Associations between serotonin transporter gene promoter region (5-HTTLPR) polymorphism and gaze bias for emotional information

Journal of Abnormal Psychology

Volumn 120, Issue 1, 2011, Pages 187-197

  Beevers, Christopher G ^a   Marti, C Nathan ^a   Lee, Han Joo ^b   Stote, Deborah L ^a   Ferrell, Robert E ^c   Hariri, Ahmad R ^d   Telch, Michael J ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

^d DUKE UNIVERSITY   (United States)

Author keywords

Cognitive bias; Emotion processing; Eye tracking; Polymorphism; Serotonin

Indexed keywords

SEROTONIN TRANSPORTER;

ADULT; ALLELE; ARTICLE; BRAIN FUNCTION; CONTROLLED STUDY; EMOTIONALITY; EYE FIXATION; EYE TRACKING; FACIAL EXPRESSION; FEMALE; GAZE; GENETIC ASSOCIATION; GENOTYPE; HETEROZYGOTE; HUMAN; HUMAN EXPERIMENT; MALE; OBSERVER BIAS; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; VISUAL STIMULATION;

EID: 79951541210     PISSN: 0021843X     EISSN: 19391846     Source Type: Journal    
DOI: 10.1037/a0022125     Document Type: Article

References (52)

1. Diagnostic and statistical manual of mental disorders 1994, American Psychiatric Association, Author, Washington, DC. 4th ed.
2. Beevers C.G. Cognitive vulnerability to depression: A dual process model. Clinical Psychology Review 2005, 25:975-1002. doi: 10.1016/j.cpr.2005.03.003.
3. Beevers C.G., Ellis A.J., Wells T.T., McGeary J.E. Serotonin transporter gene promoter region polymorphism and selective processing of emotional images. Biological Psychology 2010, 83:260-265. doi: 10.1016/j.biopsycho.2009.08.007.
4. Beevers C.G., Gibb B.E., McGeary J.E., Miller I.W. Serotonin transporter genetic variation and biased attention for emotional word stimuli among psychiatric inpatients. Journal of Abnormal Psychology 2007, 116:208-212. doi: 10.1037/0021-843X.116.1.208.
5. Beevers C.G., Wells T., Ellis A.J., McGeary J.E. Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli. Journal of Abnormal Psychology 2009, 118:670-681. doi: 10.1037/a0016198.
6. Belsky J., Pluess M. Beyond diathesis stress: Differential susceptibility to environmental influences. Psychological Bulletin 2009, 135:885-908. doi: 10.1037/a0017376.
7. Boyce W.T., Ellis B.J. Biological sensitivity to context: I. An evolutionary-developmental theory of the origins and functions of stress reactivity. Development and Psychopathology 2005, 17:271-301.
8. Bradley B.P., Mogg K., Millar N.H. Covert and overt orienting of attention to emotional faces in anxiety. Cognition and Emotion 2000, 14:789-808. doi: 10.1080/02699930050156636.
9. Canli T., Congdon E., Todd Constable R., Lesch K.P. Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing. Biological Psychology 2008, 79:118-125. doi: 10.1016/j.biopsycho.2008.01.004.
10. Canli T., Omura K., Haas B.W., Fallgatter A., Constable R.T., Lesch K.P. Beyond affect: A role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:12224-12229. doi: 10.1073/pnas.0503880102.
11. Carver C.S., Johnson S.L., Joormann J. Serotonergic function, two-mode models of self-regulation, and vulnerability to depression: What depression has in common with impulsive aggression. Psychological Bulletin 2008, 134:912-943. doi: 10.1037/a0013740.
12. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., Poulton R. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science 2003, 301:386-389. doi: 10.1126/science.1083968.
13. Chiao J.Y., Blizinsky K.D. Culture-gene coevolution of individualism-collectivism and the serotonin transporter gene. Proceedings of the Royal Society B: Biological Sciences 2010, 277:529-537. doi: 10.1098/rspb.2009.1650.
14. Ekman P., Friesen W.V. Pictures of facial affect 1976, Consulting Psychologists Press, Palo Alto, CA.
15. Ellis B.J., Boyce W.T. Biological sensitivity to context. Current Directions in Psychological Science 2008, 17:183-187. doi: 10.1111/j.1467-8721.2008.00571.x.
16. First M.B., Spitzer R.L., Gibbon M., Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders: Patient Edition (SCID I/P, Version 2.0, 8/98 revision) 1998, New York State Psychiatric Institute, Biometrics Research Department, New York, NY.
17. Fox E., Ridgewell A., Ashwin C. Looking on the bright side: Biased attention and the human serotonin transporter gene. Proceedings of the Royal Society B: Biological Sciences 2009, 276:1747-1751. doi: 10.1098/rspb.2008.1788.
18. Gelernter J., Kranzler H., Coccaro E.F., Siever L.J., New A.S. Serotonin transporter protein gene polymorphism and personality measures in African American and European American subjects. American Journal of Psychiatry 1998, 155:1332-1338.
19. Gelernter J., Kranzler H., Cubells J.F. Serotonin transporter protein (SLC6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populations and in alcohol-dependent subjects. Human Genetics 1997, 101:243-246. doi: 10.1007/s004390050624.
20. Greenwald A.G., Pratkanis A.R., Leippe M.R., Baumgardner M.H. Under what conditions does theory obstruct research progress?. Psychological Review 1986, 93:216-229. doi: 10.1037/0033-295X.93.2.216.
21. Gross J.J., Munoz R.F. Emotion regulation and mental health. Clinical Psychology: Science and Practice 1995, 2:151-164. doi: 10.1111/j.1468-2850.1995.tb00036.x.
22. Hariri A.R., Holmes A. Genetics of emotional regulation: The role of the serotonin transporter in neural function. Trends in Cognitive Sciences 2006, 10:182-191. doi: 10.1016/j.tics.2006.02.011.
23. Hariri A.R., Mattay V.S., Tessitore A., Kolachana B., Fera F., Goldman D., Weinberger D.R. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002, 297:400-403. doi: 10.1126/science.1071829.
24. Hartlage S., Alloy L.B., Vázquez C., Dykman B. Automatic and effortful processing in depression. Psychological Bulletin 1993, 113:247-278. doi: 10.1037/0033-2909.113.2.247.
25. Hasler G., Drevets W.C., Manji H.K., Charney D.S. Discovering endophenotypes for major depression. Neuropsychopharmacology 2004, 29:1765-1781. doi: 10.1038/sj.npp.1300506.
26. Heinz A., Braus D.F., Smolka M.N., Wrase J., Puls I., Hermann D., Büchel C. Amygdala-prefrontal coupling depends on a genetic variation of the serotonin transporter. Nature Neuroscience 2005, 8:20-21. doi: 10.1038/nn1366.
27. Heinz A., Jones D.W., Mazzanti C., Goldman D., Ragan P., Hommer D., Weinberger D.R. A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biological Psychiatry 2000, 47:643-649. doi: 10.1016/S0006-3223(99)00171-7.
28. Hermans D., Vansteenwegen D., Eelen P. Eye movement registration as a continuous index of attention deployment: Data from a group of spider anxious students. Cognition & Emotion 1999, 13:419-434. doi: 10.1080/026999399379249.
29. Hu X., Oroszi G., Chun J., Smith T.L., Goldman D., Schuckit M.A. An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcoholism: Clinical and Experimental Research 2005, 29:8-16. doi: 10.1097/01.ALC.0000150008.68473.62.
30. Ioannidis J.P.A., Ntzani E.E., Trikalinos T.A., Contopoulos-Ioannidis D.G. Replication validity of genetic association studies. Nature Genetics 2001, 29:306-309. doi: 10.1038/ng749.
31. Isaacowitz D.M. Motivated gaze: The view from the gazer. Current Directions in Psychological Science 2006, 15:68-72. doi: 10.1111/j.0963-7214.2006.00409.x.
32. Kaufman J., Yang B.-Z., Douglas-Palumberi H., Houshyar S., Lipschitz D., Krystal J.H., et al. Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings of the National Academy of Sciences of the United States of America 2004, 101:17316-17321. doi: 10.1073/pnas.0404376101.
33. Kellough J.L., Beevers C.G., Ellis A.J., Wells T.T. Time course of selective attention in clinically depressed young adults: An eye tracking study. Behaviour Research and Therapy 2008, 46:1238-1243.
34. Lee B.T., Ham B.J. Serotonergic genes and amygdala activity in response to negative affective facial stimuli in Korean women. Genes, Brain, and Behavior 2008, 7:899-905. doi: 10.1111/j.1601-183X.2008.00429.x.
35. Lesch K.-P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., Murphy D.L. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996, 274:1527-1531. doi: 10.1126/science.274.5292.1527.
36. Maxwell S.E. The persistence of underpowered studies in psychological research: Causes, consequences, and remedies. Psychological Methods 2004, 9:147-163. doi: 10.1037/1082-989X.9.2.147.
37. Munafò M.R., Brown S.M., Hariri A.R. Serotonin transporter (5-HTTLPR) genotype and amygdala activation: A meta-analysis. Biological Psychiatry 2008, 63:852-857. doi: 10.1016/j.biopsych.2007.08.016.
38. Munafò M.R., Durrant C., Lewis G., Flint J. Gene × environment interactions at the serotonin transporter locus. Biological Psychiatry 2008, 65:211-219.
39. Osinsky R., Reuter M., Küpper Y., Schmitz A., Kozyra E., Alexander N., Hennig J. Variation in the serotonin transporter gene modulates selective attention to threat. Emotion 2008, 8:584-588. doi: 10.1037/a0012826.
40. Pacheco J., Beevers C.G., Benavides C., McGeary J., Stice E., Schnyer D.M. Frontal-limbic white matter pathway associations with the serotonin transporter gene promoter region (5-HTTLPR) polymorphism. Journal of Neuroscience 2009, 29:6229-6233. doi: 10.1523/JNEUROSCI.0896-09.2009.
41. Pérez-Edgar K., Bar-Haim Y., McDermott J.M., Gorodetsky E., Hodgkinson C.A., Goldman D., Fox N.A. Variations in the serotonin-transporter gene are associated with attention bias patterns to positive and negative emotion faces. Biological Psychology 2010, 83:269-271. doi: 10.1016/j.biopsycho.2009.08.009.
42. Pezawas L., Meyer-Lindenberg A., Drabant E.M., Verchinski B.A., Munoz K.E., Kolachana B.S., Weinberger D.R. 5-HTTLPR polymorphism impacts human cingulated-amygdala interactions: A genetic susceptibility mechanism for depression. Nature Neuroscience 2005, 8:828-834. doi: 10.1038/nn1463.
43. Pezawas L., Meyer-Lindenberg A., Goldman A.L., Verchinski B.A., Chen G., Kolachana B.S., Weinberger D.R. Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression. Molecular Psychiatry 2008, 13:709-716. doi: 10.1038/mp.2008.32.
44. Posner M.I., Rothbart M.K. Developing mechanisms of self-regulation. Development and Psychopathology 2000, 12:427-441. doi: 10.1017/S0954579400003096.
45. Rinck M., Becker E.S. Spider fearful individuals attend to threat, then quickly avoid it: Evidence from eye movements. Journal of Abnormal Psychology 2006, 115:231-238. doi: 10.1037/0021-843X.115.2.231.
46. Rogers N.L., Cole S.A., Lan H.C., Crossa A. New saliva DNA collection method compared to buccal cell collection techniques for epidemiological studies. American Journal of Human Biology 2007, 19:319-326. doi: 10.1002/ajhb.20586.
47. Thomas K.M., Drevets W.C., Dahl R.E., Ryan N.D., Birmaher B., Eccard C.H., Casey B.J. Amygdala response to fearful faces in anxious and depressed children. Archives of General Psychiatry 2001, 58:1057-1063. doi: 10.1001/archpsyc.58.11.1057.
48. Wendland J.R., Martin B.J., Kruse M.R., Lesch K.P., Murphy D.L. Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Molecular Psychiatry 2006, 11:224-226. doi: 10.1038/sj.mp.4001789.
49. Xing C., Isaacowitz D.M. Aiming at happiness: How motivation affects attention to and memory for emotional images. Motivation and Emotion 2006, 30:243-250. doi: 10.1007/s11031-006-9032-y.
50. Yoon K.L., Zinbarg R.E. Threat is in the eye of the beholder: Social anxiety and the interpretation of ambiguous facial expressions. Behaviour Research and Therapy 2007, 45:839-847. doi: 10.1016/j.brat.2006.05.004.
51. Yoon K.L., Zinbarg R.E. Interpreting neutral faces as threatening is a default mode for socially anxious individuals. Journal of Abnormal Psychology 2008, 117:680-685. doi: 10.1037/0021-843X.117.3.680.
52. Zalsman G., Huang Y., Oquendo M.A., Burke A.K., Hu X., Brent D.A., Mann J.J. Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. American Journal of Psychiatry 2006, 163:1588-1593. doi: 10.1176/appi.ajp.163.9.1588.