Modulation of the antioxidant/pro-oxidant balance, cytotoxicity and antiviral actions of grape seed extracts

Food Chemistry

Volumn 141, Issue 4, 2013, Pages 3967-3976

  Ignea, Codruta ^a   Dorobantu, Cristina Mihaela ^b   Mintoff, Christopher Paul ^c   Branza Nichita, Norica ^b   Ladomery, Michael R ^d   Kefalas, Panagiotis ^a   Chedea, Veronica Sanda ^a,d,e  

^a MEDITERRANEAN AGRONOMIC INSTITUTE OF CHANIA   (Greece)

^b INSTITUTE OF BIOCHEMISTRY OF THE ROMANIAN ACADEMY   (Romania)

^c PETER MACCALLUM CANCER CENTRE   (Australia)

^d UNIVERSITY OF THE WEST OF ENGLAND   (United Kingdom)

^e National Institute for Research   (Romania)

Author keywords

Antioxidant prooxidant activity; Antiviral action; Cytotoxicity; Grape seed extracts; Yeast

Indexed keywords

ANTIOXIDANTS; CELL CULTURE; CELLS; CYTOLOGY; DISEASES; MOLECULAR BIOLOGY; PLANTS (BOTANY); YEAST;

ANTI-OXIDANT ACTIVITIES; ANTI-VIRAL EFFECTS; ANTIOXIDANT SYSTEMS; ANTIOXIDANT/PROOXIDANT ACTIVITIES; ANTIVIRAL ACTION; GRAPE SEED EXTRACT; GROWTH RECOVERY; PROSTATE CANCERS;

CYTOTOXICITY;

GRAPE SEED EXTRACT;

ANTIOXIDANT ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; GRAPE; HUMAN; HUMAN CELL; INDUSTRIAL WASTE; NONHUMAN; OXIDATIVE STRESS; VIRION;

HEPATITIS B VIRUS; VITACEAE;

ANTIOXIDANT/PROOXIDANT ACTIVITY; ANTIVIRAL ACTION; CYTOTOXICITY; FBS; FERRIC REDUCING ANTIOXIDANT POWER; FETAL BOVINE SERUM; FRAP; GAE; GALLIC ACID EQUIVALENTS; GRAPE SEED EXTRACT; GRAPE SEED EXTRACTS; GSE; GSH; GSSG; HBEAG; HBSAG; HBV; HCC; HEPATITIS B " E" ANTIGEN; HEPATITIS B SURFACE ANTIGEN; HEPATOCELLULAR CARCINOMA; HUMAN HEPATITIS B; MAPK; MITOGEN-ACTIVATED PROTEIN KINASE; OLD YELLOW ENZYMES; OXIDISED GLUTATHIONE; OYE; PCD; PHOSPHATIDYLINOSITIDE 3-KINASE; PI3K; PROGRAMMED CELL DEATH; REACTIVE OXIGEN SPECIES; RED GRAPE SEED AQUEOUS EXTRACT; REDUCED GLUTATHIONE; ROS; RW; TOTAL POLYPHENOLIC CONTENT; TP; WHITE GRAPE SEED AQUEOUS EXTRACT; WW; YEAST; YEAST MUTANTS DERIVED FROM THE WILD-TYPE (WT) STRAIN BY474, HARBOURING DELETION OF THE GENES CTA1, SOD1, OR GSH1 RESPECTIVELY; ΔCTA1, ΔSOD1, AND ΔGSH1;

ANTIOXIDANTS; ANTIVIRAL AGENTS; CELL LINE; CELL SURVIVAL; GRAPE SEED EXTRACT; HEPATITIS B VIRUS; HUMANS; OXIDANTS; VITIS; YEASTS;

EID: 84884667698     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2013.06.094     Document Type: Article

References (27)

1. Amari, F., Fettouche, A., Samra, M. A., Kefalas, P., Kampranis, S. C., & Makris, A. M. (2008). Antioxidant small molecules confer variable protection against oxidative damage in yeast mutants. Journal of Agriculture and Food Chemistry, 56, 11740-11751.
2. Azam, S., Hadi, N., Khan, N. U., & Hadi, S. M. (2004). Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: Implications for anticancer properties. Toxicology in Vitro: An International Journal Published in Association with BIBRA, 18, 555-561. (Pubitemid 38900862)
3. Chedea, V. S., Braicu, C., & Socaciu, C. (2010). Antioxidant/pro- oxidant activity of a polyphenolic grape seed extract. Food Chemistry, 121, 132-139.
4. Chedea, V. S., Echim, C., Braicu, C., Andjelkovic, M., Verhe, R., & Socaciu, C. (2011). Composition in polyphenols and stability of the aqueous grape seed extract from the Romanian variety "Merlot Recas". Journal of Food Biochemistry, 35, 92-108.
5. Chedea, V. S., Moussouni, S., Socaciu, C., & Kefalas, P. (2012). Evaluation of grape seeds as a source of added value natural antioxidants: aqueous extraction of high molecular weight phenolics. In R. P. Murphy & C. K. Steifler (Eds.), Grapes -Cultivation, Varieties and Nutritional Uses (pp. 79-107). New York: Nova Science Publishers Inc.
6. Cimino, S., Sortino, G., Favilla, V., Castelli, T., Madonia, M., Sansalone, S., et al. (2012). Polyphenols: Key issues involved in chemoprevention of prostate cancer. Oxidative Medicine and Cellular Longevity, 2012, 632959.
7. Dani, C., Bonatto, D., Salvador, M., Pereira, M. D., Henriques, J. A., & Eleutherio, E. (2008). Antioxidant protection of resveratrol and cathechin in Saccharomyces cerevisiae. Journal of Agriculture and Food Chemistry, 56, 4268-4272. (Pubitemid 351967974)
8. FAO STAT Database. 2012 (March 27th, 2012).
9. Haliwell, B. (2006). Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life. Plant Physiology, 141, 312-322.
10. Halliwell, B. (2008). Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies? Archives of Biochemistry and Biophysics, 476, 107-112.
11. Herrero, E., Ros, J., Belli, G., & Cabiscol, E. (2007). Redox control and oxidative stress in yeast cells. Biochimica et Biophysica Acta, 1780, 1217-1235.
12. Kumar, B., Koul, S., Khandrika, L., Meacham, R. B., & Koul, H. K. (2008). Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype. Cancer Research, 68, 1777-1785. (Pubitemid 351416563)
13. Lazar, C., Durantel, D., Macovei, A., Zitzmann, N., Zoulim, F., Dwek, R. A., et al. (2007). Treatment of hepatitis B virus-infected cells with alpha-glucosidase inhibitors results in production of virions with altered molecular composition and infectivity. Antiviral Research, 76, 30-37. (Pubitemid 47189679)
14. Nair, S., Xu, C., Shen, G., Hebbar, V., Gopalakrishnan, A., Hu, R., et al. (2006). Pharmacogenomics of phenolic antioxidant butylated hydroxyanisole (BHA) in the small intestine and liver of Nrf2 knockout and C57BL/6J mice. Pharmaceutical Research, 23, 2621-2637. (Pubitemid 44691609)
15. Nassiri-Asl, M., & Hosseinzadeh, H. (2009). Review of the pharmacological effects of Vitis vinifera (grape) and its bioactive compounds. Phytotherapy Research: PTR, 23, 1197-1204.
16. Odat, O., Matta, S., Khalil, H., Kampranis, S. C., Pfau, R., Tsichlis, P. N., et al. (2007). Old yellow enzymes, highly homologous FMN oxidoreductases with modulating roles in oxidative stress and programmed cell death in yeast. Journal of Biological Chemistry, 282, 36010-36023. (Pubitemid 350277144)
17. Patsoukis, N., Papapostolou, L., Zervoudakis, G., Georgiou, C. D., Matsokis, N. A., & Panagopoulos, N. T. (2005). Thiol redox stateand oxidative stress in midbrain and striatum of weaver mutant mice, a genetic model of nigrostriatal dopamine deficiency. Neuroscience Letters, 376, 24-28. (Pubitemid 40202931)
18. Petrova, V. Y., Drescher, D., Kujumdzieva, A. V., & Schmitt, M. J. (2004). Dual targeting of yeast catalase A to peroxisomes and mitochondria. Biochem. J, 380, 393-400. (Pubitemid 38788110)
19. Ramos, S. (2008). Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways. Molecular Nutrition & Food Research, 52, 507-526.
20. Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H. X., et al. (1993). Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature, 362, 59-62. (Pubitemid 23087289)
21. Schewe, T., Sadik, C., Klotz, L.-O., Yoshimoto, T., Kühn, H., & Sies, H. (2001). Polyphenols of cocoa: Inhibition of mammalian 15-lipoxygenase. Biological Chemistry, 382, 1687-1696. (Pubitemid 34100600)
22. Sells, M. A., Chen, M. L., & Acs, G. (1987). Production of hepatitis B virus particles in HepG2 cells transfected with cloned hepatitis B virus DNA. Proceeding of the National Academy of Sciences of the United States of America, 84, 1005-1009. (Pubitemid 17031557)
23. Stehbens, W. E. (2004). Oxidative stress in viral hepatitis and AIDS. Experimental and Molecular Pathology, 77, 121-132. (Pubitemid 39209294)
24. Surh, Y. J. (2003). Cancer chemoprevention with dietary phytochemicals. Nature Reviews Cancer, 3, 768-780.
25. Surh, Y. J. (2008). NF-kappa B and Nrf2 as potential chemopreventive targets of some anti-inflammatory and antioxidative phytonutrients with antiinflamatory and antioxidative activities. Asia Pacific Journal of Clinical Nutrition, 17(Suppl. 1), 269-272.
26. Xia, E. Q., Deng, G. F., Guo, Y. J., & Li, H. B. (2010). Biological activities of polyphenols from grapes. International Journal of Molecular Sciences, 11, 622-646.
27. Zyracka, E., Zadrag, R., Koziol, S., Krzepilko, A., Bartosz, G., & Bilinski, T. (2005). Yeast as a biosensor for antioxidants: Simple growth tests employing a Saccharomyces cerevisiae mutant defective in superoxide dismutase. Acta Biochimica Polonica, 52, 679-684. (Pubitemid 41571714)