Synthesis of new chemical entities from paracetamol and NSAIDs with improved pharmacodynamic profile

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 24, 2006, Pages 8701-8706

  Yadav, Mange Ram ^a   Nimekar, Datta M ^a   Ananthakrishnan, A ^a   Brahmkshatriya, Pathik S ^a   Shirude, Shrikant T ^a   Giridhar, Rajani ^a   Parmar, Arvind ^a   Balaraman, R ^a  

^a Faculty of Technology and Engineering   (India)

Author keywords

Analgesic activity; Anti inflammatory activity; Antipyretic activity; NSAIDs; Paracetamol; Ulcerogenicity

Indexed keywords

4 [2 (2 FLUORO 4 BIPHENYL)PROPIONAMIDO]PHENOL; 4 [2 (2 FLUORO 4 BIPHENYL)PROPIONAMIDO]PHENYLACETATE; 4 [2 (3 BENZOYLPHENYL)PROPIONAMIDO]PHENOL; 4 [2 (3 BENZOYLPHENYL)PROPIONAMIDO]PHENYLACETATE; 4 [2 (4 BIPHENYL)ACETAMIDO]PHENOL; 4 [2 (4 BIPHENYL)ACETAMIDO]PHENYLACETATE; 4 [2 (4 ISOBUTYLPHENYL)PROPIONAMIDO]PHENOL; 4 [2 (4 ISOBUTYLPHENYL)PROPIONAMIDO]PHENYLACETATE; 4 [2 (6 METHOXY 2 NAPHTHYL)ACETAMIDO]PHENOL; 4 [2 (6 METHOXY 2 NAPHTHYL)ACETAMIDO]PHENYLACETATE; 4 [2 (6 METHOXY 2 NAPHTHYL)PROPIONAMIDO]PHENOL; 4 [2 (6 METHOXY 2 NAPHTHYL)PROPIONAMIDO]PHENYLACETATE; 4 AMINOPHENOL; 5 BENZOYL N (4 HYDROXYPHENYL) 2,3 DIHYDRO 1H PYRROLIZINE 1 CARBOXAMIDE; 6 METHOXY 2 NAPHTHYLACETIC ACID; ACETIC ACID DERIVATIVE; ACETIC ANHYDRIDE; BACTERIUM LIPOPOLYSACCHARIDE; FELBINAC; FENBUFEN; FLURBIPROFEN; KETOPROFEN; KETOROLAC; N (4 ACETOXYPHENYL) 5 BENZOYL 2,3 DIHYDRO 1H PYRROLIZINE 1 CARBOXAMIDE; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PARACETAMOL DERIVATIVE; PHENOL DERIVATIVE; UNCLASSIFIED DRUG; VALDECOXIB;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIPYRETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DIGESTIVE SYSTEM ULCER; DRUG SYNTHESIS; ENZYME INHIBITION; FEMALE; FEVER; MALE; NONHUMAN; PAW EDEMA; RAT; ULCEROGENESIS; WRITHING TEST;

ACETAMINOPHEN; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; EDEMA; FEMALE; FEVER; LIPOPOLYSACCHARIDES; MALE; MICE; PAIN MEASUREMENT; PHENOLS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33750514361     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.08.017     Document Type: Article

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