5-HTTLPR S-allele: A genetic plasticity factor regarding the effects of life events on personality?

Genes, Brain and Behavior

Volumn 11, Issue 6, 2012, Pages 643-650

  Kuepper, Y ^a   Wielpuetz, C ^a   Alexander, N ^b   Mueller, E ^a   Grant, P ^a   Hennig, J ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

5 HTTLPR; Gene environment interaction; Life satisfaction; Neuroticism; Personality; Positive life events; Stressful life events

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; FEMALE; GENDER; GENETIC ASSOCIATION; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; LIFE EVENT; LIFE SATISFACTION; MAJOR CLINICAL STUDY; MALE; NEUROSIS; PERSONALITY; PRIORITY JOURNAL; S ALLELE; SELF REPORT; SEROTONIN TRANSPORTER LINKED POLYMORPHIC REGION;

ADULT; ALLELES; ENVIRONMENT; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LIFE CHANGE EVENTS; MALE; MOOD DISORDERS; NEURONAL PLASTICITY; PERSONALITY; RISK FACTORS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; YOUNG ADULT;

EID: 84864146103     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2012.00783.x     Document Type: Article

References (40)

1. Alexander, N., Kuepper, Y., Schmitz, A., Osinsky, R., Kozyra, E. & Hennig, J. (2009) Gene-environment interactions predict cortisol responses after acute stress: implications for the etiology of depression. Psychoneuroendocrinology 34, 1294-1303.
2. Beevers, C.G., Marti, C.N., Lee, H.J., Stote, D.L., Ferrell, R.E., Hariri, A.R. & Telch, M.J. (2011) Associations between serotonin transporter gene promoter region (5-HTTLPR) polymorphism and gaze bias for emotional information. J Abnorm Psychol 120, 187-197.
3. Beevers, C.G., Wells, T.T., Ellis, A.J. & McGeary, J.E. (2009) Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli. J Abnorm Psychol 118, 670-681.
4. Belli, R.F., Shay, W.L. & Stafford, F.P. (2001) Event history calendars and question list surveys: a direct comparison of interviewing methods. Public Opin Q 65, 45-74.
5. Belsky, J., Jonassaint, C., Pluess, M., Stanton, M., Brummett, B. & Williams, R. (2009) Vulnerability genes or plasticity genes? Mol Psychiatry 14, 746-754.
6. Brummett, B.H., Boyle, S.H., Siegler, I.C., Kuhn, C.M., Ashley-Koch, A., Jonassaint, C.R., Zuchner, S., Collins, A. & Williams, R.B. (2008a) Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR). Behav Genet 38, 34-43.
7. Brummett, B.H., Muller, C.L., Collins, A.L., Boyle, S.H., Kuhn, C.M., Siegler, I.C., Williams, R.B. & Ashley-Koch, A. (2008b) 5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion. Behav Genet 38, 476-483.
8. Caspi, A., Hariri, A.R., Holmes, A., Uher, R. & Moffitt, T.E. (2010) Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry 167, 509-527.
9. Caspi, A., Sugden, K., Moffitt, T.E., Taylor, A., Craig, I.W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A. & Poulton, R. (2003) Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301, 386-389.
10. Chanock, S.J., Manolio, T., Boehnke, M. et al. (2007) Replicating genotype-phenotype associations. Nature 447, 655-660.
11. Dominguez, R., Cruz-Morales, S.E., Carvalho, M.C., Xavier, M. & Brandao, M.L. (2003) Effect of steroid injection to newborn rats on serotonin activity in frontal cortex and raphe. Neuroreport 14, 597-599.
12. Du, L., Bakish, D. & Hrdina, P.D. (2000) Gender differences in association between serotonin transporter gene polymorphism and personality traits. Psychiatr Genet 10, 159-164.
13. Dumitrescu, L., Ritchie, M.D., Brown-Gentry, K., Pulley, J.M., Basford, M., Denny, J.C., Oksenberg, J.R., Roden, D.M., Haines, J.L. & Crawford, D.C. (2010) Assessing the accuracy of observer-reported ancestry in a biorepository linked to electronic medical records. Genet Med 12, 648-650.
14. Eley, T.C., Sugden, K., Corsico, A., Gregory, A.M., Sham, P., McGuffin, P., Plomin, R. & Craig, I.W. (2004) Gene-environment interaction analysis of serotonin system markers with adolescent depression. Mol Psychiatry 9, 908-915.
15. Fahrenberg, J., Hampel, R. & Selg, H. (1984) Das Freiburger Persönlichkeitsinventar (FPI-R).
16. Fink, G., Sumner, B., Rosie, R., Wilson, H. & McQueen, J. (1999) Androgen actions on central serotonin neurotransmission: relevance for mood, mental state and memory. Behav Brain Res 105, 53-68.
17. Flugge, G., Kramer, M., Rensing, S. & Fuchs, E. (1998) 5HT1A-receptors and behaviour under chronic stress: selective counteraction by testosterone. Eur J Neurosci 10, 2685-2693.
18. Fox, E., Zougkou, K., Ridgewell, A. & Garner, K. (2011) The serotonin transporter gene alters sensitivity to attention bias modification: evidence for a plasticity gene. Biol Psychiatry 70, 1049-1054.
19. Grabe, H.J., Lange, M., Wolff, B., Volzke, H., Lucht, M., Freyberger, H.J., John, U. & Cascorbi, I. (2005) Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden. Mol Psychiatry 10, 220-224.
20. Gray, M.J., Litz, B.T., Hsu, J.L. & Lombardo, T.W. (2004) Psychometric properties of the life events checklist. Assessment 11, 330-341.
21. Holmes, T.H. & Rahe, R.H. (1967) The Social Readjustment Rating Scale. J Psychosom Res 11, 213-218.
22. Kindlundh, A.M., Lindblom, J., Bergstrom, L. & Nyberg, F. (2003) The anabolic-androgenic steroid nandrolone induces alterations in the density of serotonergic 5HT1B and 5HT2 receptors in the male rat brain. Neuroscience 119, 113-120.
23. Lesch, K.P., Bengel, D., Heils, A., Sabol, S.Z., Greenberg, B.D., Petri, S., Benjamin, J., Muller, C.R., Hamer, D.H. & Murphy, D.L. (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274, 1527-1531.
24. Middeldorp, C.M., de Geus, E.J., Willemsen, G., Hottenga, J.J., Slagboom, P.E. & Boomsma, D.I. (2010) The serotonin transporter gene length polymorphism (5-HTTLPR) and life events: no evidence for an interaction effect on neuroticism and anxious depressive symptoms. Twin Res Hum Genet 13, 544-549.
25. Mizuno, T., Aoki, M., Shimada, Y., Inoue, M., Nakaya, K., Takahashi, T., Itoyama, Y., Kanazawa, M., Utsumi, A., Endo, Y., Nomura, T., Hiratsuka, M., Mizugaki, M., Goto, J., Hongo, M. & Fukudo, S. (2006) Gender difference in association between polymorphism of serotonin transporter gene regulatory region and anxiety. J Psychosom Res 60, 91-97.
26. Munafo, M.R., Johnstone, E.C., Wileyto, E.P., Shields, P.G., Elliot, K.M. & Lerman, C. (2006) Lack of association of 5-HTTLPR genotype with smoking cessation in a nicotine replacement therapy randomized trial. Cancer Epidemiol Biomarkers Prev 15, 398-400.
27. Munafo, M.R., Brown, S.M. & Hariri, A.R. (2008) Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biol Psychiatry 63, 852-857.
28. Munafo, M.R., Freimer, N.B., Ng, W., Ophoff, R., Veijola, J., Miettunen, J., Jarvelin, M.R., Taanila, A. & Flint, J. (2009) 5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data. Am J Med Genet B Neuropsychiatr Genet 150B, 271-281.
29. Nakamura, M., Ueno, S., Sano, A. & Tanabe, H. (2000) The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol Psychiatry 5, 32-38.
30. Pluess, M., Belsky, J., Way, B.M. & Taylor, S.E. (2010) 5-HTTLPR moderates effects of current life events on neuroticism: differential susceptibility to environmental influences. Prog Neuropsychopharmacol Biol Psychiatry 34, 1070-1074.
31. Risch, N., Herrell, R., Lehner, T., Liang, K.Y., Eaves, L., Hoh, J., Griem, A., Kovacs, M., Ott, J. & Merikangas, K.R. (2009) Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA 301, 2462-2471.
32. Sarason, I.G., Johnson, J.H. & Siegel, J.M. (1978) Assessing the impact of life changes - development of the life experiences survey. J Consult Clin Tsychol 46, 932-946.
33. Schinka, J.A., Busch, R.M. & Robichaux-Keene, N. (2004) A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Mol Psychiatry 9, 197-202.
34. Sen, S., Burmeister, M. & Ghosh, D. (2004) Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. Am J Med Genet B Neuropsychiatr Genet 127B, 85-89.
35. Sjoberg, R.L., Nilsson, K.W., Nordquist, N., Ohrvik, J., Leppert, J., Lindstrom, L. & Oreland, L. (2006) Development of depression: sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene. Int J Neuropsychopharmacol 9, 443-449.
36. Stoltenberg, S.F. & Vandever, J.M. (2010) Gender moderates the association between 5-HTTLPR and decision-making under ambiguity but not under risk. Neuropharmacology 58, 423-428.
37. Sundblad, C. & Eriksson, E. (1997) Reduced extracellular levels of serotonin in the amygdala of androgenized female rats. Eur Neuropsychopharmacol 7, 253-259.
38. Taylor, S.E., Way, B.M., Welch, W.T., Hilmert, C.J., Lehman, B.J. & Eisenberger, N.I. (2006) Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology. Biol Psychiatry 60, 671-676.
39. Wendland, J.R., Martin, B.J., Kruse, M.R., Lesch, K.P. & Murphy, D.L. (2006) Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry 11, 224-226.
40. Willis-Owen, S.A., Turri, M.G., Munafo, M.R., Surtees, P.G., Wainwright, N.W., Brixey, R.D. & Flint, J. (2005) The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association. Biol Psychiatry 58, 451-456.