New orally effective 3-(2-nitro)phenylpropanamide analgesic derivatives: Synthesis and antinociceptive evaluation

European Journal of Medicinal Chemistry

Volumn 69, Issue , 2013, Pages 728-734

  Since, Marc ^a,d   Freret, Thomas ^b,c   Nee, Gerald ^b,c   Terme, Thierry ^a   Vanelle, Patrice ^a   Boulouard, Michel ^b,c  

^a AIX MARSEILLE UNIVERSITY   (France)

^b NORMANDIE UNIVERSITÉ   (France)

^c UNIVERSITÉ DE CAEN   (France)

^d CENTRE D ETUDES ET DE RECHERCHE SUR LE MÉDICAMENT DE NORMANDIE   (France)

Author keywords

6 Nitrophenylpropanamide; Analgesic; Hot plate test; Peripheral antinociceptive activity; TDAE; Writhing test

Indexed keywords

1 [4 (2 HYDROXYETHYL)PIPERAZIN 1 YL] 3 (6 NITROBENZO[D][1,3]DIOXOL 5 YL)PROPAN 1 ONE; 1 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL] 3 (6 NITROBENZO[D][1,3]DIOXOL 5 YL)PROPAN 1 ONE; 1 [4 (4 FLUOROPHENYL)PIPERAZIN 1 YL] 3 (6 NITROBENZO[D][1,3]DIOXOL 5 YL)PROPAN 1 ONE; 1 [4 (4 METHOXYPHENYL)PIPERAZIN 1 YL] 3 (6 NITROBENZO[D][1,3]DIOXOL 5 YL)PROPAN 1 ONE; 3 (6 AMINOBENZ[D][1,3]DIOXOL 5 YL) 1 [4 (4 METHOXYPHENYL)PIPERAZIN 1 YL]PROPAN 1 ONE; 3 (6 NITROBENZO[D][1,3]DIOXOL 5 YL) 1 (4 PHENYLPIPERAZIN 1 YL)PROPAN 1 ONE; 3 (6 NITROBENZO[D][1,3]DIOXOL 5 YL) N (PYRIDINE 2 YL)PROPANAMIDE; 3 (6 NITROBENZO[D][1,3]DIOXOL 5 YL)PROPANAMIDE; 3 (BENZO[D][1,3]DIOXOL 5 YL) 1 (2 METHYLPIPERIDIN 1 YL)PROPAN 1 ONE; 3 (BENZO[D][1,3]DIOXOL 5 YL) 1 [4 (4 METHOXYPHENYL)PIPERAZIN 1 YL]PROPAN 1 ONE; ACETYLSALICYLIC ACID; ANALGESIC AGENT; ANTINOCICEPTIVE AGENT; HALOPERIDOL; METHYLPHENIDATE; MORPHINE; N HEXYL 3 (6 NITROBENZO[D][1,3]DIOXOL 5 YL)PROPANAMIDE; PROPIONAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; IN VIVO STUDY; LATENT PERIOD; LOCOMOTION; MOUSE; NITRATION; NONHUMAN; PARTICLE SIZE;

6-NITROPHENYLPROPANAMIDE; ANALGESIC; HOT-PLATE TEST; PERIPHERAL ANTINOCICEPTIVE ACTIVITY; TDAE; WRITHING TEST;

ACETIC ACID; ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZODIOXOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; HOT TEMPERATURE; MICE; MOLECULAR STRUCTURE; MOTOR ACTIVITY; PAIN; PAIN MEASUREMENT; PIPERAZINES;

EID: 84884776889     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.08.041     Document Type: Article

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