New benzo[h][1,6]naphthyridine and azepino[3,2-c]quinoline derivatives as selective antagonists of 5-HT4 receptors: Binding profile and pharmacological characterization

Journal of Medicinal Chemistry

Volumn 46, Issue 1, 2003, Pages 138-147

  Hinschberger, Antoine ^a   Butt, Sabrina ^a   Lelong, Véronique ^a   Boulouard, Michel ^a   Dumuis, Aline ^b   Dauphin, Françcois ^a   Bureau, Ronan ^a   Pfeiffer, Bruno ^c   Renard, Pierre ^c   Rault, Sylvain ^a  

^a UNIVERSITÉ DE CAEN   (France)

^b CCIPE   (France)

^c INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 3 INDOLECARBOXYLIC ACID [1 [2 (METHYLSULFONYLAMINO)ETHYL] 4 PIPERIDINYLMETHYL] ESTER; 5 FLUORO 2 METHOXY 1H INDOLE 3 CARBOXYLIC ACID 1 [2 (METHYLSULFONAMIDO)ETHYL] 4 PIPERIDINYLMETHYL ESTER; ACETYLSALICYLIC ACID; NAPHTHYRIDINE DERIVATIVE; PIROXICAM; QUINOLINE DERIVATIVE; SEROTONIN 4 ANTAGONIST; SEROTONIN 4 RECEPTOR;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CELL STRAIN COS7; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VIVO STUDY; MOUSE; NONHUMAN; VISCERAL PAIN; WRITHING TEST;

ACUTE TOXICITY TESTS; ANIMALS; BEHAVIOR, ANIMAL; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLIC AMP; GUINEA PIGS; LETHAL DOSE 50; MALE; MAZE LEARNING; MICE; NAPHTHYRIDINES; QUINOLINES; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT4; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037413525     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020954v     Document Type: Article

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