Hydrophobic interaction between the SH2 domain and the kinase domain is required for the activation of Csk

Journal of Molecular Biology

Volumn 399, Issue 4, 2010, Pages 618-627

  Mikkola, Esa T ^a   Gahmberg, Carl G ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Csk; Point mutation; Protein tyrosine kinase; SH2 domain; C helix

Indexed keywords

ALANINE; AMINO ACID; C TERMINAL SRC KINASE; GLYCINE; LEUCINE; PROTEIN SH2; PROTEIN TYROSINE KINASE; TYROSINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CELL STRAIN HEK293; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; HYDROPHOBICITY; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; SURFACE PROPERTY;

EID: 77954759616     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.04.045     Document Type: Article

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