Lowering of 5-nitroimidazole's mutagenicity: Towards optimal antiparasitic pharmacophore

European Journal of Medicinal Chemistry

Volumn 44, Issue 2, 2009, Pages 653-659

  Crozet, Maxime D ^a   Botta, Céline ^a   Gasquet, Monique ^b   Curti, Christophe ^a   Rémusat, Vincent ^a   Hutter, Sébastien ^b   Chapelle, Olivier ^b   Azas, Nadine ^b   De Méo, Michel ^a   Vanelle, Patrice ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b Faculty of Medecine   (France)

Author keywords

5 Nitroimidazoles; Antiparasitic activity; Arylsulfonylmethyl group; Mutagenicity

Indexed keywords

4 NITROIMIDAZOLE DERIVATIVE; ANTIPARASITIC AGENT; ANTITRICHOMONAL AGENT; METRONIDAZOLE;

ARTICLE; DRUG ACTIVITY; DRUG CYTOTOXICITY; IC 50; MONOCYTE; MUTAGEN TESTING; MUTAGENICITY; NONHUMAN; SALMONELLA; TRICHOMONAS VAGINALIS;

ANIMALS; ANTIPARASITIC AGENTS; HUMANS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MONOCYTES; MUTAGENICITY TESTS; NITROIMIDAZOLES; SALMONELLA; STRUCTURE-ACTIVITY RELATIONSHIP; TRICHOMONAS VAGINALIS;

EID: 60349095962     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.05.015     Document Type: Article

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