Neurolipidomics: Challenges and developments

Frontiers in Bioscience

Volumn 12, Issue 7, 2007, Pages 2601-2615

  Han, Xianlin ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

13C deisotoping; 13C isotopomer; Alzheimer's disease; Apolipoprotein E; Ceramide; Electrospray ionization; Lipidome; Lipidomics; Mass spectrometry; Multi dimensional mass spectrometry; Neurolipidomics; Phospholipids; Plasmalogen; Review; Shotgun lipidomics; Sphingolipids; Sulfatide

Indexed keywords

LIPID;

ANIMAL; BRAIN LEVEL; CHEMISTRY; HUMAN; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; NERVE CELL; NERVOUS SYSTEM; NEUROLOGIC DISEASE; PHYSIOLOGY; REVIEW;

ANIMALS; BRAIN CHEMISTRY; HUMANS; LIPIDS; MASS SPECTROMETRY; NERVOUS SYSTEM; NERVOUS SYSTEM DISEASES; NEURONS;

EID: 35548963066     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/2258     Document Type: Review

References (71)

1. Han X. & R. W. Gross: Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics. J Lipid Res 44, 1071-1079 (2003) (Pubitemid 37279625)
2. Lagarde M., A. Geloen, M. Record, D. Vance & F. Spener: Lipidomics is emerging. Biochim Biophys Acta 1634, 61 (2003) (Pubitemid 37487709)
3. Wenk M. R.: The emerging field of lipidomics. Nat Rev Drug Discov 4, 594-610 (2005) (Pubitemid 40975712)
4. Kitano H.: Systems biology: a brief overview. Science 295, 1662-1664 (2002) (Pubitemid 34202893)
5. Kenchaiah S., J. C. Evans, D. Levy, P. W. Wilson, E. J. Benjamin, M. G. Larson, W. B. Kannel & R. S. Vasan: Obesity and the risk of heart failure. N Engl J Med 347, 305-313 (2002) (Pubitemid 34815352)
6. Han X.: Lipid alterations in the earliest clinical stage of Alzheimer's disease: Implication of the role of lipids in the pathogenesis of Alzheimer's disease. Curr Alz Res 2, 65-77 (2005) (Pubitemid 41389260)
7. Han X. & R. W. Gross: Shotgun lipidomics: Electrospray ionization mass spectrometric analysis and quantitation of the cellular lipidomes directly from crude extracts of biological samples. Mass Spectrom Rev 24, 367-412 (2005) (Pubitemid 40665798)
8. Pulfer M. & R. C. Murphy: Electrospray mass spectrometry of phospholipids. Mass Spectrom Rev 22, 332-364 (2003)
9. Griffiths W. J.: Tandem mass spectrometry in the study of fatty acids, bile acids, and steroids. Mass Spectrom Rev 22, 81-152 (2003)
10. Welti R. & X. Wang: Lipid species profiling: a highthroughput approach to identify lipid compositional changes and determine the function of genes involved in lipid metabolism and signaling. Curr Opin Plant Biol 7, 337-344 (2004) (Pubitemid 38611055)
11. Ivanova P. T., S. B. Milne, J. S. Forrester & H. A. Brown: LIPID arrays: New tools in the understanding of membrane dynamics and lipid signaling. Mol Interv 4, 86-96 (2004) (Pubitemid 38584971)
12. Han X. & R. W. Gross: Shotgun lipidomics: multidimensional mass spectrometric analysis of cellular lipidomes. Expert Rev Proteomics 2, 253-264 (2005) (Pubitemid 40529863)
13. Power C. & K. D. Patel: Neurolipidomics: an inflammatory perspective on fat in the brain. Neurology 63, 608-609 (2004) (Pubitemid 39100811)
14. Piomelli D.: The challenge of brain lipidomics. Prostaglandins Other Lipid Mediat 77, 23-34 (2005) (Pubitemid 41133412)
15. Bazan N. G.: Synaptic lipid signaling: significance of polyunsaturated fatty acids and platelet-activating factor. J Lipid Res 44, 2221-2233 (2003) (Pubitemid 38082480)
16. Yu R. K., E. Bieberich, T. Xia & G. Zeng: Regulation of ganglioside biosynthesis in the nervous system. J Lipid Res 45, 783-793 (2004) (Pubitemid 38552848)
17. Dietschy J. M. & S. D. Turley: Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res 45, 1375-1397 (2004) (Pubitemid 39022664)
18. Van Meer G.: Cellular lipidomics. EMBO J 24, 3159-3165 (2005) (Pubitemid 41348691)
19. Woolsey T. A., J. Hanaway & M. H. Gado: The brain atlas: a visual guide to the human central nervous system. John Wiley & Sons, Inc., Hoboken, New Jersey, (2003)
20. Merrill A. H., Jr., M. C. Sullards, J. C. Allegood, S. Kelly & E. Wang: Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry. Methods 36, 207-224 (2005) (Pubitemid 40726151)
21. Liu S., J. Sjovall & W. J. Griffiths: Neurosteroids in rat brain: extraction, isolation, and analysis by nanoscale liquid chromatography- electrospray mass spectrometry. Anal Chem 75, 5835-5846 (2003) (Pubitemid 37356465)
22. Horrocks L. A. & M. Sharma: Plasmalogens and O-alkyl glycerophospholipids. In: Phospholipids. Eds: Hawthorne J. N., & Ansell G. B., Elsevier Biomedical Press, Amsterdam, The Netherlands, pp. 51-93 (1982)
23. Han X., D. M. Holtzman & D. W. Mckeel, Jr.: Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry. J Neurochem 77, 1168-1180 (2001) (Pubitemid 32467071)
24. Cheng H., S. Guan & X. Han: Abundance of triacylglycerols in ganglia and their depletion in diabetic mice: Implications for the role of altered triacylglycerols in diabetic neuropathy. J Neurochem 97, 1288-1300 (2006) (Pubitemid 43725569)
25. Bosio A., H. Bussow, J. Adam & W. Stoffel: Galactosphingolipids and axono-glial interaction in myelin of the central nervous system. Cell Tissue Res 292, 199-210 (1998) (Pubitemid 28230207)
26. Coetzee T., J. L. Dupree & B. Popko: Demyelination and altered expression of myelinassociated glycoprotein isoforms in the central nervous system of galactolipid-deficient mice. J Neurosci Res 54, 613-622 (1998) (Pubitemid 28546064)
27. Marcus J., S. Honigbaum, S. Shroff, K. Honke, J. Rosenbluth & J. L. Dupree: Sulfatide is essential for the maintenance of CNS myelin and axon structure. Glia 53, 372-381 (2006)
28. Rapport M. M.: Reflections on the great plasmalogen puzzle: effector mediated signal transduction coupled to glyceride structures. Neurochem Res 23, 273-275 (1998) (Pubitemid 128713369)
29. Han X. & R. W. Gross: Plasmenylcholine and phosphatidylcholine membrane bilayers possess distinct conformational motifs. Biochemistry 29, 4992-4996 (1990) (Pubitemid 20183766)
30. Glaser P. E. & R. W. Gross: Plasmenylethanolamine facilitates rapid membrane fusion: a stopped-flow kinetic investigation correlating the propensity of a major plasma membrane constituent to adopt an HII phase with its ability to promote membrane fusion. Biochemistry 33, 5805-5812 (1994) (Pubitemid 24184584)
31. Han X., S. Ramanadham, J. Turk & R. W. Gross: Reconstitution of membrane fusion between pancreatic islet secretory granules and plasma membranes: catalysis by a protein constituent recognized by monoclonal antibodies directed against glyceraldehyde-3-phosphate dehydrogenase. Biochim Biophys Acta 1414, 95-107 (1998) (Pubitemid 28511043)
32. Mahley R. W.: Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240, 622-630 (1988)
33. Weisgraber K. H.: Apolipoprotein E: structurefunction relationships. Adv Protein Chem 45, 249-302 (1994)
34. Han X.: The role of apolipoprotein E in lipid metabolism in the central nervous system. Cell Mol Life Sci 61, 1896-1906 (2004) (Pubitemid 39094797)
35. Han X., H. Cheng, J. D. Fryer, A. M. Fagan & D. M. Holtzman: Novel role for apolipoprotein E in the central nervous system: Modulation of sulfatide content. J Biol Chem 278, 8043-8051 (2003) (Pubitemid 36800543)
36. Lazarow P. B. & H. W. Moser: Disorders of peroxisome biogenesis. In: The metabolic and molecular bases of inherited disease. Eds: Scriver C. R., Beaudet A. L., Sly W. S., & Valle D., McGraw-Hill, New York, pp. 2287-2324 (1995)
37. Switzer J. A. & D. C. Hess: Statins in stroke: prevention, protection and recovery. Expert Rev Neurotherap 6, 195-202 (2006)
38. Shobab L. A., G.-Y. R. Hsiung & H. H. Feldman: Cholesterol in Alzheimer's disease. Lancet Neurol 4, 841-852 (2005) (Pubitemid 41619439)
39. Costantini C., R. M. K. Kolasani & L. Puglielli: Ceramide and cholesterol: possible connections between normal aging of the brain and Alzheimer's disease. Just hypotheses or molecular pathways to be identified? Alz Dement 1, 43-50 (2005) (Pubitemid 43348854)
40. Von Figura K., V. Gieselmann & J. Jaeken: Metachromatic leukodystrophy: Lysosomal disorders. In: The metabolic and molecular bases of inherited diseases. Eds: Sachdev H. S., Beaudet A. L., Sly W. S., & Valle D., McGraw-Hill, New York, pp. 3695-3724 (2001)
41. Han X., D. M. Holtzman, D. W. Mckeel, Jr., J. Kelley & J. C. Morris: Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis. J Neurochem 82, 809-818 (2002)
42. Suzuki K., Y. Suzuki & K. Suzuki: Galactosylceramide lipidosis: Globoid-cell leukodystrophy (Krabbe disease) In: The metabolic and molecular bases of inherited diseases. Eds: Scriver C. R., Beaudet A. L., Sly W. S., & Valle D., McGraw-Hill, New York, pp. 2671-2692 (1995)
43. Moser H. W.: Farber lipogranulomatosis. In: The metabolic and molecular bases of inherited diseases. Eds: Scriver C. R., Beaudet A. L., Sly W. S., & Valle D., McGraw-Hill, New York, pp. 2589-2599 (1995)
44. Mahuran D. J.: Biochemical consequences of mutations causing the GM2 gangliosidoses. Biochim Biophys Acta 1455, 105-138 (1999) (Pubitemid 29435983)
45. Horinouchi K., S. Erlich, D. P. Perl, K. Ferlinz, C. L. Bisgaier, K. Sandhoff, R. J. Desnick, C. L. Stewart & E. H. Schuchman: Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease. Nat Genet 10, 288-293 (1995)
46. Sturley S. L., M. C. Patterson, W. Balch & L. Liscum: The pathophysiology and mechanisms of NP-C disease. Biochim Biophys Acta 1685, 83-87 (2004) (Pubitemid 39311812)
47. Han X., R. A. Gubitosi-Klug, B. J. Collins & R. W. Gross: Alterations in individual molecular species of human platelet phospholipids during thrombin stimulation: electrospray ionization mass spectrometryfacilitated identification of the boundary conditions for the magnitude and selectivity of thrombin-induced platelet phospholipid hydrolysis. Biochemistry 35, 5822-5832 (1996)
48. Han X., K. Yang, H. Cheng, K. N. Fikes & R. W. Gross: Shotgun lipidomics of phosphoethanolaminecontaining lipids in biological samples after one-step in situ derivatization. J Lipid Res 46, 1548-1560 (2005) (Pubitemid 43109820)
49. Han X., K. Yang, J. Yang, H. Cheng & R. W. Gross: Shotgun lipidomics of cardiolipin molecular species in lipid extracts of biological samples. J Lipid Res 47, 864-879 (2006)
50. Han X.: Characterization and direct quantitation of ceramide molecular species from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry. Anal Biochem 302, 199-212 (2002) (Pubitemid 34229724)
51. Guan X. L., X. He, W. Y. Ong, W. K. Yeo, G. Shui & M. R. Wenk: Non-targeted profiling of lipids during kainate-induced neuronal injury. FASEB J 20, 1152-1161 (2006) (Pubitemid 44943911)
52. Guan X. L. & M. R. Wenk: Mass spectrometry-based profiling of phospholipids and sphingolipids in extracts from Saccharomyces cerevisiae. Yeast 23, 465-477 (2006) (Pubitemid 43797110)
53. Han X. & R. W. Gross: Electrospray ionization mass spectroscopic analysis of human erythrocyte plasma membrane phospholipids. Proc Natl Acad Sci U S A 91, 10635-10639 (1994) (Pubitemid 24329053)
54. Han X. & R. W. Gross: Quantitative analysis and molecular species fingerprinting of triacylglyceride molecular species directly from lipid extracts of biological samples by electrospray ionization tandem mass spectrometry. Anal Biochem 295, 88-100 (2001) (Pubitemid 32721744)
55. Han X., J. Yang, H. Cheng, H. Ye & R. W. Gross: Towards fingerprinting cellular lipidomes directly from biological samples by two-dimensional electrospray ionization mass spectrometry. Anal Biochem 330, 317-331 (2004) (Pubitemid 38760108)
56. Ikonomou M. G., A. T. Blades & P. Kebarle: Electrospray-ion spray: a comparison of mechanisms and performance. Anal Chem 63, 1989-1998 (1991)
57. Gaskell S. J.: Electrospray: principles and practice. J Mass Spectrom 32, 677-688 (1997) (Pubitemid 27301433)
58. Han X., K. Yang, J. Yang, K. N. Fikes, H. Cheng & R. W. Gross: Factors influencing the electrospray intrasource separation and selective ionization of glycerophospholipids. J Am Soc Mass Spectrom 17, 264-274 (2006) (Pubitemid 43185252)
59. Han X., H. Cheng, D. J. Mancuso & R. W. Gross: Caloric restriction results in phospholipid depletion, membrane remodeling and triacylglycerol accumulation in murine myocardium. Biochemistry 43, 15584-15594 (2004) (Pubitemid 39647484)
60. Schwudke D., J. Oegema, L. Burton, E. Entchev, J. T. Hannich, C. S. Ejsing, T. Kurzchalia & A. Shevchenko: Lipid profiling by multiple precursor and neutral loss scanning driven by the data-dependent acquisition. Anal Chem 78, 585-595 (2006) (Pubitemid 43100393)
61. Hermansson M., A. Uphoff, R. Kakela & P. Somerharju: Automated quantitative analysis of complex lipidomes by liquid chromatography/mass spectrometry. Anal Chem 77, 2166-2175 (2005) (Pubitemid 40463834)
62. Liebisch G., W. Drobnik, M. Reil, B. Trumbach, R. Arnecke, B. Olgemoller, A. Roscher & G. Schmitz: Quantitative measurement of different ceramide species from crude cellular extracts by electrospray ionization tandem mass spectrometry (ESI-MS/MS) J Lipid Res 40, 1539-1546 (1999) (Pubitemid 29379996)
63. Brugger B., G. Erben, R. Sandhoff, F. T. Wieland & W. D. Lehmann: Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry. Proc Natl Acad Sci U S A 94, 2339-2344 (1997) (Pubitemid 27136876)
64. Ekroos K. & A. Shevchenko: Simple two-point calibration of hybrid quadrupole time-of-flight instruments using a synthetic lipid standard. Rapid Commun Mass Spectrom 16, 1254-1255 (2002) (Pubitemid 34619590)
65. Koivusalo M., P. Haimi, L. Heikinheimo, R. Kostiainen & P. Somerharju: Quantitative determination of phospholipid compositions by ESI-MS: effects of acyl chain length, unsaturation, and lipid concentration on instrument response. J Lipid Res 42, 663-672 (2001) (Pubitemid 32367010)
66. Sparagna G. C., C. A. Johnson, S. A. Mccune, R. L. Moore & R. C. Murphy: Quantitation of cardiolipin molecular species in spontaneously hypertensive heart failure rats using electrospray ionization mass spectrometry. J Lipid Res 46, 1196-1204 (2005) (Pubitemid 43109834)
67. Newberry E. P., Y. Xie, S. Kennedy, X. Han, K. K. Buhman, J. Luo, R. W. Gross & N. O. Davidson: Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene. J Biol Chem 278, 51664-51672 (2003) (Pubitemid 38020412)
68. Su X., X. Han, J. Yang, D. J. Mancuso, J. Chen, P. E. Bickel & R. W. Gross: Sequential ordered fatty acid a oxidation and?9 desaturation are major determinants of lipid storage and utilization in differentiating adipocytes. Biochemistry 43, 5033-5044 (2004) (Pubitemid 38544457)
69. Cheng H., J. Xu, D. W. Mckeel, Jr. & X. Han: Specificity and potential mechanism of sulfatide deficiency in Alzheimer's disease: An electrospray ionization mass spectrometric study. Cell Mol Biol 49, 809-818 (2003)
70. Haltia M.: The neuronal ceroid-lipofuscinoses. J Neuropathol Exp Neurol 62, 1-13 (2003) (Pubitemid 36068888)
71. Hermansson M., R. Kakela, M. Berghall, A. E. Lehesjoki, P. Somerharju & U. Lahtinen: Mass spectrometric analysis reveals changes in phospholipid, neutral sphingolipid and sulfatide molecular species in progressive epilepsy with mental retardation, EPMR, brain: a case study. J Neurochem 95, 609-617 (2005) (Pubitemid 41567154)