Design and synthesis of 3,4-methylenedioxy-6-nitrophenoxyacetylhydrazone derivatives obtained from natural safrole: New lead-agents with analgesic and antipyretic properties

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 23, 2006, Pages 7924-7935

  Bezerra Netto, Heleno J C ^a   Lacerda, Daniel I ^a   Miranda, Ana Luisa P ^a   Alves, Hélio M ^a   Barreiro, Eliezer J ^a   Fraga, Carlos A M ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

1,3 Benzodioxole derivatives; Analgesic activity; Antipyretic activity; N Acylhydrazone; Privileged structure; Safrole

Indexed keywords

ANALGESIC AGENT; ANTIPYRETIC AGENT; BENZYLIDENE 2 (6 NITROBENZO[1,3]DIOXOL 5 YLOXY)ACETYLHYDRAZINE; DIPYRONE; HYDRAZONE DERIVATIVE; LASSBIO 891; NIMESULIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIPYRETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; EVALUATION; FEVER; HYBRIDIZATION; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PAW EDEMA; RAT;

ANALGESICS; ANALGESICS, NON-NARCOTIC; ANTI-INFLAMMATORY AGENTS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HYDRAZONES; SAFROLE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33750082071     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.07.046     Document Type: Article

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