메뉴 건너뛰기




Volumn 62, Issue 18, 2005, Pages 2100-2111

Mechanism-based targeting of NMDA receptor functions

Author keywords

Activation kinetics; Drug effects; Kinetic modeling; Molecular pharmacology; Multi step gating; N methyl D aspartate receptor; Single channel currents; Synaptic transmission

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

EID: 24744440576     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-005-5227-8     Document Type: Review
Times cited : (26)

References (121)
  • 1
    • 0028179069 scopus 로고
    • N-methyl-D-aspartic acid receptor structure and function
    • McBain C. J. and Mayer M. L. (1994) N-methyl-D-aspartic acid receptor structure and function. Physiol. Rev. 74: 723-760.
    • (1994) Physiol. Rev. , vol.74 , pp. 723-760
    • McBain, C.J.1    Mayer, M.L.2
  • 3
    • 0037216407 scopus 로고    scopus 로고
    • The N-methyl-D-aspartate receptor subunit NR2B: Localization, functional properties, regulation and clinical implications
    • Loftis J. M. and Janowsky A. (2003) The N-methyl-D-aspartate receptor subunit NR2B: localization, functional properties, regulation and clinical implications. Pharmacol. Ther. 97: 55-85.
    • (2003) Pharmacol. Ther. , vol.97 , pp. 55-85
    • Loftis, J.M.1    Janowsky, A.2
  • 4
    • 0347091932 scopus 로고    scopus 로고
    • Glutamate, dopamine, and schizophrenia: From pathophysiology to treatment
    • Laruelle M., Kegeles L. S. and Abi-Dargham A. (2003) Glutamate, dopamine, and schizophrenia: from pathophysiology to treatment. Ann. N. Y. Acad. Sci. 1003: 138-158.
    • (2003) Ann. N. Y. Acad. Sci. , vol.1003 , pp. 138-158
    • Laruelle, M.1    Kegeles, L.S.2    Abi-Dargham, A.3
  • 5
    • 0034859802 scopus 로고    scopus 로고
    • The NMDA receptor complex: A promising target for novel antiepileptic strategies
    • Kohl B. K. and Dannhardt G. (2001) The NMDA receptor complex: a promising target for novel antiepileptic strategies. Curr. Med. Chem. 8: 1275-1289.
    • (2001) Curr. Med. Chem. , vol.8 , pp. 1275-1289
    • Kohl, B.K.1    Dannhardt, G.2
  • 6
    • 0033789895 scopus 로고    scopus 로고
    • The role of mammalian ionotropic receptors in synaptic plasticity: LTP, LTD and epilepsy
    • Kullmann D. M., Asztely F. and Walker M. C. (2000) The role of mammalian ionotropic receptors in synaptic plasticity: LTP, LTD and epilepsy. Cell. Mol. Life Sci. 57: 1551-1561.
    • (2000) Cell. Mol. Life Sci. , vol.57 , pp. 1551-1561
    • Kullmann, D.M.1    Asztely, F.2    Walker, M.C.3
  • 7
    • 8844219777 scopus 로고    scopus 로고
    • Cellular neuroplasticity mechanisms mediating pain persistence
    • Salter M. W. (2004) Cellular neuroplasticity mechanisms mediating pain persistence. J. Orofac. Pain 18: 318-324.
    • (2004) J. Orofac. Pain , vol.18 , pp. 318-324
    • Salter, M.W.1
  • 8
    • 13544268511 scopus 로고    scopus 로고
    • N-methyl-D-aspartate receptor subtypes: Multiple roles in excitotoxicity and neurological disease
    • Waxman E. A. and Lynch D. R. (2005) N-methyl-D-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease. Neuroscientist 11: 37-49.
    • (2005) Neuroscientist , vol.11 , pp. 37-49
    • Waxman, E.A.1    Lynch, D.R.2
  • 9
    • 0036830627 scopus 로고    scopus 로고
    • NMDA receptor pathways as drug targets
    • Kemp J. A. and McKernan R. M. (2002) NMDA receptor pathways as drug targets. Nat. Neurosci. 5 Suppl.: 1039-1042.
    • (2002) Nat. Neurosci. , vol.5 , Issue.SUPPL. , pp. 1039-1042
    • Kemp, J.A.1    McKernan, R.M.2
  • 11
    • 0029944179 scopus 로고    scopus 로고
    • Kinetics of NMDA channel opening
    • Dzubay J. A. and Jahr C. E. (1996) Kinetics of NMDA channel opening. J. Neurosci. 16: 4129-4134.
    • (1996) J. Neurosci. , vol.16 , pp. 4129-4134
    • Dzubay, J.A.1    Jahr, C.E.2
  • 12
    • 0029876527 scopus 로고    scopus 로고
    • Transmitter timecourse in the synaptic cleft: Its role in central synaptic function
    • Clements J. D. (1996) Transmitter timecourse in the synaptic cleft: its role in central synaptic function. Trends Neurosci. 19: 163-171.
    • (1996) Trends Neurosci. , vol.19 , pp. 163-171
    • Clements, J.D.1
  • 13
    • 0023856147 scopus 로고
    • Slow excitatory postsynaptic currents mediated by N-methyl-D-aspartate receptors on cultured mouse central neurones
    • Forsythe I. D. and Westbrook G. L. (1988) Slow excitatory postsynaptic currents mediated by N-methyl-D-aspartate receptors on cultured mouse central neurones. J. Physiol. 396: 515-533.
    • (1988) J. Physiol. , vol.396 , pp. 515-533
    • Forsythe, I.D.1    Westbrook, G.L.2
  • 14
    • 0025361209 scopus 로고
    • Analysis of excitatory synaptic action in pyramidal cells using whole-cell recording from rat hippocampal slices
    • Hestrin S., Nicoll R. A., Perkel D. J. and Sah P. (1990) Analysis of excitatory synaptic action in pyramidal cells using whole-cell recording from rat hippocampal slices. J. Physiol. 422: 203-225.
    • (1990) J. Physiol. , vol.422 , pp. 203-225
    • Hestrin, S.1    Nicoll, R.A.2    Perkel, D.J.3    Sah, P.4
  • 15
    • 0025368726 scopus 로고
    • Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents
    • Lester R. A., Clements J. D., Westbrook G. L. and Jahr C. E. (1990) Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents. Nature 346: 565-567.
    • (1990) Nature , vol.346 , pp. 565-567
    • Lester, R.A.1    Clements, J.D.2    Westbrook, G.L.3    Jahr, C.E.4
  • 16
    • 0026582879 scopus 로고
    • High probability opening of NMDA receptor channels by L-glutamate
    • Jahr C. E. (1992) High probability opening of NMDA receptor channels by L-glutamate. Science 255: 470-472.
    • (1992) Science , vol.255 , pp. 470-472
    • Jahr, C.E.1
  • 17
    • 0028965220 scopus 로고
    • Synaptic NMDA receptor channels have a low open probability
    • Rosenmund C., Feltz A. and Westbrook G. L. (1995) Synaptic NMDA receptor channels have a low open probability. J. Neurosci. 15: 2788-2795.
    • (1995) J. Neurosci. , vol.15 , pp. 2788-2795
    • Rosenmund, C.1    Feltz, A.2    Westbrook, G.L.3
  • 18
    • 0021341121 scopus 로고
    • Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
    • Mayer M. L., Westbrook G. L. and Guthrie P. B. (1984) Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones. Nature 309: 261-263.
    • (1984) Nature , vol.309 , pp. 261-263
    • Mayer, M.L.1    Westbrook, G.L.2    Guthrie, P.B.3
  • 19
    • 0021260967 scopus 로고
    • Magnesium gates glutamate-activated channels in mouse central neurones
    • Nowak L., Bregestovski P., Ascher P., Herbet A. and Prochiantz A. (1984) Magnesium gates glutamate-activated channels in mouse central neurones. Nature 307: 462-465.
    • (1984) Nature , vol.307 , pp. 462-465
    • Nowak, L.1    Bregestovski, P.2    Ascher, P.3    Herbet, A.4    Prochiantz, A.5
  • 21
    • 0020644368 scopus 로고
    • N-methyl aspartate activates voltage-dependent calcium conductance in rat hippocampal pyramidal cells
    • Dingledine, R. (1983) N-methyl aspartate activates voltage-dependent calcium conductance in rat hippocampal pyramidal cells. J. Physiol. 343: 385-405.
    • (1983) J. Physiol. , vol.343 , pp. 385-405
    • Dingledine, R.1
  • 22
    • 0022479032 scopus 로고
    • NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
    • MacDermott A. B., Mayer M. L., Westbrook G. L., Smith S. J. and Barker J. L. (1986) NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature 321: 519-522.
    • (1986) Nature , vol.321 , pp. 519-522
    • MacDermott, A.B.1    Mayer, M.L.2    Westbrook, G.L.3    Smith, S.J.4    Barker, J.L.5
  • 23
    • 0029028313 scopus 로고
    • Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes
    • Burnashev N., Zhou Z., Neher E. and Sakmann B. (1995) Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes. J. Physiol. 485 (Pt 2): 403-418.
    • (1995) J. Physiol. , vol.485 , Issue.2 PART , pp. 403-418
    • Burnashev, N.1    Zhou, Z.2    Neher, E.3    Sakmann, B.4
  • 24
    • 0029658053 scopus 로고    scopus 로고
    • Simultaneous measurement of Ca2+ influx and reversal potentials in recombinant N-methyl-D-aspartate receptor channels
    • Schneggenburger R. (1996) Simultaneous measurement of Ca2+ influx and reversal potentials in recombinant N-methyl-D-aspartate receptor channels. Biophys. J. 70: 2165-2174.
    • (1996) Biophys. J. , vol.70 , pp. 2165-2174
    • Schneggenburger, R.1
  • 25
    • 0037204094 scopus 로고    scopus 로고
    • The life cycle of Ca(2+) ions in dendritic spines
    • Sabatini B. L., Oertner T. G. and Svoboda K. (2002) The life cycle of Ca(2+) ions in dendritic spines. Neuron 33: 439-452.
    • (2002) Neuron , vol.33 , pp. 439-452
    • Sabatini, B.L.1    Oertner, T.G.2    Svoboda, K.3
  • 27
    • 1842558602 scopus 로고    scopus 로고
    • Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury
    • Arundine M. and Tymianski M. (2004) Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury. Cell. Mol. Life. Sci. 61: 657-668.
    • (2004) Cell. Mol. Life. Sci. , vol.61 , pp. 657-668
    • Arundine, M.1    Tymianski, M.2
  • 28
    • 0034986665 scopus 로고    scopus 로고
    • A use-dependent tyrosine dephosphorylation of NMDA receptors is independent of ion flux
    • Vissel B., Krupp J. J., Heinemann S. F. and Westbrook G. L. (2001) A use-dependent tyrosine dephosphorylation of NMDA receptors is independent of ion flux. Nat. Neurosci. 4: 587-596.
    • (2001) Nat. Neurosci. , vol.4 , pp. 587-596
    • Vissel, B.1    Krupp, J.J.2    Heinemann, S.F.3    Westbrook, G.L.4
  • 29
  • 31
    • 0032790229 scopus 로고    scopus 로고
    • Subunit- and site-specific pharmacology of the NMDA receptor channel
    • Yamakura T. and Shimoji K. (1999) Subunit- and site-specific pharmacology of the NMDA receptor channel. Prog. Neurobiol. 59: 279-298.
    • (1999) Prog. Neurobiol. , vol.59 , pp. 279-298
    • Yamakura, T.1    Shimoji, K.2
  • 32
    • 0036490942 scopus 로고    scopus 로고
    • Allosteric binding sites on cell-surface receptors: Novel targets for drug discovery
    • Christopoulos A. (2002) Allosteric binding sites on cell-surface receptors: novel targets for drug discovery. Nat. Rev. Drug. Discov. 1: 198-210.
    • (2002) Nat. Rev. Drug. Discov. , vol.1 , pp. 198-210
    • Christopoulos, A.1
  • 33
    • 0025350861 scopus 로고
    • Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons
    • Traynelis S. F. and Cull-Candy S. G. (1990) Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons. Nature 345: 347-350.
    • (1990) Nature , vol.345 , pp. 347-350
    • Traynelis, S.F.1    Cull-Candy, S.G.2
  • 34
    • 0023160323 scopus 로고
    • Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons
    • Westbrook G. L. and Mayer M. L. (1987) Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons. Nature 328: 640-643.
    • (1987) Nature , vol.328 , pp. 640-643
    • Westbrook, G.L.1    Mayer, M.L.2
  • 35
    • 0024623852 scopus 로고
    • Selective modulation of NMDA responses by reduction and oxidation
    • Aizenman E., Lipton S. A. and Loring R. H. (1989) Selective modulation of NMDA responses by reduction and oxidation. Neuron 2: 1257-1263.
    • (1989) Neuron , vol.2 , pp. 1257-1263
    • Aizenman, E.1    Lipton, S.A.2    Loring, R.H.3
  • 36
    • 17444426068 scopus 로고    scopus 로고
    • Modulation of triheteromeric NMDA receptors by N-terminal domain ligands
    • Hatton C. J. and Paoletti P. (2005) Modulation of triheteromeric NMDA receptors by N-terminal domain ligands. Neuron 46: 261-274.
    • (2005) Neuron , vol.46 , pp. 261-274
    • Hatton, C.J.1    Paoletti, P.2
  • 37
    • 2442702848 scopus 로고    scopus 로고
    • Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors
    • Kloda A., Clements J. D., Lewis R. J. and Adams D. J. (2004) Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors. Mol. Pharmacol. 65: 1386-1396.
    • (2004) Mol. Pharmacol. , vol.65 , pp. 1386-1396
    • Kloda, A.1    Clements, J.D.2    Lewis, R.J.3    Adams, D.J.4
  • 38
    • 0030899291 scopus 로고    scopus 로고
    • Modulation and block of ion channels: A new biology of polyamines
    • Williams K. (1997) Modulation and block of ion channels: a new biology of polyamines. Cell. Signal. 9: 1-13.
    • (1997) Cell. Signal. , vol.9 , pp. 1-13
    • Williams, K.1
  • 39
    • 2142717327 scopus 로고    scopus 로고
    • Intracellular spermine decreases open probability of N-methyl-aspartate receptor channels
    • Turecek R., Vlcek K., Petrovic M., Horak M., Vlachova V. and Vyklicky J. L. (2004) Intracellular spermine decreases open probability of N-methyl-aspartate receptor channels. Neuroscience 125: 879-887.
    • (2004) Neuroscience , vol.125 , pp. 879-887
    • Turecek, R.1    Vlcek, K.2    Petrovic, M.3    Horak, M.4    Vlachova, V.5    Vyklicky, J.L.6
  • 40
    • 4644230563 scopus 로고    scopus 로고
    • Amino terminal domain regulation of NMDA receptor function
    • Herin G. A. and Aizenman E. (2004) Amino terminal domain regulation of NMDA receptor function. Eur. J. Pharmacol. 500: 101-111.
    • (2004) Eur. J. Pharmacol. , vol.500 , pp. 101-111
    • Herin, G.A.1    Aizenman, E.2
  • 41
    • 12844268621 scopus 로고    scopus 로고
    • The function of the amino terminal domain in NMDA receptor modulation
    • Huggins D. J. and Grant, G. H. (2005) The function of the amino terminal domain in NMDA receptor modulation. J. Mol. Graph. Model. 23: 381-388.
    • (2005) J. Mol. Graph. Model. , vol.23 , pp. 381-388
    • Huggins, D.J.1    Grant, G.H.2
  • 42
    • 0038548340 scopus 로고    scopus 로고
    • Signaling molecules and receptor transduction cascades that regulate NMDA receptor-mediated synaptic transmission
    • Kotecha S. A. and MacDonald J. F. (2003) Signaling molecules and receptor transduction cascades that regulate NMDA receptor-mediated synaptic transmission. Int. Rev. Neurobiol. 54: 51-106.
    • (2003) Int. Rev. Neurobiol. , vol.54 , pp. 51-106
    • Kotecha, S.A.1    MacDonald, J.F.2
  • 43
    • 0035369112 scopus 로고    scopus 로고
    • NMDA receptor subunits: Diversity, development and disease
    • Cull-Candy S., Brickley S. and Farrant M. (2001) NMDA receptor subunits: diversity, development and disease. Curr. Opin. Neurobiol. 11: 327-335.
    • (2001) Curr. Opin. Neurobiol. , vol.11 , pp. 327-335
    • Cull-Candy, S.1    Brickley, S.2    Farrant, M.3
  • 44
    • 16544376850 scopus 로고    scopus 로고
    • Role of distinct NMDA receptor subtypes at central synapses
    • Cull-Candy S. G. and Leszkiewicz D. N. (2004) Role of distinct NMDA receptor subtypes at central synapses. Sci. STKE 2004: re16.
    • (2004) Sci. STKE , vol.2004
    • Cull-Candy, S.G.1    Leszkiewicz, D.N.2
  • 46
    • 0026721811 scopus 로고
    • Heteromeric NMDA receptors: Molecular and functional distinction of subtypes
    • Monyer H., Sprengel R., Schoepfer R., Herb A., Higuchi M., Lomeli H. et al. (1992) Heteromeric NMDA receptors: molecular and functional distinction of subtypes. Science 256: 1217-1221.
    • (1992) Science , vol.256 , pp. 1217-1221
    • Monyer, H.1    Sprengel, R.2    Schoepfer, R.3    Herb, A.4    Higuchi, M.5    Lomeli, H.6
  • 47
    • 0032523002 scopus 로고    scopus 로고
    • Evidence for a tetrameric structure of recombinant NMDA receptors
    • Laube B., Kuhse J. and Betz H. (1998) Evidence for a tetrameric structure of recombinant NMDA receptors. J. Neurosci. 18: 2954-2961.
    • (1998) J. Neurosci. , vol.18 , pp. 2954-2961
    • Laube, B.1    Kuhse, J.2    Betz, H.3
  • 48
    • 0028973158 scopus 로고
    • Cloning and characterization of chi-1: A developmentally regulated member of a novel class of the ionotropic glutamate receptor family
    • Ciabarra A. M., Sullivan J. M., Gahn L. G., Pecht G., Heinemann S. and Sevarino K. A. (1995) Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family. J. Neurosci. 15: 6498-6508.
    • (1995) J. Neurosci. , vol.15 , pp. 6498-6508
    • Ciabarra, A.M.1    Sullivan, J.M.2    Gahn, L.G.3    Pecht, G.4    Heinemann, S.5    Sevarino, K.A.6
  • 49
    • 0032575065 scopus 로고    scopus 로고
    • Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A
    • Das S., Sasaki Y. F., Rothe T., Premkumar L. S., Takasu M., Crandall J. E. et al. (1998) Increased NMDA current and spine density in mice lacking the NMDA receptor subunit NR3A. Nature 393: 377-381.
    • (1998) Nature , vol.393 , pp. 377-381
    • Das, S.1    Sasaki, Y.F.2    Rothe, T.3    Premkumar, L.S.4    Takasu, M.5    Crandall, J.E.6
  • 51
    • 0035862957 scopus 로고    scopus 로고
    • Three pairs of cysteine residues mediate both redox and Zn2+ modulation of the NMDA receptor
    • Choi Y. B., Chen H. S. and Lipton S. A. (2001) Three pairs of cysteine residues mediate both redox and Zn2+ modulation of the NMDA receptor. J. Neurosci. 21: 392-400.
    • (2001) J. Neurosci. , vol.21 , pp. 392-400
    • Choi, Y.B.1    Chen, H.S.2    Lipton, S.A.3
  • 52
    • 0034718494 scopus 로고    scopus 로고
    • Molecular determinants of coordinated proton and zinc inhibition of N-methyl-D-aspartate NR1/NR2A receptors
    • In Process Citation
    • Low C. M., Zheng F., Lyuboslavsky P. and Traynelis S. F. (2000) Molecular determinants of coordinated proton and zinc inhibition of N-methyl-D-aspartate NR1/NR2A receptors [In Process Citation]. Proc. Natl. Acad. Sci. USA 97: 11062-11067.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11062-11067
    • Low, C.M.1    Zheng, F.2    Lyuboslavsky, P.3    Traynelis, S.F.4
  • 53
    • 0035029052 scopus 로고    scopus 로고
    • Desensitization of NMDA receptor channels is modulated by glutamate agonists
    • Nahum-Levy R., Lipinski D., Shavit S. and Benveniste M. (2001) Desensitization of NMDA receptor channels is modulated by glutamate agonists. Biophys. J. 80: 2152-2166.
    • (2001) Biophys. J. , vol.80 , pp. 2152-2166
    • Nahum-Levy, R.1    Lipinski, D.2    Shavit, S.3    Benveniste, M.4
  • 54
    • 2542551968 scopus 로고    scopus 로고
    • A steroid modulatory domain on NR2B controls N-methyl-D-aspartate receptor proton sensitivity
    • Jang M. K., Mierke D. F., Russek S. J. and Farb D. H. (2004) A steroid modulatory domain on NR2B controls N-methyl-D-aspartate receptor proton sensitivity. Proc. Natl. Acad. Sci. USA 101: 8198-8203.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 8198-8203
    • Jang, M.K.1    Mierke, D.F.2    Russek, S.J.3    Farb, D.H.4
  • 55
    • 0033051714 scopus 로고    scopus 로고
    • A regulatory domain (R1-R2) in the amino terminus of the N-methyl-D-aspartate receptor: Effects of spermine, protons and ifenprodil, and structural similarity to bacterial leucine/isoleucine/valine binding protein
    • Masuko T., Kashiwagi K., Kuno T., Nguyen N. D., Pahk A. J., Fukuchi J. et al. (1999) A regulatory domain (R1-R2) in the amino terminus of the N-methyl-D-aspartate receptor: effects of spermine, protons and ifenprodil, and structural similarity to bacterial leucine/isoleucine/valine binding protein. Mol. Pharmacol. 55: 957-969.
    • (1999) Mol. Pharmacol. , vol.55 , pp. 957-969
    • Masuko, T.1    Kashiwagi, K.2    Kuno, T.3    Nguyen, N.D.4    Pahk, A.J.5    Fukuchi, J.6
  • 56
    • 0028965140 scopus 로고
    • Unraveling the modular design of glutamate-gated ion channels
    • Wo Z. G. and Oswald R. E. (1995) Unraveling the modular design of glutamate-gated ion channels. Trends Neurosci. 18: 161-168.
    • (1995) Trends Neurosci. , vol.18 , pp. 161-168
    • Wo, Z.G.1    Oswald, R.E.2
  • 57
    • 0036483593 scopus 로고    scopus 로고
    • The structure and function of glutamate receptor ion channels
    • Madden D. R. (2002) The structure and function of glutamate receptor ion channels. Nat. Rev. Neurosci. 3: 91-101.
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 91-101
    • Madden, D.R.1
  • 58
    • 0036805481 scopus 로고    scopus 로고
    • Intramolecular interactions at protein surfaces and their impact on protein function
    • Robertson A. D. (2002) Intramolecular interactions at protein surfaces and their impact on protein function. Trends Biochem. Sci. 27: 521-526.
    • (2002) Trends Biochem. Sci. , vol.27 , pp. 521-526
    • Robertson, A.D.1
  • 59
    • 0038037859 scopus 로고    scopus 로고
    • Mechanisms of activation, inhibition and specificity: Crystal structures of the NMDA receptor NR1 ligand-binding core
    • Furukawa H. and Gouaux E. (2003) Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core. EMBO J. 22: 2873-2885.
    • (2003) EMBO J. , vol.22 , pp. 2873-2885
    • Furukawa, H.1    Gouaux, E.2
  • 60
    • 0442279279 scopus 로고    scopus 로고
    • Structure and function of AMPA receptors
    • Gouaux E. (2004) Structure and function of AMPA receptors. J. Physiol. 554: 249-253.
    • (2004) J. Physiol. , vol.554 , pp. 249-253
    • Gouaux, E.1
  • 61
    • 1542373622 scopus 로고    scopus 로고
    • Emerging structural explanations of ionotropic glutamate receptor function
    • McFeeters R. L. and Oswald R. E. (2004) Emerging structural explanations of ionotropic glutamate receptor function. FASEB J. 18: 428-438.
    • (2004) FASEB J. , vol.18 , pp. 428-438
    • McFeeters, R.L.1    Oswald, R.E.2
  • 62
    • 0017649331 scopus 로고
    • Effect of magnesium ions on the responses of spinal neurones to excitatory amino acids and acetylcholine
    • Davies J. and Watkins J. C. (1977) Effect of magnesium ions on the responses of spinal neurones to excitatory amino acids and acetylcholine. Brain Res. 130: 364-368.
    • (1977) Brain Res. , vol.130 , pp. 364-368
    • Davies, J.1    Watkins, J.C.2
  • 63
    • 0021892574 scopus 로고
    • Dual-component amino-acid-mediated synaptic potentials: Excitatory drive for swimming in Xenopus embryos
    • Dale N. and Roberts A. (1985) Dual-component amino-acid-mediated synaptic potentials: excitatory drive for swimming in Xenopus embryos. J. Physiol. 363: 35-59.
    • (1985) J. Physiol. , vol.363 , pp. 35-59
    • Dale, N.1    Roberts, A.2
  • 64
    • 0026470993 scopus 로고
    • Activity-dependent decrease in NMDA receptor responses during development of the visual cortex
    • Carmignoto G. and Vicini S. (1992) Activity-dependent decrease in NMDA receptor responses during development of the visual cortex. Science 258: 1007-1011.
    • (1992) Science , vol.258 , pp. 1007-1011
    • Carmignoto, G.1    Vicini, S.2
  • 65
    • 0031023896 scopus 로고    scopus 로고
    • A direct comparison of the single-channel properties of synaptic and extrasynaptic NMDA receptors
    • Clark B. A., Farrant M. and Cull-Candy S. G. (1997) A direct comparison of the single-channel properties of synaptic and extrasynaptic NMDA receptors. J. Neurosci. 17: 107-116.
    • (1997) J. Neurosci. , vol.17 , pp. 107-116
    • Clark, B.A.1    Farrant, M.2    Cull-Candy, S.G.3
  • 66
    • 0036618260 scopus 로고    scopus 로고
    • Activity-dependent recruitment of extrasynaptic NMDA receptor activation at an AMPA receptor-only synapse
    • Clark B. A. and Cull-Candy S. G. (2002) Activity-dependent recruitment of extrasynaptic NMDA receptor activation at an AMPA receptor-only synapse. J. Neurosci. 22: 4428-4436.
    • (2002) J. Neurosci. , vol.22 , pp. 4428-4436
    • Clark, B.A.1    Cull-Candy, S.G.2
  • 67
    • 0026770417 scopus 로고
    • Developmental regulation of NMDA receptor-mediated synaptic currents at a central synapse
    • Hestrin S. (1992) Developmental regulation of NMDA receptor-mediated synaptic currents at a central synapse. Nature 357: 686-689.
    • (1992) Nature , vol.357 , pp. 686-689
    • Hestrin, S.1
  • 68
    • 0027405347 scopus 로고
    • Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro
    • Williams K., Russell S. L., Shen Y. M. and Molinoff P. B. (1993) Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro. Neuron 10: 267-278.
    • (1993) Neuron , vol.10 , pp. 267-278
    • Williams, K.1    Russell, S.L.2    Shen, Y.M.3    Molinoff, P.B.4
  • 69
    • 0031844719 scopus 로고    scopus 로고
    • Developmental changes in localization of NMDA receptor subunits in primary cultures of cortical neurons
    • Li J. H., Wang Y. H., Wolfe B. B., Krueger K. E., Corsi L., Stocca G. et al. (1998) Developmental changes in localization of NMDA receptor subunits in primary cultures of cortical neurons. Eur. J. Neurosci. 10: 1704-1715.
    • (1998) Eur. J. Neurosci. , vol.10 , pp. 1704-1715
    • Li, J.H.1    Wang, Y.H.2    Wolfe, B.B.3    Krueger, K.E.4    Corsi, L.5    Stocca, G.6
  • 70
    • 0033562610 scopus 로고    scopus 로고
    • The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro
    • Tovar K. R. and Westbrook G. L. (1999) The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro. J. Neurosci. 19: 4180-4188.
    • (1999) J. Neurosci. , vol.19 , pp. 4180-4188
    • Tovar, K.R.1    Westbrook, G.L.2
  • 71
    • 0037417988 scopus 로고    scopus 로고
    • Developmental loss of miniature N-methyl-D-aspartate receptor currents in NR2A knockout mice
    • Townsend M., Yoshii A., Mishina M. and Constantine-Paton M. (2003) Developmental loss of miniature N-methyl-D-aspartate receptor currents in NR2A knockout mice. Proc. Natl. Acad. Sci. USA 100: 1340-1345.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 1340-1345
    • Townsend, M.1    Yoshii, A.2    Mishina, M.3    Constantine-Paton, M.4
  • 72
    • 2642598047 scopus 로고    scopus 로고
    • Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors
    • Vicini S., Wang J. F., Li J. H., Zhu W. J., Wang Y. H., Luo J. H. et al. (1998) Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors. J. Neurophysiol. 79: 555-566.
    • (1998) J. Neurophysiol. , vol.79 , pp. 555-566
    • Vicini, S.1    Wang, J.F.2    Li, J.H.3    Zhu, W.J.4    Wang, Y.H.5    Luo, J.H.6
  • 73
    • 0034019958 scopus 로고    scopus 로고
    • Exon 5 and spermine regulate deactivation of NMDA receptor subtypes
    • Rumbaugh G, Prybylowski K., Wang J. F. and Vicini S. (2000) Exon 5 and spermine regulate deactivation of NMDA receptor subtypes. J. Neurophysiol. 83: 1300-6
    • (2000) J. Neurophysiol. , vol.83 , pp. 1300-1306
    • Rumbaugh, G.P.1    Rybylowski, K.2    Wang, J.F.3    Vicini, S.4
  • 74
    • 0023091647 scopus 로고
    • Glycine potentiates the NMDA response in cultured mouse brain neurons
    • Johnson J. W. and Ascher P. (1987) Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 325: 529-531.
    • (1987) Nature , vol.325 , pp. 529-531
    • Johnson, J.W.1    Ascher, P.2
  • 75
    • 0023754192 scopus 로고
    • Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes
    • Kleckner N. W. and Dingledine R. (1988) Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes. Science 241: 835-837.
    • (1988) Science , vol.241 , pp. 835-837
    • Kleckner, N.W.1    Dingledine, R.2
  • 76
    • 0023819752 scopus 로고
    • [3H]D-2-amino-5-phosphonopentanoate as a ligand for N-methyl-D-aspartate receptors in the mammalian central nervous system
    • Olverman H. J., Jones A. W. and Watkins J. C. (1988) [3H]D-2-amino-5- phosphonopentanoate as a ligand for N-methyl-D-aspartate receptors in the mammalian central nervous system. Neuroscience 26: 1-15.
    • (1988) Neuroscience , vol.26 , pp. 1-15
    • Olverman, H.J.1    Jones, A.W.2    Watkins, J.C.3
  • 77
    • 0023778275 scopus 로고
    • Excitatory amino acid receptors expressed in Xenopus oocytes: Agonist pharmacology
    • Verdoorn T. A. and Dingledine R. (1988) Excitatory amino acid receptors expressed in Xenopus oocytes: agonist pharmacology. Mol. Pharmacol. 34: 298-307.
    • (1988) Mol. Pharmacol. , vol.34 , pp. 298-307
    • Verdoorn, T.A.1    Dingledine, R.2
  • 78
    • 0025456905 scopus 로고
    • Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors
    • Patneau D. K. and Mayer M. L. (1990) Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors. J. Neurosci. 10: 2385-2399.
    • (1990) J. Neurosci. , vol.10 , pp. 2385-2399
    • Patneau, D.K.1    Mayer, M.L.2
  • 79
    • 0025974234 scopus 로고
    • Kinetic analysis of antagonist action at N-methyl-D-aspartic acid receptors. Two binding sites each for glutamate and glycine
    • Benveniste M. and Mayer M. L. (1991) Kinetic analysis of antagonist action at N-methyl-D-aspartic acid receptors. Two binding sites each for glutamate and glycine. Biophys. J. 59: 560-573.
    • (1991) Biophys. J. , vol.59 , pp. 560-573
    • Benveniste, M.1    Mayer, M.L.2
  • 80
    • 0026689872 scopus 로고
    • Activation and desensitization of N-methyl-D-aspartate receptors in nucleated outside-out patches from mouse neurones
    • Sather W., Dieudonne S., MacDonald J. F. and Ascher P. (1992) Activation and desensitization of N-methyl-D-aspartate receptors in nucleated outside-out patches from mouse neurones. J. Physiol. 450: 643-672.
    • (1992) J. Physiol. , vol.450 , pp. 643-672
    • Sather, W.1    Dieudonne, S.2    MacDonald, J.F.3    Ascher, P.4
  • 81
    • 0028823737 scopus 로고
    • Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells
    • Priestley T., Laughton P., Myers J., Le Bourdelles B., Kerby J. and Whiting P. J. (1995) Pharmacological properties of recombinant human N-methyl-D-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells. Mol. Pharmacol. 48: 841-848.
    • (1995) Mol. Pharmacol. , vol.48 , pp. 841-848
    • Priestley, T.1    Laughton, P.2    Myers, J.3    Le Bourdelles, B.4    Kerby, J.5    Whiting, P.J.6
  • 82
    • 0026601970 scopus 로고
    • NMDA channel behavior depends on agonist affinity
    • Lester R. A. and Jahr C. E. (1992) NMDA channel behavior depends on agonist affinity. J. Neurosci. 12: 635-643.
    • (1992) J. Neurosci. , vol.12 , pp. 635-643
    • Lester, R.A.1    Jahr, C.E.2
  • 83
    • 78651189765 scopus 로고
    • On the nature of allosteric transitions: A plausible model
    • Monod J., Wyman J. and Changeux J. P. (1965) On the nature of allosteric transitions: a plausible model. J. Mol. Biol. 12: 88-118.
    • (1965) J. Mol. Biol. , vol.12 , pp. 88-118
    • Monod, J.1    Wyman, J.2    Changeux, J.P.3
  • 84
    • 0023924551 scopus 로고
    • On the kinetics of large-conductance glutamate-receptor ion channels in rat cerebellar granule neurons
    • Howe J. R., Colquhoun D. and Cull-Candy S. G. (1988) On the kinetics of large-conductance glutamate-receptor ion channels in rat cerebellar granule neurons. Proc. R. Soc. Lond. B. Biol. Sci. 233: 407-422.
    • (1988) Proc. R. Soc. Lond. B. Biol. Sci. , vol.233 , pp. 407-422
    • Howe, J.R.1    Colquhoun, D.2    Cull-Candy, S.G.3
  • 85
    • 0026082581 scopus 로고
    • Glutamate activation of a single NMDA receptor-channel produces a cluster of channel openings
    • Gibb A. J. and Colquhoun D. (1991) Glutamate activation of a single NMDA receptor-channel produces a cluster of channel openings. Proc. R. Soc. Lond. B. Biol. Sci. 243: 39-45.
    • (1991) Proc. R. Soc. Lond. B. Biol. Sci. , vol.243 , pp. 39-45
    • Gibb, A.J.1    Colquhoun, D.2
  • 86
    • 0026053684 scopus 로고
    • Currents through single glutamate receptor channels in outside-out patches from rat cerebellar granule cells
    • Howe J. R., Cull-Candy S. G. and Colquhoun D. (1991) Currents through single glutamate receptor channels in outside-out patches from rat cerebellar granule cells. J. Physiol. 432: 143-202.
    • (1991) J. Physiol. , vol.432 , pp. 143-202
    • Howe, J.R.1    Cull-Candy, S.G.2    Colquhoun, D.3
  • 87
    • 0023684229 scopus 로고
    • Sites of antagonist action on N-methyl-D-aspartic acid receptors studied using fluctuation analysis and a rapid perfusion technique
    • Mayer M. L., Westbrook G. L. and Vyklicky L. Jr. (1988) Sites of antagonist action on N-methyl-D-aspartic acid receptors studied using fluctuation analysis and a rapid perfusion technique. J. Neurophysiol. 60: 645-663.
    • (1988) J. Neurophysiol. , vol.60 , pp. 645-663
    • Mayer, M.L.1    Westbrook, G.L.2    Vyklicky Jr., L.3
  • 88
    • 0028292558 scopus 로고
    • Patch-clamp analysis of direct steroidal modulation of glutamate receptor-channels
    • Wong M. and Moss R. L. (1994) Patch-clamp analysis of direct steroidal modulation of glutamate receptor-channels. J. Neuroendocrinol. 6: 347-355.
    • (1994) J. Neuroendocrinol. , vol.6 , pp. 347-355
    • Wong, M.1    Moss, R.L.2
  • 89
    • 12144271737 scopus 로고    scopus 로고
    • Protons trap NR1/NR2B NMDA receptors in a nonconducting state
    • Banke T. G., Dravid S. M. and Traynelis S. F. (2005) Protons trap NR1/NR2B NMDA receptors in a nonconducting state. J. Neurosci. 25: 42-51.
    • (2005) J. Neurosci. , vol.25 , pp. 42-51
    • Banke, T.G.1    Dravid, S.M.2    Traynelis, S.F.3
  • 90
    • 0027099647 scopus 로고
    • Single-channel conductances of NMDA receptors expressed from cloned cDNAs: Comparison with native receptors
    • Stern P., Behe P., Schoepfer R. and Colquhoun D. (1992) Single-channel conductances of NMDA receptors expressed from cloned cDNAs: comparison with native receptors. Proc. Biol. Sci. 250: 271-277.
    • (1992) Proc. Biol. Sci. , vol.250 , pp. 271-277
    • Stern, P.1    Behe, P.2    Schoepfer, R.3    Colquhoun, D.4
  • 91
    • 0027249572 scopus 로고
    • Properties of NMDA receptor channels in neurons acutely isolated from epileptic (kindled) rats
    • Kohr G., De Koninck Y. and Mody I. (1993) Properties of NMDA receptor channels in neurons acutely isolated from epileptic (kindled) rats. J. Neurosci. 13: 3612-3627.
    • (1993) J. Neurosci. , vol.13 , pp. 3612-3627
    • Kohr, G.1    De Koninck, Y.2    Mody, I.3
  • 92
    • 0029797664 scopus 로고    scopus 로고
    • Single-channel currents from recombinant NMDA NR1a/NR2D receptors expressed in Xenopus oocytes
    • Wyllie D. J., Behe P., Nassar M., Schoepfer R. and Colquhoun D. (1996) Single-channel currents from recombinant NMDA NR1a/NR2D receptors expressed in Xenopus oocytes. Proc. R. Soc. Lond. B. Biol. Sci. 263: 1079-1086.
    • (1996) Proc. R. Soc. Lond. B. Biol. Sci. , vol.263 , pp. 1079-1086
    • Wyllie, D.J.1    Behe, P.2    Nassar, M.3    Schoepfer, R.4    Colquhoun, D.5
  • 93
    • 0033166267 scopus 로고    scopus 로고
    • Properties of single NMDA receptor channels in human dentate gyrus granule cells
    • Lieberman D. N. and Mody I. (1999) Properties of single NMDA receptor channels in human dentate gyrus granule cells. J. Physiol. 518 (Pt 1): 55-70.
    • (1999) J. Physiol. , vol.518 , Issue.1 PART , pp. 55-70
    • Lieberman, D.N.1    Mody, I.2
  • 94
    • 0033841358 scopus 로고    scopus 로고
    • Single channel analysis of a novel NMDA channel from Xenopus oocytes expressing recombinant NR1a, NR2A and NR2D subunits
    • Cheffings C. M. and Colquhoun D. (2000) Single channel analysis of a novel NMDA channel from Xenopus oocytes expressing recombinant NR1a, NR2A and NR2D subunits. J. Physiol. 526: 481-491.
    • (2000) J. Physiol. , vol.526 , pp. 481-491
    • Cheffings, C.M.1    Colquhoun, D.2
  • 95
    • 0037407919 scopus 로고    scopus 로고
    • Modal gating of NMDA receptors and the shape of their synaptic response
    • Popescu G. and Auerbach A. (2003) Modal gating of NMDA receptors and the shape of their synaptic response. Nat. Neurosci. 6: 476-483.
    • (2003) Nat. Neurosci. , vol.6 , pp. 476-483
    • Popescu, G.1    Auerbach, A.2
  • 96
    • 1942468735 scopus 로고    scopus 로고
    • Modal gating of NMDA receptors
    • Magleby K. L. (2004) Modal gating of NMDA receptors. Trends Neurosci. 27: 231-233.
    • (2004) Trends Neurosci. , vol.27 , pp. 231-233
    • Magleby, K.L.1
  • 97
    • 2442638851 scopus 로고    scopus 로고
    • The NMDA receptor gating machine: Lessons from single channels
    • Popescu G. and Auerbach A. (2004) The NMDA receptor gating machine: lessons from single channels. Neuroscientist 10: 192-198.
    • (2004) Neuroscientist , vol.10 , pp. 192-198
    • Popescu, G.1    Auerbach, A.2
  • 98
    • 14944364531 scopus 로고    scopus 로고
    • Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles
    • Erreger K., Dravid S. M., Banke T. G., Wyllie D. J. A. and Traynelis S. F. (2005) Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles. J. Physiol. 563: 345-358.
    • (2005) J. Physiol. , vol.563 , pp. 345-358
    • Erreger, K.1    Dravid, S.M.2    Banke, T.G.3    Wyllie, D.J.A.4    Traynelis, S.F.5
  • 99
    • 4043142755 scopus 로고    scopus 로고
    • Reaction mechanism determines NMDA receptor response to repetitive stimulation
    • Popescu G., Robert A., Howe J. R. and Auerbach A. (2004) Reaction mechanism determines NMDA receptor response to repetitive stimulation. Nature 430: 790-793.
    • (2004) Nature , vol.430 , pp. 790-793
    • Popescu, G.1    Robert, A.2    Howe, J.R.3    Auerbach, A.4
  • 100
    • 0033966834 scopus 로고    scopus 로고
    • Fast NMDA receptor-mediated synaptic currents in neurons from mice lacking the epsilon2 (NR2B) subunit
    • Tovar K. R., Sprouffske K. and Westbrook G. L. (2000) Fast NMDA receptor-mediated synaptic currents in neurons from mice lacking the epsilon2 (NR2B) subunit. J. Neurophysiol. 83: 616-620.
    • (2000) J. Neurophysiol. , vol.83 , pp. 616-620
    • Tovar, K.R.1    Sprouffske, K.2    Westbrook, G.L.3
  • 101
    • 0028360327 scopus 로고
    • Regulation of NMDA receptors by tyrosine kinases and phosphatases
    • Wang Y. T. and Salter M. W. (1994) Regulation of NMDA receptors by tyrosine kinases and phosphatases. Nature 369: 233-235.
    • (1994) Nature , vol.369 , pp. 233-235
    • Wang, Y.T.1    Salter, M.W.2
  • 102
    • 0031053363 scopus 로고    scopus 로고
    • NMDA channel regulation by channel-associated protein tyrosine kinase Src
    • Yu X. M., Askalan R., Keil G. J. 2nd and Salter M. W. (1997) NMDA channel regulation by channel-associated protein tyrosine kinase Src. Science 275: 674-678.
    • (1997) Science , vol.275 , pp. 674-678
    • Yu, X.M.1    Askalan, R.2    Keil II, G.J.3    Salter, M.W.4
  • 103
    • 0037109755 scopus 로고    scopus 로고
    • Direct effects of calmodulin on NMDA receptor single-channel gating in rat hippocampal granule cells
    • Rycroft B. K. and Gibb A. J. (2002) Direct effects of calmodulin on NMDA receptor single-channel gating in rat hippocampal granule cells. J. Neurosci. 22: 8860-8868.
    • (2002) J. Neurosci. , vol.22 , pp. 8860-8868
    • Rycroft, B.K.1    Gibb, A.J.2
  • 104
    • 0023699843 scopus 로고
    • Structure/activity relations of N-methyl-D-aspartate receptor ligands as studied by their inhibition of [3H]D-2-amino-5-phosphonopentanoic acid binding in rat brain membranes
    • Olverman H. J., Jones A. W., Mewett K. N. and Watkins J. C. (1988) Structure/activity relations of N-methyl-D-aspartate receptor ligands as studied by their inhibition of [3H]D-2-amino-5-phosphonopentanoic acid binding in rat brain membranes. Neuroscience 26: 17-31.
    • (1988) Neuroscience , vol.26 , pp. 17-31
    • Olverman, H.J.1    Jones, A.W.2    Mewett, K.N.3    Watkins, J.C.4
  • 105
    • 0031961764 scopus 로고    scopus 로고
    • Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors
    • Anson L. C., Chen P. E., Wyllie D. J. A., Colquhoun D. and Schoepfer R. (1998) Identification of amino acid residues of the NR2A subunit that control glutamate potency in recombinant NR1/NR2A NMDA receptors. J. Neurosci. 18: 581-589.
    • (1998) J. Neurosci. , vol.18 , pp. 581-589
    • Anson, L.C.1    Chen, P.E.2    Wyllie, D.J.A.3    Colquhoun, D.4    Schoepfer, R.5
  • 106
    • 0032199006 scopus 로고    scopus 로고
    • Binding, gating, affinity and efficacy: The interpretation of structure-activity relationships for agonists and of the effects of mutating receptors
    • Colquhoun D. (1998) Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors. Br. J. Pharmacol. 125: 924-947.
    • (1998) Br. J. Pharmacol. , vol.125 , pp. 924-947
    • Colquhoun, D.1
  • 107
    • 0035139057 scopus 로고    scopus 로고
    • Changes in agonist concentration dependence that are a function of duration of exposure suggest N-methyl-D-aspartate receptor nonsaturation during synaptic stimulation
    • Chen N., Ren J., Raymond L. A. and Murphy T. H. (2001) Changes in agonist concentration dependence that are a function of duration of exposure suggest N-methyl-D-aspartate receptor nonsaturation during synaptic stimulation. Mol. Pharmacol. 59: 212-219.
    • (2001) Mol. Pharmacol. , vol.59 , pp. 212-219
    • Chen, N.1    Ren, J.2    Raymond, L.A.3    Murphy, T.H.4
  • 108
    • 0033551327 scopus 로고    scopus 로고
    • Synaptic calcium transients in single spines indicate that NMDA receptors are not saturated
    • Mainen Z. F., Malinow R. and Svoboda K. (1999) Synaptic calcium transients in single spines indicate that NMDA receptors are not saturated. Nature 399: 151-155.
    • (1999) Nature , vol.399 , pp. 151-155
    • Mainen, Z.F.1    Malinow, R.2    Svoboda, K.3
  • 109
    • 0027235488 scopus 로고
    • Three-dimensional structures of the periplasmic lysine/arginine/ ornithine-binding protein with and without a ligand
    • Oh B. H., Pandit J., Kang C. H., Nikaido K., Gokcen S., Ames G. F. et al. (1993) Three-dimensional structures of the periplasmic lysine/arginine/ ornithine-binding protein with and without a ligand. J. Biol. Chem. 268: 11348-11355.
    • (1993) J. Biol. Chem. , vol.268 , pp. 11348-11355
    • Oh, B.H.1    Pandit, J.2    Kang, C.H.3    Nikaido, K.4    Gokcen, S.5    Ames, G.F.6
  • 110
    • 0032578635 scopus 로고    scopus 로고
    • Structure of a glutamate-receptor ligand-binding core in complex with kainate
    • Armstrong N., Sun Y., Chen G. Q. and Gouaux E. (1998) Structure of a glutamate-receptor ligand-binding core in complex with kainate. Nature 395: 913-917.
    • (1998) Nature , vol.395 , pp. 913-917
    • Armstrong, N.1    Sun, Y.2    Chen, G.Q.3    Gouaux, E.4
  • 111
    • 0032478818 scopus 로고    scopus 로고
    • The structure of the potassium channel: Molecular basis of K+ conduction and selectivity
    • Doyle D. A., Morais Cabral J., Pfuetzner R. A., Kuo A., Gulbis J. M., Cohen S. L. et al. (1998) The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science 280: 69-77.
    • (1998) Science , vol.280 , pp. 69-77
    • Doyle, D.A.1    Morais Cabral, J.2    Pfuetzner, R.A.3    Kuo, A.4    Gulbis, J.M.5    Cohen, S.L.6
  • 113
    • 2342462388 scopus 로고    scopus 로고
    • Structure and function of glutamate receptor ion channels
    • Mayer M. L. and Armstrong N. (2004) Structure and function of glutamate receptor ion channels. Annu. Rev. Physiol. 66: 161-181.
    • (2004) Annu. Rev. Physiol. , vol.66 , pp. 161-181
    • Mayer, M.L.1    Armstrong, N.2
  • 114
    • 2542507333 scopus 로고    scopus 로고
    • Structure and gating of the glutamate receptor ion channel
    • Wollmuth L. P. and Sobolevsky A. I. (2004) Structure and gating of the glutamate receptor ion channel. Trends Neurosci. 27: 321-328.
    • (2004) Trends Neurosci. , vol.27 , pp. 321-328
    • Wollmuth, L.P.1    Sobolevsky, A.I.2
  • 116
    • 0037312558 scopus 로고    scopus 로고
    • Activation of NR1/NR2B NMDA receptors
    • Banke T. G. and Traynelis S. F. (2003) Activation of NR1/NR2B NMDA receptors. Nat. Neurosci. 6: 144-152.
    • (2003) Nat. Neurosci. , vol.6 , pp. 144-152
    • Banke, T.G.1    Traynelis, S.F.2
  • 117
    • 0035176112 scopus 로고    scopus 로고
    • Bidirectional synaptic plasticity correlated with the magnitude of dendritic calcium transients above a threshold
    • Cormier R. J., Greenwood A. C. and Connor J. A. (2001) Bidirectional synaptic plasticity correlated with the magnitude of dendritic calcium transients above a threshold. J. Neurophysiol. 85: 399-406.
    • (2001) J. Neurophysiol. , vol.85 , pp. 399-406
    • Cormier, R.J.1    Greenwood, A.C.2    Connor, J.A.3
  • 118
    • 7744229724 scopus 로고    scopus 로고
    • The kinetic profile of intracellular calcium predicts long-term potentiation and long-term depression
    • Ismailov I., Kalikulov D., Inoue T. and Friedlander M. J. (2004) The kinetic profile of intracellular calcium predicts long-term potentiation and long-term depression. J. Neurosci. 24: 9847-9861.
    • (2004) J. Neurosci. , vol.24 , pp. 9847-9861
    • Ismailov, I.1    Kalikulov, D.2    Inoue, T.3    Friedlander, M.J.4
  • 119
    • 0027195617 scopus 로고
    • Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus
    • Dudek S. M. and Bear M. F. (1993) Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus. J. Neurosci. 13: 2910-2918.
    • (1993) J. Neurosci. , vol.13 , pp. 2910-2918
    • Dudek, S.M.1    Bear, M.F.2
  • 120
    • 0022499320 scopus 로고
    • Frequency-dependent involvement of NMDA receptors in the hippocampus: A novel synaptic mechanism
    • Herron C. E., Lester R. A., Coan E. J. and Collingridge G. L. (1986) Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanism. Nature 322: 265-268.
    • (1986) Nature , vol.322 , pp. 265-268
    • Herron, C.E.1    Lester, R.A.2    Coan, E.J.3    Collingridge, G.L.4
  • 121
    • 24744463754 scopus 로고    scopus 로고
    • Principles of NMDA receptor allosteric modulation
    • published online July 20, 2005; DOI 0.1124/mol.105.013896
    • Popescu G. (2005) Principles of NMDA receptor allosteric modulation. Mol. Pharm. 68: published online July 20, 2005; DOI 0.1124/mol.105.013896
    • (2005) Mol. Pharm. , pp. 68
    • Popescu, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.