Proteins at work: A combined small angle x-ray scattering and theoretical determination of the multiple structures involved on the protein kinase functional landscape

Journal of Biological Chemistry

Volumn 285, Issue 46, 2010, Pages 36121-36128

  Jamros, Michael A ^a   Oliveira, Leandro C ^a   Whitford, Paul C ^a,c   Onuchic, José N ^a   Adams, Joseph A ^b   Blumenthal, Donald K ^d   Jennings, Patricia A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b San Diego   (United States)

^c LOS ALAMOS NATIONAL LABORATORY   (United States)

^d UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSEMBLY PROCESS; ATOM STRUCTURE; BIOLOGICAL MACROMOLECULE; C-TERMINAL SRC KINASE; COMBINATION ANALYSIS; COMPACT STRUCTURES; CRYSTALLOGRAPHIC STUDIES; ENERGY BASINS; EXPERIMENTAL DATA; EXTENDED STRUCTURES; LOCAL INTERACTIONS; MULTIPLE STRUCTURES; OPEN CONFORMATION; PROTEIN KINASE; REGULATORY DOMAIN; RIGID MODEL; SCATTERING CURVE; SMALL ANGLE X-RAY SCATTERING; SRC FAMILY; STRUCTURAL STUDIES; THERMAL FLUCTUATIONS; TYROSINE KINASE;

AMINO ACIDS; CONFORMATIONS; LAWS AND LEGISLATION; POPULATION STATISTICS; SCATTERING; X RAY SCATTERING;

CRYSTAL ATOMIC STRUCTURE;

PROTEIN TYROSINE KINASE;

ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DOWN REGULATION; ENTROPY; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME STRUCTURE; MACROMOLECULE; METHODOLOGY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; X RAY CRYSTALLOGRAPHY;

ALGORITHMS; CRYSTALLIZATION; ENERGY TRANSFER; ESCHERICHIA COLI; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN CONFORMATION; PROTEIN-TYROSINE KINASES; RECOMBINANT PROTEINS; SCATTERING, SMALL ANGLE; SRC HOMOLOGY DOMAINS; X-RAY DIFFRACTION;

EID: 78149258244     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.116947     Document Type: Article

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