Association between dementia and elevated TSH: A community-based study

Biological Psychiatry

Volumn 40, Issue 8, 1996, Pages 714-725

  Ganguli, Mary ^a,b,d   Burmeister, Lynn A ^a   Seaberg, Eric C ^b   Belle, Steven ^b,c   DeKosky, Steven T ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

aging; cognition; dementia; epidemiology; thyroid; thyrotropin

Indexed keywords

THYROTROPIN;

AGED; ARTICLE; BRAIN DYSFUNCTION; BRAIN METABOLISM; DEMENTIA; FEMALE; HUMAN; HYPOTHYROIDISM; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

EID: 0030588113     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-3223(95)00489-0     Document Type: Article

References (108)

1. Ain KB, Smith CD (1994): Effects of acute hypothyroidism on human brain phosphorus metabolism [Abstract]. Thyroid 4 (Suppl1):S60.
2. Amaducci LA, Fratiglioni L, Rocca WA, et al (1986): Risk factors for clinically diagnosed Alzheimer's disease: A case-control study of an Italian population. Neurology 36:922-931.
3. Asher R (1949): Myxoedematous madness. BMJ 2:555-562.
4. American Psychiatric Association (1987): Diagnostic and Statistical Manual of Mental Disorders, 3rd ed rev. Washington, DC: American Psychiatric Association, pp 103-107.
5. Atkinson RL, Dahms WT, Fisher DA, Nichols AL (1978): Occult thyroid disease in an elderly hospitalized population. J Gerontol 33(3):372-376.
6. Bagchi N, Brown TR, Parish RF (1990): Thyroid dysfunction in adults over age 55 years: a study in an urban US community. Arch Intern Med 150(4):785-787.
7. Bahemuka M, Hodkinson HM (1975): Screening for hypothyroidism in elderly inpatients. BMJ 2:601-603.
8. Bantle JP (1987): Replacement therapy with levothyroxine: evolving concepts. Thyroid Today 10(4):1-7.
9. Barclay LL, Kheyfets S, Zemcov A, Blass JP, McDowell FH (1986): Risk factors in Alzheimer's disease. In: Fisher A, Hanin I, Lachman C, (eds), Alzheimer's and Parkinson's Diseases: Strategies for Research and Development. New York: Plenum Press, pp 141-146.
10. Barker SB, Klitgaard HM (1952): Metabolism of tissues excised from thyroxine-injected rats. Am J Physiol 170:81-86.
11. Benvenga S, Cahnemann H, Robbins J (1993): Characterization of thyroid hormone binding to apolipoprotem-E: localization of the binding site in the exon 3-coded domain. Endocrinol 133:1300-1305.
12. Berlowitz I, Ramot Y, Rosenberg T, Gilboa Y (1990): Prevalence of thyroid disorders among the elderly in Israel. Isr J Med Sci 26:496-498.
13. Bhakri H, Fisher R, Khadri A, MacMahon D (1990): Longitudinal study of thyroid function in acutely ill elderly patients using a sensitive TSH assay - defer testing until recovery. Gerontology 36(3):140-144.
14. Brent GA, Hershman JM, Braunstein GD (1986): Patients with severe nonthyroidal illness and serum thyrotropin concentrations in the hypothyroid range. Am J Med 81:463-466.
15. Breteler MMB, Van Duijn C, Chandra V, et al (1991): Medical history and the risk of Alzheimer's disease: a collaborative re-analysis of case-control studies. Intern J Epidem 20(Suppl2):S36-S42.
16. Brochmann H, Bjoro T, Gaarder PI, Hanson F, Frey HM (1988): Prevalence of thyroid dysfunction in elderly subjects: A randomized study in a Norwegian rural community (Naeroy). Acta Endocrinol 117(1):7-12.
17. Broe GA, Henderson AS, Creasey H, et al (1990): A case-control study of Alzheimer's disease in Australia. Neurology 40(11): 1698-1707.
18. Brown CA, Hennessey JV (1989): Clinical significance of mildly elevated thyrotropin levels with normal thyroxine levels. South Med J 82(6):681-685.
19. Burrows AW, Shakespear RA, Hesch RD, Cooper E, Aickin CM, Burke CW (1975): Thyroid hormones in the elderly sick: "T4 euthyroidism". BMJ 4:437-439.
20. Chandra V, Philipose V, Bell PA, Lazaroff A, Schoenberg BS (1987): Case-control study of late onset "probable Alzheimer's disease". Neurology 37(8):1295-1300.
21. Chapa F, Kunnecke B, Calco R, del Rey FE, de Escobar GM, Cerdan S (1995): Adult-onset hypothyroidism and the cerebral metabolism of (1,2-13C2) acetate as detected by 13C nuclear magnetic resonance. Endocrinol 136:296-305.
22. Clinical Society of London (1888): Report of a Committee of the Society nominated December 14, 1883 to investigate the subject of myxoedema. Trans Clin Soc Lond 21(Suppl):1-215.
23. Cummings JL (1992): Neuropsychiatrie aspects of Alzheimer's disease and other dementing illnesses. In: Yudofsky SC, Hales RE, (eds), The American Psychiatric Press Textbook of Neuropsychialry, 2nd ed. Washington DC: American Psychiatric Press, pp 605-620.
24. Cummings JL, Benson DF (1992): Laboratory aids in the diagnosis of dementia. In: Cummings JL, Benson DF, (eds), Dementia: A Clinical Approach, 2nd ed. Stoneham, MA: Butterworth-Heineman, pp 345-364.
25. Cunha UGV (1990): An investigation of dementia among elderly outpatients. Acta Psychiatr Scand 82:261-263.
26. Dratman M, Crutchfield F, Axelrod J, Colburn R, Thoa N (1976): Localization of triiodothyronine in nerve-ending fractions of brain. Proc Natl Acad Sci USA 73:941-944.
27. Drinka PJ, Nolten WE (1990): Prevalence of previously undiagnosed hypothyroidism in residents of a midwestern nursing home. South Med J 83(11):1259-1261 [published erratum appears in South Med J 1991;84(7):936].
28. Evered DC, Ormston BJ, Smith PA, Hall R, Bird T (1973): Grades of hypothyroidism. BMJ 1:657-662.
29. Ewins DL, Rossor MN, Butler J, Roques PK, Mullan MJ, McGregor AM (1991): Association between autoimmune thyroid disease and familial Alzheimer's disease. Clin Endocrinol 35:93-96.
30. Falkenberg M, Kadekal B, Norr A (1983): Screening of an elderly female population for hypo and hyperthyroidism by use of a thyroid hormone panel. Acta Med Scand 214:361-365.
31. Finucane P, Rudra T, Church H (1989): Thyroid function tests in elderly patients with and without an acute illness. Age and Ageing 18(6):398-402.
32. Forciea MA, Schwartz HL, Towle HC, Mariash CN, Kaiser FE, Oppenheimer JH (1981): Thyroid hormone-carbohydrate interaction in the rat: correlation between age-related reductions in the inducibility of hepatic malic enzyme by triiodo-L-thyronine and a high carbohydrate, fat-free diet. J Clin Invest 67(6):739-747.
33. French LR, Schuman LM, Mortimer JA, Hutton JT, Boatman RA, Christians B (1985): A case-control study of dementia of the Alzheimer type. Am J Epidemiol 121:414-421.
34. Ganguli M, Ratcliff G, Huff FJ, et al (1991): Effects of age, gender, and education on cognitive tests in a rural elderly community sample: Norms from the Monongahela Valley Independent Elders Survey. Neuroepidemiology 10(1):42-52.
35. Ganguli M, Belle S, Ratcliff G, et al (1993a): Sensitivity and specificity for dementia of population-based criteria for cognitive impairment: the MoVIES Project. J Gerontol 48(4): M152-M161.
36. Ganguli M, Seaberg E, Belle S, Fischer L, Kuller LH (1993b): Cognitive impairment and the use of health services in an elderly rural population: the MoVIES Project. J Am Geriatr Soc 41(10):1065-1070.
37. Giordano T, Pan JB, Casuto D, Watanabe S, Arnerie SP (1992): Thyroid hormone regulation of NGF, NT-3, and BDNF RNA in the adult rat brain. Mol Brain Res 16:239-245.
38. Gordin A, Lamberg BA (1981): Spontaneous hypothyroidism in symptomless autoimmune thyroiditis. A long-term follow-up study. Clinical Endocrinol 15:537-543.
39. Graves AB, White E, Koepsell TD, et al (1990): A case-control study of Alzheimer's disease. Ann Neurol 28(6):766-774.
40. Graves AB, Kukull WA (1994): The epidemiology of dementia. In: Morris JC, (ed), Handbook of Dementing Illnesses. New York: Marcel Dekker, Inc, pp 23-69.
41. Gull WW (1874): On a cretinoid state supervening in adult life in women. Trans Clin Soc Lond 7:180-185.
42. Haggerty JJ, Garbutt JC, Evans DL, et al (1990): Subclinical hypothyroidism; a review of neuropsychiatric aspects. Intern J Psychiatry Med 20(2):193-208.
43. Hamblin PS, Dyer SA, Mohr VS (1986): Relationship between thyrotropin and thyroxine changes during recovery from severe hypothroxinemia of critical illness. J Clin Endocrinol Metab 62:717-722.
44. Haupt M, Kurz A (1993): Reversibility of dementia in hypothyroidism. J Neurol 240:333-335.
45. Hemon P (1968): Malate dehydrogenase (decarboxylating) (NADP) and a-glycerophosphate oxidase in the developing rat. Biochim Biophys Acta 151:681-683.
46. Heyman A, Wilkinson WE, Stafford JA, Helms MJ, Sigmon AH, Weinberg T (1984): Alzheimer's disease: a study of epidemiological aspects. Ann Neurol 15(4):335-341.
47. Horvath TB, Siever LJ, Mohs RC, Davis K (1989): Organic mental syndromes and disorders. In: Kaplan HI, Sadock BJ, (eds). Comprehensive Textbook of Psychiatry, 5th ed. Baltimore: Williams & Wilkins, pp 599-641.
48. Hughes CP, Berg L, Danziger WL, et al (1982): A new scale for the staging of dementia. Br J Psychiatry 140:566-572.
49. Iniguez M, Rodriguez-Pena A, Ibarrola N, Escobar GM, Bernal J (1992): Adult rat brain is sensitive to thyroid hormone. Regulation of RC3/Neurogranin mRNA. J Clin Invest 90: 554-558.
50. Jellinek EH (1962): Fits, faints, coma, and dementia in myxoedema. Lancet 2:1010-1012.
51. Jorm AF (1990): The Epidemiology of Alzheimer's Disease and Related Disorders. New York: Von Nostrand Reinhold, pp 83.
52. Katzman R (1993a): Education and the prevalence of dementia and Alzheimer's disease. Neurology 43:13-20.
53. Katzman R (1993b): Clinical and epidemiological aspects of Alzheimer's disease. Clin Neuroscience 1:165-170.
54. Kinlaw W (1991): Atherosclerosis and the thyroid. Thyroid Today XIV:1-8.
55. Kokmen E, Beard CM, Chandra V, Offord KP, Schoenberg BS, Ballard DJ (1991): Clinical risk factors for Alzheimer's disease: a population-based case-control study. Neurology 41(9):1393-1397.
56. Larsen PR (1992): The Thyroid. In: Wyngaarden JB, Smith LH, Bennett JC, (eds), Cecil Textbook of Medicine, 19th ed. Philadelphia: WB Saunders, pp 1248-1271.
57. Larson EB, Reifler BV, Featherstone HJ, English DR (1984): Dementia in elderly outpatients: a prospective study. Ann Intern Med 100:417-423.
58. Larson EB, Reifler BV, Sumi SM, Canfield CG, Chinn NM (1986): Diagnostic tests in the evaluation of dementia: a prospective study of 200 elderly outpatients. Ann Intern Med 146:1917-1922.
59. Lee YP, Lardy HA (1965): Influence of thyroid hormones on L-a-glycerophosphate dehydrogenases in various organs of the rat. J Biol Chem 240:1427-1436.
60. Livingston E, Hershman JM, Sawin CT, Yoshikawa T (1987): Prevalence of thyroid disease and abnormal thyroid tests in older hospitalized and ambulatory persons. J Am Geriatr Soc 35:109-114.
61. Lopez O, Huff FJ, Martinez AJ, Bedetti CD (1989): Prevalence of thyroid abnormalities is not increased in Alzheimer's disease. Neurobiology of Aging 10:247-251.
62. Marsh A, Burns A (1986): Thyroid stimulating hormone (TSH) measurements in dementing patients [Letter]. Med Lab Sci 43:294.
63. Mason G, Walker C, Prange A (1993): L-Triiodothyronine: Is this peripheral hormone a central neurotransmitter? Neuropsychopharmacology 8:253-258.
64. Monzani F, Del Guerra P, Caraccio N, et al (1993): Subclinical hypothyroidism: neurobehavioral features and beneficial effect of L-thyroxine treatment. Clin Investig 71:367-371.
65. Morris JC, Heyman A, Mohs RC, Hughes JP, van Belle G, Fillenbaum GG, Mellits D, Clark C, and the CERAD investigators (1993): The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part 1. Clinical and neuropsychological assessment of Alzheimer's disease. Neurology 39:1159-1165.
66. Mortimer JA, Graves AB (1993): Education and other socioeconomic determinants of dementia and Alzheimer's disease. Neurology 43(Suppl4):S39-S44.
67. Nickel SN, Frame B (1958): Neurological manifestations of myxedema. Neurology 8:511-517.
68. Nystrom E, Caidahl K, Fager G, Wikkelso C, Lundberg PA, Lindstet G (1988): A double-blind cross-over 12-month study of L-thyroxine treatment of women with subclinical hypothyroidism. Clin Endocrinol 29:63-76.
69. O'Kane MJ, Neely RDG, Trimble ER, Nicholls DP (1991): The incidence of asymptomatic hypothyroidism in new referrals to a hospital lipid clinic. Ann Clin Biochem 28:509-511.
70. Olivarius B de F, Roder E (1970): Reversible psychosis and dementia in myxedema. Acta Psychiatr Scand 46:1-13.
71. Ord WM (1878): On myxoedema, a term proposed to be applied to an essential condition in the "cretinoid" affection occasionally observed in middle-aged women. Med Chir Trans 61: 57-78.
72. Osterweil D, Syndulko K, Cohen SN (1992): Cognitive function in non-demented older adults with hypothyroidism. J Am Geriatr Soc 40(4):325-335.
73. Peabody CA, Thornton JE, Tinklenberg JR (1986): Progressive dementia associated with thyroid disease [Letter]. J Clin Psychiatry 47(2):100.
74. Percy ME, Dalton AJ, Markovic VD (1990): Autoimmune thyroiditis associated with mild "subclinical" hypothyroidism in adults with Down Syndrome: a comparison of patients with and without manifestations of Alzheimer's disease. Am J Med Genet 36(2):148-154.
75. Rabinowe SL, Rubin IL, George KL, Adri MNS, Eisenbarth GS (1989): Trisomy 21 (Down's Syndrome): autoimmunity, aging and monoclonal antibody-defined T-cell abnormalities. J Autoimmunity 2:25-30.
76. Read S (1991): The dementias. In: Sadavoy J, Lazarus LW, Jarvik LF, (eds), Comprehensive Review of Geriatric Psychiatry, Washington DC: American Psychiatric Press, pp 287-309.
77. Riisoen H (1988): Reduced prealbumin (transthyretin) in CSF of severely demented patients with Alzheimer's disease. Acta Neurol Scand 78:455-459.
78. Rosenthal MJ, Sanchez CJ (1985): Thyroid disease in the elderly; missing diagnosis or over diagnosis? West J Med 143:643-647.
79. Rosenthal MJ, Hunt WC, Garry PJ, Goodwin JS (1987): Thyroid failure in the elderly: microsomal antibodies as discriminant for therapy. JAMA 258(2):209-213.
80. Saunders AM, Strittmatter WJ, Schmechel D, et al (1993): Association of apolipoprotein E allele E4 with late-onset familial and sporadic Alzheimer's disease. Neurology 43: 1467-1472.
81. Sawin CT, Chopra D, Azizi F, Mannix JE, Bacharach P (1979): The aging thyroid. Increased prevalence of elevated serum thyrotropin levels in the elderly. JAMA 242(3):247-250.
82. Sawin CT, Castelli WP, Hershman JM, McNamara P, Bacharach P (1985): The aging thyroid. Thyroid deficiency in the Framingham Study. Arch Intern Med 145:1386-1388.
83. Sawin CT, Geller A, Hershman JM, Castelli W, Bacharach P (1989): The aging thyroid. The use of thyroid hormone in older persons. JAMA 261(18):2653-2655.
84. Schapiro S (1966): Metabolic and maturational effect of thyroxine on the intact rat. Endocrinol 78:527-532.
85. Schapiro S, Percin CJ (1966): Thyroid hormone induction of a-glycerophosphate dehydronase in rats of different ages. Endocrinol 79:1075-1078.
86. Scheinberg P, Stead E, Brannon E, Warren J (1950): Correlative observations on cerebral metabolism and cardiac output in myxedema. J Clin Invest 29:1139-1146.
87. Sensenbach W, Madison L, Eisenberg S, Ochs L (1954): Cerebral circulation and metabolism in hyperthyroidism and myxedema. J Clin Invest 33:1434-1440.
88. Shalat SL, Seltzer B, Pidcock C, Baker EL (1987): Risk factors for Alzheimer's disease: a case-control study. Neurology 37(10):1630-1633.
89. Siegrist-Kaiser CA, Juge-Aubry C, Tranter MP, Ekenbarger DM, Leonard JL (1990): Thyroxine dependent modulation of actin polymerization in cultured astrocytes: a novel, extra-nuclear action of thyroid hormone. J Biol Chem 265(9):5296-5302.
90. Silva JE, Leonard JL (1985): Regulation of rat cerebrocortical and adenohypophyseal type II 5′-deiodinase by thyroxine, triiodothyronine, and reverse triiodothyronine. Endocrinol 116:1627.
91. Skoog I, Nilsson L, Palmertz B, et al (1993): A population-based study of dementia in 85-year-olds. N Engl J Med 328(3):153-158.
92. Smith SJ, Kiloh LG (1981): The investigation of dementia: results in 200 consecutive admissions. Lancet (April 11): 824-827.
93. Smith CL, Granger CV (1992): Hypothyroidism producing reversible dementia: a challenge for medical rehabilitation. Am J Phys Med Rehabil 71(1):28-30.
94. Spencer CA, Eigen A, Shen D (1987): Specificity of sensitive assays of thyrotropin used to screen for thyroid disease in hospitalized patients. Clin Chem 33:1391-1396.
95. Spencer CA, Nicoloff JT (1990): Serum TSH measurement: A 1990 status report. Thyroid Today 13(4).
96. Strittmatter WJ, Saunders AM, Schmechel D, et al (1993): Apolipoprotein E: High-avidity binding to B-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci USA 90(5):1977-1981.
97. Sundbeck G, Lundberg F, Lindstedt G, Jagenburg R, Eden S (1991): Incidence and prevalence of thyroid disease in elderly women; results from the longitudinal population study of elderly people in Gothenburg, Sweden. Age and Ageing 20:291-298.
98. Surks M (1977): Laboratory aids in the diagnosis of hypothyroidism. Thyroid Today 1:1-5.
99. Tappy L, Randin JP, Schwed P, Wertheimer J, Lemarchand-Beraud T (1987): Prevalence of thyroid disorders in psychogeriatric inpatients: a possible relationship of hypothyroidism with neurotic depression but not with dementia. J Am Geriatr Soc 35(6):526-531.
100. Thomas DR, Hailwood R, Harris B, Williams PA, Scanlon MF, John R (1987): Thyroid status in senile dementia of the Alzheimer type (SDAT). Acta Psychiatr Scand 76:158-163.
101. Tunbridge WMG, Evered DC, Hall R, et al (1977): The spectrum of thyroid disease in a community: The Whickham Survey. Clin Endocrinol 7:481-493.
102. Tunbridge WMG, Brewis M, French JM, et al (1981): Natural history of autoimmune thyroiditis. BMJ 282:258-282.
103. Walker P, Weichsel M, Fisher DA, Guo S, Fisher DA (1979): Thyroxine increases nerve growth factor concentration in adult mouse brain. Science 204:427-429.
104. Wartofsky L (1994): Diseases of the thyroid. In: Isselbacher KJ, Braunwald E, Wilson JD, Martin JB, Fauci AS, Kasper DL, (eds), Harrison's Principles of Internal Medicine, 13th ed. MacGraw Hill, pp 1930-1953.
105. Wenzel KW, Meinhold H, Raffenberg M, Adlkofer F, Schleusener H (1974): Classification of hypothyroidism in evaluating patients after radioiodine therapy by serum cholesterol, T3 uptake, total T4, FT4 index, total T3, basal TSH, and TRH-test. European J Clin Invest 4:141-148.
106. Whybrow PC, Prange AJ, Treadway CR (1969): Mental changes accompanying thyroid gland dysfunction; a reappraisal using objective psychological measurement. Arch Gen Psychiat 20:48-63.
107. Wong ET, Bradley SG, Schultz AL (1981): Elevations of thyroid-stimulating hormone during acute nonthyroidal illness. Arch Int Med 141:873-875.
108. Yoshimasu F, Kokmen E, Hay ID, Beard CM, Offord KP, Kurland LT (1991): The association between Alzheimer's disease and thyroid disease in Rochester, Minnesota. Neurology 41:1745-1747.