Modal gating of NMDA receptors and the shape of their synaptic response

Nature Neuroscience

Volumn 6, Issue 5, 2003, Pages 476-483

  Popescu, Gabriela ^a   Auerbach, Anthony ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT;

ARTICLE; CHANNEL GATING; DISSOCIATION; EMBRYO; EXCITATORY POSTSYNAPTIC POTENTIAL; HUMAN; HUMAN CELL; KINETICS; PRIORITY JOURNAL; RECEPTOR OCCUPANCY; SYNAPSE;

EID: 0037407919     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1044     Document Type: Article

References (44)

1. Attwell, D. & Laughlin, S.B. An energy budget for signaling in the grey matter of the brain. J. Cereb. Blood Flow Metab. 21, 1133-1145 (2001).
2. McBain, C.J. & Mayer, M.L. N-methyl-D-aspartic acid receptor structure and function. Physiol. Rev. 74, 723-760 (1994).
3. Dingledine, R., Borges, K., Bowie, D. & Traynelis, S.F. The glutamate receptor ion channels. Pharmacol. Rev. 51, 7-61 (1999).
4. Rosenmund, C., Stern-Bach, Y. & Stevens, C.F. The tetrameric structure of a glutamate receptor channel [see comments]. Science 280, 1596-1599 (1998).
5. Behe, P. et al. Determination of NMDA NR1 subunit copy number in recombinant NMDA receptors. Proc. R. Soc. Lond. B Biol. Sci. 262, 205-213 (1995).
6. Premkumar, L.S. & Auerbach, A. Stoichiometry of recombinant N-methyl-D-aspartate receptor channels inferred from single-channel current patterns. J. Gen. Physiol. 110, 485-502 (1997).
7. Lester, R.A. & Jahr, C.E. NMDA channel behavior depends on agonist affinity. J. Neurosci. 12, 635-643 (1992).
8. Jahr, C.E. & Stevens, C.F. A quantitative description of NMDA receptor-channel kinetic behavior. J. Neurosci. 10, 1830-1837 (1990).
9. Howe, J.R., Cull-Candy, S.G. & Colquhoun, D. Currents through single glutamate receptor channels in outside-out patches from rat cerebellar granule cells. J. Physiol. (Lond.) 432, 143-202 (1991).
10. Gibb, A.J. & Colquhoun, D. Glutamate activation of a single NMDA receptor-channel produces a cluster of channel openings. Proc. R. Soc. Lond. B Biol. Sci. 243, 39-45 (1991).
11. Kleckner, N.W. & Pallotta, B.S. Burst kinetics of single NMDA receptor currents in cell-attached patches from rat brain cortical neurons in culture. J. Physiol. 486, 411-426 (1995).
12. Stern, P., Cik, M., Colquhoun, D. & Stephenson, F.A. Single channel properties of cloned NMDA receptors in a human cell line: comparison with results from Xenopus oocytes. J. Physiol. (Lond.) 476, 391-397 (1994).
13. Willie, D.J., Behe, P. & Colquhoun, D. Single-channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors. J. Physiol. 510, 1-18 (1998).
14. Sakmann, B., Patlak, J. & Neher, E. Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist. Nature 286, 71-73 (1980).
15. Premkumar, L.S. & Auerbach, A. Identification of a high affinity divalent cation binding site near the entrance of the NMDA receptor channel. Neuron 16, 869-880 (1996).
16. 2+ block of the N-methyl-D-aspartate receptor channel. J. Gen. Physiol. 117, 275-286 (2001).
17. Vissel, B., Krupp, J.J., Heinemann, S.F. & Westbrook, G.L. A use-dependent tyrosine dephosphorylation of NMDA receptors is independent of ion flux. Nat. Neurosci. 4, 587-596 (2001).
18. Leffler, J.E. & Grunwald, E. Rates and Equilibria of Organic Reactions (Wiley, New York, 1963).
19. Jahr, C.E. High probability opening of NMDA receptor channels by L-glutamate. Science 255, 470-472 (1992).
20. Forsythe, I.D. & Westbrook, G.L. Slow excitatory postsynaptic currents mediated by N-methyl-D-aspartate receptors on cultured mouse central neurones. J. Physiol. 396, 515-533 (1988).
21. Hestrin, S., Sah, P. & Nicoll, R.A. Mechanisms generating the time course of dual component excitatory synaptic currents recorded in hippocampal slices. Neuron 5, 247-253 (1990).
22. Lester, R.A., Clements, J.D., Westbrook, G.L. & Jahr, C.E. Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents. Nature 346, 565-567 (1990).
23. Vicini, S. et al. Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors. J. Neurophysiol. 79, 555-566 (1998).
24. Jahr, C.E. & Stevens, C.F. Glutamate activates multiple single channel conductances in hippocampal neurons. Nature 325, 522-525 (1987).
25. Howe, J.R., Colquhoun, D. & Cull-Candy, S.G. On the kinetics of large-conductance glutamate-receptor ion channels in rat cerebellar granule neurons. Proc. R. Soc. Lond. B Biol. Sci. 233, 407-422 (1988).
26. Auerbach, A. & Lingle, C.J. Heterogeneous kinetic properties of acetylcholine receptor channels in Xenopus myocytes. J. Physiol. 378, 119-140 (1986).
27. Naranjo, D. & Brehm, P. Modal shifts in acetylcholine receptor channel gating confer subunit-dependent desensitization. Science 260, 1811-1814 (1993).
28. Milone, M. et al. Mode switching kinetics produced by a naturally occurring mutation in the cytoplasmic loop of the human acetylcholine receptor epsilon subunit. Neuron 20, 575-588 (1998).
29. Howe, J.R. & Ritchie, J.M. Multiple kinetic components of sodium channel inactivation in rabbit Schwann cells. J. Physiol. 455, 529-566 (1992).
30. + channels expressed in Xenopus oocytes. J. Physiol. 524, 737-755 (2000).
31. + channel in the heart. Modal regulation by G protein beta gamma subunits. J. Gen. Physiol. 112, 199-210 (1998).
32. + channel switches between two distinct gating modes resulting in either inward-rectifying or "leak" current. FEBS Lett. 505, 233-239 (2001).
33. Delcour, A.H., Lipscombe, D. & Tsien, R.W. Multiple modes of N-type calcium channel activity distinguished by differences in gating kinetics. J. Neurosci. 13, 181-194 (1993).
34. Delcour, A.H. & Tsien, R.W. Altered prevalence of gating modes in neurotransmitter inhibition of N- type calcium channels. Science 259, 980-984 (1993).
35. Catacuzzeno, L., Trequattrini, C., Petris, A. & Franciolini, F. Bimodal kinetics of a chloride channel from human fibroblasts. J. Membr. Biol. 170, 165-172 (1999).
36. Banke, T.G. & Traynelis, S.F. Activation of NR1/NR2B NMDA receptors. Nat. Neurosci. 6, 144-152 (2003).
37. Grosman, C. & Auerbach, A. The dissociation of acetylcholine from open nicotinic receptor channels. Proc. Natl. Acad. Sci. USA 98, 14102-14107 (2001).
38. Moriyoshi, K. et al. Molecular cloning and characterization of the rat NMDA receptor [see comments]. Nature 354, 31-37 (1991).
39. Monyer, H. et al. Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 256, 1217-1221 (1992).
40. Chen, C. & Okayama, H. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7, 2745-2752 (1987).
41. Hamill, O.P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F.J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391, 85-100 (1981).
42. Qin, F., Auerbach, A. & Sachs, F. Maximum likelihood estimation of aggregated Markov processes. Proc. R. Soc. Lond. B Biol. Sci. 264, 375-383 (1997).
43. Magleby, K.L. & Pallotta, B.S. Burst kinetics of single calcium-activated potassium channels in cultured rat muscle. J. Physiol. 344, 605-623 (1983).
44. Clements, J.D., Lester, R.A., Tong, G., Jahr, C.E. & Westbrook, G.L. The time course of glutamate in the synaptic cleft. Science 258, 1498-1501 (1992).