Dementia and Alzheimer's disease: A new direction. the 2010 Jay L. Foster Memorial Lecture

Alzheimer's and Dementia

Volumn 7, Issue 5, 2011, Pages 540-550

  Kuller, Lewis H ^a   Lopez, Oscar L ^b  

^a UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Amyloid; Dementia; Epidemiology; Hypertension

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; ANTIHYPERTENSIVE AGENT; ANTIINFLAMMATORY AGENT; APOLIPOPROTEIN E4; CHOLESTEROL; DOCOSAHEXAENOIC ACID; GLUCOSE; PREALBUMIN;

AGING; ALZHEIMER DISEASE; ANTIHYPERTENSIVE THERAPY; ATHEROSCLEROSIS; BLOOD BRAIN BARRIER; BRAIN METABOLISM; CEREBROSPINAL FLUID ANALYSIS; CEREBROVASCULAR DISEASE; CHOLESTEROL METABOLISM; DEMENTIA; ENCEPHALITIS; GLUCOSE METABOLISM; HEART ATRIUM FIBRILLATION; HUMAN; HYPERTENSION; IN VIVO STUDY; NEUROFIBRILLARY TANGLE; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; REVIEW; RISK FACTOR;

AGED; ALZHEIMER DISEASE; DEMENTIA; DIAGNOSTIC IMAGING; EARLY DIAGNOSIS; HUMANS; RISK FACTORS;

EID: 80052310115     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2011.05.901     Document Type: Review

References (144)

1. A.F. Jorm, and D. Jolly The incidence of dementia: a meta-analysis Neurology 51 1998 728 733 (Pubitemid 28449250)
2. E.H. Corder, A.M. Saunders, W.J. Strittmatter, D.E. Schmechel, P.C. Gaskell, and G.W. Small Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families Science 261 1993 921 923 (Pubitemid 23275809)
3. K. Herrup Re-imagining Alzheimer's disease: an age-based hypothesis J Neurosci 30 2010 16755 16762
4. C. Ballard, S. Gauthier, A. Corbett, C. Brayne, D. Aarsland, and E. Jones Alzheimer's disease Lancet 377 2011 1019 1031
5. H.W. Querfurth, and F.M. LaFerla Alzheimer's disease N Engl J Med 362 2010 329 344
6. D.M. Walsh, and D.J. Selkoe A beta oligomers: a decade of discovery J Neurochem 101 2007 1172 1184
7. A. Goate, M.C. Chartier-Harlin, M. Mullan, J. Brown, F. Crawford, and L. Fidani Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease Nature 349 1991 704 706 (Pubitemid 21912142)
8. D.J. Selkoe Alzheimer's disease: genes, proteins, and therapy Physiol Rev 81 2001 741 766 (Pubitemid 32267077)
9. R.E. Tanzi, and L. Bertram Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective Cell 120 2005 545 555 (Pubitemid 40269768)
10. D.M. Holtzman In vivo effects of ApoE and clusterin on amyloid-β metabolism and neuropathology J Mol Neurosci 23 2004 247 254
11. A. Sagare, R. Deane, R.D. Bell, B. Jonson, K. Hamm, and R. Pendu Clearance of amyloid-β by circulating lipoprotein receptors Nat Med 13 2007 1029 1031 (Pubitemid 47517512)
12. J. Saxton, O.L. Lopez, G.R. Ratcliff, C. Dulberg, L.P. Fried, and M.C. Carlson Preclinical Alzheimer disease. Neuropsychological test performance 1.5 to 8 years prior to onset Neurology 63 2004 2341 2347 (Pubitemid 40024347)
13. R.S. Wilson, S.E. Leurgans, P.A. Boyle, and D.A. Bennett Cognitive decline in prodromal Alzheimer disease and mild cognitive impairment Arch Neurol 68 2011 351 356
14. C. DeCarli, J. Massaro, D. Harvey, J. Hald, M. Tullberg, and R. Au Measures of brain morphology and infarction in the Framingham heart study: establishing what is normal Neurobiol Aging 26 2005 491 510 (Pubitemid 40093933)
15. M.M. Breteler, J.C. van Sweiten, M.L. Bots, D.E. Grobee, J.J. Claus, and J.H. van den Hout Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study Neurology 44 1994 1246 1252 (Pubitemid 24232223)
16. L.H. Kuller, O.L. Lopez, A. Newman, N.J. Beauchamp, G. Burke, and C. Dulberg Risk factors for dementia in the Cardiovascular Health Cognition Study Neuroepidemiology 22 2003 13 22 (Pubitemid 36131969)
17. D.C. Alsop, and J.A. Detre Multisection cerebral blood flow MR imaging with continuous arterial spin labeling Radiology 208 1998 410 416 (Pubitemid 28373748)
18. S. Gao, H.C. Hendrie, K.S. Hall, and S. Hui The relationship between age, sex, and the incidence of dementia and Alzheimer disease: a meta-analysis Arch Gen Psychiatry 55 1998 809 815 (Pubitemid 28413043)
19. L. Fratiglioni, L.J. Launer, K. Andersen, M.M. Breteler, J.R. Copeland, and J.F. Dartiques Neurologic Diseases in the Elderly Research Group. Incidence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts Neurology 54 2000 S10 S15 (Pubitemid 30390599)
20. K. Ritchie, I. Carriere, C.W. Ritchie, C. Berr, S. Artero, and M.L. Ancelin Designing prevention programmes to reduce incidence of dementia: prospective cohort study of modifiable risk factors BMJ 341 2010 c3885 DOI: 10.1136/bmj.c3885
21. C. Purnell, S. Gao, C.M. Callahan, and H.C. Hendrie Cardiovascular risk factors and incident Alzheimer disease: a systematic review of the literature Alzheimer Dis Assoc Disord 23 2009 1 10
22. J. Zaccai, P. Ince, and C. Brayne Population-based neuropathological studies of dementia: design, methods and areas of investigation - a systematic review BMC Neurol 6 2006 2
23. M.M. Corrada, R. Brookmeyer, A. Paganini-Hill, D. Berlau, and C.H. Kawas Dementia incidence continues to increase with age in the oldest old: the 90+ Study Ann Neurol 67 2010 114 121
24. O.T. Carmichael, L.H. Kuller, O.L. Lopez, P.M. Thompson, R.A. Dutton, and A. Lu Cerebral ventricular changes associated with transitions between normal cognitive function, mild cognitive impairment, and dementia Alzheimer Dis Assoc Disord 21 2007 14 24 (Pubitemid 46398951)
25. L.H. Kuller, A.M. Arnold, W.T. Longstreth Jr. , T.A. Manolio, D.H. O'Leary, and G.L. Burke White matter grade and ventricular volume on brain MRI as markers of longevity in the Cardiovascular Health Study Neurobiol Aging 28 2007 1307 1315 (Pubitemid 47081226)
26. G. Chetelat, B. Desgranges, V. de la Sayette, F. Viader, F. Eustache, and J.C. Baron Mild cognitive impairment. Can FDG-PET predict who is to rapidly convert to Alzheimer's disease? Neurology 60 2003 1374 1377 (Pubitemid 36461002)
27. A. Convit, J. de Sasis, M.J. de Leon, C.Y. Tarshish, S. De Santi, and H. Rusinek Atrophy of the medial occipitotemporal, inferior, and middle temporal gyri in non-demented elderly predict decline to Alzheimer's disease Neurobiol Aging 21 2000 19 26 (Pubitemid 30224781)
28. D. Holland, J.B. Brewer, D.J. Hagler, C. Fennema-Notestine, and A.M. Dale Alzheimer's Disease Neuroimaging Initiative. Subregional neuroanatomical change as a biomarker for Alzheimer's disease Proc Natl Acad Sci USA 106 2009 20954 20959
29. L.H. Kuller, O.L. Lopez, W.J. Jagust, J.T. Becker, S.T. DeKosky, and C. Lyketsos Determinants of vascular dementia in the Cardiovascular Health Cognition Study Neurology 64 2005 1548 1552 (Pubitemid 40617690)
30. J.A. Schneider, Z. Arvanitakis, W. Bang, and D.A. Bennett Mixed brain pathologies account for most dementia cases in community-dwelling older persons Neurology 69 2007 2197 2204 (Pubitemid 350294674)
31. T. Polvikoski, R. Sulkava, L. Myllykangas, I.L. Notkola, L. Niinisto, and A. Verkkoniemi Prevalence of Alzheimer's disease in very elderly people: a prospective neuropathological study Neurology 56 2001 1690 1696 (Pubitemid 32574568)
32. G. McKhann, D. Drachman, M. Folstein, R. Katzman, D. Price, and E.M. Stadlan Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group Neurology 34 1984 939 944
33. J.C. Morris, A. Heyman, R.C. Mohs, J.P. Hughes, G. van Belle, and G. Fillenbaum The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I: clinical and neuropsychological assessment of Alzheimer's disease Neurology 39 1989 1159 1165 (Pubitemid 19239715)
34. Z.S. Khachaturian Diagnosis of Alzheimer's disease: two decades of progress Alzheimer Dement 1 2005 93 98 (Pubitemid 43348827)
35. M. Prince, C.P. Ferri, D. Acosta, E. Albanese, R. Arizaga, M. Dewey, and S.I. Gavrilova The protocols for the 10/66 dementia research group population-based research programme BMC Public Health 7 2007 165 Doi: 10.1186/1471-2458-7-165 (Pubitemid 47376595)
36. L.J. Rodriguez, C.P. Ferri, D. Acosta, M. Guerra, Y. Huang, and K.S. Jacob Prevalence of dementia in Latin America, India, and China: a population-based cross-sectional survey Lancet 372 2008 464 474
37. M. Prince, D. Acosta, H. Chiu, M. Scazufca, M. Varghese 10/66 Dementia Research Group Dementia diagnosis in developing countries: a cross-cultural validation study Lancet 361 2003 909 917 (Pubitemid 36332106)
38. M. Storandt, and J.C. Morris Ascertainment bias in the clinical diagnosis of Alzheimer disease Arch Neurol 67 2010 1364 1369
39. R.S. Wilson, D.R. Weir, S.E. Leurgans, D.A. Evans, L.E. Hebert, K.M. Langa, B.L. Plassman, B.J. Small, and D.A. Bennett Sources of variability in estimates of the prevalence of Alzheimer's disease in the United States Alzheimers Dement 7 2011 74 79
40. W.A. Rocca, R.C. Petersen, D.S. Knopman, L.E. Hebert, D.A. Evans, and K.S. Hall Trends in the incidence and prevalence of Alzheimer's disease, dementia, and cognitive impairment in the United States Alzheimers Dement 7 2011 80 93
41. C.R. Jack, R.C. Petersen, Y.C. Xu, P.C. O'Brien, G.E. Smith, and R.J. Ivnik Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment Neurology 52 1999 1397 1403 (Pubitemid 29190530)
42. R.C. Petersen Mild cognitive impairment as a diagnostic entity J Intern Med 256 2006 183 194
43. V. Chandra, M. Ganguli, R. Pandav, J. Johnston, S. Belle, and S.T. DeKosky Prevalence of Alzheimer's disease and other dementias in rural India: the Indo-US study Neurology 51 1998 1000 1008 (Pubitemid 28473391)
44. H.C. Hendrie, A. Ogunniyi, K.S. Hall, O. Baiyewu, F.W. Unverzagt, and O. Gureje Incidence of dementia and Alzheimer disease in 2 communities. Yoruba residing in Ibadan, Nigeria, and African Americans residing in Indianapolis, Indiana JAMA 285 2001 739 747 (Pubitemid 32167232)
45. B.L. Plassman, J.W. Williams Jr. , J.R. Burke, T. Holsinger, and S. Benjamin Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life Ann Intern Med 153 2010 182 193
46. J. Chen, and J. Schwartz Neurobehavioral effects of ambient air pollution on cognitive performance in US adults Neurotoxicology 30 2009 231 239
47. P. Hall, H.O. Adami, D. Trichopaulos, N.L. Pedersen, P. Lagiou, and A. Ekbom Effect of low doses of ionizing radiation in infancy on cognitive function in adulthood: Swedish population based cohort study BMJ 328 2004 19
48. P. Hollingworth, D. Harold, R. Sims, A. Gerrish, J.C. Lambert, and M.M. Carrasquillo Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease Nat Genet 43 2011 429 435
49. L.J. Launer, G.W. Ross, H. Petrovitch, K. Masaki, D. Foley, and L.R. White Midlife blood pressure and dementia: the Honolulu-Asia Aging Study Neurobiol Aging 21 2000 49 55 (Pubitemid 30224785)
50. M. Rusanen, M. Kivipelto, C.P. Quesenberry Jr. , J. Zhou, and R.A. Whitmer Heavy smoking in midlife and long-term risk of Alzheimer disease and vascular dementia Arch Intern Med 171 2011 333 339
51. R. Peila, B.L. Rodriguez, and L.J. Launer Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: the Honolulu-Asia Aging Study Diabetes 51 2002 1256 1262 (Pubitemid 34438377)
52. S. Magnoni, and D.L. Brody New perspectives on amyloid-β dynamics after acute brain injury Arch Neurol 67 2010 1068 1073
53. M. Valenzuela, and P. Sachdev Can cognitive exercise prevent the onset of dementia? Systematic review of randomized clinical trials with longitudinal follow-up Am J Geriatr Psychiatry 17 2009 179 187
54. C.H. Hillman, K.I. Erickson, and A.F. Kramer Be smart, exercise your heart: exercise effects on brain and cognition Nat Rev 9 2008 58 65 (Pubitemid 350295689)
55. Alzheimer's disease prevention: a reality check Lancet Neurol 9 2010 643
56. R.H. Mackey, and L.H. Kuller Blood pressure and cognitive outcome Curr Cardiovasc Risk Rep 4 2010 369 375
57. T. Arendt Synaptic degeneration in Alzheimer's disease Acta Neuropathol 118 2009 167 179
58. D.R. George Overcoming the social death of dementia through language Lancet 376 2010 586 587
59. T.E. Golde, L.S. Schneider, and E.H. Koo Anti-Aβ therapeutics in Alzheimer's disease: the need for a paradigm shift Neuron 69 2011 203 213
60. J.L. Whitwell Longitudinal imaging: change and causality Curr Opin Neurol 21 2008 410 416
61. M.W. Weiner Commentary on "Diagnosis of Alzheimer's disease: two decades of progress." Central role of technology in the treatment and prevention of Alzheimer's disease Alzheimers Dement 1 2005 112 113 (Pubitemid 43348833)
62. Jack CR Jr, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol 20109:119-128.
63. M.S. Forman, J.Q. Trojanowski, and V.M. Lee Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs Nat Med 10 2004 1055 1063 (Pubitemid 39424865)
64. O.C. Okonkwo, M.M. Mielke, R. Griffith, A.R. Moghekar, R.J. O'Brien, and L.M. Shaw Cerebrospinal fluid profiles and prospective course and outcome in patients with amnestic mild cognitive impairment Arch Neurol 68 2011 113 119
65. L. Bertram, B.M. McQueen, K. Mullin, D. Blacker, and R.E. Tanzi Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database Nat Genet 39 2007 17 23 (Pubitemid 46026496)
66. S. Seshadri, A.L. Fitzpatrick, M.A. Ikram, A.L. DeStefano, V. Gudnason, M. Boada, and J.C. Bis Genome-wide analysis of genetic loci associated with Alzheimer disease JAMA 303 2010 1832 1840
67. C.C. Rowe, S. Ng, U. Ackermann, K. Pike, G. Savage, and T.F. Cowie Imaging beta-amyloid burden in aging and dementia Neurology 68 2007 1718 1725 (Pubitemid 46763260)
68. W.E. Klunk, H. Engler, A. Nordberg, Y. Wang, G. Blomgvist, and D.P. Holt Imaging brain amyloid in Alzheimer's disease with Pittsburgh compound-B Ann Neurol 55 2004 306 319 (Pubitemid 38269583)
69. P. Edison, H.A. Archer, R. Hinz, A. Hammers, N. Pavese, and Y.F. Tai Amyloid, hypometabolism, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study Neurology 68 2007 501 508
70. K. Blennow Biomarkers in Alzheimer's disease drug development Nat Med 16 2010 1218 1222
71. L.H. Kuller Dementia: is it time for a change in focus? Alzheimers Dement 4 2008 S77 S84
72. Cholesterol Treatment Trialists' (CTT) Collaboration Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials Lancet 376 2010 1670 1681
73. R. Ardehali, K. Nasir, A. Kolandaivelu, M.J. Budoff, and R.S. Blumenthal Screening patients for subclinical atherosclerosis with non-contrast cardiac CT Atherosclerosis 192 2007 235 242 (Pubitemid 46729718)
74. P. Raggi, M.C. Gongora, A. Gopal, T.Q. Callister, M. Budoff, and L. Shaw Coronary artery calcium to predict all-cause mortality in elderly men and women J Am Coll Cardiol 52 2008 17 23 (Pubitemid 351858598)
75. P.G. O'Malley A double take on serial measurement of coronary artery calcification Arch Intern Med 169 2009 2051 2052
76. J.L. Cummings, H.V. Vinters, G.M. Cole, and Z.S. Khachaturian Alzheimer's disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities Neurology 51 1998 S2 17
77. R.J. Bateman, L.Y. Munsell, J.C. Morris, R. Swarm, K.E. Yarasheski, and D.M. Holtzman Human amyloid-β synthesis and clearance rates as measured in cerebrospinal fluid in vivo Nat Med 12 2006 856 861 (Pubitemid 44050079)
78. M. Storandt, M.A. Mintun, D. Head, and J.C. Morris Cognitive decline and brain volume loss as signatures of cerebral amyloid-β peptide deposition identified with Pittsburgh compound B Arch Neurol 66 2009 1476 1481
79. The Australian Imaging Biomarkers and Lifestyle flagship study of ageing 2010 Australian ADNI Toronto, Canada
80. M.D. Ikonomovic, K. Uryu, E.E. Abrahamson, J.R. Ciallella, J.Q. Trojanowski, and V.M. Lee Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury Exp Neurol 190 2004 192 203 (Pubitemid 39335718)
81. S.T. DeKosky, M.D. Ikonomovic, and S. Gandy Traumatic brain injury - football, warfare, and long-term effects N Engl J Med 363 2010 1293 1296
82. P.B. Gorelick, and M. William Feinberg lecture: cognitive vitality and the role of stroke and cardiovascular risk factors Stroke 36 2005 875 879
83. S.E. Vermeer, T. Den Heijer, P.J. Koudstaal, M. Oudkerk, A. Hofman, and M.M. Breteler Rotterdam Scan Study. Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study Stroke 34 2003 392 396 (Pubitemid 36206336)
84. J.A. Salerno, D.G. Murphy, B. Horwitz, C. DeCarli, J.V. Haxby, S.I. Rapoport, and M.B. Schapiro Brain atrophy in hypertension: a volumetric magnetic resonance imaging study Hypertension 20 1992 340 348
85. H. Lewis, D. Beher, N. Cookson, A. Oakley, M. Piggott, and C.M. Morris Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-β(42) peptide in vascular dementia Neuropathol Appl Neurobiol 32 2006 103 118
86. L. Pantoni, and P. Gorelick Advances in vascular cognitive impairment 2010 Stroke 42 2011 291 293
87. S.E. Vermeer, N.D. Prins, T. den Heijer, A. Hofman, P.J. Koudstaal, and M.M. Breteler Silent brain infarcts and the risk of dementia and cognitive decline N Engl J Med 348 2003 1215 1222 (Pubitemid 36359297)
88. O. Carmichael, C. Schwarz, D. Drucker, E. Fletcher, D. Harvey, and L. Beckett Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer Disease Neuroimaging Initiative Arch Neurol 67 2010 1370 1378
89. H. Petrovitch, L.R. White, G. Izmirilian, G.W. Ross, R.J. Havlik, and W. Markesbery Midlife blood pressure and neuritic plaques, neurofibrillary tangles, and brain weight at death: the HAAS Neurobiol Aging 21 2000 57 62 (Pubitemid 30224786)
90. F.E. Matthews, C. Brayne, J. Lowe, I. McKeith, S.B. Wharton, and P. Ince Epidemiological pathology of dementia: attributable-risks at death in the Medical Research Council Cognitive Function and Ageing Study PLoS Med 6 2009 e1000180
91. Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS) Pathological correlates of late-onset dementia in a multicentre community-based population in England and Wales Lancet 357 2001 169 175
92. D.A. Snowden, L.H. Greiner, J.A. Mortimer, K.P. Riley, P.A. Greiner, and W.R. Markesbery Brain infarction and the clinical expression of Alzheimer's disease: the Nun Study JAMA 227 1997 813 817 (Pubitemid 27111317)
93. S. Pendlebury, and P.M. Rothwell Prevalence, incidence, factors associated with pre-stroke and post-stroke dementia: a systematic review and meta-analysis Lancet Neurol 8 2009 1006 1018
94. G.F. Mitchell Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage J Appl Physiol 105 2008 1652 1660
95. L.T. Grinberg, and D.R. Thal Vascular pathology in the aged human brain Acta Neuropathol 119 2010 277 290
96. O. Godin, C. Tzourio, P. Maillard, B. Mazoyer, and C. Dufouil Antihypertensive treatment and change in blood pressure are associated with the progression of white matter lesion volumes. The Three-City (3C)-Dijon Magnetic Resonance Imaging Study Circulation 123 2011 266 273
97. A. Sekita, T. Ninomiya, Y. Tanizaki, Y. Doi, J. Hata, and K. Yonemoto Trends in prevalence of Alzheimer's disease and vascular dementia in a Japanese community: the Hisayama Study Acta Psychiatr Scand 122 2010 319 325
98. C. Ikejima, F. Yasuno, K. Mizukami, M. Sasaki, S. Tanimukai, and T. Asada Prevalence and causes of early-onset dementia in Japan: a population-based study Stroke 40 2009 2709 2714
99. T. Yoshitake, Y. Kiyohara, I. Kato, T. Ohmura, H. Iwamoto, and K. Nakayama Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: the Hisayama Study Neurology 45 1995 1161 1168
100. A. Sekikawa, L.H. Kuller, H. Ueshima, J.E. Park, I. Suh, S.H. Jee, H.K. Lee, and W.H. Pan Coronary heart disease mortality trends in men in the post World War II birth cohorts aged 35-44 in Japan, South Korea and Taiwan compared with the United States Int J Epidemiol 28 1999 1044 1049 (Pubitemid 30021302)
101. Y. Matsui, Y. Tanizaki, H. Arima, K. Yonemoto, Y. Doi, and T. Ninomiya Incidence and survival of dementia in a general population of Japanese elderly: the Hisayama Study J Neurol Neurosurg Psychiatry 80 2009 366 370
102. C.R. Hooijmans, and A.J. Kiliaan Fatty acids, lipid lowering metabolism and Alzheimer pathology Eur J Pharmacol 585 2008 176 196
103. S. Florent-Bechard, C. Malaplate-Armand, V. Koziel, B. Kriem, J.L. Olivier, and T. Pillot Towards a nutritional approach for prevention of Alzheimer's disease: biochemical and cellular aspects J Neurol Sci 262 2007 27 36 (Pubitemid 47398892)
104. F.J. He, and G.A. MacGregor A comprehensive review on salt and health and current experience of worldwide salt reduction programmes J Hum Hypertens 23 2009 363 384
105. L. D'elia, G. Barba, F.P. Cappuccio, and P. Strazzullo Potassium intake, stroke, and cardiovascular disease: a meta-analysis of prospective studies J Am Coll Cardiol 57 2011 1210 1219
106. C.S. Kwok, Y.K. Loke, R. Hale, J.F. Potter, and P.K. Myint Atrial fibrillation and incidence of dementia. A systematic review and meta-analysis Neurology 76 2011 914 922
107. J.A. Luchsinger Type 2 diabetes and related conditions in relation to dementia: an opportunity for prevention? J Alzheimers Dis 20 2010 723 736
108. L.D. Baker, D.J. Cross, S. Minoshima, D. Belongia, G.S. Watson, and S. Craft Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes Arch Neurol 68 2011 51 57
109. M. Martin, C.G. Doti, and M.D. Ledesma Brain cholesterol in normal and pathological aging Biochim Biophys Acta 1801 2010 934 944
110. S. Merlo, S. Spampinato, P.L. Canonico, A. Copani, and M.A. Sortino Alzheimer's disease: brain expression of a metabolic disorder? Trends Endocrinol Metab 21 2010 537 544
111. J.E. Donahue, and C.E. Johanson Apolipoprotein e, amyloid-β, and blood-brain barrier permeability in Alzheimer disease J Neuropathol Exp Neurol 67 2008 261 270 (Pubitemid 351507482)
112. M.P. Marzolo, and G. Bu Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease Semin Cell Dev Biol 20 2009 191 201
113. L.H. Kuller Statins and dementia Curr Atheroscler Rep 9 2007 154 161 (Pubitemid 47376986)
114. G. Di Paolo, and T.W. Kim Linking lipids to Alzheimer's disease: cholesterol and beyond Nat Rev Neurosci 12 2011 284 296
115. F. Zipp, S. Waiczies, O. Aktas, O. Neuhaus, B. Hemmer, and B. Schraven Impact of HMG-CoA reductase inhibition on brain pathology Trends Pharmacol Sci 28 2007 342 349 (Pubitemid 47016681)
116. M. Thambisetty, A. Simmons, L. Velayudhan, A. Hye, J. Campbell, and Y. Zhang Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease Arch Gen Psychiatry 67 2010 739 748
117. E.M. Schrijvers, P.J. Koudstaal, A. Hofman, and M.M. Breteler Plasma clusterin and the risk of Alzheimer disease JAMA 305 2011 1322 1326
118. L. Jones, D. Harold, and J. Williams Genetic evidence for the involvement of lipid lowering metabolism in Alzheimer's disease Biochim Biophys Acta 1801 2010 754 761
119. R. Deane, and B.V. Zlokovic Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease Curr Alzheimer Res 4 2007 191 197 (Pubitemid 46562394)
120. X. Chen, D. Stern, and S.D. Yan Cellular targets of amyloid b peptide D. Dawbarn, S.J. Allen, Neurobiology of Alzheimer's Disease 2007 Oxford University Press, Inc New York, NY 227 243
121. S. Rossner, M. Sastre, K. Bourne, and S.F. Lichtenthaler Transcriptional and translational regulation of BACE1 expression-implications for Alzheimer's disease Prog Neurobiol 79 2006 95 111 (Pubitemid 44247281)
122. T. Wyss-Coray Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat Med 12 2006 1005 1015 (Pubitemid 44353380)
123. B.A. In 't Veld, L.J. Launer, M.M. Breteler, A. Hofman, and B.H. Stricker Pharmacologic agents associated with preventive effect on Alzheimer's disease: a review of the epidemiologic evidence Epidemiol Rev 24 2002 248 268 (Pubitemid 36553843)
124. C. Barnabe, B.J. Martin, and W.A. Ghali Systematic review and meta-analysis: anti-tumor necrosis factor α therapy and cardiovascular events in rheumatoid arthritis Arthrit Care Res 63 2011 522 529
125. I.J. Deary, J. Corely, A.J. Gow, S.E. Harris, L.M. Houlihan, and R.E. Marioni Age-associated cognitive decline Br Med Bull 92 2009 135 152
126. T. Hedeen, and J.D. Gabrieli Insights into the ageing mind: a view from cognitive neuroscience Nat Rev Neurosci 5 2004 87 97
127. T.A. Salthouse When does age-related cognitive decline begin? Neurobiol Aging 30 2009 507 514
128. S. Eshaghian, S. Kaul, and P.K. Shah Cardiac amyloidosis: new insights into diagnosis and management Rev Cardiovasc Med 8 2007 189 199
129. R.H. Falk, and S.W. Dubrey Amyloid heart disease Prog Cardiovasc Dis 52 2010 347 361
130. K.A. Bates, G. Verdile, Q.X. Li, D. Ames, P. Hudson, and C.L. Masters Clearance mechanisms of Alzheimer's amyloid-β peptide: implications for therapeutic design and diagnostic tests Mol Psychiatry 14 2009 469 486
131. A.B. Newman, R.M. Boudreau, B.L. Naydeck, L.F. Fried, and T.B. Harris A physiologic index of comorbidity: relationship to mortality and disability J Gerontol A Biol Sci Med Sci Am 63 2008 603 609
132. L.P. Fried, Q. Xue, A.R. Cappola, L. Ferrucci, P. Chaves, and R. Varadhan Nonlinear multisystem physiologic dysregulation associated with frailty in older women: implications for etiology and treatment J Gerontol A Biol Sci Med Sci Am 64 2010 1049 1057
133. Kuller LH, Chang Y, Becker JT, Lopez OL. Does Alzheimer's disease over 80 years old have a different etiology? Abstract accepted for presentation at: Alzheimer's Association 2011 International Conference on Alzheimer's Disease; July 12-21, 2011; Paris, France.
134. C. Power, B.J. Jefferis, and O. Manor Childhood cognition and risk factors for cardiovascular disease in mid-adulthood: the 1958 British Birth Cohort Study Am J Public Health 100 2010 129 136
135. L.J. Whalley, I.J. Deary, C.L. Appleton, and J.M. Starr Cognitive reserve and the neurobiology of cognitive aging Ageing Res Rev 3 2004 369 382 (Pubitemid 39487896)
136. M. Olive, I. Harten, R. Mitchell, J.K. Beers, K. Djabali, and K. Cao Cardiovascular pathology in Hutchinson-Gilford progeria: correlation with the vascular pathology of aging Arterioscler Thromb Vasc Biol 30 2010 2301 2309
137. F. Sierra, E. Hadley, R. Suzman, and R. Hodes Prospects for life span extension Ann Rev Med 60 2009 457 469
138. S.L. Rea, N. Ventura, and T.E. Johnson Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans PLoS Biol 5 2007 e259
139. A. Larbi, C. Franceschi, R. Mazzatti Solana, A. Wikby, and G. Pawelec Aging of the immune system as a prognostic factor for human longevity Physiology 23 2008 64 74
140. B.J. Willcox, T.A. Donlon, Q. He, R. Chen, J.S. Grove, and K. Yano FOXO3A genotype is strongly associated with human longevity Proc Natl Acad Sci 105 2008 13987 13992
141. T. Minamino Role of cellular senescence in lifestyle-related disease Circ J 74 2010 2527 2533
142. R.J. Coman, R.M. Anderson, S.C. Johnson, E.K. Kastman, K.J. Kosmatka, and T.M. Beasley Caloric restriction delays disease onset and mortality in rhesus monkeys Science 325 2009 201 204
143. C. Zhang, A. Browne, D. Child, and R.E. Tanzi Curcumin decreases amyloid-β peptide levels by attenuating the maturation of amyloid-β precursor protein J Biol Chem 285 2010 28472 28480
144. K. Christensen, G. Doblhammer, R. Rau, and J.W. Vaupel Ageing populations: the challenges ahead Lancet 374 2009 1196 1208