995
35. Berry M, Kates A, Larsen P 1990 Thyroid hormone regulates type I deiodinase messenger RNA in rat liver. Mol Endocrinol 4:743-748
36. Amasino R 1986 Acceleration of nucleic acid hybridization rate by polyethylene glycol. Anal Biochem 152:304-307
37. Feinberg A, Vogelstein B 1983 A technique for radiolabeling DNA restriction endonuclease fragments to high specific radioactivity. Anal Biochem 132:6-13
38. 125I using intensifying screens and hypersensitive film. FEBS Lett 82:314-316
39. Correa-Rotter R, Mariash C, Rosenberg M 1992 Loading and transfer control for Northern hybridization. Biotechnology 12:154-158
40. Bradford M 1976 A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
41. 1992 Analysis of variance. In: SYSTAT: Statistics, Version 5.2 Edition. SYSTAT, Inc., Evanston, IL, pp 209-363
42. St Germain D, Dittrich W, Morganelli C, Cryns V 1990 Molecular cloning by hybrid arrest of translation in xenopus laevis oocytes. J Biol Chem 265:20087-20090
43. Berry M, Banu L, Larsen P 1991 Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature 349:438-440
44. Escobar-Morreale H, Obregón M, Hernández A, Escobar del Rey F, Morreale de Escobar G 1997 Regulation of iodothyronine deiodinase activity as studied in thyroidectomized rats infused with thyroxine or triiodothyronine. Endocrinology 138:2559-2568
45. Morreale de Escobar B, Calvo R, Escobar del Rey F, Obregón M 1994 Thyroid hormones in tissues from fetal and adult rats. Endocrinology 134:2410-2415
46. Escobar-Morreale H, Escobar del Rey F, Obregon M, Morreale de Escobar G 1996 Only the combined treatment with thyroxine and triiodothyronine ensures euthyroidism in all tissues of the thyroidectomized rat. Endocrinology 137:2490-2502