Acute responsivity of the serotonergic system to S-citalopram and positive emotionality-The moderating role of the 5-HTTLPR

Frontiers in Human Neuroscience

Volumn , Issue AUG, 2013, Pages

  Wielpuetz, Catrin ^a   Kuepper, Yvonne ^a   Grant, Phillip ^a   Munk, Aisha J L ^a   Hennig, Juergen ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

5 HTTLPR; Neuroendocrine challenge test; Positive emotionality; S citalopram; Serotonin

Indexed keywords

ESCITALOPRAM;

5 HTTLPR GENE; ADULT; ARTICLE; BODY MASS; BRAIN FUNCTION; CONTROLLED STUDY; EMOTIONALITY; GENE; GENE FREQUENCY; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; POSITIVE EMOTIONALITY; SEROTONINERGIC SYSTEM;

EID: 84884698745     PISSN: 16625161     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnhum.2013.00486     Document Type: Article

References (88)

1. Aiken, L. S., and West, S. G. (1991). Multiple Regression: Testing and Interpreting Interactions. Newbury Park, CA: Sage.
2. Alexander, N., Kuepper, Y., Schmitz, A., Osinsky, R., Kozyra, E., and Hennig, J. (2009). Gene-environment interactions predict cortisol responses after acute stress: implications for the etiology of depression. Psychoneuroendocrinology 34, 1294-1303. doi: 10.1016/j.psyneuen.2009.03.017
3. Angleitner, A., Langert, R., Schilling, J., and Spinath, F. M. (1993). Deutsche Form des Multidimensional Personality Questionnaire (MPQ). Bielefeld: University Bielefeld.
4. Baron, R. M., and Kenny, D. A. (1986). The moderator mediator variable distinction in social psychological-research-conceptual, strategic, and statistical considerations. J. Pers. Soc. Psychol. 51, 1173-1182. doi: 10.1037/0022-3514.51.6.1173
5. Beevers, C. G., Marti, C. N., Lee, H. J., Stote, D. L., Ferrell, R. E., Hariri, A. R., et al. (2011). Associations between serotonin transporter gene promoter region (5-HTTLPR) polymorphism and gaze bias for emotional information. J. Abnorm. Psychol. 120, 187-197. doi: 10.1037/a0022125
6. Beevers, C. G., Wells, T. T., Ellis, A. J., and McGeary, J. E. (2009). Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli. J. Abnorm. Psychol. 118, 670-681. doi: 10.1037/a0016198
7. Belsky, J., Jonassaint, C., Pluess, M., Stanton, M., Brummett, B., and Williams, R. (2009). Vulnerability genes or plasticity genes? Mol. Psychiatry 14, 746-754. doi: 10.1038/mp.2009.44
8. Bennett, A. J., Lesch, K. P., Heils, A., Long, J. C., Lorenz, J. G., Shoaf, S. E., et al. (2002). Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol. Psychiatry 7, 118-122. doi: 10.1038/sj.mp.4000949
9. Brummett, B. H., Boyle, S. H., Kuhn, C. M., Siegler, I. C., and Williams, R. B. (2008). Associations among central nervous system serotonergic function and neuroticism are moderated by gender. Biol. Psychol. 78, 200-203. doi: 10.1016/j.biopsycho.2008.03.002
10. Canli, T., Omura, K., Haas, B. W., Fallgatter, A., Constable, R. T., and Lesch, K. P. (2005). Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proc. Natl. Acad. Sci. U.S.A. 102, 12224-12229. doi: 10.1073/pnas.0503880102
11. Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., et al. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301, 386-389. doi: 10.1126/science.1083968
12. Christian, B. T., Fox, A. S., Oler, J. A., Vandehey, N. T., Murali, D., Rogers, J., et al. (2009). Serotonin transporter binding and genotype in the nonhuman primate brain using [C-11]DASB PET. Neuroimage 47, 1230-1236. doi: 10.1016/j.neuroimage.2009.05.090
13. Church, A. T. (1994). Relating the tellegen and 5-factor models of personality structure. J. Pers. Soc. Psychol. 67, 898-909. doi: 10.1037/0022-3514.67.5.898
14. Costa, P. T. Jr., and McCrae, R. R. (1992). Revised NEO Personality Inventory and NEO Five Factor Inventory Professional Manual. Odesssa, FL: Psychological Assessment Resources.
15. Depue, R. A., and Collins, P. F. (1999). Neurobiology of the structure of personality: dopamine, facilitation of incentive motivation, and extraversion. Behav. Brain Sci. 22, 491-517. doi: 10.1017/S0140525X99002046
16. Depue, R. A., and Fu, Y. (2011). Neurogenetic and experiential processes underlying major personality traits: implications for modelling personality disorders. Int. Rev. Psychiatry 23, 258-281. doi: 10.3109/09540261.2011.599315
17. Depue, R. A., and Lenzenweger, M. F. (2001). "A neurobehavorial dimensional model, " in Handbook of Personality Disorders: Theory, Research and Treatment, ed W. J. Livesley (New York, NY: The Guilford Press), 136-174.
18. Depue, R. A., Luciana, M., Arbisi, P., Collins, P., and Leon, A. (1994). Dopamine and the structure of personality-relation of agonist-induced dopamine activity to positive emotionality. J. Pers. Soc. Psychol. 67, 485-498. doi: 10.1037/0022-3514.67.3.485
19. Depue, R. A., and Morrone-Strupinsky, J. V. (2005). Modeling human behavioral traits and clarifying the construct of affiliation and its disorders. Behav. Brain Sci. 28, 371-395. doi: 10.1017/S0140525X0543006X
20. Ditzen, B., Schaer, M., Gabriel, B., Bodenmann, G., Ehlert, U., and Heinrichs, M. (2009). Intranasal oxytocin increases positive communication and reduces cortisol levels during couple conflict. Biol. Psychiatry 65, 728-731. doi: 10.1016/j.biopsych.2008.10.011
21. Emiliano, A. B. F., Cruz, T., Pannoni, V., and Fudge, J. L. (2007). The interface of oxytocin-labeled cells and serotonin transporter-containing fibers in the primate hypothalamus: a substrate for SSRIs therapeutic effects? Neuropsychopharmacology 32, 977-988. doi: 10.1038/sj.npp.1301206
22. Flory, J. D., Manuck, S. B., Matthews, K. A., and Muldoon, M. F. (2004). Serotonergic function in the central nervous system is associated with daily ratings of positive mood. Psychiatry Res. 129, 11-19. doi: 10.1016/j.psychres.2004.06.010
23. Fox, E., Ridgewell, A., and Ashwin, C. (2009). Looking on the bright side: biased attention and the human serotonin transporter gene. Proc. R. Soc. B Biol. Sci. 276, 1747-1751. doi: 10.1098/rspb.2008.1788
24. Fox, E., Zougkou, K., Ridgewell, A., and Garner, K. (2011). The serotonin transporter gene alters sensitivity to attention bias modification: evidence for a plasticity gene. Biol. Psychiatry 70, 1049-1054. doi: 10.1016/j.biopsych.2011.07.004
25. Gray, J. A. (1982). The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-Hippocampal System. New York, NY: Oxford University Press.
26. Greenberg, B. D., Tolliver, T. J., Huang, S. J., Li, Q., Bengel, D., and Murphy, D. L. (1999). Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am. J. Med. Genet. 88, 83-87.
27. Hariri, A. R., Mattay, V. S., Tessitore, A., Kolachana, B., Fera, F., Goldman, D., et al. (2002). Serotonin transporter genetic variation and the response of the human amygdala. Science 297, 400-403. doi: 10.1126/science.1071829
28. Hautzinger, M., Bailer, M., Worall, H., and Keller, F. (1995). Beck-Depressions-Inventar (BDI); Testhandbuch. Bern: Hans Huber.
29. Heinrichs, M., Baumgartner, T., Kirschbaum, C., and Ehlert, U. (2003). Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol. Psychiatry 54, 1389-1398. doi: 10.1016/S0006-3223(03)00465-7
30. Heinz, A., Braus, D. F., Smolka, M. N., Wrase, J., Puls, I., Hermann, D., et al. (2005). Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nat. Neurosci. 8, 20-21. doi: 10.1038/nn1366
31. Hennig, J., Reuter, M., Netter, P., Burk, C., and Landt, O. (2005). Two types of aggression are differentially related to serotonergic activity and the A779C TPH polymorphism. Behav. Neurosci. 119, 16-25. doi: 10.1037/0735-7044.119.1.16
32. Herrmann, M. J., Huter, T., Muller, F., Muhlberger, A., Pauli, P., Reif, A., et al. (2007). Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing. Cereb. Cortex 17, 1160-1163. doi: 10.1093/cercor/bhl026
33. Hesketh, S., Jessop, D. S., Hogg, S., and Harbuz, M. S. (2005). Differential actions of acute and chronic citalopram on the rodent hypothalamic-pituitary-adrenal axis response to acute restraint stress. J. Endocrinol. 185, 373-382. doi: 10.1677/joe.1.06074
34. Homberg, J. R., and Lesch, K. P. (2011). Looking on the bright side of serotonin transporter gene variation. Biol. Psychiatry 69, 513-519. doi: 10.1016/j.biopsych.2010.09.024
35. Jorgensen, H., Riis, M., Knigge, U., Kjaer, A., and Warberg, J. (2003). Serotonin receptors involved in vasopressin and oxytocin secretion. J. Neuroendocrinol 15, 242-249. doi: 10.1046/j.1365-2826.2003.00978.x
36. Kalbitzer, J., Frokjaer, V. G., Erritzoe, D., Svarer, C., Cumming, P., Nielsen, F. A., et al. (2009). The personality trait openness is related to cerebral 5-HTT levels. Neuroimage 45, 280-285. doi: 10.1016/j.neuroimage.2008.12.001
37. Karg, K., Burmeister, M., Shedden, K., and Sen, S. (2011). The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited evidence of genetic moderation. Arch. Gen. Psychiatry 68, 444-454. doi: 10.1001/archgenpsychiatry.2010.189
38. Kazantseva, A. V., Gaysina, D. A., Faskhutdinova, G. G., Noskova, T., Malykh, S. B., and Khusnutdinova, E. K. (2008). Polymorphisms of the serotonin transporter gene (5-HTTLPR, A/G SNP in 5-HTTLPR, and STin2 VNTR) and their relation to personality traits in healthy individuals from Russia. Psychiatr. Genet. 18, 167-176. doi: 10.1097/YPG.0b013e328304deb8
39. Klucken, T., Wehrum, S., Schweckendiek, J., Merz, C. J., Hennig, J., Vaitl, D., et al. (2012). The 5-HTTLPR polymorphism is associated with altered hemodynamic responses during appetitive conditioning. Hum. Brain Mapp. doi: 10.1002/hbm.22085. [Epub ahead of print].
40. Kuepper, Y., Alexander, N., Osinsky, R., Mueller, E., Schmitz, A., Netter, P., et al. (2010). Aggression-interactions of serotonin and testosterone in healthy men and women. Behav. Brain Research 206, 93-100. doi: 10.1016/j.bbr.2009.09.006
41. Kuepper, Y., Bausch, S., Iffland, J., Reuter, M., and Hennig, J. (2006). S-Citalopram in neuroendocrine challenge-tests: serotonergic responsivity in healthy male and female human participants. Psychoneuroendocrinology 31, 1200-1207. doi: 10.1016/j.psyneuen.2006.09.001
42. Kuepper, Y., Wielpuetz, C., Alexander, N., Mueller, E., Grant, P., and Hennig, J. (2012). 5-HTTLPR S-allele: a genetic plasticity factor regarding the effects of life events on personality? Genes Brain Behav. 11, 643-650. doi: 10.1111/j.1601-183X.2012.00783.x
43. Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274, 1527-1531. doi: 10.1126/science.274.5292.1527
44. Lucki, I. (1998). The spectrum of behaviors influenced by serotonin. Biol. Psychiatry 44, 151-162. doi: 10.1016/S0006-3223(98)00139-5
45. Manuck, S. B., Flory, J. D., Ferrell, R. E., and Muldoon, M. F. (2004). Socio-economic status covaries with central nervous system serotonergic responsivity as a function of allelic variation in the serotonin transporter gene-linked polymorphic region. Psychoneuroendocrinology 29, 651-668. doi: 10.1016/S0306-4530(03)00094-5
46. Manuck, S. B., Flory, J. D., McCaffery, J. M., Matthews, K. A., Mann, J. J., and Muldoon, M. F. (1998). Aggression, impulsivity, and central nervous system serotonergic responsivity in a nonpatient sample. Neuropsychopharmacology 19, 287-299.
47. Margraf, J. (1994). Diagnostisches Kurz-Interview bei psychischen Störungen: Mini-DIPS. Berlin: Springer. doi: 10.1007/978-3-662-06753-6
48. Markus, C. R., and De Raedt, R. (2011). Differential effects of 5-httlpr genotypes on inhibition of negative emotional information following acute stress exposure and tryptophan challenge. Neuropsychopharmacology 36, 819-826. doi: 10.1038/npp.2010.221
49. Markus, C. R., and Firk, C. (2009). Differential effects of tri-Allelic 5-HTTLPR polymorphisms in healthy subjects on mood and stress performance after tryptophan challenge. Neuropsychopharmacology 34, 2667-2674. doi: 10.1038/npp.2009.92
50. Marsh, A. A., Finger, E. C., Buzas, B., Soliman, N., Richell, R. A., Vythilingham, M., et al. (2006). Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletion. Psychopharmacology 189, 387-394. doi: 10.1007/s00213-006-0581-2
51. McEwen, B. S. (2001). Genome and hormones: gender differences in physiology-invited review: estrogens effects on the brain: multiple sites and molecular mechanisms. J. Appl. Physiol. 91, 2785-2801.
52. Minelli, A., Bonvicini, C., Scassellati, C., Sartori, R., and Gennarelli, M. (2011). The influence of psychiatric screening in healthy populations selection: a new study and meta-analysis of functional 5-HTTLPR and rs25531 polymorphisms and anxiety-related personality traits. BMC Psychiatry 11:50. doi: 10.1186/1471-244X-11-50
53. Munafo, M. R., Brown, S. M., and Hariri, A. R. (2008). Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biol. Psychiatry 63, 852-857. doi: 10.1016/j.biopsych.2007.08.016
54. Munafo, M. R., Clark, T. G., Moore, L. R., Payne, E., Walton, R., and Flint, J. (2003). Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis. Mol. Psychiatry 8, 471-484. doi: 10.1038/sj.mp.4001326
55. Munafo, M. R., Clark, T. G., Roberts, K. H., and Johnstone, E. C. (2006). Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression. Neuropsychobiology 53, 1-8. doi: 10.1159/000089915
56. Munafo, M. R., Freimer, N. B., Ng, W., Ophoff, R., Veijola, J., Miettunen, J., et al. (2009). 5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B, 271-281. doi: 10.1002/ajmg.b.30808
57. Murthy, N. V., Selvaraj, S., Cowen, P. J., Bhagwagar, Z., Riedel, W. J., Peers, P., et al. (2010). Serotonin transporter polymorphisms (SLC6A4 insertion/deletion and rs25531) do not affect the availability of 5-HTT to [C-11] DASB binding in the living human brain. Neuroimage 52, 50-54. doi: 10.1016/j.neuroimage.2010.04.032
58. Neumeister, A., Hu, X. Z., Luckenbaugh, D. A., Schwarz, M., Nugent, A. C., Bonne, O., et al. (2006). Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls. Arch. Gen. Psychiatry 63, 978-986. doi: 10.1001/archpsyc.63.9.978
59. Nordquist, N., and Oreland, L. (2010). Serotonin, genetic variability, behaviour, and psychiatric disorders-a review. Ups. J. Med. Sci. 115, 2-10. doi: 10.3109/03009730903573246
60. Owens, M. J., Knight, D. L., and Nemeroff, C. B. (2001). Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine. Biol. Psychiatry 50, 345-350. doi: 10.1016/S0006-3223(01)01145-3
61. Parker, K. J., Buckmaster, C. L., Schatzberg, A. F., and Lyons, D. M. (2005). Intranasal oxytocin administration attenuates the ACTH stress response in monkeys. Psychoneuroendocrinology 30, 924-929. doi: 10.1016/j.psyneuen.2005.04.002
62. Patrick, C. J., Curtin, J. J., and Tellegen, A. (2002). Development and validation of a brief form of the multidimensional personality questionnaire. Psychol. Assess. 14, 150-163. doi: 10.1037/1040-3590.14.2.150
63. Pergamin-Hight, L., Bakermans-Kranenburg, M. J., van IJzendoorn, M. H., and Bar-Haim, Y. (2012). Variations in the promoter region of the serotonin transporter gene and biased attention for emotional information: a meta-analysis. Biol. Psychiatry 71, 373-379. doi: 10.1016/j.biopsych.2011.10.030
64. Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., et al. (2005). 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat. Neurosci. 8, 828-834. doi: 10.1038/nn1463
65. Pluess, M., Belsky, J., Way, B. M., and Taylor, S. E. (2010). 5-HTTLPR moderates effects of current life events on neuroticism: differential susceptibility to environmental influences. Prog. Neuropsychopharmacol. Biol. Psychiatry 34, 1070-1074. doi: 10.1016/j.pnpbp.2010.05.028
66. Praschak-Rieder, N., Kennedy, J., Wilson, A. A., Hussey, D., Boovariwala, A., Willeit, M., et al. (2007). Novel 5-HTTLPR allele associates with higher serotonin transporter binding in putamen: a [C-11] DASB positron emission tomography study. Biol. Psychiatry 62, 327-331. doi: 10.1016/j.biopsych.2006.09.022
67. Pruessner, J. C., Kirschbaum, C., Meinlschmid, G., and Hellhammer, D. H. (2003). Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrinology 28, 916-931. doi: 10.1016/S0306-4530(02)00108-7
68. Reimold, M., Smolka, M. N., Schumann, G., Zimmer, A., Wrase, J., Mann, K., et al. (2007). Midbrain serotonin transporter binding potential measured with [C-11]DASB is affected by serotonin transporter genotype. J. Neural Transm. 114, 635-639. doi: 10.1007/s00702-006-0609-0
69. Reist, C., Helmeste, D., Albers, L., Chhay, H., and Tang, S. W. (1996). Serotonin indices and impulsivity in normal volunteers. Psychiatry Res. 60, 177-184. doi: 10.1016/0165-1781(95)02830-7
70. Sen, S., Villafuerte, S., Nesse, R., Stoltenberg, S. F., Hopcian, J., Gleiberman, L., et al. (2004). Serotonin transporter and GABA(A) alpha 6 receptor variants are associated with neuroticism. Biol. Psychiatry 55, 244-249. doi: 10.1016/j.biopsych.2003.08.006
71. Smith, G. S., Lotrich, F. E., Malhotra, A. K., Lee, A. T., Ma, Y. L., Kramer, E., et al. (2004). Effects of serotonin transporter promoter polymorphisms on serotonin function. Neuropsychopharmacology 29, 2226-2234. doi: 10.1038/sj.npp.1300552
72. Sogaard, B., Mengel, H., Rao, N., and Larsen, F. (2005). The pharmacokinetics of escitalopram after oral and intravenous administration of single and multiple doses to healthy subjects. J. Clin. Pharmacol. 45, 1400-1406. doi: 10.1177/0091270005280860
73. Spoont, M. R. (1992). Modulatory role of serotonin in neural information-processing-implications for human psychopathology. Psychol. Bull. 112, 330-350. doi: 10.1037/0033-2909.112.2.330
74. Tatsumi, M., Groshan, K., Blakely, R. D., and Richelson, E. (1997). Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur. J. Pharmacol. 340, 249-258. doi: 10.1016/S0014-2999(97)01393-9
75. Taylor, S. E., Way, B. M., Welch, W. T., Hilmert, C. J., Lehman, B. J., and Eisenberger, N. I. (2006). Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology. Biol. Psychiatry 60, 671-676. doi: 10.1016/j.biopsych.2006.04.019
76. Tellegen, A. (1985). "Structures of mood and personality and their relevance to assessing anxiety, with an emphasis on self-report, " in Anxiety and the Anxiety Disorders, ed A. H. Tuma and, J. Maser (Hillsdale, NY: Lawrence Erlbaum Associates), 681-706.
77. Tellegen, A., and Waller, N. G. (2008). "Exploring personality through test construction: development of the multidimensional personality questionnaire, " in Handbook of Personality Theory and Testing: Personality Measurement and Assessment, Vol. 2, ed G. J. Boyle, G. Matthews, and D. H. Saklofske (Greenwich, CT: JAI Press), 261-292.
78. Terracciano, A., Tanaka, T., Sutin, A. R., Deiana, B., Balaci, L., Sanna, S., et al. (2010). BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism. Neuropsychopharmacology 35, 1083-1089. doi: 10.1038/npp.2009.213
79. Uher, R., and McGuffin, P. (2008). The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis. Mol. Psychiatry 13, 131-146. doi: 10.1038/sj.mp.4002067
80. Uvnas-Moberg, K., Bjorkstrand, E., Hillegaart, V., and Ahlenius, S. (1999). Oxytocin as a possible mediator of SSRI-induced antidepressant effects. Psychopharmacology 142, 95-101. doi: 10.1007/s002130050867
81. Watson, D., Clark, L. A., and Tellegen, A. (1988). Development and validation of brief measures of positive and negative affect-the panas scales. J. Pers. Soc. Psychol. 54, 1063-1070. doi: 10.1037/0022-3514.54.6.1063
82. Whale, R., Quested, D. J., Laver, D., Harrison, P. J., and Cowen, P. J. (2000). Serotonin transporter (5-HTT) promoter genotype may influence the prolactin response to clomipramine. Psychopharmacology 150, 120-122. doi: 10.1007/s002130000432
83. Whitaker-Azmitia, P. M. (2005). Behavioral and cellular consequences of increasing serotonergic activity during brain development: a role in autism? Int. J. Dev. Neurosci. 23, 75-83. doi: 10.1016/j.ijdevneu.2004.07.022
84. Willeit, M., and Praschak-Rieder, N. (2010). Imaging the effects of genetic polymorphisms on radioligand binding in the living human brain: a review on genetic neuroreceptor imaging of monoaminergic systems in psychiatry. Neuroimage 53, 878-892. doi: 10.1016/j.neuroimage.2010.04.030
85. Windle, R. J., Shanks, N., Lightman, S. L., and Ingram, C. D. (1997). Central oxytocin administration reduces stress-induced corticosterone release and anxiety behavior in rats. Endocrinology 138, 2829-2834. doi: 10.1210/en.138.7.2829
86. Wong, W. M., Hasemann, S., Schwarz, M., Zill, P., Koller, G., Soyka, M., et al. (2008). Citalopram neuropharmacological challenge in alcohol-dependent patients and controls: pharmacogenetic, endocrine and psychobehavioral results. Pharmacopsychiatry 41, 72-78. doi: 10.1055/s-2007-1004595
87. Yatham, L. N., and Steiner, M. (1993). Neuroendocrine probes of serotonergic function-a critical-review. Life Sci. 53, 447-463. doi: 10.1016/0024-3205(93)90696-Z
88. Zald, D. H., and Depue, R. A. (2001). Serotonergic functioning correlates with positive and negative affect in psychiatrically healthy males. Pers. Individ. Differ. 30, 71-86. doi: 10.1016/S0191-8869(00)00011-8