Novel antagonists of serotonin-4 receptors: Synthesis and biological evaluation of pyrrolothienopyrazines

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 6, 2009, Pages 2607-2622

  Lemaître, Stéphane ^a   Lepailleur, Alban ^a   Bureau, Ronan ^a   Butt Gueulle, Sabrina ^a   Lelong Boulouard, Véronique ^a   Duchatelle, Pascal ^a   Boulouard, Michel ^a   Dumuis, Aline ^b   Daveu, Cyril ^a   Lezoualc'h, Frank ^c   Pfeiffer, Bruno ^d   Dauphin, François ^a   Rault, Sylvain ^a  

^a CENTRE D ETUDES ET DE RECHERCHE SUR LE MÉDICAMENT DE NORMANDIE   (France)

^b CCIPE   (France)

^c Universite Paris Sud   (France)

^d INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

5 HT4 ligands; Antagonists; Pharmacophore; Pyrrolo 1,2 a thieno 2,3 e pyrazine; Pyrrolo 1,2 a thieno 3,2 e pyrazine

Indexed keywords

1 METHYL 3 INDOLECARBOXYLIC ACID [1 [2 (METHYLSULFONYLAMINO)ETHYL] 4 PIPERIDINYLMETHYL] ESTER; 1 METHYL 5 [(1 PROPYLPIPERIDIN 4 YL)METHYLOXY]PYRROLO[1,2 A]THIENO[2,3 E]PYRAZINE FUMARATE; 5 FLUORO 2 METHOXY 1H INDOLE 3 CARBOXYLIC ACID 1 [2 (METHYLSULFONAMIDO)ETHYL] 4 PIPERIDINYLMETHYL ESTER; ARECOLINE; AROMATIC COMPOUND; METHYL GROUP; PYRAZINE DERIVATIVE; PYRROLE DERIVATIVE; RADIOLIGAND; SEROTONIN 4 ANTAGONIST; SEROTONIN 4 RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CELL STRAIN COS7; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PHARMACOPHORE; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; INDOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRAZINES; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN, 5-HT4; SEROTONIN ANTAGONISTS; SULFONAMIDES;

EID: 62149128617     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.11.045     Document Type: Article

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