Using neurolipidomics to identify phospholipid mediators of synaptic (dys)function in Alzheimer's Disease

Frontiers in Physiology

Volumn 4 JUL, Issue , 2013, Pages

  Bennett, Steffany A L ^a,b,c   Valenzuela, Nicolas ^b,c,d   Xu, Hongbin ^a,b,c   Franko, Bettina ^a,b,c   Fai, Stephen ^c,d   Figeys, Daniel ^a,c  

^a UNIVERSITY OF OTTAWA   (Canada)

^b Neural Regeneration Laboratory   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

^d CARLETON UNIVERSITY   (Canada)

Author keywords

Alzheimer's Disease; Amyloid beta; Lipidomics; Mass spectrometry; Neurolipidomics; Phospholipid; Super resolution nanoscopy; Synaptotoxicity.

Indexed keywords

APOLIPOPROTEIN E; DOCOSAHEXAENOIC ACID; GLYCEROPHOSPHOLIPID; INOSITOL PHOSPHATE; OLEIC ACID; PHOSPHOETHANOLAMINE; PHOSPHOLIPASE; PHOSPHOLIPID; PLASMALOGEN; PRESENILIN 1; SNARE PROTEIN; SYNAPTOTAGMIN I; THROMBOCYTE ACTIVATING FACTOR;

ALZHEIMER DISEASE; ARTICLE; BIOGENESIS; BIOSYNTHESIS; CORRELATION ANALYSIS; DENDRITIC SPINE; DISEASE SEVERITY; ELECTROSPRAY; ENZYME SPECIFICITY; FLUORESCENCE CORRELATION SPECTROSCOPY; HUMAN; HYDROLYSIS; LIPID BILAYER; LIPID RAFT; LIPIDOMICS; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MEMBRANE RECONSTITUTION; MILD COGNITIVE IMPAIRMENT; MOLECULAR DYNAMICS; MORPHOLOGY; NERVOUS SYSTEM INFLAMMATION; NEUROFIBRILLARY TANGLE; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOGENESIS; PHOSPHOLIPID METABOLISM; PROTEIN DATABASE; PROTEIN DEPLETION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STEREOSPECIFICITY; SYNAPSE; SYNAPSE VESICLE; SYNAPTIC MEMBRANE; SYNAPTIC TRANSMISSION; SYNAPTOSOME;

EID: 84884560388     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2013.00168     Document Type: Article

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