Synthesis and biological evaluation of amide derivatives of (6-chloro-2,3-dihydro-1H-inden-1-yl)acetic acid as potential anti-inflammatory agents with lower gastrointestinal toxicity

Chemical and Pharmaceutical Bulletin

Volumn 56, Issue 5, 2008, Pages 626-635

  Sharma, Meenakshi ^a   Ray, Saumendra Mohan ^a,b  

^a BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

^b NSCB Institute of Pharmacy   (India)

Author keywords

Amide derivative; Anti inflammatory; Indene; Ulcerogenecity

Indexed keywords

1 [(6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL)ACETYL]PIPERAZINE; 1 [(6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL)ACETYL]PIPERIDINE; 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL) N (2 HYDROXYETHYL)ACETAMIDE; 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL) N (3 CHLOROPHENYL)ACETAMIDE; 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL) N (3 METHYLPHENYL)ACETAMIDE; 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL) N (4 CHLOROPHENYL)ACETAMIDE; 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL) N (4 METHOXYPHENYL)ACETAMIDE; 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL) N (4 METHYLPHENYL)ACETAMIDE; 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL) N (4 NITROPHENYL)ACETAMIDE; 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL) N ETHYLACETAMIDE; 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL) N HEXYLACETAMIDE; 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL) N ISOPROPYLACETAMIDE; 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL) N METHYLACETAMIDE; 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL) N PENTYLACETAMIDE; 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL) N PHENYLACETAMIDE; 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL) N PROPYLACETAMIDE; 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL) N PYRIDIN 4 YLACETAMIDE; 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL) N PYRISIN 3 YLACETAMIDE; 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL)ACETAMIDE; ACETIC ACID; ACETYLSALICYLIC ACID; ANTIINFLAMMATORY AGENT; INDOMETACIN; N (4 BROMOPHENYL) 2 (6 CHLORO 3 2,3 DIHYDRO 1H INDEN 1 YL)ACETAMIDE; N [4 (ACETYLAMINO)PHENYL] 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL)ACETAMIDE; N BENZYL 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL)ACETAMIDE; N BUTYL 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL)ACETAMIDE; N CYCLOHEXYL 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL)ACETAMIDE; N CYCLOPENTYL 2 (6 CHLORO 2,3 DIHYDRO 1H INDEN 1 YL)ACETAMIDE; PROADIFEN;

ACUTE TOXICITY; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ANTIPYRETIC ACTIVITY; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENTEROPATHY; FEMALE; MOUSE; NONHUMAN; PAW EDEMA; RAT; ULCEROGENESIS; WRITHING TEST;

ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS, EXPERIMENTAL; CARRAGEENAN; CYTOCHROME P-450 ENZYME SYSTEM; EDEMA; ENZYME INHIBITORS; FEMALE; FEVER; GASTROINTESTINAL DISEASES; INDENES; INDICATORS AND REAGENTS; LIPOPOLYSACCHARIDES; MAGNETIC RESONANCE SPECTROSCOPY; MICE; PROADIFEN; RATS; RATS, WISTAR; STOMACH ULCER;

EID: 43449102503     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.56.626     Document Type: Article

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