Amyloid-β42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 49, 2009, Pages 20936-20941

  Ryan, Scott D ^a   Whitehead, Shawn N ^a   Swayne, Leigh Anne ^a   Moffat, Tia C ^a   Hou, Weimin ^a,b   Ethier, Martin ^a   Bourgeois, André J G ^a   Rashidian, Juliet ^b   Blanchard, Alexandre P ^a   Fraser, Paul E ^c   Park, David S ^b   Figeys, Daniel ^a,b   Bennetta, Steffany A L ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Alzheimer disease; Glycerophosphocholine; Lipidomics

Indexed keywords

1 O HEXADECYL 2 ACETYL SN GLYCERO 3 PHOSPHOCHOLINE; 1 O HEXADECYLGLYCEROPHOSPHOCHOLINE; ACYLALKYLGLYCEROPHOSPHORYLCHOLINE; AMYLOID BETA PROTEIN[1-42]; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 3; CYCLIN DEPENDENT KINASE 7; PALMITIC ACID; PHOSPHORYLCHOLINE; TAU PROTEIN; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); CALPAIN; CASPASE; EPITOPE; ETHER PHOSPHOLIPID; GLYCOGEN SYNTHASE KINASE 3; PEPTIDE FRAGMENT; PHOSPHATIDYLCHOLINE; TAU PROTEIN KINASE; TAU-PROTEIN KINASE;

ALZHEIMER DISEASE; ARTICLE; BRAIN NERVE CELL; CELL DEATH; CELL VIABILITY; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; HUMAN; HYDROLYSIS; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TEMPORAL CORTEX; AGED; ANIMAL; CELL PROTECTION; CELL SURVIVAL; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; IMMUNOLOGY; INTRACELLULAR SPACE; METABOLISM; NERVE CELL; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGICAL STRESS; PROTEIN QUATERNARY STRUCTURE; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

MUS MUSCULUS;

AGED; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CALPAIN; CASPASES; CELL SURVIVAL; CYTOPROTECTION; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; EPITOPES; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INTRACELLULAR SPACE; MICE; MICE, TRANSGENIC; NEURONS; PEPTIDE FRAGMENTS; PHOSPHATIDYLCHOLINES; PHOSPHOLIPID ETHERS; PHOSPHORYLATION; PROTEIN STRUCTURE, QUATERNARY; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TAU PROTEINS;

EID: 73949084240     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0905654106     Document Type: Article

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