Distal Loop Flexibility of a Regulatory Domain Modulates Dynamics and Activity of C-Terminal Src Kinase (Csk)

PLoS Computational Biology

Volumn 9, Issue 9, 2013, Pages

  Barkho, Sulyman ^a   Pierce, Levi C T ^a,d   McGlone, Maria L ^a   Li, Sheng ^b   Woods, Virgil L ^b   Walker, Ross C ^a,c   Adams, Joseph A ^b   Jennings, Patricia A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SCHRÖDINGER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DYNAMICS; ENZYMES;

C-TERMINAL SRC KINASE; CATALYTIC FUNCTIONS; CD LOOPS; KINASE DOMAINS; NATIVE PROTEINS; PROTEIN DYNAMICS; SH2 DOMAIN; SRC FAMILY; SURFACE SITES; TYROSINE KINASE;

CATALYSIS;

PROTEIN TYROSINE KINASE;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; NONHUMAN; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; SIMULATION;

AMINO ACID SEQUENCE; BIOCATALYSIS; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; SEQUENCE HOMOLOGY, AMINO ACID; SRC HOMOLOGY DOMAINS; SRC-FAMILY KINASES;

EID: 84884690289     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003188     Document Type: Article

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