Murine cathepsin D deficiency is associated with dysmyelination/myelin disruption and accumulation of cholesteryl esters in the brain

Journal of Neurochemistry

Volumn 112, Issue 1, 2010, Pages 193-203

  Mutka, Aino Liisa ^a   Haapanen, Aleksi ^a   Käkelä, Reijo ^a   Lindfors, Maria ^a   Wright, Ann K ^b   Inkinen, Teija ^a   Hermansson, Martin ^a   Rokka, Anne ^c   Corthals, Garry ^c   Jauhiainen, Matti ^d   Gillingwater, Thomas H ^b   Ikonen, Elina ^a   Tyynelä, Jaana ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF TURKU   (Finland)

^d NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Cathepsin D; Lipidomics; Mouse model; Myelin; Proteomics; Ultrastructure

Indexed keywords

ABC TRANSPORTER A1; APOLIPOPROTEIN E; CATHEPSIN D; CHOLESTEROL ESTER; GLYCOSPHINGOLIPID; MYELIN; MYELIN BASIC PROTEIN; PROTEOLIPID PROTEIN;

ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CATHEPSIN D DEFICIENCY; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; KNOCKOUT MOUSE; LIPID METABOLISM; MOUSE; MYELIN DEFICIENCY; MYELIN SHEATH; NEUROLOGIC DISEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PERINATAL PERIOD; PRIORITY JOURNAL; ULTRASTRUCTURE;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; BRAIN; CATHEPSIN D; CHOLESTEROL ESTERS; DEMYELINATING DISEASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELIN SHEATH;

MURINAE; MUS; OVIS ARIES;

EID: 71649106379     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.06440.x     Document Type: Article

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