5-HTTLPR moderates effects of current life events on neuroticism: Differential susceptibility to environmental influences

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 34, Issue 6, 2010, Pages 1070-1074

  Pluess, Michael ^a   Belsky, Jay ^a   Way, Baldwin M ^b   Taylor, Shelley E ^b  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

5 HTTLPR; Differential susceptibility; Gene environment interaction; Neuroticism; Plasticity; Serotonin transporter

Indexed keywords

SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN;

ADOLESCENT; ADULT; ARTICLE; ASIAN; CAUCASIAN; DISEASE PREDISPOSITION; DNA EXTRACTION; DNA POLYMORPHISM; EFFECT SIZE; ETHNICITY; FEMALE; GENE FREQUENCY; GENETIC VARIABILITY; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HOMOZYGOSITY; HUMAN; LIFE EVENT; MAJOR CLINICAL STUDY; MALE; NEGATIVE SYNDROME; NEUROSIS; POSITIVE SYNDROME; PREDICTION; QUESTIONNAIRE; ALLELE; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; HOMOZYGOTE; INDIVIDUALITY; PHENOTYPE; POLYMERASE CHAIN REACTION; REGRESSION ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SOCIAL ENVIRONMENT;

ALLELES; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOMOZYGOTE; HUMANS; INDIVIDUALITY; LIFE CHANGE EVENTS; NEUROTIC DISORDERS; PHENOTYPE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; QUESTIONNAIRES; REGRESSION ANALYSIS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SOCIAL ENVIRONMENT;

EID: 77955050993     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2010.05.028     Document Type: Article

References (50)

1. Beck A.T., Ward C.H., Mendelson M., Mock J., Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry 1961, 4:561-571. Jun.
2. Belsky J. Variation in susceptibility to rearing influences: an evolutionary argument. Psychol Inq 1997, 8:182-186.
3. Belsky J. Theory testing, effect-size evaluation, and differential susceptibility to rearing influence: the case of mothering and attachment. Child Dev 1997, 68(4):598-600. Aug.
4. Belsky J. Differential susceptibility to rearing influences: an evolutionary hypothesis and some evidence. Origins of the social mind: evolutionary psychology and child development 2005, 139-163. New York, Guildford. B. Ellis, D. Bjorklund (Eds.).
5. Belsky J., Pluess M. Beyond diathesis-stress: differential susceptibility to environmental influences. Psychol Bull 2009, 135(6):885-908. Nov.
6. Belsky J., Bakermans-Kranenburg M.J., van IJzendoorn M.H. For better and for worse: differential susceptibility to environmental influences. Curr Dir Psychol Sci 2007, 16(6):300-304.
7. Belsky J., Jonassaint C., Pluess M., Stanton M., Brummett B., Williams R. Vulnerability genes or plasticity genes?. Mol Psychiatry 2009, 14:746-754. May 19.
8. Boyce W.T., Ellis B.J. Biological sensitivity to context: I. An evolutionary-developmental theory of the origins and functions of stress reactivity. Dev Psychopathol 2005, 17(2):271-301. Spring.
9. Brummett B.H., Boyle S.H., Siegler I.C., Kuhn C.M., Ashley-Koch A., Jonassaint C.R., et al. Effects of environmental stress and gender on associations among symptoms of depression and the serotonin transporter gene linked polymorphic region (5-HTTLPR). Behav Genet 2008, 38(1):34-43. Jan.
10. Brummett B.H., Boyle S.H., Kuhn C.M., Siegler I.C., Williams R.B. Associations among central nervous system serotonergic function and neuroticism are moderated by gender. Biol Psychol 2008, 78(2):200-203. May.
11. Burmeister M., McInnis M.G., Zollner S. Psychiatric genetics: progress amid controversy. Nat Rev Genet 2008, 9(7):527-540. Jul.
12. Caspi A., McClay J., Moffitt T.E., Mill J., Martin J., Craig I.W., et al. Role of genotype in the cycle of violence in maltreated children. Science 2002, 297(5582):851-854. Aug 2.
13. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003, 301(5631):386-389. Jul 18.
14. Caspi A., Roberts B.W., Shiner R.L. Personality development: stability and change. Annu Rev Psychol 2005, 56:453-484.
15. Costa P.T., McCrae R.R. Revised NEO personality factor inventory (NEO PI-R) and NEO five factor inventory. Professional manual 1992, Psychological Assessment Resources, Odessa.
16. Crisan L.G., Pana S., Vulturar R., Heilman R.M., Szekely R., Druga B., et al. Genetic contributions of the serotonin transporter to social learning of fear and economic decision making. Soc Cogn Affect Neurosci 2009, 4(4):399-408. Dec.
17. Eaves L., Heath A., Martin N., Maes H., Neale M., Kendler K., et al. Comparing the biological and cultural inheritance of personality and social attitudes in the Virginia 30,000 study of twins and their relatives. Twin Res 1999, 2(2):62-80. Jun.
18. Eley T.C., Sugden K., Corsico A., Gregory A.M., Sham P., McGuffin P., et al. Gene-environment interaction analysis of serotonin system markers with adolescent depression. Mol Psychiatry 2004, 9(10):908-915. Oct.
19. Ellis B.J., Boyce W.T. Biological sensitivity to context. Curr Dir Psychol Sci 2008, 17(3):183-187. 2008/06//.
20. Fisher R.A. On a distribution yielding the error functions of several well known statistics. Proceedings of the International Congress of Mathematics; 1924; Toronto 1924, 805-813.
21. Flory J.D., Manuck S.B., Ferrell R.E., Dent K.M., Peters D.G., Muldoon M.F. Neuroticism is not associated with the serotonin transporter (5-HTTLPR) polymorphism. Mol Psychiatry 1999, 4(1):93-96. Jan.
22. Garpenstrand H., Annas P., Ekblom J., Oreland L., Fredrikson M. Human fear conditioning is related to dopaminergic and serotonergic biological markers. Behav Neurosci 2001, 115(2):358-364. Apr.
23. Goldberg L.R. A broad-bandwidth, public-domain, personality inventory measuring the lower-level facets of several five-factor models. Personal Psychol Eur 1999, 7:7-28.
24. Hu X.Z., Lipsky R.H., Zhu G., Akhtar L.A., Taubman J., Greenberg B.D., et al. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 2006, 78(5):815-826.
25. Hurt S.W., Widiger T.A., Frances A., Gilmore M., Clarkin J.F. Diagnostic efficiency and DSM-III. Arch Gen Psychiatry 1984, 41(10):1005-1012. Oct.
26. Jang K.L., Livesley W.J., Vernon P.A. Heritability of the big five personality dimensions and their facets: a twin study. J Pers 1996, 64(3):577-591. Sep.
27. Kendler K.S., Gardner C.O., Prescott C.A. Personality and the experience of environmental adversity. Psychol Med 2003, 33(7):1193-1202. Oct.
28. Lang U.E., Bajbouj M., Wernicke C., Rommelspacher H., Danker-Hopfe H., Gallinat J. No association of a functional polymorphism in the serotonin transporter gene promoter and anxiety-related personality traits. Neuropsychobiology 2004, 49(4):182-184.
29. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996, 274(5292):1527-1531. Nov 29.
30. Lonsdorf T.B., Weike A.I., Nikamo P., Schalling M., Hamm A.O., Ohman A. Genetic gating of human fear learning and extinction: possible implications for gene-environment interaction in anxiety disorder. Psychol Sci 2009, 20(2):198-206. Feb.
31. McCrae R., Costa P. The stability of personality: observation and evaluations. Curr Dir Psychol Sci 1994, 3:173-175.
32. Middeldorp C.M., de Geus E.J., Beem A.L., Lakenberg N., Hottenga J.J., Slagboom P.E., et al. Family based association analyses between the serotonin transporter gene polymorphism (5-HTTLPR) and neuroticism, anxiety and depression. Behav Genet 2007, 37(2):294-301. Mar.
33. Mroczek D.K., Spiro A. Modeling intraindividual change in personality traits: findings from the normative aging study. J Gerontol B Psychol Sci Soc Sci 2003, 58(3):P153-P165. May.
34. Munafo M.R., Clark T.G., Moore L.R., Payne E., Walton R., Flint J. Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis. Mol Psychiatry 2003, 8(5):471-484. May.
35. Munafo M.R., Clark T., Flint J. Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis. Mol Psychiatry 2005, 10(4):415-419. Apr.
36. Munafo M.R., Brown S.M., Hariri A.R. Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis. Biol Psychiatry 2008, 63(9):852-857. May 1.
37. Munafo M.R., Freimer N.B., Ng W., Ophoff R., Veijola J., Miettunen J., et al. 5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data. Am J Med Genet B Neuropsychiatr Genet 2009, 150B(2):271-281. Mar 5.
38. Plomin R., Owen M.J., McGuffin P. The genetic basis of complex human behaviors. Science 1994, 264(5166):1733-1739. Jun 17.
39. Roberts B.W., Walton K.E., Viechtbauer W. Patterns of mean-level change in personality traits across the life course: a meta-analysis of longitudinal studies. Psychol Bull 2006, 132(1):1-25. Jan.
40. Schinka J.A., Busch R.M., Robichaux-Keene N. A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Mol Psychiatry 2004, 9(2):197-202. Feb.
41. Scollon C.N., Diener E. Love, work, and changes in extraversion and neuroticism over time. J Pers Soc Psychol 2006, 91(6):1152-1165. Dec.
42. Sen S., Burmeister M., Ghosh D. Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. Am J Med Genet B Neuropsychiatr Genet 2004, 127B(1):85-89. May 15.
43. SPSS for Windows 2007, SPSS, SPSS, Chicago. 16.0.2 ed.
44. Stein M.B., Schork N.J., Gelernter J. Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders. Neuropsychopharmacology 2008, 33(2):312-319. Jan.
45. Taylor S.E., Way B.M., Welch W.T., Hilmert C.J., Lehman B.J., Eisenberger N.I. Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology. Biol Psychiatry 2006, 60(7):671-676. Oct 1.
46. Uher R., McGuffin P. The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis. Mol Psychiatry 2008, 13(2):131-146. Feb.
47. Vinberg M., Mellerup E., Andersen P.K., Bennike B., Kessing L.V. Variations in 5-HTTLPR: relation to familiar risk of affective disorder, life events, neuroticism and cortisol. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2009, 34(1):86-91. Feb 1.
48. Way B.M., Gurbaxani B.M. A genetics primer for social health research. Social and Personality Psychology Compass 2008, 2(2):785-816.
49. Wilhelm K., Mitchell P.B., Niven H., Finch A., Wedgwood L., Scimone A., et al. Life events, first depression onset and the serotonin transporter gene. Br J Psychiatry 2006, 188:210-215. Mar.
50. Willis-Owen S.A., Turri M.G., Munafo M.R., Surtees P.G., Wainwright N.W., Brixey R.D., et al. The serotonin transporter length polymorphism, neuroticism, and depression: a comprehensive assessment of association. Biol Psychiatry 2005, 58(6):451-456. Sep 15.